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Search suggestions for "51-48-9".

  1. CEBS Data Related to Pubertal phenobarbital study (50-06-6) https://cebs.niehs.nih.gov/cebs/test_article/50-06-6


229 results found for "51-48-9".

  1. TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf

    ... Levels of Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free Thyroxine (G, H) for Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate ...

  2. TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf

    ... Levels of Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free Thyroxine (G, H) in Male Sprague Dawley Rats Administered Perfluorohexanoic Acid, ...

  3. TR-372: 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325... 12.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr372.pdf

    ... Serum triiodothyronine (T3) and thyroxin (T4) concentrations in females receiving 330 ppm or more and T4 concentrations in males receiving 170 ppm or more were significantly lower ...

  4. Presentation: Using Adverse Outcome Pathway Analysis to Identify... 2.2MB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/paul-508.pdf

    Maternal thyroid hormone (free T4) 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 ... Small IQ point ↓ at 7-9 yrs (Haddow et al. 1999). Rat models of maternal T4 ...

  5. TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

    ... Curves for Plasma Free and Total Thyroxine, Triiodothyronine, and Thyroid ... Free and total serum thyroxine (T4) were significantly decreased in the 10 and 25 mg/kg/...

  6. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... Act SE Standard error SEP Special Emphasis Panel SSE Error sum of squares T3 Triiodothyronine T4 Thyroxine TA Transcriptional activation TPA Tetradecanoylphorbol-13 acetate t ...

  7. TR-457: Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats... 18.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr457.pdf

    ... Hypothyroidism, evidenced by decreased serum tri- iodothyronine and thyroxine ... There were no differences in triiodo- thyronine, thyroxine, or thyroid-stimulating hormone ...

  8. TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf

    ... hormone concentrations and decreased thyroxine and triiodothyronine concentrations of ... male and female mice, and thyroxine concentrations were decreased in exposed females. ...

  9. TOX-66: 3,3',4,4'-Tetrachloroazoxybenzene 3.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox066.pdf

    ... A marked decrease in circulating thyroxine concentrations was observed in dosed males and ... Furthermore, a marked decrease in circulating thyroxine concentrations was observed in ...

  10. TOX-65: 3,3',4,4'-Tetrachloroazobenzene 2.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox065.pdf

    ... Sharp decreases in circulating thyroxine concentrations were observed in males and females ... Furthermore, in the 13-week studies, a sharp decrease in circulating thyroxine ...

  11. Abstract for TR-457 80KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr457

    Hypothyroidism, evidenced by decreased serum triiodothyronine and thyroxine concentrations ... There were no differences in triiodothyronine, thyroxine, or thyroid-stimulating hormone ...

  12. TR-285: C.I. Basic Red 9 Monohydrochloride (Pararosaniline) ... 13.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr285.pdf

    ... CURVE FOR RADIOIMMUNOASSAY O F SERUM THYROXINE IN C.I. BASIC RED 9 MONOHYDROCHLORIDE ... BASIC RED 9 MONOHYDROCHLORIDE . . ... . .....231 RADIOIMMUNOASSAY OF SERUM THYROXINE ..... ...

  13. TOX-71: Malachite Green Chloride and Leucomalachite Green (CASRNs... 2.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox071.pdf

    ... On days 4 and 21, the concentration of thyroxine was significantly decreased in male rats ... stimulating hormone (TSH), triiodothyronine (T 3 ), and thyroxine (T 4 ) concentrations. ...

  14. Abstract for TOX-77 69KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox077

    The absolute kidney weight of the 25 mg/kg/day group was also significantly increased compared to the vehicle control group. Free and total serum thyroxine (T4) were significantly ...

  15. TR-516: 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and... 9.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr516.pdf

    ... thyroid hormone concentra- tions; serum thyroxine and triiodothyronine concentra- tions ... for triiodothyronine, thyroxine, and thyroid stimulating hor- mone concentrations. ...

  16. Abstract for TOX-97 125KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox097

    ... In most PFAS, total thyroxine (T4) and free T4 were decreased with no compensatory increase in thyroid stimulating hormone. Histopathologic findings observed in more than one PFAS ...

  17. Abstract for TR-372 66KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr372

    ... Serum triiodothyronine (T3) and thyroxin (T4) concentrations in females receiving 330 ppm or more and T4 concentrations in males receiving 170 ppm or more were significantly lower ...

  18. TR-461: Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1Mice... 21.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr461.pdf

    ... On day 23, transient decreases in ,conbols. The absolute liver weight of male mice in serum triiodothyronine, thyroxine, 'and free thyroxine the 750 ppm group and the' relative ...

  19. TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 22.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr558.pdf

    ... Serum con- centrations of total thyroxine (T ) and free T were 4 4 significantly decreased ... Circulating thyroxine (T ) concentrations 4 were significantly decreased in all dosed ...

  20. Abstract for TR-388 72KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr388

    ... The principal toxic effects of ethylene thiourea involved the thyroid gland. Serum levels of thyroxine (T4) and/or triiodothyronine (T3) were significantly decreased in rats ...

  21. TR-244: Polybrominated Biphenyl Mixture (Firemaster FF-1) in... 8.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr244.pdf

    ... Levels of porphyrin tended to decrease gradually, primarily in mice, following cessation of exposure. The significant decreases in serum thyroxine (T4) and triiodothyronine (T3)in ...

  22. Developmental Neurotoxicity Assessment Using In Vitro Assays 6.8MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2022/20220125-iccvam-cop-hogberg-508.pdf

    ... B B+ 3Dr A A A A 3Dh B C C C+ ZFE B B A B+ t4 Workshop Report* Recommendation on Test ... Marie-Gabrielle Zurich 5,13 and klarcel Leist4,9 Cellular system NEP Neuro- ReNcell Neural ...

  23. Abstract for TR-520 76KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr520

    ... Alterations in serum thyroid hormone levels were evaluated at the 14-, 31- and 53- week interim evaluations. In the 550 and 1,000 ng/kg rats, total thyroxine (T4) and free T4 were ...

  24. Abstract for TR-521 77KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr521

    ... At 14 weeks, there were significant decreases in serum total and free thyroxine (T4) levels and increases in serum total triiodothyronine (T3) and thyroid stimulating hormone ...

  25. Abstract for TR-529 71KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr529

    ... Mean body weights of 3,000 µg/kg core study rats were less than those of the vehicle controls after week 69 of the study. Thyroid hormone concentrations Serum total thyroxine (T4)...

  26. Abstract for TR-525 75KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr525

    ... Alterations in serum thyroid hormone levels were evaluated at the 14-, 31- and 53-week interim evaluations. There were significant decreases in total serum thyroxine (T4) levels at ...

  27. Presentation: Fish Early Life Stage: Developing AOPs to Support... 3.5MB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/villeneuve-508.pdf

    ... MIE(s) 2-mercapto benzothiazole (MBT) Thyroid peroxidase inhibition Reduced T3, T4 synthesis Reduced serum T3, T4 Impaired swim bladder inflation Reduced young of year ...

  28. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... substances (oxazepam, phenobarbital, L-thyroxine, ammonium perchlorate, and ... † ER - Y 407; F and M-PA; **; 2G inhibits T3/T4 synthesis; being tested in vivo by EPA ...

  29. Minutes: BSC TRRS; July 14, 1987 821KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1987/july/87july14trrsmin_508.pdf

    of 2-amino-4-nitrophenol for 6a -le T3 _447N rats, as shown by incre~s_ed ... activity of nitrofurantoin for male T3 -44/N rats as shown by increased incidences ...

  30. TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf

    ... The principal toxic effects of ethylene thiourea involved the thyroid gland. Serum levels of thy- roxine (T4)and/or triiodothyronine (T3)were significantly decreased in rats ...

  31. TR-390: 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82... 12.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr390.pdf

    ... Decreases in serum triiodothyronine (T3) values were observed in exposed females, and ... A n increase in serum T3values was observed in exposed males, and a decrease in mean T4 ...

  32. RR-08: In Vivo Repeat Dose Biological Potency Study of Triphenyl... 1.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr08_508.pdf

    ... Five mL of blood was collected into a tube void of anticoagulant and the serum harvested for clinical chemistry, free thyroxine (T4), and cholinesterase measurements. The following ...

  33. Abstract for TOX-67 70KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox067

    ... hormone concentrations and decreased thyroxine and triiodothyronine concentrations of ... male and female mice, and thyroxine concentrations were decreased in exposed females. ...

  34. Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

    ... to be mutagenic in S=tomyces coelicor T4 bacteriophage, or &12ergillus nidula TCA ... organisms. b) Trichloroacetic Acid 0 T4 bactedephage: The mutagenic potential of ...

  35. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... False negative rate of 4% (1/28) Only L-thyroxine was false negative in the BG1Luc ER TA ... (human breast adenocarcinoma) showed no estrogenic response when exposed to L-thyroxine. ...

  36. TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf

    ... in the concentrations of serum total thyroxine (T 4 ) and free T 4 in all dosed groups. ... Thyroxine (T 4 ) production and secretion are controlled by thyroid stimulating hormone ...

  37. Abstract for TR-558 90KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr558

    ... The hematology results indicate that TCAB induced a microcytic normochromic responsive anemia in male Sprague-Dawley rats. Serum concentrations of total thyroxine (T4) and free T4 ...

  38. RR-09: The CLARITY-BPA Core Study: A Perinatal and Chronic Extended... 5.1MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr09_508.pdf

    ... - Glucose - - - Triglycerides - - - Insulin - - - Leptin - - - Triiodothyronine (T3) - - - Thyroxine (T4) - - - Thyroid-stimulating hormone (TSH) - - ‚­ (0.5) Male hematology, ...

  39. National Institute of Environmental Health Sciences: NIEHS-04 152KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-04

    The effects include increased relative liver weight, decreased total thyroxine concentration, decreased serum bile salt/acid concentration, increased absolute liver weight, ...

  40. National Institute of Environmental Health Sciences: NIEHS-07 155KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-07

    In male rats, the effects included significantly decreased total thyroxine concentration, increased relative liver weight, increased albumin concentration, increased relative left ...

  41. National Institute of Environmental Health Sciences: NIEHS-09 155KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-09

    In male rats, the effects included significantly decreased reticulocyte count, increased thyroid stimulating hormone concentration, and decreased total thyroxine concentration. The ...

  42. National Institute of Environmental Health Sciences: NIEHS-10 155KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-10

    In male rats, the effects included significantly decreased total thyroxine concentration, increased absolute liver weight, increased relative liver weight, and decreased total ...

  43. TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf

    ... In the 550 and 1,000 ng/kg rats, total thyroxine (T 4 ) and free T 4 levels were ... Thyroxine (T 4 ) produc- tion and secretion are controlled by thyroid stimulating hormone ...

  44. Abstract for TR-244 63KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr244

    Levels of porphyrin tended to decrease gradually, primarily in mice, following cessation of exposure. The significant decreases in serum thyroxine (T4) and triiodothyronine (T3) in ...

  45. Abstract for TR-589 89KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr589

    ... Mean body weights of 500 mg/kg males and females and 100 mg/kg females were significantly less than those of the vehicle controls. Dose-related decreases in serum thyroxine (T4) ...

  46. TR-517: Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and... 10.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr517.pdf

    ... Serum concentrations of thyroxine and triiodothyronine were significantly reduced in 1,000 ... Thyroid function, as measured by serum thyroxine levels, did not appear to be altered in ...

  47. TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf

    ... At 14 weeks, there were significant decreases in serum total and free thyroxine (T 4 ) ... Thyroxine (T 4 ) production and secretion is controlled by thyroid stimu- lating hormone ...

  48. TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf

    ... There were significant decreases in total serum thyroxine (T 4 ) levels at the 14-week ... hormone, tri- iodothyronine, and free thyroxine (T 4 ) using a Packard Cobra II ...

  49. TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 7.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr529.pdf

    ... Hormone Concentrations Serum total thyroxine (T 4 ), free T 4 , and total triiodothy- ... total triiodothyronine (T 3 ), and free thyroxine (T 4 ) using a Packard Cobra II gamma ...

  50. Abstract for TOX-66 65KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox066

    ... A marked decrease in circulating thyroxine concentrations was observed in dosed males and ... Furthermore, a marked decrease in circulating thyroxine concentrations was observed in ...

 
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