TR-515: Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7... 9.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr515.pdf

THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE GLYCOL MONO-t-BUTYL ETHER (CAS NO. 57018-52-7) IN F344/N RATS AND B6C3F 1 MICE AND A TOXICOLOGY STUDY OF PROPYLENE GLYCOL ...

CERHR Monograph: Potential Human Reproductive and Developmental... 1.4MB

https://ntp.niehs.nih.gov/ntp/ohat/egpg/propylene/pg_monograph.pdf

... Appendix II II-1 1.0 CHEMISTRY, USAGE, AND EXPOSURE 1.1 Chemistry 1.1.1 Nomenclature The Chemical Abstracts Service Registry Number (CAS RN) for propylene glycol is 57-55-6. ...

Abstract for TR-515 77KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr515

5abs Abstract for TR-515 Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol ...

Abstract for RACB84068 60KB

https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84068

Propylene Glycol: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water CASRN: 57-55-6 Chemical Formula: C3H8O2 Molecular Weight: 76.09 Report ...

Abstract for RACB85069 60KB

https://ntp.niehs.nih.gov/publications/abstracts/repro/racb85069

9abs Abstract for RACB85069 Propylene Glycol Monomethyl Ether: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water CASRN: 107-98-2 Chemical ...

Target Organs and Levels of Evidence for TR-515 59KB

https://ntp.niehs.nih.gov/data/tr/500s/tr515levels

6 Target Organs and Levels of Evidence for TR-515 Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and ...

CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB

https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf

NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Ethylene Glycol January 2004 NIH Publication No. 04-4481 Table of Contents Preface ...

Minutes: BSC TRRS; May 22, 2003 842KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2003/may/trrs22may2003mins_508.pdf

National Toxicology Program Board of Scientific Counselors Technical Reports Review Subcommittee Meeting May 22, 2003 NIEHS, Research Triangle Park, NC Summary Minutes National ...

Abstract for TR-191 61KB

https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr191

1abs Abstract for TR-191 Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity CASRN: 108-60-1 Chemical Formula: C6H12Cl2O Molecular Weight: ...

West Virginia Chemical Spill 92KB

https://ntp.niehs.nih.gov/whatwestudy/topics/wvspill

wvspill West Virginia Chemical Spill NTP has completed the West Virginia chemical spill research program. The Final NTP Update serves as NTP's overall interpretation of its studies ...

Abstract for TR-239 65KB

https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr239

9abs Abstract for TR-239 Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70%) (CAS No. 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30%) (CAS ...

TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 10.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr511.pdf

ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIPROPYLENE GLYCOL (CAS NO. 25265-71-8) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. ...

WV Spill: 5-Day Rat Toxicogenomic Studies; June 2015 Update 205KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/micronucleus_update_508.pdf

West Virginia Chemical Spill: 5-Day Rat Toxicogenomic Studies June 2015 NTP Update* Synopsis The National Toxicology Program (NTP) 1 evaluated three chemicals spilled into the Elk ...

WV Spill: TGMX Update; July 2016 246KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/tgmx_update_july2016_508.pdf

West Virginia Chemical Spill: 5-Day Rat Toxicogenomic Studies July 2016 NTP Update Synopsis The National Toxicology Program (NTP) 1 evaluated three chemicals spilled into the Elk ...

Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

... 1,2- Dihydroxypropane// 1,2- Propanediol 57-55-6 glycol// dihydric alcohol cosmetics and ... 94-13-3 - - +/- Propylene glycol 57-55-6 - - - Resorcinol 108-46-3 - - - Salicylic ...

WV Spill: NTP Research Project Plan Summary 79KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/wvprojectsummary_508.pdf

West Virginia Chemical Spill: NTP Research Project Plan Summary In January 2014, a liquid used to wash coal was spilled into the Elk River, a municipal water source that serves ...

Agenda: BSC TRRS; May 22, 2003 89KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2003/may/trrs22may2003agenda_508.pdf

NATIONAL TOXICOLOGY PROGRAM BOARD OF SCIENTIFIC COUNSELORS Technical Reports Review Subcommittee Meeting Agenda May 22, 2003 8:30 a.m - 5:00 p.m. National Institute of ...

Poster: Assessment of Genotoxic Potential of Elk River Chemical... 623KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/auerbach_sot_201603_508.pdf

Assessment of Genotoxic Potential of Elk River Chemical Contaminants Using In Vivo Micronucleus and Bacterial Mutagenicity Assays Swartz CD 1 , Hobbs C 1 , Recio L 1 , Auerbach S 2 ...

WV Spill: 5-Day Toxicogenomic Studies: In Vivo Micronucleus Assay... 130KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/micronucleus_wvfeb2015_508.pdf

West Virginia Chemical Spill: 5-Day Toxicogenomic Studies: In Vivo Micronucleus Assay Component February 2015 NTP Update Synopsis The National Toxicology Program (NTP) 1 evaluated ...

Abstract for TR-477 72KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr477

7abs Abstract for TR-477 Toxicology and Carcinogenesis Studies of 1-Chloro-2-propanol (Technical Grade) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) CASRN: 127-00-4 ...

Abstract for TR-511 72KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr511

1abs Abstract for TR-511 Toxicology and Carcinogenesis Studies of Dipropylene Glycol in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) CASRN: 25265-71-8 Chemical Formula: ...

WV Spill: NTP Research Project Plan 185KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/project_508.pdf

West Virginia Chemical Spill: NTP Research Project Plan Background and Rationale In January 2014, about 10,000 gallons of a liquid used to wash coal and remove impurities was ...

Abstract for TER91032 60KB

https://ntp.niehs.nih.gov/publications/abstracts/dev/ter91032

2abs Abstract for TER91032 Developmental Toxicology of Iowa Pesticide/Fertilizer Mixture in Sprague Dawley (CD) Rats CASRN: PestFertMix3 Report Date: August 1992 Abstract The ...

TR-072: Phenoxybenzamine Hydrochloride (CASRN 63-92-3) 3.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr072.pdf

Institute CARCIIMOGENESIS Technical Report Series No. 72 BIOASSAY OF PHENOXYBENZAMINE HYDROCHLORIDE FOR POSSIBLE CARCINOGENICITY CAS No. 63-92-3 NCI-CG-TR-72 U.S. DEPARTMENT OF ...

TOX-36: Pesticide/Fertilizer Mixtures 5.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox036.pdf

6 N T P Technical Report on Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F, Mice National Toxicology Program Post Office ...

Abstract for TR-72 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr072

2abs Abstract for TR-72 Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity CASRN: 63-92-3 Chemical Formula: C18H22ClNO.ClH Molecular Weight: 340.292 Synonyms/...

ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf

... 1,2- Dihydroxypropane; 1,2-Propanediol 57-55-6 76.0944 0.43 Minimal Liquid Alcohols ... unpublished 2009 + Propylene glycol 57-55-6 50 1.57 + - + - - - - - - - - - - + + ...

Eye, Cornea - Necrosis - Nonneoplastic Lesion Atlas 288KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Necrosis

Necrosis of corneal epithelial cells is characterized by shrunken, hypereosinophilic necrotic cells (suggestive of single-cell necrosis) are scattered through the epithelium ...

Eye, Cornea - Necrosis 209KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/crnecr/eye-cornea-necrosis_508.pdf

Necrosis Figure Legend: Figure 1 Eye, Cornea - Necrosis in a female F344/N rat from a chronic study. There are shrunken, hypereosinophilic, necrotic cells (arrows) and corneal ...

Minutes: BSC; June 16, 2015 579KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2015/june/bsc_jun2015_minutes_508-.pdf

Summary Minutes NTP Board of Scientific Counselors June 16, 2015 Summary Minutes June 16, 2015 NTP Board of Scientific Counselors 1 Table of Contents I. Frequently Used ...

RoC Profile: Melphalan; 15th RoC 2021 124KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/melphalan.pdf

Melphalan CAS No. 148-82-3 Known to be a human carcinogen First listed in the First Annual Report on Carcinogens (1980) N CH 2 CH 2 C H 2 H 2 C Cl Cl HC CH 2 C OH O H 2 N ...

RoC Profile: Phenazopyridine Hydrochloride; 15th RoC 2021 120KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenazopyridinehydrochloride.pdf

Phenazopyridine Hydrochloride CAS No. 136-40-3 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as Pyridium ...

NIEHS Update: ICCVAM Public Forum 2015 1.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/niehs-iccvampubforum-2015-508.pdf

NIEHS Update Nigel Walker, PhD, DABT Deputy Director for Research Division of the National Toxicology Program National Institute of Environmental Health Sciences ...

Presentation: Conducting and Interpreting the Murine Local Lymph... 495KB

https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/4-woolhiser.pdf

Toxicology & Environmental Research and Consulting Conducting and Interpreting the Murine Local Lymph Node Assay (LLNA) Mike Woolhiser, Ph.D. Science & Technology Leader, TERC The ...

RoC Profile: Phenoxybenzamine Hydrochloride; 15th RoC 2021 122KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenoxybenzaminehydrochloride.pdf

Phenoxybenzamine Hydrochloride CAS No. 63-92-3 Reasonably anticipated to be a human carcinogen First listed in the Fifth Annual Report on Carcinogens (1989) Cl H 2 C C H 2 N CH H 2 ...

RoC Profile: Safrole; 15th RoC 2021 130KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/safrole.pdf

Safrole CAS No. 94-59-7 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as 5-(2-propenyl)-1,3-benzodioxole ...

Presentation: Report on NTP Respsonse to WV Spill 6.6MB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/presentation_withnotes_june2015.pdf

Report on the National Toxicology Program's yearlong research program into the toxicity of chemicals spilled into the Elk River in Charleston, West Virginia on January 9, 2014. 1 ...

Abstract for RACB90029 59KB

https://ntp.niehs.nih.gov/publications/abstracts/repro/racb90029

9abs Abstract for RACB90029 Reproductive Toxicity of Iowa Pesticide/Fertilizer Mixture in CD-1 Swiss Mice CASRN: PESTFERTMIX3 Report Date: August 1992 Abstract The following ...

Eye, Cornea - Mineralization - Nonneoplastic Lesion Atlas 294KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Mineralization

Corneal mineralization in rats and mice can be a sequela to trauma or inflammation, can result from exposure to topical irritants or systemic toxins, or can occur as a spontaneous ...

RoC Profile: Butylated Hydroxyanisole; 15th RoC 2021 132KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butylatedhydroxyanisole.pdf

Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Butylated Hydroxyanisole CAS No. 25013-16-5 Reasonably anticipated to be a human carcinogen First ...

RoC Profile: Methyl Methanesulfonate; 15th RoC 2021 113KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylmethanesulfonate.pdf

Methyl Methanesulfonate CAS No. 66-27-3 Reasonably anticipated to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) O S CH 3 O O H 3 C ...

Historical Controls: All Routes and Vehicles for Mice; Studies... 255KB

https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_allrte2006_508.pdf

All Routes and Vehicles MICE 2006 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study ...

Historical Controls: All Routes and Vehicles for Rats; Studies... 252KB

https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/r_hcrpt_allrte20070300_508.pdf

March 2007 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study Summary page. The report ...

WV Spill: Final Update; July 2016 445KB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/wv_finalupdate_july2016_508.pdf

July 8, 2016 1 NTP Research Program on Chemicals Spilled into the Elk River in West Virginia Final Update Summary The U.S. National Toxicology Program (NTP) completed a yearlong ...

Eye, Cornea - Mineralization 252KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/crmin/eye-cornea-mineralization_508.pdf

Mineralization Figure Legend: Figure 1 Eye, Cornea - Mineralization in a female F344/N rat from a chronic study. There are basophilic linear deposits within and subjacent to the ...

Monographs 71KB

https://ntp.niehs.nih.gov/publications/monographs

monographs Monographs This is a list of Report on Carcinogens monographs (cancer health effects) and NTP monographs (noncancer health effects). You can search by type of monograph, ...

Historical Controls: All Routes and Vehicles for Rats; Studies... 270KB

https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/r_hcrpt_allrte2006_508.pdf

All Routes and Vehicles F 344/N RATS 2006 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the ...

Historical Controls: All Routes and Vehicles for Mice; Studies... 317KB

https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20070300_508.pdf

March 2007 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study Summary page. The report ...

Presentation: Application of Genomic Benchmark Dose Analysis... 1.0MB

https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/auerbach_dose_sot_201603_508.pdf

Application of Genomic Benchmark Dose Analysis to the Elk River Chemical Spill Scott S. Auerbach PhD DABT SOT Workshop on Bioactivity-Based Margin of Exposure Safety Assessment: ...

RoC Profile: Methoxsalen with Ultraviolet A Therapy; 15th RoC... 131KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methoxsalenwithuva.pdf

Methoxsalen with Ultraviolet A Therapy CAS No.: none assigned Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Methoxsalen is also ...