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TR-395: Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1Mice... 16.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr395.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 395 ~ ss~VlCC~s O .,~ ~ ' ~ " - ~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROBENECID (CAS NO. 57-66-9) IN F344/N RATS AND ...
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Abstract for TR-395 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr395
Abstract for TR-395 Toxicology and Carcinogenesis Studies of Probenecid in F344/N Rats and B6C3F1 (Gavage Studies) CASRN: 57-66-9 Chemical Formula: C13H19NO4S Molecular Weight: ...
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Target Organs and Levels of Evidence for TR-395 57KB
https://ntp.niehs.nih.gov/data/tr/300s/tr395levels
Target Organs and Levels of Evidence for TR-395 Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study ...
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Minutes: BSC TRRS; Nov. 19, 1990 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1990/nov/trrs19nov1990mins_508.pdf
D i r e c t B l u e Methyl Bromide M o n o c h l o r o a c e t i c A c i d Probenecid T i ... Long-Term S t u d i e s 103-90-2 7782-50-5 10599-90-3 2429-74-5 74-83-9 79-11-8 57-66-9 ...
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TR-384: 1,2,3-Trichloropropane (CASRN 96-18-4)in F344 Rats and... 5.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr384.pdf
... Hexachloroethane Phenylbutazone Probenecid Titanocene.2Cl 0/50 0/50 0/50 0/50 0/50 ... Hexachloroethane Phenylbutazone Probenecid Titanocene.2Cl 0/50 0/50 0/50 0/50 0/50 ...
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TOX-48: Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN... 18.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox048.pdf
... inhibitor, but was unaffected by pretreatment with inhibitors of ADH, aldehyde dehydrogenase, or probenecid, a renal organic anion transporter inhibitor (Horvath eta!., 1992). ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... NE No Evidence NE No Evidence NE No Evidence NE No Evidence TR-395 11/20/90 Probenecid 57-66-9 NE No Evidence NE No Evidence NE No Evidence SE Some Evidence TR-394 11/19/90 ...
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TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB
https://ntp.niehs.nih.gov/go/tr426
... 0/50 0150 Phenylbutazone 3/50 0150 Probenecid 0150 0/50 Titanocene dichloride 0159 0/... 2/50 0150 Phenylbutazone 2/50 2/50 Probenecid 2/49 0/49 Titanocene dichloride 5/58 0/...
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TR-357: Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and... 12.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr357.pdf
... Secretion is via the organic anion transport system in the proximal tubules and is Hydrochlorothiazide, NTP TR 357 14 I. INTRODUCTION sensitive to inhibition by probenecid (Gilman ...
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TR-446: 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3... 16.4MB
https://ntp.niehs.nih.gov/go/tr446
... Hexachloroethane Phenylbutazone Probenecid Promethazine Hydrochloride Titanocene ... Hexachloroethane Phenylbutazone Probenecid Promethazine Hydrochloride Titanocene ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-395 PDF (16.63 MB) Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1991 Technical Report TR-394 ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-395 PDF (16.63 MB) Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1991 Technical Report TR-394 ...
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TR-399: Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats... 8.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr399.pdf
... Hexachloroethane Phenylbutazone Probenecid Diglycidyl resorcinol ether Diglycidyl .../50 2/50 Phenylbutazone 0/50 O b 0 0/50 Probenecid 1/50 0/50 1/50 Diglycidyl resorcinol ...
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TR-450: Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and... 21.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr450.pdf
... by tetrafluoroethylene-mercapturic acid could be inhibited by probenecid, suggesting that the two tetrafluoroethylene compounds are transported by a different carrier system. ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-395 PDF (16.63 MB) Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1991 Long-Term ...
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RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf
... 10 mg!kg) in the presence or absence of probenecid (competes for and inhibits renal tubular secretion of organic ions). Probenecid was administered (500 mg) 2 and 12 hours ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf
... W.M.M. (1979) Pharmacodynamic analy- sis of the furosemide-probenecid interaction in man. ... Ther. 229:440-446. 43. Hook, J.B.; Williamson, H.E. (1965) Influ- ence of probenecid and ...
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TR-569: Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr569_508.pdf
... and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob. ... idation and renal excretion of zidovudine by probenecid in rats. J. Pharmacol. Exp. ...
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GMM-14: Genetically Modified Model Report on 3'-Azido-3'-Deoxythymidin... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm14_508.pdf
... and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob. ... and renal excretion of zidovudine by probenecid in rats. J. Pharmacol. Exp. ...
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TR-522: Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1... 5.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr522.pdf
... and its catabolites and interactiosn with probenecid in rhesus monkeys. Antimicrob. ... and renal excretion of zidovudine by probenecid in rats. J. Pharmacol. Exp. ...
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GMM-16: Genetically Modified Model Report on Study of Mixtures... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm16_508.pdf
... and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob. ... and renal excretion of zidovudine by probenecid in rats. J. Pharmacol. Exp. ...
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RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf
... by tetrafluoroethylene-mercapturic acid could be inhib- ited by probenecid, suggesting that the two tetra- fluoroethylene compounds are transported by a different carrier system. ...
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TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf
... Gavage 394 Acetaminophen Feed 395 Probenecid Gavage 396 Monochloroacetic Acid Gavage ... Toxicology and Carcinogenesis Studies of Probenecid (CAS No. 57-66-9) in F344/N Rats and ...
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TR-401: 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in... 12.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr401.pdf
... 060 0150 Phenylbutazone 0149 0149 0149 Probenecid 0149 0149 0149 Overall Historical ... 395 393 392 391 3 9 0 Probenecid Sodium Fluoride Chlorinated Water and ...
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TR-469: AZT (CASRN 30516-87-1) and AZT/a-Interferon A/D B6C3F1Mice... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr469.pdf
... Pharmacokinetics of 3N-azido-3N-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob. Agents Chemother. 35, 801-807. Cretton, E.M., ...
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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr417.pdf
... Fluoride 354 Dimethoxane 394 Acetaminophen 355 Diphenhydramine Hydrochloride 395 Probenecid 356 Furosemide 3% Monochloroacetic Acid 357 Hydrochlorothiazide 397 C.I. Direct Blue ...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf
... Phosphate Chlorinated Water and Chloraminated Water Sodium Fluoride Acetaminophen Probenecid Monochloroacetic Acid C.I. Direct Blue 15 Polybrominated Biphenyls Titanocene ...
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TR-410: Naphthalene (CASRN 91-20-3) in B6C3F1Mice (Inhalation... 8.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr410.pdf
... 8-Methoxypsoralen Ochratoxin A Hydrochlorothiazide 395 393 392 391 390 Probenecid Sodium Fluoride Chlorinated Water and Chloraminated Water Tris(2-chloroethyl) ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr413.pdf
... Fluoride 355 Diphenhydramine Hydrochloride 394 Acetaminophen 356 Furosemide 395 Probenecid 357 Hydrochlorothiazide 396 Monochloroacetic Acid 358 Ochratoxin A 397 C.I. Direct ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... FF-1) (Feed) 398 Polysorbate 80 (Glycol) 415 Polyvinyl Alcohol 474 Primidone 476 Probenecid 395 Promethazine Hydrochloride 425 Propylene 272 Propylene Glycol Mono-t-butyl Ether ...
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TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf
... Fluoride 348 a-Methyldopa Sesquihydrate 394 Acetaminophen 349 Pentachlorophenol 395 Probenecid 350 Tribromomethane 3% Monochloroacetic Acid 35 1 p-Chloroaniline Hydrochloride 397 ...
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TR-412: 4,4'-Diamino-2,2'-Stilbenedisulfonic Acid Disodium Salt... 11.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr412.pdf
... Water and Chloraminated Water W i u m Huoride Probenecid Monahlomcetic Acid "itanusme Dichloride 2.4-Diaminophenol Dihydmhloride Resorcinol C.I. Acid Red 114 +Wymlactone C I . ...
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TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB
https://ntp.niehs.nih.gov/go/tr385
... 3,3-Dimethylbenzidine Dihydrochloride Tris(2-chloroethyl) Phosphate Sodium Fluoride Probenecid 362 363 364 365 4-Vinyl-1-Cyclohexene Diepoxide Bromoethane (Ethyl Bromide) ...
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TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf
... Hexachbmethane 391 393 3% Tris(2chloroethyl) Phosphate Sodium Fluoride Probenecid 362 363 364 365 4-Vinyl-l -Cydohexene Diepaxide Bromoethane (Ethyl Bromide) ...
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TR-397: C.I. Direct Blue 15 (CASRN 2429-74-5) in F344 Rats (Drinking... 13.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr397.pdf
... 8-Methcaypsoralen 399 3% 395 Titanocene Dichloride Monochloroacetic Acid Probenecid 370 369 368 367 366 365 364 363 362 Benzofuran Alpha-Methylbenzyl Alcohol Nalidixic ...
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TR-405: C.I. Acid Red 114 (CASRN 6459-94-5) in F344/N Rats (Drinking... 12.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr405.pdf
... Dihydrochloride 391 Tris(2chlomethyl) Phosphate 393 Sodium Fluoride . 395 Probenecid 399 Titanocene Dichloride These N T P Technical Reports are available for sale from ...
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TR-406: g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1Mice... 11.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr406.pdf
... 361 360 359 Hacscbloroethane N,N-Dimethyianiline S-MethoJrypsoralen 395 393 391 Probenecid Sodium Fluoride Tris(2chlorcethyl) Phosphate 365 364 363 362 Pentaerythritol ...
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TR-408: Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and... 12.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr408.pdf
... Phosphate Chlorinated Water and Chloraminated Water Sodium Fluoride Acetaminophen Probenecid Monochloroacetic Acid C.I. Direct Blue 15 Titanocene Dichloride 2,4-Diaminophenol ...
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TR-414: Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr414.pdf
... Fluoride 354 Dimethoxane 394 Acetaminophen 355 Diphenhydramine Hydrochloride 395 Probenecid 356 Furosemide 3% Monuchloroacetic Acid 357 Hydmhlorothiazide 397 C.I. Direct Blue ...
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TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf
... FF-1) (Feed) 398 Polysorbate 80 (Glycol) 415 Polyvinyl Alcohol 474 Primidone 476 Probenecid 395 Promethazine Hydrochloride 425 Propylene 272 1,2-Propylene Oxide 267 Propyl ...
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TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf
... FF-1) (Feed) 398 Polysorbate 80 (Glycol) 415 Polyvinyl Alcohol 474 Primidone 476 Probenecid 395 Promethazine Hydrochloride 425 Propylene 272 1,2-Propylene Oxide 267 Propyl ...
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TR-394: Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1Mice... 14.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr394.pdf
... Water 355 Diphenhydramine Hydrochloride 393 Sodium Fluoride 356 Furosemide 395 Probenecid 357 Hydrochlorothiazide 3% Monochloroacetic Acid 358 Ochratoxin A 397 C.I. Direct ...
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TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf
... Fluoride 352 N-Methylolacrylamide 394 Acetaminophen 353 2,4-Diehlorophenol 395 Probenecid 354 Dimethoxane 396 Monochloroacetic Acid 355 Diphenhydramine Hydrochloride 397 C.I. ...
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TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr402.pdf
... Chloraminated Water 356 Furosemide 393 Sodium Fluoride 357 Hydrochlorothiazide 395 Probenecid 358 Ochratoxin A 396 Monochloroacetic Acid 359 8-Methoxypsoralen 397 C.I. Direct ...
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TR-403: Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1Mice... 15.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr403.pdf
... Water 359 8-Methoxypaoralen 393 Sodium Fluoride 360 N,N-Dimethylaniline 395 Probenecid 361 Hexachloroethane 396 Monochloroacetic Acid 362 4-Vinyl-l-Cyclohexene Diepoxide ...
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TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf
... Fluoride 348 a-Methyldopa Sesquihydrate 394 Acetaminophen 349 Pentachlorophenol 395 Probenecid 350 Tribromomethane 396 Monochloroacetic Acid 351 p-Chloroaniline Hydrochloride 397 ...
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TR-407: C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr407.pdf
... Furosemide Diphenhydramine Hydrochloride 395 393 391 390 389 387 386 Probenecid Sodium Fluoride Tris(2chloroethyl) Phosphate 3 , 3 '-Dimethylbenzidine ...
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TR-411: C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and... 15.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr411.pdf
... Thiourea 358 357 Ochratoxin A Hydrochlorothiazide 3% 395 Monochloroacetic Acid Probenecid 361 360 359 Hexachloroethane N,N-Dimethylaniline 8-Methoxypsoralen 401 399 397 ...
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TR-421: Talc (CASRN 14807-96-6)(Non-Asbestiform) in F344/N Rats... 16.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr421.pdf
... 392ChlorinatedWaterandChloraminatedWater 393 Sodium Fluoride 394 Acetaminophen 395 Probenecid 3% Monochloroacetic Acid 397 C.I. DirectBlue15 398 Polybrominated Biphenyls 399 ...
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TR-424: o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats... 15.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr424.pdf
... Rmrsone 393 W i u m Fluoride 346 Chloroethane 394 Acetaminophen 347 D-Limonene 395 Probenecid 348 a-Methyldopa Sesquihydrate 3% Monochloroacetic Acid 349 Pentachlorophenol 397 ...