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Search suggestions for "57-63-6".

  1. Report on Carcinogens Endocrine disruptor (Ethinyl estradiol... https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/estrogenssteroidal.pdf
  2. CEBS Data Related to Transgenic model evaluation (Ethinyl estradiol... https://cebs.niehs.nih.gov/cebs/test_article/57-63-6


54 results found for "57-63-6".

  1. TR-547: Multigenerational Reproductive Toxicology Study of Ethinyl... 4.7MB

    https://ntp.niehs.nih.gov/go/tr547

    MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDIES) NTP TR 547 AUGUST 2010 NTP TECHNICAL REPORT ON THE ...

  2. TR-548: Toxicology and Carcinogenesis Studies of Ethinyl Estradiol... 4.1MB

    https://ntp.niehs.nih.gov/go/tr548

    TOXICOLOGY AND CARCINOGENESIS STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDY) NTP TR 548 JULY 2010 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND ...

  3. Abstract for TR-547 72KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr547

    Abstract for TR-547 Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol in Sprague-Dawley Rats (Feed Studies) CASRN: 57-63-6 Chemical Formula: C20H24O2 Molecular ...

  4. Abstract for TR-548 66KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr548

    Abstract for TR-548 Toxicology and Carcinogenesis Study of Ethinyl Estradiol in Sprague-Dawley Rats (Feed Study) CASRN: 57-63-6 Chemical Formula: C20H24O2 Molecular Weight: 296.40 ...

  5. Target Organs and Levels of Evidence for TR-548 54KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr548levels

    Target Organs and Levels of Evidence for TR-548 Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) Chemical (Study ...

  6. DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB

    https://ntp.niehs.nih.gov/go/dart05

    .........13 Ethinyl Estradiol ............14 Ethinyl Estradiol ......

  7. Uterotrophic Assay: Oxybenzone, Octylmethoxycinnamate, Octylsalate... 15.4MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-04/uv1_uterotrophic_redacted_disclaimer.pdf

    ... 2.5 Reference Substance: 17α-Ethinyl Estradiol ......octocrylene or 0.1 mg/kg 17α-Ethinyl estradiol (positive control) for three ...

  8. Uterotrophic Assay Report: Avobenzone, Ensulizole, Homosalate... 15.2MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-04/uv2_uterotrophic_redacted_disclaimer.pdf

    ... 2.5 Reference Substance: 17α-Ethinyl Estradiol......or Padimate-O or 0.5 mg/kg/day 17α-ethinyl estradiol (positive control) for 3 consecutive ...

  9. Abstract for RACB20103, RACB20104, RACB20105, RACB20106, and... 63KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb20104

    Dawley Rats and Methoxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague ... Methoxychlor (CASRN 72-43-5) Ethinyl Estradiol (CASRN 57-63-6) Report Date: May ...

  10. Reproductive Abstracts 197KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... in Male Sprague Dawley Rats and Methoxychlor (CASRN: 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn ...

  11. CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf

    ... rats were exposed to ethinyl estradiol at 0, 10, 50, or 200 mg/kg bw/day for 28 days. ... Male rats from the mid- and high-dose ethinyl estradiol groups experienced decreased ...

  12. Testis, Interstitial Cell - Vacuolation - Nonneoplastic Lesion... 277KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/InterstitialCell-Vacuolation

    The transgenic mice in Figure 1, Figure 2, and Figure 3 were treated with ethinyl estradiol. Testicular macrophages can also become vacuolated, independent of interstitial cells. ...

  13. ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure... 1016KB

    https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2022/unnikrishnan_ascct-2022-poster_fd.pdf

    ... Estrogenic chemicals: . 17-Methyltestosterone . 17-alpha-Ethinyl estradiol . ... exposure 17-Methyltestosterone Bisphenol A 17-beta-Estradiol 17-alpha-Ethinyl estradiol . ...

  14. Seminal Vesicle, Epithelium - Hyperplasia - Nonneoplastic Lesion... 282KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/seminal-vesicle/Epithelium-Hyperplasia

    Seminal vesicle hyperplasia in rats has been reported following exposure to methylnitrosourea in the presence of either ethinyl estradiol or testosterone. In contrast to ...

  15. Study Abstracts 370KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... in Male Sprague Dawley Rats and Methoxychlor (CASRN: 72-43-5), Ethinyl Estradiol (CASRN: 57-63-6) and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn ...

  16. Testis, Interstitial Cells - Vacuolation 914KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/testis/intcvac/testis_interstitial_cell-vacuolation_508.pdf

    The transgenic mice in Figure 1, Figure 2, and Figure 3 were treated with ethinyl estradiol. Testicular macrophages can also become vacuolated, independent of interstitial cells. ...

  17. RR-09: Lay Summary; Bisphenol A (CASRN 80-05-7) 221KB

    https://ntp.niehs.nih.gov/sites/default/files/2024-08/rr09_summary_508.pdf

    pregnant rats and offspring that received 0.05 or 0.5 μg ethinyl estradiol/kg-bw per day. Ethinyl estradiol is a synthetic estrogen with well-known effects, and this ...

  18. Seminal Vesicle, Epithelium - Hyperplasia PDF 951KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/seminal_vesicle/epihyperpl/seminal_vesicle-epithelium-hyperplasia-pdf_508.pdf

    Seminal vesicle hyperplasia in rats has been reported following exposure to methylnitrosourea in the presence of either ethinyl estradiol or testosterone. In contrast to ...

  19. CLARITY-BPA Program 71KB

    https://ntp.niehs.nih.gov/research/topics/bpa

    ... kilogram of body weight per day of ethinyl estradiol, so the animals' response to a ... internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and ...

  20. BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf

    ... effective concentration EE 17α-ethinyl estradiol EDSP Endocrine Disruptor Screening ... o,p'-DDT, diethylstilbestrol, 17α-ethinyl estradiol, and flavone) covering a range of ER ...

  21. Abstract for DART-05 118KB

    https://ntp.niehs.nih.gov/publications/reports/dart/dart05

    for the subsequent MOG study; ethinyl estradiol (EE), a synthetic form of estrogen, ... EE = ethinyl estradiol; GD = gestation day; LD = lactation day; PND = postnatal day. [M] = ...

  22. DART-05: Lay Summary; 2-Hydroxy-4-methoxybenzophenone (CASRN... 228KB

    https://ntp.niehs.nih.gov/sites/default/files/2025-03/dart05_summary_508.pdf

    Vehicle control animals were fed diets with no chemical added (0 ppm 2H4MBP), and positive control animals were fed diets containing 0.05 ppm ethinyl estradiol (EE), a synthetic ...

  23. Appendix G; 15th RoC 2021 69KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf

    57-41-0 (phenytoin) see Phenytoin and Phenytoin Sodium 57-57-8 see β-Propiolactone 57-63-6 (ethinylestradiol) see Estrogens, Steroidal 57-83-0 see Progesterone 58-89-9 (lindane) ...

  24. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... CE Clear Evidence CE Clear Evidence P Clear Evidence TR-548 05/16/07 Ethinyl Estradiol 57-63-6 EE Equivocal Evidence EE Equivocal Evidence TR-547 05/16/07 Ethinyl Estradiol ...

  25. Abstract for RR-18 54KB

    https://ntp.niehs.nih.gov/publications/reports/rr/rr18

    As a positive estrogen control, animals were similarly dosed with ethinyl estradiol ([EE2]; 0.05 or 0.5 μg/kg bw/day) from GD 6 through 2 years of age. This report presents a ...

  26. TOX-79: Reproductive Dose Range-Finding Toxicity Study of Genistein... 1.4MB

    https://ntp.niehs.nih.gov/go/tox079

    ... p-nonylphenol; and the potent and widely used synthetic estrogen, ethinyl estradiol. ... The sensitivity of the NCTR CD rat to the potent estrogen ethinyl estradiol was evaluated ...

  27. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... 17∝-Estradiol 57-91-0 POS POS POS (1/1) POS (3/3) POS (2/2) 17∝-Ethinyl estradiol 57-63-6 POS POS POS (3/3) POS (3/3) POS (3/3) 17ß-Estradiol 50-28-2 POS POS POS (1/1) ...

  28. Actions: TRPRP; Oct. 14, 2021 216KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2021/october/actionstrprp20211014_508.pdf

    ... Exposure to 2H4MBP was associated with nonneoplastic kidney lesions in the F 0 , F 1 , and F 2 generations. Expected estrogenic responses were observed in the ethinyl estradiol ...

  29. Abstract for RR-09 129KB

    https://ntp.niehs.nih.gov/publications/reports/rr/rr09

    .../day) of the orally active estrogen ethinyl estradiol (EE2) were also included in the continuous-dose arm to assess the sensitivity of the test system to low doses of an estrogen. ...

  30. RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000 1.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf

    ... O 2 fine white to creamy white odorless 57-63-6 1,3,5(10)-estratriene-3,17∞-diol; ... J Natl Cancer Inst 57:1057-1062. 73. Mosby, Inc. 2000. Ethinyl Estradiol; Ethynodiol ...

  31. RR-09: The CLARITY-BPA Core Study: A Perinatal and Chronic Extended... 5.1MB

    https://ntp.niehs.nih.gov/go/rr09

    .../day) of the orally active estrogen ethinyl estradiol (EE 2 ) were also included in the ... Dietary ethinyl estradiol (EE 2 ) exposure studies in this strain 15; 16; 18; 20 resulted ...

  32. TR-545: Toxicology and Carcinogenesis Study of Genistein (CASRN... 2.8MB

    https://ntp.niehs.nih.gov/go/tr545

    ... p-nonylphenol; and the potent and widely used synthetic estrogen, ethinyl estradiol. ... The sensitivity of the NCTR CD rat to the potent estrogen ethinyl estradiol was evaluated ...

  33. CERHR Monograph: Soy Infant Formula 122.6MB

    https://ntp.niehs.nih.gov/go/soy_monograph

    ... Genistein and ethinyl estradiol dietary exposure in multigenerational and chronic studies ... TABLE 143. Adverse Effects in Rats Treated with Ethinyl Estradiol and Given Soy-Containing ...

  34. TR-539: Multigenerational Reproductive Toxicology Study of Genistein... 5.6MB

    https://ntp.niehs.nih.gov/go/tr539

    ... The sensitivity of the NCTR CD rat to the potent estrogen ethinyl estradiol was evaluated ... Chronic toxicity was also examined for two test com- pounds (ethinyl estradiol and ...

  35. Technical Reports 858KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Report TR-548 PDF (6.58 MB) Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) 2010 Technical Report TR-547 PDF ...

  36. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... Hiyoshi KFDA Hiyoshi KFDA 2 17α-Ethinyl estradiol POS (3/3) POS (3/3) POS (1/1) POS ... Confirmation Overall 2 17α-Ethinyl estradiol POS (7/7) POS (1/1) POS 2 Apigenin ...

  37. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... c Agonism d Antag e,f EPA Proposed In Vivo Studies g,h,I,j Comments 17α-Ethinyl estradiol 57-63-6 Steroid Pharmaceutical, Veterinary Agent † ER AR ER+++/ AR++ ER+++/ AR- Y U/...

  38. Study Reports 1.0MB

    https://ntp.niehs.nih.gov/publications/reports

    ... Report TR-548 PDF (6.58 MB) Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) 2010 Technical Report TR-547 PDF ...

  39. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/research/apptoxres/cartox

    ... TR-548 PDF (6.58 MB) Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) 2010 Long-Term Carcinogenicity TR-547 ...

  40. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... Hormone Estrone 53-16-7 Steroid, phenolic; Estrene Pharmaceutical 17α-Ethinyl estradiol 57-63-6 Steroid, phenolic Pharmaceutical Ethyl paraben 120-47-8 Paraben; Organic acid ...

  41. EPA Health Effects Test Guidelines: Estrogen Receptor Transcriptional... 431KB

    https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/epa/epa-890-1300.pdf

    ... Class 2 Test concentration range Note Diethylstilbestrol (DES) 56-53-1 Positive 10 -14 - 10 -8 M 17α-Ethynyl estradiol (EE) 57-63-6 Positive 10 -14 - 10 -8 M Hexestrol 84-16-2 ...

  42. Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf

    ... diethylstilbestrol (DES), 17α-ethinyl estradiol EE), some with moderate EA (GEN, ... Estrene 1E-4 - 1E-16 98% Sigma 17α-Ethinyl estradiol 57-63-6 Steroid, phenolic 1E-4 - ...

  43. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... Sigma Powder 17alpha-Ethynyl Estradiol 57-63-6 Steroid, phenolic Pharmaceutical Steroid ... 1.00E+00 12% 17alpha-Ethynyl Estradiol 57-63-6 P + - - - Active Viable 1.44E-11 - ...

  44. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... Sigma Powder 17alpha-Ethynyl Estradiol 57-63-6 Steroid, phenolic Pharmaceutical Steroid ... 1.00E+00 12% 17alpha-Ethynyl Estradiol 57-63-6 P + - - - Active Viable 1.44E-11 - ...

  45. TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB

    https://ntp.niehs.nih.gov/go/tr597

    ... (2-50 parts per billion [ppb]) of ethinyl estradiol have shown to be associated with ... Exposure to ultra-low dose (2- 50 ppb) ethinyl estradiol has been reported to be ...

  46. Appendices A-G; 15th RoC 2021 433KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf

    ... 57-41-0 (phenytoin) see Phenytoin and Phenytoin Sodium 57-57-8 see β-Propiolactone 57-63-6 (ethinylestradiol) see Estrogens, Steroidal 57-83-0 see Progesterone 58-89-9 (lindane) ...

  47. Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf

    ... Table 5-7: alpha symbol for estradiol and ethinyl estradiol. Page 5-7, line 100: after "antagonist testing" add (Table 5-3) L130: "... listed in Table 5-5 5-7 L136: "... listed in ...

  48. NTP-CERHR Monograph: Potential Human Reproductive and Developmental... 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

    Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP) November 2006 NIH Publication No. 06 - 4476 iii Table of ConTenTs ...

  49. Public Health Impact 1.9MB

    https://ntp.niehs.nih.gov/media/impact

    ... National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis study of ethinyl estradiol (CASRN 57-63-6) in Sprague-Dawley rats (feed study). ...

  50. Handbook for Conducting a Literature-Based Health Assessment... 4.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookmarch2019_508.pdf

    ... with bisphenol a or ethinyl estradiol causes few alterations on early preweaning measures. ... Comments: 0.005 or 0.010 mg/kg/day ethinyl estradiol (EE2) used as postive control ...

 
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