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48 results found for "52-90-4".

  1. RoC Monograph: Trichloroethylene; January 2015 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/monographs/finaltce_508.pdf

    ... 2.7.5. S-(1,2-dichlorovinyl)-L-cysteine (DCVC), S-(1,2-dichlorovinyl)glutathion... DCVC = S- dichlorovinyl-L-cysteine; DCVG = S-dichlorovinyl-glutathione; ...

  2. TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf

    ...acetyl-S-(2-cyanoethyl)-L-cysteine concentrations as markers of exposure to acrylonitrile. ... Dose-related increases in urinary thiocyanate and N-acetyl-S-(2-cyanoethyl)-L-cysteine ...

  3. TR-497: Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr497.pdf

    ... Catabolism of SGTP results in the formation of N-acetyl-S-(2-hydroxy- propyl)-L-cysteine ... NAHPC=N-acetyl-S-(2-hydroxypropyl)-L-cysteine; SGTCP =1-(S-glutathionyl)-2-cyanopropa...

  4. RoC Profile: 1-Bromopropane; 15th RoC 2021 194KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf

    ... The major metabolite, N-acetyl- S-(n-propyl)-l-cysteine, has been detected in the urine of ... Hanley KW, Petersen MR, Cheever KL, Luo L. 2009. N-acetyl-S-(n-propyl)-l-cysteine in urine ...

  5. Abstract for TR-506 71KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr506

    ...acetyl-S-(2-cyanoethyl)-L-cysteine concentrations as markers of exposure to acrylonitrile. ... Dose-related increases in urinary thiocyanate and N-acetyl-S-(2-cyanoethyl)-L-cysteine ...

  6. RoC Monograph: 1-Bromopropane; September 2013 1.9MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

    ... ion (Br (-) ), N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys) (see Section 2.2 for a ... (N- acetyl-S-(n-propyl)-L-cysteine or AcPrCys) for workers in a Chinese ...

  7. RoC Background Document: 1,2,3-Trichloropropane; Nov. 18-19,... 2.6MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/trichloropropane_508.pdf

    ... N-Acetyl-(3-chloro-2-hydroxypropyl)-L-cysteine 1 ,2,-Dibromo-3 -chloropropane 1 ... Both mice and rats produced the metabolite N-acetyl-(3-chloro-2-hydroxypropyl)-L-cysteine ...

  8. NTP at the SOT; March 6, 2005 308KB

    https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf

    ... Repair, Apoptosis and Lymphoid Progenitor Cell Survival are Dysregulated by N-acetyl-L-cysteine 704 R03 Stokes, William Current Status and Future Considerations for the Development ...

  9. 1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf

    ... EA. 1964. Formation of n-acetyl-s-(2-hydroxypropyl)-l-cysteine from 1-bromopropane in rat. ... (n-propyl)-l-cysteine, the major urinary metabolite of 1-bromopropane in human urine. ...

  10. Epididymis - Sperm Granuloma - Nonneoplastic Lesion Atlas 294KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/epididymis/SpermGranuloma

    ... Sawamoto O, Yamate J, Kuwamura M, Kotani T, Kurisu K. 2003. Development of sperm granulomas in the epididymides of L-cysteine-treated rats. Toxicol Pathol 31:281-289. Abstract: ...

  11. Epididymis - Sperm Granuloma 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/epididymis/spgranuloma/epididymis_sperm_granuloma_508_pdf.pdf

    ...//www.ncbi.nlm.nih.gov/pubmed/10797625 Sawamoto O, Yamate J, Kuwamura M, Kotani T, Kurisu K. 2003. Development of sperm granulomas in the epididymides of L-cysteine-treated rats. ...

  12. RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf

    ... TFE was metabolized to S-(1,1 ,2,2-tetrafluoroethyl)-L-cysteine, in in vitro preparations ... (DCVG), S-(1 ,2-dichlorovinyl)-L-cysteine (DCVC), chlorotrifluoroethylene, ...

  13. RoC Background Document: Trichloroethylene (TCE); Oct. 30-31... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/trichl_tce1997_2apps_508.pdf

    ...orovinyl)-L-cysteine (10) Dekant et al. (1986); Commandeur and Vermeulen (1990); Dekant et al. (1990); all cited by IARC (1995e) N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine (isomer ...

  14. RoC Concept:1-Bromopropane 268KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/1-bp_concdocroc8-30-12_508.pdf

    ... ion [Br (-) ], N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys), and 1-bromopropane in urine, ...yl-S-(n-propyl)-L-cysteine, the major urinary metabolite of 1-bromopropane in human urine. ...

  15. RoC Concept: Trichloroethylene 729KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/tce_revised_concdocroc12-31-13_508.pdf

    ... are S-dichlorovinyl-cysteine (DCVC) and N-acetyl-S-dichlorovinyl-L- cysteine (NAcDCVC). ... (DCVG), S-(1,2- dichlorovinyl)-L-cysteine (DCVC), N-acetyl-1,2- ...

  16. TR-450: Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and... 21.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr450.pdf

    ... Oral administration of the cysteine conjugate [ S-(1,1,2,2-- tetrafluoroethyl)- L-cysteine... acetyl)-S-(1,1,2,2-tetrafluoroethyl)- L-cysteine (Commandeur et al., 1989) from rat ...

  17. TR-500: Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation... 8.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr500.pdf

    ... 2-Naphthol (11) N-Acetyl-S-(1,2-dihydro-1-hydroxy-2-naphthyl)-L-cysteine (12) N-Acetyl-S-(1-naphthyl)-L-cysteine (1-naphthyl mercapturic acid) GSH = Glutathione R 1 = Sulphate ...

  18. Protocol: Methods for preparing the RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/tce_final20140625_508.pdf

    ...-dichlorovinyl)glutathione (DCVG), S-(1,2- dichlorovinyl)-L-cysteine (DCVC), N-acetyl- 1,2-S-(1,2-dichlorovinyl-L-cysteine (NAcDCVC), S-(1,2-dichlorovinyl)thiol (DCVSH/DCVT)] ...

  19. Protocol: Methods for preparing the draft RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/tce_protocol12-31-13_508.pdf

    ...-dichlorovinyl)glutathione (DCVG), S-(1,2- dichlorovinyl)-L-cysteine (DCVC), N-acetyl- 1,2-S-(1,2-dichlorovinyl-L-cysteine (NAcDCVC), S-(1,2-dichlorovinyl)thiol (DCVSH/DCVT)] ...

  20. TOX-47: Methacrylonitrile 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox047.pdf

    ... of N-acetyl-S-(2-hydroxypropyl)-L-cysteine, which was identified in the 11 ... Rats excreted 7% of the 11.5 mg/kg dose as N-acetyl-S-(2-hydroxypropyl)-L-cysteine, ...

  21. NTP Response to Peer Review report: RoC Peer Review; Aug. 12... 226KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2014/august/ntpresponsereporttceoct23_508.pdf

    ... metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2- dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. ...

  22. RoC Profile: Trichloroethylene; 15th RoC 2021 237KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichloroethylene.pdf

    ... eral GSH-conjugation-derived metabolites, two of which (N-acetyl-S- dichlorovinyl-l-cysteine and S-[2,2-dichlorovinyl]glutathione) have been detected in the urine of humans and ...

  23. RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf

    ... et al., 1992), or N-acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine (Nauhaus et al., 1996). ... These metabolites were N-acetyl-S-(2-hydroxy-3-butenyl)-L- cysteine (44% in mouse, 8% in ...

  24. TR-555: 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344... 6.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr555.pdf

    ... was N-acetyl-S-(2,4-dicyanobutane)-L-cysteine (Figure 1). 1,2-Dibromo-2,4-dicyanobuta... (II), N-acetyl-S-(2,4-dicyanobutane)-L-cysteine (III), 14 N-acetyl-S-(2,4-dicyanobutan-...

  25. TR-572: Methyl trans-styryl ketone (CASRN 1896-62-4) in F344... 8.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr572_508.pdf

    ...henylacetyl-L-glycine, N-benzyl-L-glycine and N-acetyl-S-(4-phenyl-2-butanone)-L-cysteine. ... (VI) N-acetyl-S-(4-phenyl-2-butan-one)-L-cysteine (VII) N-acetyl-S-(4-phenyl-2-butan-ol)-...

  26. TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

    ... of the glycine and glutamate residues resulting in pentachlorophenyl-N-acetyl-L-cysteine. ... for the active renal secretion of S-pentachlorophenyl-N- acetyl-L-cysteine by female rats. ...

  27. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ...phthalenyl)-L-cysteine, and the major 49 9/19/02 RoC Background Document for Naphthalene sulfur-containing derivative N-acetyl-S-(1-hydroxy-1,2-dihydro-2-naphthalenyl)-L- cysteine. ...

  28. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf

    ... Alternatively, S-(1,2-dichloro- vinyl)cysteine can be N-acetylated by L-cysteine S-conjugate N-acetyltransferase [EC 2.3.1.80] to produce a mercapturic acid conjugate which is ...

  29. TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB

    https://ntp.niehs.nih.gov/go/tr385

    ... The metabo- lites S -methyl-L-cysteine and S -methylglutathione were negative for the ... 86 42.8 50 41.8 98 53 39.0 91 57 32.8 77 52 90 43.7 49 43.5 100 52 40.5 93 55 32.7 75 50 ...

  30. RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB

    https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf

    ... Rocha OGF, Frézard F, Demicheli C. 2006. Kinetics of antimony(V) reduction by L-cysteine. ... generation high-resolution ICP-MS combined with prereduction of Sb(V) with L-cysteine. ...

  31. TOX-1: Hexachloro-1,3-butadiene(CASRN 87-68-3) 415KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox001.pdf

    ... New York: Van Nos- trand Reinhold Co., p. 436. 4. Derr, R.F.; Schultze, M.O. (1963) The metabo- lism of 35 S(1,12-dichlorovinyl)-L-cysteine in the rat. Biochem. Pharmacol. ...

  32. Background Document: RoC: Styrene; 2010 4.3MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf

    ... form both R- and S- diastereoisomers of specific mercapturic acids, N-acetyl-S-(1-phenyl-2-hydroxyethyl)-L- cysteine (M1) and N-acetyl-S-(2-phenyl-2-hydroxyethyl)-L-cysteine (M2). ...

  33. Minutes: BSC; Sept. 23, 1982 738KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1982/september/bsc_mins19820923_508.pdf

    ... e s t e r o l 6) C h o l e s t e r o l 56, 6 5-epoxi de 7 ) 8 ) C o l c h i c i n e L-Cysteine RECOMMENDATION ( P r i o r i t y ) REMARKS Salmonel 1 a assay Mouse lymphoma Concur ...

  34. TR-582: Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr582_508.pdf

    ... metabolized to the cysteine conjugate, S-(1,2-dichlorovinyl)-L-cysteine (DCVC) 48; 146 . ... metabolites of S-(1, 2-dichlorovinyl)-L-cysteine and S-(1, 2, 2-trichlorovinyl)-L-cystei...

  35. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... 273 Bromobenzene 3.46 17.2 2700.7 274 L-Cysteine 3.56 5.45 660.4 275 Nitrilotriacetic ... 123 35 Isoniazid 7.49 4.74 650.1 274 L-Cysteine 3.56 5.45 660.4 12 Puromycin 0.00033 ...

  36. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... 6.45 273 Bromobenzene 108-86-1 543.29 3.46 2700.7 17.2 NA NA 157.02 17.2 274 L- Cysteine 52-90-4 431.37 3.56 NA NA 660.4 5.45 121.17 5.45 275 Nitrilotriacetic acid 139-13-9 ...

  37. RoC Monograph: Antimony Trioxide; October 2018 2.6MB

    https://ntp.niehs.nih.gov/ntp/roc/monographs/antimony_final20181019_508.pdf

    ... antimoniate to antimony(III) by L-cysteine in vitro indicate a peak rate constant ... Rocha OGF, Frézard F, Demicheli C. 2006. Kinetics of antimony(V) reduction by L-cysteine. ...

  38. Background Document: RoC: Captafol; 2010 1.1MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf

    ... in diet at 1,500 ppm or captafol + L-cysteine in drinking water at 1,500 ppm weeks ... foci in a medium-term bioassay, and protection by L- cysteine of the enhancement in rats. ...

  39. Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf

    ... antimoniate to antimony(III) by L-cysteine in vitro indicate a peak rate constant ... Rocha OGF, Frézard F, Demicheli C. 2006. Kinetics of antimony(V) reduction by L-cysteine. ...

  40. Antimony Draft Monograph; Nov. 29, 2017 3.5MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph.pdf

    ... antimoniate to antimony(III) by L- cysteine in vitro indicate a peak rate constant ... Rocha OGF, Frézard F, Demicheli C. 2006. Kinetics of antimony(V) reduction by L-cysteine. ...

  41. GMM-07: Genetically Modified Model Report on Allyl Bromide (Dermal... 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm07_508.pdf

    ... Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Sulfoxides as urinary metabolites of S-allyl-l-cysteine in Zeiger, E. (1983). Salmonella mutagenicity test results rats: ...

  42. TR-536: bis(2-Chloroethoxy)methane (CASRN 111-91-1) in Male F344... 9.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr536.pdf

    ... methylthio)lactic acid as major human biotrans- formation products of S-carboxymethyl-L-cysteine. Drug Metab. Dispos. 19, 222-226. Hollander, M., and Wolfe, D.A. (1973). ...

  43. Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf

    ... The major urinary metabolites were N- acetyl-S-(3-chloro-2-hydroxypropyl)-L-cysteine (36% of the administered dose) and 3- MPCD (4%). These metabolites are consistent with epoxide ...

  44. TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB

    https://ntp.niehs.nih.gov/go/tr575

    ... N-Acetyl-S-(1- carbamoyl-2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic ...

  45. Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf

    ... mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2- dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. ...

  46. TR-498: p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1Mice... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr498.pdf

    ... Louis, MO). p-Nitrobenzylmercapturic acid was synthesized from N-acetyl-L-cysteine and p-nitrobenzyl bromide. Radiochemical purity of the [ 14 C]-p-nitrotoluene was determined to ...

  47. RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf

    ... J Environ Sci Health Part A Tox Hazard Subst Environ Eng 36:501-508. 374. Yusof, M., D. Yildiz, and N. Ercal. 1999. N-acetyl-L-cysteine protects against delta-aminolevulinic ...

  48. TR-460: Effect of Dietary Restriction on Toxicology and Carcinogenesis... 30.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr460.pdf

    i~AT~IONAL TOX~ICOLOGY II~OG~ AM Teeh~eall Report Series No. 46~ ~ s£~VIc~8, o % ~.~'~" '~,~V~ ~ " E F F E C T OF ~IIETARY I~EST~...ICT~I©H ©H T©Z~IC©L©GY AND ...

 
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