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Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf
FDA Pregnancy Category*** 5-Fluorouracil 3 NA D 6-Mercaptopurine 3 NA D ... acid" OR "4 epidoxorubicin" OR "5 fluorouracil" OR "6 mercaptopurine" OR "6 ...
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NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf
......... 37 5.2 5-Fluorouracil ......Table 18: Pharmacology of 5-fluorouracil in adult humans ......
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Response to 81 FR 42718: Miguel Sogorb 100KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/sogorb-81fr42718.pdf
The model chemicals for testing the performance of our methodology were 5-fluorouracil and retinoic acid as strong embryotoxicants (those able to induce embryotoxicity in vivo ...
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TOWARD VALIDATION OF A HUMAN IN... 1.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf
... classified strong teratogens 5-
fluorouracil, all-trans retinoic acid, busulfan, ... Acetaminophen Pharmaceutical NON 300 5-Fluorouracil Pharmaceutical TER 3 Acycloguanosine ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
... DT 2-Methoxyethanol N/A N/A N/A n.d. DT n.d. DT (6) n.d. NON (11) NON (10) NON (14) n.d. NON 5-Fluorouracil 4.25 N/A N/A D DT DT (1) DT (1,2,4) DT (2,4) DT (2) DT (9; High, 2; ...
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A BIOMARKER BASED DEVELOPMENTAL ... 919KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-sot.pdf
... Saccharin NON NON NON Thiamine NON NON NON 13-cis Retinoic Acid TER TER TER 5-Fluorouracil ... Busulfan Carbamazepine Diphenhydramine 5-Fluorouracil Hydroxyurea Doxylamine Retinol ...
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Predicting human developmental toxicity of pharmaceuticals using... 510KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf
... 0.0909 (Shoda et al., 2007) 5-Fluorouracil 27.3 (Muller et al., 1997) Busulfan ... drugs cytosine arabinoside and 5-fluorouracil often resulted in the most profound ...
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PowerPoint Presentation 925KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/knudsenposter.pdf
... 100 negative NA 0.20 NA 0.58 Chlorendic acid >100 100 negative NA 0.63 NA 1.46 5-Fluorouracil 6.52 1 marginal 1.0, NA 2.46 NA, NA 0.41 discordant Warfarin 7.63 1 marginal 1.0, ...
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DEVELOPMENT OF A TARGETED BIOMARKER... 3.4MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/palmerposter.pdf
... B4: Metoclopramide NON 218 NON 69 NON 13-cis Retinoic Acid TER 0.001 TER 0.002 TER 5-Fluorouracil TER 3.2 TER 3.5 TER All-trans Retinoic Acid TER 0.00004 TER 0.00007 TER Busulfan ...
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Comparison of the Stemina devTOX quickPredict system with other... 2.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf
... DT (6) n.d. NON (11) NON (10) NON (14) 0.78 n.d. NON N/A N/A N/A N/A Rodent 5-Fluorouracil DT D DT (1) DT (1,2,4) DT (2,4) DT (2) DT (9,2,5,6) DT (4,5) 0.71 DT DT 4.25 N/A N/A ...
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Presentation: The EURL ECVAM Toxicokinetics Report and EURL ECVAM... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/0-2-paini-508.pdf
... 504881 4-hydroxy-2-ethyl-2-phenyl glutarimide 1 5,5-diphenylhydantoin 57410 2 2 1 5-fluorouracil 51218 1 1 1 L-glutamate 1676739 R-methadone 76993 1 R-thalidomide 50351 1 ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
... enhanced the antineoplastic action of 5-fluorouracil by threefold. vii Toxicological ... enhanced the antineoplastic action of 5-fluorouracil by threefold. 9.6 Genotoxicity ...
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NTP Monograph: Systematic Review of Occupational Exposure to... 6.2MB
https://ntp.niehs.nih.gov/ntp/ohat/oeccaaho/mgraph/occchemo_final20190300_508.pdf
... agent (e.g., cyclophosphamide versus 5-fluorouracil), or the same type of sample location ... included: ifosfamide (n = 42), 5-fluorouracil (n = 35), methotrexate (n = 27), and ...
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Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf
... In Phase II (Bantle et al., 1994b), caffeine, 5-fluorouracil, saccharin, and sodium ... cyclamate) and positive (caffeine, 5-fluorouracil) performance in previous FETAX ...
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RoC Background Document: Cyclosporin A; Nov. 18-19, 1996 4.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cyclosporin_a1_508.pdf
... In mice treated with CsA and 5-fluorouracil (15 mg/kg/day every other day) for 22 days, ... 6-wk-old 6M(CsA CDFI alone) mice 6M (5-
fluorouracil [15 mglkglday, every other day for22 ...
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Minutes: MPRP; Oct. 1-2, 2012 559KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf
... Anti-metabolites: 5-Fluorouracil First reviewer Dr. Polifka agreed with Dr. Mulvihill's ... She said that in the summary for 5-fluorouracil it would be important to mention that 3 of ...
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OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1018KB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201510_508.pdf
... OR "4 epidoxorubicin"[tiab] OR "5
fluorouracil"[tiab] OR "6 mercaptopurine"[tiab] OR ... acid" OR "4 epidoxorubicin" OR "5 fluorouracil" OR "6 mercaptopurine" OR "6 ...
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OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201812_508.pdf
... OR "4 epidoxorubicin"[tiab] OR "5 fluorouracil"[tiab] OR "6 mercaptopurine"[tiab] OR ... acid" OR "4 epidoxorubicin" OR "5 fluorouracil" OR "6 mercaptopurine" OR "6 ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... Cytotoxic agents, such as 5-fluorouracil, vincristine, and cytosine arabinoside, cause ... 10.0 0.052 19.3 0.1 192.53 0.052 17 5-
Fluorouracil 51-21-8 0.34 0.0026 230.3 1.77 114.5 ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... mustard * HCl 0.0026 0.052 10.0 17 5-Fluorouracil 0.0026 1.77 230.3 149 Chromium VI ... 201.1 212 p-Cresol 0.22 1.91 206.6 17 5-Fluorouracil 0.0026 1.77 230.3 206 Diquat ...
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RoC Background Document: Azacitidine; Nov. 18-19, 1996 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/azacitidine1_508.pdf
... One recent 1993 report on DNA-active developmental toxicants was considered but not selected because the title compound was 5-fluorouracil. TOXLIT: The same strategy that was used ...
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TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox103_508.pdf
... Ionic Liquids, NTP TOX 103 79 27. Goindi S, Arora P, Kumar N, Puri A. Development of novel ionic liquid-based microemulsion formulation for dermal delivery of 5-Fluorouracil. ...
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CERHR Monograph: Hydroxyurea 3.6MB
https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf
... Pediatr Hematol Oncol 16:221-232. Kosazuma T, Kawauchi S, Chou M, Shiota K. 1994. Susceptibility of day- 12.5 and day-13.5 fetal mouse palates cultured in vitro to 5-
fluorouracil ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
... 129.61 0.27 34.99 0.81 105.0 Cobalt II chloride 129.83 0.16 20.77 0.62 80.5 5-Fluorouracil 130.09 0.0026 0.34 1.77 230.3 1,1,1-Trichloroethane 133.4 10.3 1374.0 77.2 10298.5 ...
