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TR-583: Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N... 4.7MB
https://ntp.niehs.nih.gov/go/tr583
... of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ... rat liver) and plating on minimal glucose agar plates was carried out as described above. ...
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TR-549: Bromochloroacetic Acid (CAS 5589-96-8) in F344/N Rats... 20.0MB
https://ntp.niehs.nih.gov/go/tr549
... at 37° C. Top agar supplemented with l-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TR-537: Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and... 9.3MB
https://ntp.niehs.nih.gov/go/tr537
... in increased oxidation of glucose, lactate, and pyruvate (Stacpoole et al., 1998). ... of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TR-304: Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1Mice... 14.6MB
https://ntp.niehs.nih.gov/go/tr304
... Efficiency Total Growth (mutants/1()8 (pg/ml) (percent) (percent) clonable cells) DMSO 1% 118 109 16 36 134 98 15 46 112 114 16 33 75 105 13 24 Methylmethane- sulfonate 15 ...
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TR-524: Photocarcinogenesis Study of Glycolic Acid and Salicylic... 17.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr524.pdf
ON THE PHOTOCARCINOGENESIS STUDY OF GLYCOLIC ACID AND SALICYLIC ACID (CAS NOS. 79-14-1 and 69-72-7) IN SKH-1 MICE (SIMULATED SOLAR LIGHT AND TOPICAL APPLICATION STUDY) NATIONAL ...
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TR-368: Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1Mice... 13.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr368.pdf
... the addition of soft agar supple- mented with L-histidine and D-biotin and subsequent plating on minimal glucose agar plates. Incuba- tion was continued for an additional 48 hours. ...
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TR-396: Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats... 14.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr396.pdf
... urine volume, or urine composition (osmolality, sodium, potassium, glucose, and protein). ... specific gravihj,pH' P r o t e i n ,glucose, blood, mtritea, urobilinogen,ketones, ...
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TR-480: Lauric Acid Diethanolamine Condensate (CASRN 120-40-1... 8.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr480.pdf
... at 37E C. Top agar supplemented with L-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TR-598: Perfluorooctanoic Acid (CASRN 335-67-1) Administered... 5.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr598_508.pdf
... conditions; however, the percentage of DMSO, a known free radical scavenger that was ... Clinical chemistry: albumin, urea nitrogen, creatinine, creatine kinase, glucose, total ...
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TR-324: Boric Acid (CASRN 10043-35-3) in B6C3F1Mice (Feed Studies... 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr324.pdf
... Dose SCE/Cell Dose SCE/Cell Medium 8.4 Medium 8.6 DMSO 9.2 DMSO 10.3 Boric acid Boric acid 200 7.7 250 9.7 300 9.6 500 9.7 400 9.7 1,600 9.8 500 10.1 2,000 9.8 Mitomycin C ...
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TR-481: Oleic Acid Diethanolamine Condensate (CASRN 93-83-4)... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr481.pdf
... at 37E C. Top agar supplemented with L-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TOX-19: Formic Acid (CASRN 64-18-6) 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox019.pdf
... Measurements included volume, pH, concentrations of glucose and protein, and activities of ... the testis in PBS containing 10% DMSO. Homogenization-resistant spermatid nuclei ...
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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf
PHOTOCOCARCINOGENESIS STUDY OF RETINOIC ACID AND RETINYL PALMITATE [CAS Nos. 302-79-4 (All-trans-retinoic acid) and 79-81-2 (All-trans-retinyl palmitate)] IN SKH-1 MICE (SIMULATED ...
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TOX-104: (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed... 4.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox104_508.pdf
... (s)-(+)-3-benzylnirvanol (CYP2C19), quinidine (CYP2D6), and ketoconazole (CYP3A4/5). ... concentration, mean cell volume, glucose, total protein, albumin, creatine kinase, ...
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TR-442: p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr442.pdf
... o f the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ... mG RF Power 0.05 End Sweep 0 ppm Sample Temp.-C Solvent DMSO-d6 Spectrum 330N mGof No. ...
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TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf
... at 37E C. Top agar supplemented with L-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TR-247: L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr247.pdf
... The cause of death was not stated. Hypercholesterolemia, an increase in blood glucose, and a decrease in blood urea nitrogen, has been found in male and female Helwan farm rats 15 ...
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TR-335: C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and... 12.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr335.pdf
... This lesion is produced in laboratory animals by several analgesics, such as aspirin, ... the renal papilla in rats administered aspirin has been re- ported (Kincaid-Smith, 1967; ...
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TR-405: C.I. Acid Red 114 (CASRN 6459-94-5) in F344/N Rats (Drinking... 12.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr405.pdf
... Q i n i c o l - urea nitrogen, creatinine, serum glucose, alanine aminotransferase, ... with I-histidine and d-biotin and subsequent plating on minimal glucose agar plates. ...
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GMM-11: Genetically Modified Model Report on Dichloroacetic Acid... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm11_508.pdf
... at 37° C. Top agar supplemented with L-histidine and d-biotin was added, and the contents of the tubes were mixed and poured onto the surfaces of minimal glucose agar plates. ...
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TR-216: 11-Aminoundecanoic Acid (CASRN 2432-99-7) in F344 Rats... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr216.pdf
6 CARCINOGENESIS BIOASSAY OF 11-AMINOUNDECANOIC ACID (CAS NO. 2432-99-7) IN F344 RATS AND B6C3F1 MICE (FEED STUDY) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health ...
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TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox105_508.pdf
... Platelets ↑ Alkaline phosphatase ↑ Glucose ↑ Creatinine ↑ Creatinine Estrous ... comparable on a weight basis to that of aspirin. 51 Analgesic and Antipyretic Activity In ...
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RoC Background Document: Strong Inorganic Acid Mists Containing... 2.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/sulfuric_acid_mists1_2apps_508.pdf
STRONG INORGANIC ACID MISTS CONTAINING SULFURIC ACID FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of ...
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TR-211 Carcinogenesis Studies of C.I. Acid Orange 10 (CASRN 1936... 7.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr211.pdf
... No. 1112} APPENDIX G (3) Nuclear magnetic resonance Instrument: Varian HA-100 Solvent: DMSO-d6:D 2 O (1:2) with internal TSP Assignments: (Refer to Figure 7) a. 6 = 6.97 ppm b.,c. ...
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TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf
... concentration of dimethyl sulfoxide (DMSO) (2.5%) for their experiments, which may have been a factor in the lack of observed response. DMSO is a known scavenger of free radicals ...
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Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB
https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf
Toxicology Program NTP NTP Monograph Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate September 2016 NTP MONOGRAPH ON IMMUNOTOXICITY ...
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TR-412: 4,4'-Diamino-2,2'-Stilbenedisulfonic Acid Disodium Salt... 11.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr412.pdf
... I T - None C h i c d c h m i w y glucose, total protein, albumin, albumin/globulin ratio, ... with I-histidine and d-biotin, and subsequent plating on minimal glucose agar plates. ...
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Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf
... were collected and the concentrations of lactate and glucose levels were measured in each sample. Changes in plasma glucose and liver lactate concentrations in all of the test ...
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TR-175: Lithocholic Acid (CASRN 434-13-9) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr175.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series o o I o No. 175 n 1979 O > o o 6 9 H 3} BIOASSAY OF UTHOCHOLIC ACID FOR POSSIBLE CARCINOGENICITY CAS No. 434-13-9 ...
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Aristolochic Acid/Riddelliine Related Exposures Expert Panel... 335KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/aapanelreportparta_508.pdf
Aristolochic Acid/Riddelliine Related Exposures Expert Panel Report Part A - Peer Review of the Background Document on Aristolochic Acid- Related Exposures: (1) Aristolochic Acid ...
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Draft TR-598: Perfluorooctanoic Acid (CASRN 335-67-1) Administered... 5.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2019/december/tr598draft.pdf
... conditions; however, the percentage of DMSO, a known free radical scavenger that was ... Clinical chemistry: albumin, urea nitrogen, creatinine, creatine kinase, glucose, total ...
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TR-036: Anthranilic Acid (CASRN 118-92-3) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr036.pdf
6 BIOASSAY OF ANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS NO. 118-92-3 NCI-CG-TR-36 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National ...
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NTP Monograph: Identifying Research Needs for Assessing Safe... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/folicacid/final_monograph_508.pdf
... anemia), ethnicity, alcohol consumption, aspirin use, smoking, fatty acid levels, ... diabetes, and measures of impaired glucose or insulin homeostasis or metabolism in adults. ...
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TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf
... et al. 74 was the final concentration of dimethyl sulfoxide (DMSO) (0.04% versus 2.5%, respectively). DMSO is a known scavenger of free radicals and can protect DNA from ...
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TR-220: C.I. Acid Red 14 (CASRN 3567-69-9) in F344/N Rats and... 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr220.pdf
... Consistent with Solvent: DMSO:D 2 O (1:2, v:v) with structure and previous internal sodium 3-trimethyl- spectrum obtained at MRI silyl-propionate-2,2,3,3-d4) (Lot No. A77716). ...
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RoC Profile: Strong Inorganic Acid Mists Containing Sulfuric... 150KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/stronginorganicacidmists.pdf
Strong Inorganic Acid Mists Containing Sulfuric Acid CAS No. 7664-93-9 (Sulfuric acid) Known to be human carcinogens First listed in the Ninth Report on Carcinogens (2000) HO S OH ...
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TR-052: 3-Nitropropionic Acid (CASRN 504-88-1) 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr052.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 52 1978 BIOASSAY OF 3-NITROPROPIONIC ACID FOR POSSIBLE CARCINOGENICITY CAS No. 504-88-1 NCI-CG-TR-52 U.S. ...
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TR-109: 4-Nitroanthranilic Acid (CASRN 619-17-0) 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr109.pdf
09 BIOASSAY OF 4-NITROANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS No. 619-17-0 NCI-CG-TR-109 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National ...
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RoC Profile: Nitrilotriacetic Acid; 15th RoC 2021 135KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrilotriaceticacid.pdf
Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Nitrilotriacetic Acid CAS No. 139-13-9 Reasonably anticipated to be a human carcinogen First listed ...
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RoC Profile: Chlorendic Acid; 15th RoC 2021 124KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorendicacid.pdf
Chlorendic Acid CAS No. 115-28-6 Reasonably anticipated to be a human carcinogen First listed in the Fifth Annual Report on Carcinogens (1989) C OH OH C O O Cl Cl Cl Cl Cl Cl ...
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Aristolochic Acid Related Exposures Expert Panel Report Part... 294KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/aapanelreportpartb_508.pdf
Aristolochic Acid Related Exposures Expert Panel Report Part B - Recommendation for listing status for "aristolochic acids" in the Report on Carcinogens and scientific ...
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Nitrilotriacetic acid (NTA): Target Organs and Levels of Evidence... 62KB
https://ntp.niehs.nih.gov/data/tr/000s/tr006levels
LOE-TR-006 Nitrilotriacetic acid (NTA): Target Organs and Levels of Evidence for TR-006 Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, ...
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Aspirin, phenacetin, and caffeine: Target Organs and Levels of... 57KB
https://ntp.niehs.nih.gov/data/tr/000s/tr067levels
6 Aspirin, phenacetin, and caffeine: Target Organs and Levels of Evidence for TR-067 Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity (CASRN ...
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Nomination Background: Dibromoacetic acid (CASRN: 631-64-1) 266KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dibromoaceticacid_508.pdf
INFORMATION PROFILE FOR NIEHS NOMINATIONS OF CHEMICALS TO THE NATIONAL TOXICOLOGY PROGRAM Date: 6/27/96 Nominator: EPA Phone: 1-3440 Address: NIEHS CHEMICAL IDENTIFICATION Common ...
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Abstract for GMM-11 80KB
https://ntp.niehs.nih.gov/publications/reports/gmm/gmm11
1abs Abstract for GMM-11 Toxicology Studies of Dichloroacetic Acid in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity ...
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Abstract for TR-583 81KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr583
3abs Abstract for TR-583 Toxicology Studies of Bromodichloroacetic Acid in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in ...
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TR-067: a Mixture of Aspirin, Phenacetin, and Caffeine (CASRN... 3.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr067.pdf
No. 67 1978 BIOASSAY OF A MIXTURE OF ASPIRIN, PHENACETIN, AND CAFFEINE FOR POSSIBLE ... Health Service BIOASSAY OF A MIXTURE OF ASPIRIN, PHENACETIN, AND CAFFEINE FOR POSSIBLE ...
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TR-006: Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr006.pdf
Institute CARCINOGENESIS Technical Report Series No. 6 January 1977 BIOASSAYS OF NITRILOTRIACETIC ACID (NTA) AND NITRILOTRIACETIC ACID, TRISODIUM SALT, MONOHYDRATE (Na 3 NTA. H 2 ...
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Response to Request for Data and Information on Zebrafish Embryo... 1.6MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-26605/kanungo-508.pdf
... embryos from toxicities induced by verapamil and ketamine: An in vivo assessment ... embryos from toxicities induced by verapamil and ketamine: An in vivo assessment ...
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Abstract for TR-396 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr396
6abs Abstract for TR-396 Toxicology and Carcinogenesis Studies of Monochloroacetic Acid in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 79-11-8 Chemical Formula: C2H3ClO2 ...
