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TR-547: Ethinyl Estradiol (multigenerational) (CASRN 57-63-6... 8.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr547.pdf
TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED ... TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED ...
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TR-548: Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats... 6.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr548.pdf
TOXICOLOGY AND CARCINOGENESIS STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN ... TOXICOLOGY AND CARCINOGENESIS STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN ...
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TR-059: Estradiol Mustard (CASRN 22966-79-6) 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr059.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 59 1978 BIOASSAY OF ESTRADIOL MUSTARD FOR POSSIBLE CARCINOGENICITY CAS No. 22966-79-6 NCI-CG-TR-59 U.S. ...
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Estradiol mustard: Target Organs and Levels of Evidence for TR... 57KB
https://ntp.niehs.nih.gov/data/tr/000s/tr059levels
0 Estradiol mustard: Target Organs and Levels of Evidence for TR-059 Bioassay of Estradiol Mustard for Possible Carcinogenicity (CASRN 22966-79-6) Chemical (Study Title) CASRN Peer ...
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Abstract for TR-547 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr547
Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol in Sprague-Dawley Rats (Feed Studies) CASRN: 57-63-6 Chemical Formula: C20H24O2 Molecular Weight: 296.40 ...
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Abstract for TR-548 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr548
Toxicology and Carcinogenesis Study of Ethinyl Estradiol in Sprague-Dawley Rats (Feed Study) CASRN: 57-63-6 Chemical Formula: C20H24O2 Molecular Weight: 296.40 Synonyms/Common ...
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CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf
National Toxicology Program U.S. Department of Health and Human Services C E R H R N T P Center for the Evaluation of Risks to Human Reproduction NIH Publication No. 10-5995 ...
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Abstract for TR-59 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr059
9abs Abstract for TR-59 Bioassay of Estradiol Mustard for Possible Carcinogenicity CASRN: 22966-79-6 Chemical Formula: C42H50Cl4N2O4 Molecular Weight: 788.679 Synonyms/Common ...
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Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf
National Toxicology Program's Report of the Organized by the National Institute of Environmental Health Sciences, NIH National Toxicology Program Sponsored by the U.S. ...
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Target Organs and Levels of Evidence for TR-548 60KB
https://ntp.niehs.nih.gov/data/tr/500s/tr548levels
57-63-6) in Sprague-Dawley Rats (Feed Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Endocrine disruptor (Ethinyl estradiol) 57-63-6 ...
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Expert Panel Evaluation of the Validation Status of In Vitro... 1.1MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/expertpanfinalrpt/panelrpt1102.pdf
Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional ...
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Minutes: BSC TRRS; May 17, 2007 271KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2007/may/trrs17may2007mins_508.pdf
NATIONAL TOXICOLOGY PROGRAM BOARD OF SCIENTIFIC COUNSELORS Technical Reports Review Subcommittee May 16-17, 2007 NIEHS, Research Triangle Park, NC Summary Minutes Contents Page ...
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RoC Profile: Estrogens, Steroidal; 15th RoC 2021 161KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/estrogenssteroidal.pdf
Estrogens, Steroidal CAS No.: none assigned Known to be human carcinogens First listed in the Tenth Report on Carcinogens (2002) Introduction Steroidal estrogens are cholesterol ...
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RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000 1.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf
... O 2 fine white to creamy white odorless 57-63-6 1,3,5(10)-estratriene-3,17∞-diol; ... CONJUGATED) ETHINYLESTRADIOL CAS No. 57-63-6 First Listed in the Fourth Annual Report ...
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DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart05_508.pdf
... NTP technical report on the multigenerational reproductive toxicology study of ethinyl estradiol (CAS No. 57-63-6) in Sprague-Dawley rats (feed studies). Research Triangle Park, ...
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Draft DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxyben... 3.3MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart05_508.pdf
... NTP technical report on the multigenerational 29 reproductive toxicology study of ethinyl estradiol (CAS No. 57-63-6) in Sprague-Dawley rats 30 (feed studies). Research Triangle ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
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Abstract for RACB20103, RACB20104, RACB20105, RACB20106, and... 69KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb20104
Vinclozolin (CASRN 50471-44-8) Flutamide (CASRN 13311-84-7) Phenobarbital (CASRN 50-06-6) Methoxychlor (CASRN 72-43-5) Ethinyl Estradiol (CASRN 57-63-6) Report Date: May 2004 ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... Sigma Powder 17alpha-Ethynyl Estradiol 57-63-6 Steroid, phenolic Pharmaceutical Steroid ... 1.00E+00 12% 17alpha-Ethynyl Estradiol 57-63-6 P + - - - Active Viable 1.44E-11 - ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... Sigma Powder 17alpha-Ethynyl Estradiol 57-63-6 Steroid, phenolic Pharmaceutical Steroid ... 1.00E+00 12% 17alpha-Ethynyl Estradiol 57-63-6 P + - - - Active Viable 1.44E-11 - ...
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BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf
... 56-53-1 +++ - A 17α-Ethinyl estradiol 57-63-6 +++ - A Bisphenol B 77-40-7 ++ H O O H O ... 99% N0007 R00109 17α-ethinyl estradiol 57-63-6 Sigma-Aldrich Corp E4876 99% N0008 R00110 ...
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Agenda: BSC TRRS; May 16-17, 2007 102KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2007/may/trrs16may2007agenda_508.pdf
57-63-6 Multigenerational Study TR 547 Synthetic steroidal estrogen; used as a component of oral contraceptives. Feed, male and female rats Ethinyl Estradiol, 57-63-6 2-year ...
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Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf
... - 1E-16 98% Sigma 17α-Ethinyl estradiol 57-63-6 Steroid, phenolic 1E-4 - 1E-16 98% Sigma ... (+/-) Comments 17α-Ethinyl estradiol 57-63-6 Steroid, phenolic 4.0E-11 + 1.1E-11 + ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... (3/3) POS (2/2) 17∝-Ethinyl estradiol 57-63-6 POS POS POS (3/3) POS (3/3) POS (3/3) ... XDS ECVAM Hiyoshi 17α-Ethinyl estradiol 57-63-6 NEG NEG NEG (1/1) NEG (1/1) NEG (1/1) ...
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NTP Report on Endocrine Disruptors Low-Dose Peer Review 60KB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdoseprogram.pdf
October 10 - 12, 2000 Sheraton Imperial Hotel and Convention Center Research Triangle Park, North Carolina Organized by the National Institute of Environmental Health Sciences, ...
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ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure... 1016KB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2022/unnikrishnan_ascct-2022-poster_fd.pdf
. The Integrated Chemical Environment (ICE) is an open-source resource containing curated chemical property and bioactivity data, and tools for summarizing, analyzing, and ...
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Reproductive Abstracts 202KB
https://ntp.niehs.nih.gov/publications/abstracts/repro
... 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague ... 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague ...
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NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf
... Positive NT NT 17∝-Ethinyl estradiol 57-63-6 POS Positive Positive Positive ... CCi Hiyoshi KFDA 17α-Ethinyl estradiol 57-63-6 NEG Negative NT NT 4- Hydroxytamoxifen ...
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TOX-79: Genistein (CASRN 446-72-0) 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox079.pdf
... Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CAS No. 57-63-6) in ... Toxicology and Carcinogenesis Study of Ethinyl Estradiol (CAS No. 57-63-6) in ...
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Presentation: Developing AOPs from PPAR Activation Leading to... 738KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/nepelska-508.pdf
www.jrc.ec.europa.eu Serving society Stimulating innovation Supporting legislation Peroxisome proliferator-activated receptors (PPARs) activation leading to reproductive toxicity ...
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CLARITY-BPA Program 76KB
https://ntp.niehs.nih.gov/whatwestudy/topics/bpa
bpa CLARITY-BPA Program The CLARITY-BPA Core Study Research Report, CLARITY-BPA Grantee Studies data, and CLARITY-BPA Compendium Report are now available. Various sizes of metal ...
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TOX-62: WY-14,643 (CASRN 50892-23-4) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox062.pdf
NATIONAL TOXICOLOGY PROGRAM Toxicity Report Series Number 62 NTP Technical Report on the Toxicity Studies of Wy-14,643 (CAS No. 50892-23-4) Administered in Feed to Sprague-Dawley ...
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NTP at the SOT; 2007 433KB
https://ntp.niehs.nih.gov/ntp/meetings/2007/ntpsot20070329_508.pdf
Society of Toxicology Annual Meeting NTP Presentations March 26-29, 2007 Time Room Presenter Session: Presentation Title: (Indicates NIEHS/NTP Authors) Poster/ Abstract # MARCH 26 ...
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Vagina, Epithelium - Hyperplasia - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/vagina/Epithelium-Hyperplasia
Hyperplasia of the rodent vaginal epithelium (Figure 1 image opens in a pop-up window , Figure 2 image opens in a pop-up window , Figure 3 image opens in a pop-up window and Figure ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... Pharmaceutical 17α-Ethinyl estradiol 57-63-6 Steroid, phenolic Pharmaceutical Ethyl ... Phenol 17α-Ethinyl estradiol e 57-63-6 148 (100 - 867) 10/10 7 U; 407; F-PA ...
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Study Abstracts 375KB
https://ntp.niehs.nih.gov/publications/abstracts
... 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague ... 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague ...
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Seminal Vesicle, Epithelium - Hyperplasia - Nonneoplastic Lesion... 292KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/seminal-vesicle/Epithelium-Hyperplasia
Hyperplasia of the seminal vesicle is characterized by an increase in the number of glandular epithelial cells. The proliferating epithelium may form papillary structures with ...
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Testis, Interstitial Cell - Vacuolation - Nonneoplastic Lesion... 288KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/InterstitialCell-Vacuolation
Cytoplasmic vacuolation of interstitial cells can be seen as a chemically induced change and most likely represents a disturbance in steroidogenesis. It generally consists of ...
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Prostate - Inflammation - Nonneoplastic Lesion Atlas 297KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/prostate/Inflammation
Prostatitis is a common microscopic observation in rodents observed during the safety and chronic toxicity assessments of chemicals. Prostatitis can be acute (Figure 1 image opens ...
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BG1 Luc ER TA Agonist Protocol (Appendix B of ICCVAM BRD) 411KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c2-appxb.pdf
05 Appendix B Protocol for the LUMI-CELL ® Estrogen Receptor (ER) Transcriptional Activation Test Method for the Detection of ER Agonists ICCVAM BG1Luc ER TA Evaluation Report ...
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Testis, Interstitial Cells - Vacuolation 914KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/testis/intcvac/testis_interstitial_cell-vacuolation_508.pdf
Testis, Interstitial cell - Vacuolation Figure Legend: Figure 1 Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial ...
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Machine Learning in Toxicology: Towards Intelligent Access to... 6.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2020/september/present/3-3-patton-508.pdf
Machine Learning in Toxicology: Towards Intelligent Access to the Content of Research SACATM Meeting, September 2-3, 2020 Robert M. Patton, Ph.D. Computer Science and Mathematics ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... g,h,I,j Comments 17α-Ethinyl estradiol 57-63-6 Steroid Pharmaceutical, Veterinary Agent ... Veterinary Agent 17a-Ethinyl estradiol 57-63-6 296.4 Y +++ insoluble - 3.67 $35 Steroid ...
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ICCVAM Recommended Protocol for the LUMI-CELL ER Agonist Assay 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/ivsdocs/lumiag12mar09.pdf
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 LUMI-CELL ® ER ASSAY AGONIST PROTOCOL National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative ...
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NICEATM Pre-Screen Evaluation of the LUMI-CELL ER Test Method... 595KB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/xdseval2.pdf
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 NOMINATION OF THE LUMI-CELL(tm) ER HIGH-THROUGHPUT SYSTEM FOR SCREENING ...
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Vagina, Epithelium - Hyperplasia 368KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/vagina/ephyper/vagina-epithelium-hyperplasi-pdf-508.pdf
Vagina, Epithelium - Hyperplasia Figure Legend: Figure 1 Vagina, Epithelium - Hyperplasia in a female B6C3F1/N mouse from a chronic study. There is a focal area of basal cell ...
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Seminal Vesicle, Epithelium - Hyperplasia PDF 951KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/seminal_vesicle/epihyperpl/seminal_vesicle-epithelium-hyperplasia-pdf_508.pdf
Vesicle, Epithelium - Hyperplasia Figure Legend: Figure 1 Seminal Vesicle, Epithelium - Hyperplasia. Hyperplasia of seminal vesicle epithelium in a male F344/N rat from a chronic ...
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Prostate - Inflammation 894KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/prostate/inflamm/prostate_inflammation_508_pdf.pdf
- Inflammation, [Acute, Suppurative, Chronic, Chronic-active, Granulomatous] Figure Legend: Figure 1 Prostate - Inflammation. Arrows indicate neutrophils passing through the ...
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Presentation: Quantitative Considerations of Dose-Response for... 653KB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/wksp-ppts/1-3-simon-508.pdf
Quantitative Prediction of Phenotypic Change from High Throughput Assay Results Ted W. Simon, Ph.D., DABT Ted Simon LLC EPA/NTP Workshop on IVIVE February 17, 2016 Road Map . For ...
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BG1Luc ER TA Agonist Protocol: Appendix C of ICCVAM BRD 369KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c3-appxc.pdf
45 Appendix C Protocol for the LUMI-CELL ® Estrogen Receptor (ER) Transcriptional Activation Test Method for the Detection of ER Antagonists ICCVAM BG1Luc ER TA Evaluation Report ...
