Abstract for TR-50 62KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr050

Full Report PDF Abstract Acetohexamide is an oral hypoglycemic agent of the arylsulfonyl-urea group with a potency between that of tolbutamide and chlorpropamide. A bioassay of ...

Abstract for TR-266 62KB

https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr266

...ethyl-3-(p-chlorophenyl)urea Report Date: August 1988 Full Report PDF Abstract Carcinogenesis studies of monuron (greater than 99% pure), a substituted urea herbicide, were ...

CERHR Monograph: Hydroxyurea 3.6MB

https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf

... as. cytotoxicity.and.myelosuppression,.and.hydroxy- urea.is.genotoxic.(can.damage.DNA).. ... sure of men to therapeutic doses of hydroxy- urea may adversely affect sperm production. ...

Final RoC Background Document for Formaldehyde 5.8MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf

... production of industrial resins (mainly urea-formaldehyde, phenol-formaldehyde, ... Unmetabolized formaldehyde reacts non-enzymatically with sulfhydryl groups or urea, binds ...

TR-266: Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1Mice... 11.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr266.pdf

... Chlorophenyl)urea; CMU; Karmex Monuron Herbicide; Telvar ABSTRACT Carcinogenesis studies of monuron (greater than 99% pure), a substituted urea herbicide, were con- ducted by ...

Presentation: Mechanisms of Acute Toxicity 2.4MB

https://ntp.niehs.nih.gov/iccvam/meetings/at-wksp-2015/session4/1-wilson-508.pdf

... Lipogenesis, Pyrimidine/Purine biosynthesis, Urea cycle, Glycolysis, Vitamins... ... → protein; carbons → carbohydrate/lipid; amino "N" as urea Carbohydrate Digestion . ...

TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf

... the exception of significantly lower blood urea nitrogen levels in female rats exposed ... aspartate aminotransferase, blood urea nitrogen, creatine, albumin, protein, ...

TR-452: 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) (CASRN... 31.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr452.pdf

... Blood urea nitrogen concentrations of 5,000 ppm females and 10,000 ppm males and females ... globulin, glucose, total protein, and urea nitrogen Urinalysis: glucose, protein, ...

Abstract for TR-195 62KB

https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr195

CASRN: 2164-17-2 Chemical Formula: C10H11F3N2O Molecular Weight: 232.2039 Synonyms/Common Names: 1,1-dimethyl-3-(a,a,a-trifluoro-m-tolyl) urea Report Date: August 1980 Full Report ...

NCTR SOT Presentations; SOT; March 19-23, 2023 289KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/pressctr/ntp_news/2023/sot_nctr_508.pdf

Abstract Number 3005, Poster Board Number P106. Poster Title: Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes ...

Abstract for TR-430 75KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr430

C.I. Direct Blue 218 is a copper chelated dye used for cellulose, acetate, nylon, silk, wool, tissue, papers, and textile goods with a urea-formaldehyde finish. C.I. Direct Blue ...

Supplemental Information on Changes from ITS-2 to ITS-2 Lipid... 196KB

https://ntp.niehs.nih.gov/iccvam/methods/immunotox/its-os/its2toits2lipidsuppl-16dec13-508.pdf

Benzoic acid (training set) . Imidazolidinyl urea (test set) Second, the method for calculating the bioavailability parameters was changed to improve the transparency and ...

TOX-38: Sodium Selenate and Sodium Selenite (CASRNs 13410-01... 1.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox038.pdf

... alanine aminotransferase activities, urea nitrogen, and urine specific gravity were ... Clinical chemistry parameters included urea nitrogen, creatinine, alanine aminotransferase ...

TR-251: Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate... 8.9MB

https://ntp.niehs.nih.gov/go/tr251

... Structure of N,N'-Bis(3-isocyanato-4-methylphenyl)urea ...... 18 Figure 2 Polymeric Analog of N,N'-Bis(3-isocyanato-4-methyl-phenyl)urea . . . . . . . . . . . 19 ...

TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf

... 300 mg/kg or more in male rats. The blood urea nitrogen level was increased slightly in ... tri- glycerides, blood urea nitrogen, glucose, total protein, and globulin fractions. ...

TR-430: C.I. Direct Blue 218 (CASRN 28407-37-6) in F344/N Rats... 16.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr430.pdf

... nylon, silk, wool, tissue, papers, and textile goods with a urea-formaldehyde finish. ... nylon, silk, wool, tissue, papers, and textile goods with a urea-formaldehyde finish. ...

Nomination Background: Decabromodiphenyl ether (CASRN: 1163-19... 246KB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/cpscfrsnomination_supp_062_508.pdf

... Orleans, LA. In a common commercial process, THPC is first combined with urea to form a 2:1 THPC: urea compound (pre-condensate) (Albright & Wilson 1998; Sanders 1978) (Figure 1). ...

TR-396: Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats... 14.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr396.pdf

... In rats, dose-related increases in blood urea nitrogen, alanine aminotransferase, and ... chloride (rats), phosphonrs (rats), Mood urea nitrogen, aeatinine (rats), total ...

ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf

... Hydrocarbons, Other 24.0 (8.5) 13.636 (4.8) Imidazolidinyl urea * Cosmetics; Personal care products; Pesticides Urea 24.0 (5.5) 49.545 (1.6) Ethylene glycol dimethacrylate * ...

TOX-43: o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9... 5.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox043.pdf

... caused decreased urine volume, elevated urea nitrogen concentration, and decreased ... Renal effects including hematuria, proteinuria, decreased urine volume, and increased urea ...

TOX-104: (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed... 4.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox104_508.pdf

... moderate significant increases in blood urea nitrogen were observed at exposure levels ... ↑ Alanine aminotransferase ↑ Blood urea nitrogen ↑ Creatinine ↑ Alanine ...

Abstract for TR-163 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr163

Other products prepared from calcium cyanamide include urea, thiourea, and guanidine. Fusion of calcium cyanamide with sodium chloride produces calcium cyanide, which is required ...

RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf

... rats when co-administered with ethyl urea and sodium nitrite. vi 05/08/03 RoC ...hydroxyethylnitrosamine; EU/NaNO 2 = ethyl urea and sodium nitrite; PbSA = lead ...

RoC Background Document: Azacitidine; Nov. 18-19, 1996 3.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/azacitidine1_508.pdf

... D-Ribose Urea Biuret is soluble in water, freely soluble in alcohol, and very slightly soluble in ether. D-Ribose is soluble in water and slightly soluble in alcohol. Urea is ...

TOX-61: Benzophenone 2.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox061.pdf

... Males in the 100 and 500 mg/kg groups had increased urea nitrogen concentrations; total ... and differentials Clinical Chemistry: urea nitrogen, creatinine, total protein, ...

Modernizing Drug Discovery Using (ICCVAM Communities of Practice... 6.0MB

https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-ewart-508.pdf

... Readouts: Morphology, Albumin, ALT, Urea " Timepoints: Day 0 Day 1 Da Bottom Channel: . ... Healthy hepatocellular functionality was demonstrated by measurement of albumin and urea ...

Abstract for TOX-38 64KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox038

Decreases in urine volume and increases in erythrocyte counts, hematocrit, hemoglobin concentrations, alanine aminotransferase activities, urea nitrogen, and urine specific gravity ...

TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf

... By the fourth day after exposure, urea nitrogen clearance was reduced, with values ... and differentials Clinical chemistry: urea nitrogen, creatinine, alanine ...

Abstract for TR-396 65KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr396

Final mean body weights of surviving rats and mice receiving monochloroacetic acid were similar to those of controls. In rats, dose-related increases in blood urea nitrogen, ...

Comment: Toxicology and Carcinogenesis Studies of Sodium Tungstate... 143KB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/publiccomm/lemus20210318_trprp_508.pdf

... organ for tungstate: Sachdeva, et al., (2013) noted an increase in creatinine, and urea levels in rats after rat exposure to 238 mg/kg-day (and intraperitoneal injection of 41 ...

NTP Monograph on Health Effects of Low-Level Lead Appendix D... 543KB

https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixd_final_508.pdf

... serum creatinine urea total protein Mann Whitney test and Spearman correlation Exposed vs Reference group comparisons total protein (↔, p=0.08) urea (↑, p≤0.01) serum ...

Abstract for RDGT94009 61KB

https://ntp.niehs.nih.gov/publications/abstracts/water/rdgt94009

... a 14 % increase in liver-to-body weight ratio in the 400 ppm A males, and an increase of 12% and 10%, respectively, in blood urea nitrogen and serum albumin in the 400 ppm A males. ...

Abstract for TR-577 79KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr577

... Hematology and clinical chemistry values were similar to controls, with the exception of significantly lower blood urea nitrogen levels in female rats exposed 1.5%, 2.0%, and 3.0% ...

TOX-48: Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN... 18.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox048.pdf

... and differentials Clinical chemistry: urea nitrogen, creatinine, total protein, ... and differentials Clinical chemistry: urea nitrogen, creatinine, total protein, ...

ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf

... Hydrocarbons, Other 23.750 (8.5) 8.674 (5.7) Imidazolidinyl urea 5 Cosmetics; Personal care products; Pesticides Urea 24.000 (5.5) 6.275 (4.7) Ethylene glycol dimethacrylate 4 ...

BSC Meeting: Draft RoC Concept: Helicobacter pylori: Chronic... 235KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/april/hpylori_508.pdf

... All H. pylori strains express urease, which converts urea to ammonia and carbon dioxide, raising the pH of the surrounding area. A neutral pH environment, found in the mucosal ...

Background Document: RoC: Aristolochic Acids ; 2010 2.7MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/aristolochic_acids_final_508.pdf

... The primary features include tubular necrosis, elevated plasma creatinine and urea levels, ... At day 8, plasma urea and creatinine, urine volume, and urinary glucose, protein, and ...

Abstract for RDGT94013 62KB

https://ntp.niehs.nih.gov/publications/abstracts/water/rdgt94013

... The blood urea nitrogen level of the 100 ppm males was increased by 19%, a small but biologically significant indicator of mild renal damage. However, this may be attributable to ...

Abstract for TR-319 68KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr319

... Serum triglycerides were reduced by doses of 300 mg/kg or more in male rats. The blood urea nitrogen level was increased slightly in male rats dosed with 900 mg/kg or more. Urinary ...

Abstract for TR-452 70KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr452

... Clinical findings included abnormal posture and hypoactivity in 10,000 ppm male and female mice. Blood urea nitrogen concentrations of 5,000 ppm females and 10,000 ppm males and ...

TOX-84: Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8... 5.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox084_508.pdf

... Sorbitol dehydrogenase (↑,-,-);Urea nitrogen (↑,↑,-); Cholesterol ... Sorbitol dehydrogenase (↑,-,-); Urea nitrogen (↑,↑,-); Cholesterol ...

RoC Profile: Thiourea; 15th RoC 2021 126KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/thiourea.pdf

... Thiourea may also be present in animal-hide glues and in diazo papers (WHO 2003). Thio- urea has been found to occur naturally in laburnum shrubs and as a metabolite of the fungi ...

TR-408: Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and... 12.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr408.pdf

... 2, 4, and 6 months. Uinicul chanimy: Rats- urea nitrogen, creatinine, sodium (2 and 4 ... cholinesterase, pH (2 and 4 months) Mice- urea nitrogen (2 and 4 months), calcium (4 ...

TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf

... 5-methyl hydantoin and 2-methylhydantoic acid, an unidentified metabolite, and urea. ... and differentials Clinical chemistry: urea nitrogen, creatinine, total protein, ...

CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB

https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf

... concentration versus time curve BUN blood urea nitrogen bw body weight C Celsius 13 C 2 ... or blood chemistry (including urea nitrogen, creatinine, and plasma pH) ...

RoC Profile: Ethylene Thiourea; 15th RoC 2021 152KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethylenethiourea.pdf

... Exposure Evidence that the U.S. general population is exposed to ethylene thio- urea comes from the National Health and Nutrition Examination Survey for 2007-2008, which found that ...

Formaldehyde Expert Panel Report Part A - Peer Review of the... 567KB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_parta.pdf

... Formaldehyde releasers that are used in cosmetics include quaternium-15, imidazolidinyl urea, diazolidinyl urea, DMDM hydantoin, and 2-bromo-2-nitropropane-1,3-diol (de Groot et ...

TOX-9: Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) 6.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox009.pdf

... bile acids, urea nitrogen, sorbitol dehydrogenase, 5'-nucleotidase, and creat- inine. ... a Analysis Day 5 Day 21 Day 43 Day 90 Male Urea nitrogen ) (30,000 ppm) NS ) (30,000 ppm) ...

TR-505: Citral (Microencapsulated) (CASRN 5392-40-5) in F344... 10.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr505.pdf

... rather than dehydration, as was urea nitrogen concentration, and felt that both ... and differentials Clinical chemistry: urea nitrogen, creatinine, total protein, ...

TOX-12: Castor Oil (CASRN 8001-79-4) 367KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox012.pdf

... phosphatase activity (ALP), albumin (ALB), urea nitrogen (UN), creatinine (CREA), alanine ... receiving 10% diets, and an increase in urea nitrogen at study termination in males ...