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RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000 1.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf
Steroidal Estrogens December 13 - 14, 2000 Meeting of the NTP Board of Scientific Counselors Report on Carcinogens Subcommittee Prepared for the: U.S. Department of Health and ...
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CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf
National Toxicology Program U.S. Department of Health and Human Services C E R H R N T P Center for the Evaluation of Risks to Human Reproduction NIH Publication No. 10-5995 ...
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Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf
National Toxicology Program's Report of the Organized by the National Institute of Environmental Health Sciences, NIH National Toxicology Program Sponsored by the U.S. ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential ...
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RoC Profile: Dichlorodiphenyltrichloroethane; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichlorodiphenyltrichloroethane.pdf
Dichlorodiphenyltrichloroethane CAS No. 50-29-3 Reasonably anticipated to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Also known as DDT or ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of ...
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Presentation: The Murine Local Lymph Node Assay: BrdU-ELISA 889KB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/6-strickland.pdf
Murine Local Lymph Node Assay: 5-Bromo-2-deoxyuridine Enzyme-linked Immunosorbent Assay (LLNA: BrdU-ELISA) ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: ...
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Presentation: The Murine Local Lymph Node Assay: DA 1010KB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/7-salicru.pdf
Murine Local Lymph Node Assay: Daicel Chemical Industries, Ltd., Based on ATP Content (LLNA: DA) ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: Assessing ...
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Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf
Advancing Flexibility for Defined Approach Guidelines: Developing Performance Standards to Incorporate Alternate Information Sources into the Defined Approach for Skin ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds The Results of an Independent Peer Review Evaluation ...
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RoC Profile: Benzene; 15th RoC 2021 110KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf
Benzene CAS No. 71-43-2 Known to be a human carcinogen First listed in the First Annual Report on Carcinogens (1980) Carcinogenicity Benzene is known to be a human carcinogen based ...
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RoC Profile: Estrogens, Steroidal; 15th RoC 2021 161KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/estrogenssteroidal.pdf
Estrogens, Steroidal CAS No.: none assigned Known to be human carcinogens First listed in the Tenth Report on Carcinogens (2002) Introduction Steroidal estrogens are cholesterol ...
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In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity... 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Kreutz-poster.pdf
In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models A. Kreutz 1 , X. Chang 1 , M. Lawless 2 , T.J. ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity Based on Recommendations from an International Workshop Organized by the Interagency ...
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TR-505: Citral (Microencapsulated) (CASRN 5392-40-5) in F344... 10.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr505.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box ...
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Recommended Performance Standards for the LLNA 2.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf
Recommended Performance Standards: Murine Local Lymph Node Assay Interagency Coordinating Committee on the Validation of Alternative Methods National Toxicology Program ...
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TOX-15: t-Butyl Perbenzoate (CASRN 614-45-9) 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox015.pdf
National Toxicology Program Toxicity Report Series Number 15 NTP Technical Report on Toxicity Studies of t-Butyl Perbenzoate (CAS NUMBER: 614-45-9) Administered by Gavage to F344/N ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
NIH Publication Number 11-7709 . . . . . . . . . . . . 1000000 . ...... _ . ...... . 100000 1 . : 1 ... . i... . >. 1000 . . . :.. ~ - . .. +----.- i. y A r : 10000 100 ...
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Public Comment on 81 FR 42718: C. Elegans Models for Developmental... 2.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/hunt-81fr42718.pdf
From: Hunt, Piper (FDA/CFSAN) To: NIEHS NICEATM Subject: [NTP Web] NTP Interagency Center for the Evaluation of Alternative Toxicological Methods Public Comments Submission ...
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TR-276: 8-Hydroxyquinoline (CASRN 148-24-3) in F344/N Rats and... 8.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr276.pdf
PROGRAM Technical Reoort Series No. 276 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 8-HYDROXYQUINOLINE (CAS NO. 148-24-3) IN F344/N RATS AND B6C3Fi MICE (FEED STUDIES) U.S. DEPARTMENT ...
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OECD Test Guideline 429: Skin Sensitisation: Local Lymph Node... 291KB
https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-tg429-2010.pdf
OECD/OCDE 429 Adopted: 22 July 2010 © OECD, (2010) You are free to use this material for personal, non-commercial purposes without seeking prior consent from the OECD, provided ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters DMAE Aceglutamate [3342-61-8] DMAE p-Acetamidobenzoate [281131-6] and [3635-74-3] DMAE Bitartrate [5988-51-2] ...
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CERHR Monograph: Amphetamines 4.1MB
https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf
Amphetamines July 2005 NIH Publication No. 05 - 4474 iii Table of Contents Preface......
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TOX-12: Castor Oil (CASRN 8001-79-4) 367KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox012.pdf
N T P T E C H N I C A L R E P O R T O N T H E TOXICI TY STUDIES OF CASTOR OIL IN F344/N RATS AND B6C3F 1 MICE (DOSED FEED STUDIES) R i c h a r d I r w i n, P h . D . , S t u d y S ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
ICCVAM Test Method Evaluation Report The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential ...
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TR-593: NTP Technical Report on the Toxicology and Carcinogenesis... 7.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr593_508.pdf
oN The Toxicology aNd caRciNogeNesis sTudies of 2,3-BuTaNedioNe (casRN 431-03-8) iN WisTaR haN [cRl:Wi (haN)] RaTs aNd B6c3f1/N Mice (iNhalaTioN sTudies) NTP TR 593 AUGUST 2018 NTP ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity Results of an International Workshop Organized by the Interagency Coordinating ...
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TR-235: Zearalenone (CASRN 17924-92-4) in F344/N Rats and B6C3F1Mice... 6.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr235.pdf
5 CARClNOGENESlS BIOASSAY OF ZEARALENONE (CAS NO. 17924-92-4) IN F344/N RATS A N D B6C3F1 MICE (FEED STUDY) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
The chemical aNd Physical chaRacTeRizaTioN of Recycled TiRe cRumb RubbeR NTP RR 11 JULY 2019 NTP Research Report on the Chemical and Physical Characterization of Recycled Tire ...
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TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf
1 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F, MICE (FEED STUDIES) U.S.DEPARTMENT OF HEALTHANDHUMANSERVICES ...
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TOX-79: Genistein (CASRN 446-72-0) 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox079.pdf
National Toxicology Program x Toxicity Report Series Number 79 NTP Technical Report on the Reproductive Dose Range-Finding Toxicity Study of Genistein (CAS No. 446-72-0) ...
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CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB
https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf
Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP) November 2006 NIH Publication No. 06 - 4476 iii Table of ConTenTs ...
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TR-250: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr250.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 250 +~~,.,. su"'"t.r (~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS N 0 . 140-11 -4) IN F344/N RATS AND ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
CADMIUM FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by Integrated ...
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TOX-40: b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox040.pdf
0 NTP Technical Report on Toxicity Studies of -Bromo- -nitrostyrene (CAS No. 7166-19-0) Administered by Gavage to F344/N Rats and B6C3F Mice 1 John R. Bucher, Ph.D., Study ...
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Peer Review Panel Report: Updated Validation Status of the LLNA... 807KB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2009.pdf
Independent Scientific Peer Review Panel Report: Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Fluoxetine November 2004 NIH Publication No. 05 - 4471 iii Table of Contents Preface ...
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TR-547: Ethinyl Estradiol (multigenerational) (CASRN 57-63-6... 8.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr547.pdf
MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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TR-555: 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344... 6.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr555.pdf
1,2-DIbROmO-2,4-DICYANObUTANE (CAS NO. 35691-65-7) IN F344/N RATS AND b6C3F1 mICE (DERmAL STUDIES) NATIONAL TOXICOLOGY PROGRAm P.O. box 12233 Research Triangle Park, NC 27709 June ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
HTML NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
Methods for Estimating Acute Oral Systemic Toxicity Background Review Document Volume 2 of 2 Prepared by The National Toxicology Program (NTP) Interagency Center for the Evaluation ...