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TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf
OF MALACHITE GREEN CHLORIDE AND LEUCOMALACHITE GREEN (CAS NOS. 569-64-2 AND 129-73-7) IN ... AND LEUCOMALACHITE GREEN (CAS NOS. 569-64-2 AND 129-73-7) IN F344/N RATS AND B6C3F 1 ...
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TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr585_508.pdf
--%multipart-mixed-boundary-26247.1.1712000946.253.1804289383% X-Anytotx-Content-Type: application/pdf X-Anytotx-Identified-By: command-line Content-Type: text/plain; ...
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TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr585_508.pdf
40.1.1712002430.775.1804289383% X-Anytotx-Content-Type: application/pdf X-Anytotx-Identified-By: command-line Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: ...
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TOX-71: Malachite Green Chloride and Leucomalachite Green (CASRNs... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox071.pdf
and Leucomalachite Green (CAS Nos. 569-64-2 and 129-73-7) Administered in Feed to ... and Leucomalachite Green (CAS Nos. 569-64-2 and 129-73-7) Administered in Feed to ...
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Abstract for TR-527 76KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr527
Substances: Malachite Green Chloride (CASRN 569-64-2) Leucomalachite Green (CASRN 129-73-7) Report Date: February 2005 Full Report PDF Abstract Malachite green chloride is a ...
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Abstract for TOX-71 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox071
Toxicity Studies of Malachite Green Chloride and Leucomalachite Green Administered in Feed to F344/N Rats and B6C3F1 Mice Substances: Malachite green chloride (CASRN 569-64-2) ...
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Abstract for TR-585 80KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr585
5abs Abstract for TR-585 Toxicology Studies of Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han ...
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Minutes: BSC TRRS; Feb. 17, 2004 661KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf
... and combustion byproduct (PCB 126, TCDD, PeCDF ) Gavage, female rats Malachite Green/569-64-2 and TR 527 Dye; antifungal for fish Leucomalachite Green/129-73-7 Diet, Malachite ...
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Target Organs and Levels of Evidence for TR-527 61KB
https://ntp.niehs.nih.gov/data/tr/500s/tr527levels
and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) in F344/N Rats and B6C3F1 ... Levels Study Laboratory Malachite green 569-64-2 02/17/2004 Dosed-Feed R: 0, 100, 300, OR ...
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Target Organs and Levels of Evidence for TR-585 61KB
https://ntp.niehs.nih.gov/data/tr/500s/tr585levels
51 Target Organs and Levels of Evidence for TR-585 Toxicology Studies of Green Tea Extract (CASRN GREENTEAEXTR) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and ...
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OHAT Risk of Bias Rating Tool for Human and Animal Studies 583KB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/riskofbiastool_508.pdf
OHAT Risk of Bias Tool (January 2015) 1 OHAT Risk of Bias Rating Tool for Human and Animal Studies INTRODUCTION This document is written to outline a tool for evaluating ...
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Appendix 2: Risk of Bias Guidance for BPA Exposure and Obesity... 505KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/appendix2bpa_draft.pdf
DRAFT (April 9, 2013) 1 This draft document is being disseminated to obtain public comment. It does not represent and should not be construed to represent final NTP determination ...
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Appendix 2: Guidance for Assessing Risk Of Bias in the Protocol... 500KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/appendix_2_pfoa_pfos_riskofbias.pdf
Draft (April 9, 2013) Risk of Bias Tool for Evaluation of PFOA or PFOS Exposure and Immunotoxicity 1 This draft document is being disseminated to obtain public comment. It does not ...
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Abstract for TR-509 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr509
9abs Abstract for TR-509 Toxicology and Carcinogenesis Studies of 2,4-Hexadienal in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 142-83-6 Chemical Formula: C6H8O Molecular ...
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Bone marrow - Pigment - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment
Iron is stored as hemosiderin in resident macrophages of the bone marrow. An increase in the amount of hemosiderin within the bone marrow is recorded as (increased) pigment. ...
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Minutes: TR Panel; May 22, 2014 273KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/minutes20140522_508.pdf
National Toxicology Program Technical Reports Peer Review Panel Meeting May 22, 2014 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes ...
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Botanical Dietary Supplements 78KB
https://ntp.niehs.nih.gov/whatwestudy/topics/botanical
botanical Botanical Dietary Supplements Botanical dietary supplements pills in a glass bowl Research Overview Status: Ongoing Substances: Vinpocetine Senna (powdered) Black Cohosh ...
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Abstract for TR-41 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr041
1abs Abstract for TR-41 Bioassay of Chlorothalonil for Possible Carcinogenicity CASRN: 1897-45-6 Chemical Formula: C8Cl4N2 Molecular Weight: 265.914 Synonyms/Common Names: ...
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Application of Defined Approaches for Skin Sensitization for... 1.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-strickland-poster.pdf
Application of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency Interest J. Strickland 1 , J. Truax 1 , K.T. To 1 , E.N. Reinke 1 , T. Gulledge 2 , V.J. ...
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Get Involved 63KB
https://ntp.niehs.nih.gov/getinvolved
getinvolved Get Involved Get Involved Green desktop calendar Calendar & Events View upcoming meetings and events. Go » Red phone extending from laptop screen Contact NTP Email NTP ...
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Documents Provided to the NTP Board of Scientific Counselors... 55.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf
DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review NTP Monograph 08 September ...
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Epididymis - Amyloid - Nonneoplastic Lesion Atlas 286KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/epididymis/Amyloid
Amyloidosis is an age-related, incidental background finding most commonly seen in mice. It is generally a systemic condition, but the epididymis is a common site for deposition. ...
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Support 63KB
https://ntp.niehs.nih.gov/support
https://ntp.niehs.nih.gov/go/support Support Web Support Green accessibility button integrated into a computer keyboard Accessibility Information NTP is committed to making our ...
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Nomination Background: 1-Butyl-3-methylimidazolium chloride ... 1.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ionic_liquids_508.pdf
Ionic Liquids 1-Butyl-3-methylimidazolium Chloride (CAS No. 79917-90-1) 1-Butyl-1-methylpyrrolidinium Chloride (CAS No. 479500-35-1) N-Butylpyridinium Chloride (CAS No. 1124-64-7) ...
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Kidney - Amyloid 451KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/urinary/kidney/amyloid/kidney-amyloid-pdf_508.pdf
Amyloid 1 Kidney - Amyloid Figure Legend: Figure 1 Kidney, Glomerulus - Amyloid in a female B6C3F1 mouse from a chronic study. Glomeruli contain a pale, amorphous, eosinophilic ...
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Kidney - Amyloid - Nonneoplastic Lesion Atlas 296KB
https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/Amyloid
Amyloid deposition is a spontaneous and age-related disease that occasionally can be related to test item administration. It is commonly noted in some strains of mouse, ...
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Agenda: BSC TRRS; Feb. 17-18, 2004 82KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004agenda_508.pdf
) TR 526 Insulator and combustion byproduct Gavage, female rats Malachite Green /569-64-2 and Leucomalachite Green /129-73-7 Anthraquinone /84-65-1 TR 527 TR 494 Dye; ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
Cobalt and Cobalt CoMpounds that Release Cobalt ions in ViVo ROC MONOGRAPH 06 APRIL 2016 Report on Carcinogens Monograph on Cobalt and Cobalt Compounds That Release Cobalt Ions In ...
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Handbook for Conducting a Literature-Based Health Assessment... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookjan2015_508.pdf
Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration January 9, 2015 Office of Health Assessment and ...
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Minutes: SACATM; Aug. 12-13, 2003 466KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2003/minutes20030813_508be.pdf
___... Page No. I. CALL TO ORDER AND INTRODUCTIONS 2 II. WELCOME 2 III. UPDATE ON ICCVAM AND NICEATM 3 IV. UPDATE ON ...
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Minutes: SACATM; Mar. 10-11, 2004 961KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2004/minutes20040311_508be.pdf
___... Scientific Advisory Committee on Alternative Toxicological Methods Hyatt Regency Bethesda Bethesda, Maryland ...
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Developing a Defined Approach for Eye Irritation Testing 1.4MB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2020/posters/choksi-ascct2020-poster.pdf
Kandarova H, Letasiova S, Adriaens E, Guest R, Willoughby JA Sr, Drzewiecka A, Gruszka K, Alépée N, Verstraelen S, Van Rompay AR. 2018. Toxicol In Vitro. 49:34-52. Kolle SN, Van ...
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NTP Working Group Report: Draft State of the Science Monograph... 20.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/wgrptbsc20230400.pdf
NTP Board of Scientific Counselors Working Group Report on the Draft State of the Science Monograph and the Draft Meta-Analysis Manuscript on Fluoride April 2023 NTP BSC Working ...
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NTP Board of Scientific Counselors Working Group Report on the... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/bsc_wg_report_final_version_bsc_approved051623_508.pdf
NTP Board of Scientific Counselors Working Group Report on the Draft State of the Science Monograph and the Draft Meta-Analysis Manuscript on Fluoride Final Report: Approved by the ...
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NTP Working Group Report: Draft State of the Science Monograph... 9.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/meeting_materials/wgrptbsc20230400_interimver_508.pdf
PLEASE NOTE: On May 4, 2023, the NTP Board of Scientific Counselors voted to accept the report in full, with the exception of text for 8.P (page 323) related to an IQ statistic ...
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Minutes: SACATM; Dec. 12, 2005 223KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2005/minutes20051212_508be.pdf
Minutes from the December 12, 2005 SACATM Meeting I. Location of Background Materials/Presentations and Frequently Used Abbreviations......
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National Institute of Environmental Health Sciences: Responsive... 149KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/responsive
Skip Navigation Responsive Research Programs National Institute of Environmental Health Sciences (NIEHS) NTP Logo Much of the work carried out by DTT is in support of the National ...
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Presentation: Report on Workshop: Addressing Challenges in the... 2.3MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/june/presentations/botanicals_508.pdf
Report on Workshop: Addressing Challenges in the Assessment of Botanical Dietary Supplement Safety Workshop Cynthia V. Rider, Ph.D. Toxicology Branch National Institute of ...
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National Institute of Environmental Health Sciences: Safe and... 149KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/responsive/sustainable
Safe and Sustainable Alternatives Program National Institute of Environmental Health Sciences (NIEHS) NTP Logo Much of the work carried out by DTT is in support of the National ...
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Comment: National Toxicology Program Board of Scientific Counselors... 150KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/maas20230427_bsc_508.pdf
1 William R Maas Subject: Flawed Measurement of IQ Outcome in the MIREC Studies I am writing to express concerns about studies relying on the Maternal-Infant Research on ...
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Minutes: SACATM; Dec. 5, 2002 172KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2002/minutes20021205_508.pdf
Scientific Advisory Committee on Alternative Toxicological Methods Meeting on December 5, 2002 Crystal Gateway Marriott, Arlington, Virginia Summary Minutes Page No. I. ...
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TR Panel: Actions; TRs 583, 584, 585, 586; May 22, 2014 86KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/actionstrsep20140522_508.pdf
Actions on Draft NTP Technical Reports Peer Reviewed at the NTP Technical Reports Peer---Review Meeting May 22, 2014 The NTP convened the NTP Technical Reports Peer---Review Panel ...
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Historical Controls: Pathology Tables by Gavage/Water for B6C3F1... 132KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/micegavwater2013_508.pdf
93 Contract/Lab: All Laboratories Tumor Incidence for Selected Control Animal Groups Report Date: 06/05/2013 Species: MICE Route: GAVAGE Strain: B6C3F1 Vehicle: WATER Length of ...
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Historical Controls: Pathology Tables by Gavage/Water for Wistar... 78KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/whanratsgavwater2013_508.pdf
Version: Jun2013 Toxicology Data Management System Page: 28 Contract/Lab: All Laboratories Tumor Incidence for Selected Control Animal Groups Report Date: 06/12/2013 Species: RATS ...
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Historical Controls: Pathology Tables by Gavage/Water for B6C3F1... 105KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/path_micegavwater2014_508.pdf
4 Contract/Lab: All Laboratories Tumor Incidence for Selected Control Animal Groups Report Date: 11/11/2014 Species: MICE Route: GAVAGE Strain: B6C3F1 Vehicle: WATER Length of ...
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Historical Controls: Pathology Tables by Gavage/Water for Wistar... 180KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/path_rathangavage_water2014_508.pdf
33 Contract/Lab: All Laboratories Tumor Incidence for Selected Control Animal Groups Report Date: 11/11/2014 Species: RATS Route: GAVAGE Strain: Wistar Han Vehicle: WATER Length of ...
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Draft Handbook for Conducting a Literature-Based Health Assessment... 4.4MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookdraftmarch2019.pdf
January 9, 2015 REVISON: March 4, 2019) ii TABLE OF CONTENTS NOTE: page numbers and headings reflect the 2019 OHAT Handbook revisions. Table of Contents ......
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Handbook for Conducting a Literature-Based Health Assessment... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookmarch2019_508.pdf
March 4, 2019) ii TABLE OF CONTENTS Table of Contents ......
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Abstract for TR-451 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr451
1abs Abstract for TR-451 Toxicology and Carcinogenesis Studies of Nickel Oxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 1313-99-1 Chemical Formula: NiO Molecular ...
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Bone Marrow - Pigment 383KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/pigment/bone_marrow-pigment_508.pdf
Pigment Figure Legend: Figure 1 Low amounts of golden brown pigment in bone marrow in a male B6C3F1 mouse from a subchronic study. Figure 2 Moderate amounts of golden brown pigment ...
