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Biopsy-Derived Human Intestine-Chips to Investigate Region-Specific... 8.1MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_04_Ville Kujala_GutModels2023_508.pdf
... Indomethacin Toxicity Indomethacin Toxicity ADME/TOX: DUODENUM INTESTINE-CHIP The Duodenum Intestine-Chip was treated with indomethacin, a known gastrointestinal (GI) toxicant, to ...
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Stomach, Forestomach, Epithelium - Degeneration - Nonneoplastic... 292KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-forestomach/Epithelium-Degeneration
... Abstract: http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0773.1980.tb01567.x/abstract Satoh H, Inada I, Hirata T, Mak Y. 1970. Indomethacin produces gastric antral ulcers in the ...
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Stomach, Forestomach, Epithelium - Degeneration 260KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/alimentary/forestomach/epdegen/stomach-forestomach-epithelium-degeneration-pdf_508.pdf
.../j.1600-0773.1980.tb01567.x/abstract Satoh H, Inada I, Hirata T, Mak Y. 1970. Indomethacin produces gastric antral ulcers in the refed rat. Gastroenterology 81:719-725. ...
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Presentation: Predictive Power of PBPK Modeling and In Silico... 5.0MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/3-1-fraczkiewicz-508.pdf
... Reported F% values 2 varied from 3% (fluphenazine) to 99% (diazepam, galantamine, glimepiride, indomethacin, and tamsulosin), with an average of 60% . F% was predicted by ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf
... An additional indomethacin-sensitive action of furosemide is to decrease the left atrial ... E2 but not I2 restores furo- semide response in indomethacin-treated rats. Am. ...
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TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf
... formation of prostaglandins, effects which were reduced by pretreatment with indomethacin. ... of prostaglandin synthe- sis (indomethacin or aspirin) reduced thelaxative effect ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... D-penicillamine, sodium valproate, and indomethacin were investigated by using both the ... 0.15 315.3 1.22 NA NA 258.44 1.22 60 Indomethacin 53-86-1 57.25 0.16 12.2 0.034 19.0 ...
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TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf
... a 48% reduction in prostaglandin synthesis compared with a 63% reduction by indomethacin. ... and Duraccio, M. R. (1983). Effect of indomethacin on aloin and 1,8 dioxianthraquinone-in...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 205 Versalide 0.15 1.22 315.3 60 Indomethacin 0.16 0.034 12.2 61 p,p'-DDT 0.16 0.32 ... mustard * HCl 0.0026 0.052 10.0 60 Indomethacin 0.16 0.034 12.2 14 Mitomycin C 0.00084 ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
... antigen (MB) 1.0 mg cortisol 1.0 mg indomethacin Group 1: 2.5 mg NhS2 i.m. injection ... Group 4: 2.5 mg NhS2 + 1.0 mg indomethacin i.m. injection Group 5: 2.5 mg NhS2 ...
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TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox105_508.pdf
... and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. ... and c-myc expression in primary rat hepatocyte cultures is modulated by indomethacin. ...
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Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf
... pneumothoraxes, and patent ductus arteriosus (which closed after indomethacin was given). ... pneumothoraces, and patent ductus arteriosus; this closed after indomethacin was given. ...
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TR-367: Phenylbutazone (CASRN 50-33-9) in F344/N Rats and B6C3F1Mice... 10.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr367.pdf
... phenylbutazone, indomethacin, and paraceta- mol, all lower medullary blood flow. ... the acute effects of phenyl- butazone, oxyphenbutazone and indomethacin on the rat kidney. ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
... Indomethacin, N-phenylthiourea, and bis(tributyltin)oxide were underclassified by 56%, ... 9 4 5 Thiosemicarbazide 12 9 Indomethacin 13 4 5 Class 2 (25 - 200 mg/kg) ...
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TOX-21: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) 21.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox021.pdf
... 222-226, 692-693. Arnold, L., Collins, C., and Starmer, G.A. (1976) Further studies of the acute effects of phenylbutazone, oxyphenbutaxzone, and indomethacin on the rat kidney. ...
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TOX-104: (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed... 4.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox104_508.pdf
... 119. Skouteris GG, McMenamin M. Transforming growth factor-alpha-induced DNA synthesis and c-myc expression in primary rat hepatocyte cultures is modulated by indomethacin. ...
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TR-420: Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1Mice... 20.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr420.pdf
... Cancer Inst. 61, 1311-1314. Weinberg, M.S., Quigg, R.J., Salant, D;J., and Bernard, D.B. (1985). .Anuric renal failure precipi- tated by indomethacin and triamterene. Nephron 40, ...
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TR-357: Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and... 12.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr357.pdf
... R.S.; Holmes, G.I.; Huber, P.; Gee, W.L.; Lin, E.T.; Benet, L.Z. (1982) Hydrochlorothiazide Pharma- cokinetics and pharmacologic effect: The influ- ence of indomethacin. J. Clin. ...
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TR-457: Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats... 18.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr457.pdf
... Toxicol. 12, 629-697. Hillier, K., Mason, P.J., Pacheco, S . , and Smith, C.L. (1982). Ulcerative colitis: Effect of sulphasalazine, its metabolitesand indomethacin on the ability ...
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TOX-62: WY-14,643 (CASRN 50892-23-4) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox062.pdf
... Plasma samples were analyzed at CEDRA Corporation, Inc. (Austin, TX). Plasma samples (0.2 mL) were spiked with indomethacin, an internal standard, and then combined with 100 µL of ...
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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf
... Blood 76, 1704-1709. Catz, P., and Friend, D.R. (1989). Alkyl esters as skin permeation enhancers for indomethacin. Int. J. Pharm. 55, 17-23. Center for Food Safety and Applied ...
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NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf
... second trimester to idarubicin and all- trans retinoic acid (Carradice et al. 2002); the patent ductus arteriosus observed in this infant closed after treatment with indomethacin. ...
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Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
... Christian University, Taiwan.) 271. Lee SH, Norppa H. 1995. Effects of indomethacin and arachidonic acid on sister chromatid exchange induction by styrene and styrene-7,8-oxide. ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
... 354.48 0.16 56.7 0.32 113.4 Benzylpenicillin sodium 356.4 5.73 2042.2 19.4 6914.2 Indomethacin 357.81 0.16 57.2 0.034 12.2 Quinine * HCl 360.92 0.075 27.1 1.72 620.8 ...
