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Search suggestions for "57-83-0".

  1. Report on Carcinogens Progesterone https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/progesterone.pdf
  2. CEBS Data Related to Progesterone (57-83-0) https://cebs.niehs.nih.gov/cebs/test_article/57-83-0


100 results found for "57-83-0".

  1. RoC Profile: Progesterone; 15th RoC 2021 138KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/progesterone.pdf

    Progesterone CAS No. 57-83-0 Reasonably anticipated to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) O CH 3 CH 3 C H 3 C O Carcinogenicity ...

  2. Abstract for RR-17 64KB

    https://ntp.niehs.nih.gov/publications/reports/rr/rr17

    Introduction Endogenous progesterone is a sex hormone, one role of which is to maintain the uterine lining to support pregnancy. Drugs that exert progesterone action, collectively ...

  3. Progestogens and Adverse Health Outcomes 62KB

    https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/progestogens

    Status: Evaluation completed Background Information Progesterone produced by the body is ... produce effects similar to the natural progesterone in the body; they include both ...

  4. BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf

    ... C-114 12.2.6 N0014 - Progesterone ......C-155 14.4.4 N0014 - Progesterone ......

  5. Vagina - Mucification - Nonneoplastic Lesion Atlas 288KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/vagina/Mucification

    in a pop-up window and Figure 2 image opens in a pop-up window ) is induced by progesterone excess. Therefore, it occurs normally during proestrus, pregnancy, and pseudopregnancy. ...

  6. Protocol (Revised) for Scoping Review of Adverse Health Effects... 370KB

    https://ntp.niehs.nih.gov/ntp/ohat/progestogens/protocol_revised_508.pdf

    ... BACKGROUND AND SIGNIFICANCE Background Progesterone is a steroid hormone that is involved ... Progesterone drugs fall into one of two categories: natural progesterone and synthetic ...

  7. RR-17: Scoping Review of Prenatal Exposure to Progestogens and... 960KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr17_508.pdf

    ... Endogenous progesterone is a sex hormone, one role of which is to maintain the uterine lining to support pregnancy. Drugs that exert progesterone action, collectively ...

  8. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... pmol Picomole Pos. Positive PR Progesterone receptor pSG5 A eukaryotic expression ... to, or have minimal response levels for, the glucocorticoid and progesterone receptors. ...

  9. Ovary, Corpus Luteum - Cyst - Nonneoplastic Lesion Atlas 291KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/CorpusLuteum-Cyst

    progesterone stimulation. Luteal cysts must be differentiated from corpora lutea that did not fill in normally but that progress through the estrous cycle. Progesterone ...

  10. Vagina - Mucification 282KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/vagina/mucif/vagina-mucification-pdf-508.pdf

    Comment: In general, vaginal mucification (Figure 1 and Figure 2) is induced by progesterone excess. Therefore, it occurs normally during proestrus, pregnancy, and pseudopregnancy. ...

  11. CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

    ...ric.acid.type.A.(GABA A ).(157, 158),. progesterone.(159, 160),.aryl.hydrocarbon.recep- ... increase. the. expression. of. progesterone. receptor. mRNA. in. the. frontal. ...

  12. Human Breast Cancer Studies; Pam Schwingl; ROCPRP; Oct. 5, 2018 2.4MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/05schwingl_rocprp_508.pdf

    Breast cancer subtypes and etiology . ~2 out of 3 breast cancers are ER+ or PR+ (estrogen or progesterone positive). For hormone positive tumor subtypes, high estrogen levels ...

  13. Risk Assessment of Exposure to Triazole Fungicides by Human Biomonitor... 1.3MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Marciano-poster.pdf

    with fungicide exposure. § Notably, HTS identified perturbations with androgen, progesterone and estrogen metabolic processes, xenobiotic metabolism, and aromatase activity at ...

  14. RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000 1.7MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf

    ... Do not use in cows producing milk for human consumption. 21 CFR 522.1940-Progesterone and ... Amounts used are 100 mg U.S. Codes: 21 U.S.C. 360b. of progesterone and 10 mg of estradiol ...

  15. Ovary, Corpus Luteum - Cyst 339KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/ovary/clcyst/ovary-corpus-luteum-cyst-pdf-508.pdf

    progesterone stimulation. Luteal cysts must be differentiated from corpora lutea that did not fill in normally but that progress through the estrous cycle. Progesterone ...

  16. Appendix G; 15th RoC 2021 73KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    see β-Propiolactone 57-63-6 (ethinylestradiol) see Estrogens, Steroidal 57-83-0 see Progesterone 58-89-9 (lindane) see Lindane, Hexachlorocyclohexane (Technical Grade), and ...

  17. NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf

    ... for estrogen-receptor-positive, progesterone-receptor-positive, and ... or negative estrogen receptor [ER], progesterone receptor [PR], human epidermal growth ...

  18. CERHR Monograph: Soy Infant Formula 122.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf

    ... (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globu- lin ... of breast lobular epithelium and progesterone receptor expression in women who ate ...

  19. RoC Profile: Tamoxifen; 15th RoC 2021 149KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tamoxifen.pdf

    ... therapy unopposed by progesterone had highly elevated risks of endo- ... node-positive, and estrogen- or progesterone-receptor-positive women since the mid ...

  20. RoC Background Document on Human Papillomaviruses: Genital-Mucosal... 2.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hpv_rg2_public_508.pdf

    ... and that progesterone may increase expression of HPV-16 E6 and E7 transcripts. ... mice were implanted with hormone pellets that contained either progesterone or estradiol. ...

  21. NCATS Update: ICCVAM Public Forum 2017 1.2MB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2017/03n-low-ncats-508.pdf

    EVATAR An ex vivo female reproductive tract Liver Ovary Ectocervix Uterus SHBG Albumin IGF-1 Estrogen Progesterone Steroid hormones affect liver metabolism Liver proteins affect ...

  22. Comment: Toxicology and Carcinogenesis Studies of Sodium Tungstate... 143KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/publiccomm/lemus20210318_trprp_508.pdf

    ... Tungstate treatment did not modify alanine aminotransferase (ALT) activity, progesterone, ... treatment had a considerable effect on the expression of the progesterone receptor. ...

  23. ICCVAM 2018 Public Forum Presentation: Dept. of the Interior... 1.9MB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2018/12-doi.pdf

    Luciferase transactivation cell bioassays - 4 stably transfected human cell lines . Estrogen (ERα, ERα/ERβ) pathways . Androgen/Glucocorticoid/Progesterone pathways . Androgen/...

  24. Presentation: Developing AOPs from PPAR Activation Leading to... 738KB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/nepelska-508.pdf

    ... 17β-HSD IV StAR TSPO cholesterol pregnenolone P450scc 3 β -HSD-III cholesterol progesterone androstenedione aromatase KE 8 KE KE AO Chemical Initiator Decreased testosterone ...

  25. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... NEG (3/3) NEG (3/3) p.p'-DDE 72-55-9 NEG NEG NEG (1/1) NEG (1/1) NEG (1/1) Progesterone 57-83-0 NEG NEG NEG (3/3) NEG (3/3) NEG (3/3) Raloxifene HCl 82640-04-8 POS POS POS (1/1) ...

  26. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... (3/3) POS (1/1) NEG (1/1) POS NEG 2 Progesterone b NEG (3/3) NEG (3/3) POS (1/1) NT NEG ... test these substances. b p,p'-DDE and progesterone were tested in Phase 2 by Hiyoshi and ...

  27. Adrenal Gland, Cortex, X-Zone - Atrophy - Nonneoplastic Lesion... 298KB

    https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/CortexX-Zone-Atrophy

    ... Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y. 2007. Adrenal 20α-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is ...

  28. Notice: BG1Luc4E2 Cells Are Being Renamed VM7Luc4E2 Cells 1.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/bg1luc/bg1luc-vm7luc-june2016-508.pdf

    ... carcinoma cell line with estrogen and progesterone receptors, Cancer 63, 280-288. (1989) ... The human pS2/TFF1 and PGR (progesterone receptor) genes are well-character- ized ...

  29. RoC Background Document: Tamoxifen; Oct. 30-31, 1997 2.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tamoxifen2_2apps_508.pdf

    ... therapy unopposed by progesterone have a highly elevated risk for endometrial cancer. ... node-positive, and estrogen or progesterone receptor- positive women since the ...

  30. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... by EPA and in vivo by OECD Medroxy progesterone acetate 71-58-9 Steroid Pharmaceutical ... in vitro by EPA and in vivo by OECD Progesterone 57-83-0 Steroid Pharmaceutical, ...

  31. Adrenal Gland, Cortex, X-Zone - Atrophy 412KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/cxzatrophy/adrenal-gland-cortex-xzone-atrophy-pdf_508.pdf

    ... F, Klammer S, Krup M, Weinstein Y. 2007. Adrenal 20α-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. ...

  32. Expert Panel Evaluation of the Validation Status of In Vitro... 1.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/expertpanfinalrpt/panelrpt1102.pdf

    ... However, as R1881 binds to the progesterone receptor (PR), binding assays based on cells ... levels of the glucocorticoid and progesterone receptors, and the use of a reporter ...

  33. TR-485: Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology... 12.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr485.pdf

    ... This action was blocked by administration of an equal amount of progesterone. Oxymetholone did not promote the capacity of micro- somal hydroxylases to hydroxylate progesterone; ...

  34. Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf

    ... 1 3.2544 26530-20-1 Octhilinone 0.6864 APR_MitoticArrest 1 1.4569 57-83-0 Progesterone 0.2007 APR_MitoMembPot 1 4.9835 83-79-4 Rotenone 0.3131 APR_MitoticArrest 1 ...

  35. Nomination Background: p-Synephrine (CASRN: 94-07-5) 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bitterorange_508.pdf

    ... Additionally, octopamine and synephrine (1 µM - 1 mM) enhanced progesterone production in ... Additionally, octopamine and synephrine (1 µM - 1 mM) enhanced progesterone production in ...

  36. RoC Profile: Diethylstilbestrol; 15th RoC 2021 141KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diethylstilbestrol.pdf

    ... Prenatal exposure to diethylstilbestrol also caused uterine cancer (adenocarcinoma) in Donryu rats (a carcinogen-sensitive strain with an increased estro- gen-to-progesterone ...

  37. National Institute of Environmental Health Sciences: NIEHS-08 155KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-08

    ... The most sensitive gene sets in male rats for which a reliable estimate of the BMD could be made were regulation of myeloid leukocyte mediated immunity and response to progesterone ...

  38. Tox21 Cross-partner Projects 101KB

    https://ntp.niehs.nih.gov/iccvamreport/2021/technology/tox21

    ... The targets being examined for this project are androgen receptor, estrogen receptor, glucocorticoid receptor, peroxisome proliferator-activated receptor gamma, progesterone ...

  39. Mechanistic and Other Relevant Data; Stan Atwood; ROCPRP; Oct... 1017KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/08atwood_rocprp_508.pdf

    ... Melatonin regulates sex hormone rhythms LAN/Shift Work: Biological Effects . ↑ Gonadotropins . Testosterone . Progesterone . Estrogens . Altered estrous function & rhythm ...

  40. Comment: Draft Report 06 Dated March 21, 2021; J.C. DiNardo;... 151KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/publiccomm/dinardo_octinoxate20210928_trprp_508.pdf

    ... JAMA 2020; 323:256-267. 4) Rehfeld A et al. Chemical UV Filters Mimic the Effect of Progesterone on Ca 2+ Signaling in Human Sperm Cells. Endocrinology 2016; 157:4297-4308. 5) ...

  41. Comment: Draft Report 05 Dated March 21, 2021; J.C. DiNardo;... 243KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/publiccomm/dinardo_oxybenzone20210928_trprp_508.pdf

    ... JAMA 2020; 323:256-267. 3) Rehfeld A et al. Chemical UV Filters Mimic the Effect of Progesterone on Ca 2+ Signaling in Human Sperm Cells. Endocrinology 2016; 157:4297-4308. 4) ...

  42. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    ... Biphenyls Polychlorinated Biphenyls Procarbazine and Its Hydrochloride Progesterone 1,3-Propane Sultone β-Propiolactone Propylene Oxide Propylthiouracil Reserpine ...

  43. Casey et al: BG1Luc ER TA Test Method: Results of an International... 228KB

    https://ntp.niehs.nih.gov/iccvam/meetings/8wc/ms/105107_casey3-508.pdf

    ... between the BG1luc eR tA and eR binding data. the only discordant substance (me- droxy-progesterone acetate) was positive in BG1 luc eR tA and negative based on eR binding data. ...

  44. TR-446: 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3... 16.4MB

    https://ntp.niehs.nih.gov/go/tr446

    ... and serumestradiol,progesterone,andprolactin levels resumed (Smith et al., 1 9 8 3 ) . ... thyroxin, testosterone, estrogen, and progesterone, which in turn affects the maturation ...

  45. DART-06: Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnam... 5.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart06_508.pdf

    ... repression of transcription of human progesterone receptor (PR) in PR CALUX cells ... which is normally associated with the progesterone-induced acrosomal reaction via the ...

  46. Monograph: Night Shift Work and Light at Night; Appendix B: Shiftwork... 1.6MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph_appb.pdf

    ... Only confirmed cases were included; estrogen and progesterone receptor status determined ... combined in analyses, except for estrogen receptor/progesterone receptor (ER/PR) analyses. ...

  47. Draft DART-06: Modified One-Generation Study of 2-Ethylhexyl... 2.7MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart06_508.pdf

    ... repression of transcription of human progesterone receptor 15 (PR) in PR CALUX cells ... which is normally associated with the progesterone-induced acrosomal reaction via the ...

  48. TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf

    ... that 2H4MBP can act as ERα, ERβ, and progesterone receptor antagonists. 35; 39; 37 In ... in assays measuring stimulation of ER, progesterone receptor, constitutive androstane ...

  49. TR-547: Ethinyl Estradiol (multigenerational) (CASRN 57-63-6... 8.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr547.pdf

    ... and the expression of ER-$ and progesterone receptor in females (Takagi et al., 2005). ... Thalidomide does not alter estro- gen-progesterone hormone single dose pharmacokinet- ics. ...

  50. Monograph: Summary of NTP Cancer Hazard Conclusions: Exposure... 870KB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal_summary20210400_508.pdf

    ... Finally, the evidence from human cancer studies is stronger for estrogen-receptor-positive, progesterone-receptor-positive, and human-epidermal- growth-factor-receptor 2-positive ...

 
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