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OECD Test Guideline 441: Hershberger Bioassay in Rats: A Short... 407KB
https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-tg441.pdf
OECD/OCDE 441 Adopted: 7 September 2009 OECD GUIDELINE FOR THE TESTING OF CHEMICALS Hershberger Bioassay in Rats: A Short-term Screening Assay for (Anti)Androgenic Properties ...
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Update on NICEATM Computational Resources 6.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2021/ppt/2021_sacatm_s4-1_kleinstreuer_v2_508.pdf
... inpu t (one per line) .0 .. 1016 1-33-8 57-85-2 58-18-4 58-22-0 65 -04-3 1071-83-6 Tan ... per line) O 10161-33-8 57-85-2 58-18-4 58-22-0 65-04-3 1071-83 -6 Tanimo Coeffici v-,.. ...
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Cobalt Literature Search StrategyRoC Peer Review; July 22, 2015 374KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_litsearchstrategy_508.pdf
Literature Search Strategy for Preparing the Report on Carcinogens Monograph on Cobalt and Certain Cobalt Compounds Introduction and objective The objective of the literature ...
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Revised Draft RoC Monograph Cobalt: RoC Peer Review; July 22... 3.0MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt.pdf
Monograph on Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo November 6, 2015 Office of the Report on Carcinogens Division of the National Toxicology Program National ...
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RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf
Genomic stability Oxidative damage Hypoxia-responsive target genes Resistance to apoptosis Accumulation of critical mutations Dysregulation of cell growth and proliferation Tumor ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
Cobalt and Cobalt CoMpounds that Release Cobalt ions in ViVo ROC MONOGRAPH 06 APRIL 2016 Report on Carcinogens Monograph on Cobalt and Cobalt Compounds That Release Cobalt Ions In ...
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OECD Guidance Document 129: Using Cytotoxicity Tests to Estimate... 1.4MB
https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd129.pdf
___... ENV/JM/MONO(2010)20 Unclassified English - Or. English Unclassified ENV/JM/MONO(2010)20 ...
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Draft RoC Monograph Cobalt: RoC Peer Review; July 22, 2015 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph.pdf
Cobalt and Certain Cobalt Compounds June 5, 2015 Office of the Report on Carcinogens Division of the National Toxicology Program National Institute of Environmental Health ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... being tested in vitro by EPA but no in vivo testing planned Testosterone propionate 57-85-2 Steroid Pharmaceutical - - H no binding or TA data; being tested by OECD in vivo A-16 ...
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TR-560: Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr560.pdf
ANd CARCINOGENESIS STUdIES OF ANdROSTENEdIONE (CAS NO. 63-05-8) IN F344/N RATS ANd B6C3F1 MICE (GAVAGE STUdIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, ...
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Revised Draft RoC Monograph Cobalt Appendix: RoC Peer Review... 1.7MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt_append.pdf
Monograph on Cobalt and Certain Cobalt Compounds That Release Cobalt Ions In Vivo Appendices November 6, 2015 Office of the Report on Carcinogens Division of the National ...
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Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf
National Toxicology Program's Report of the Organized by the National Institute of Environmental Health Sciences, NIH National Toxicology Program Sponsored by the U.S. ...
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ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
NIH Publication No: 02-4502 ICCVAM Evaluation of EPISKIN(tm), EpiDerm(tm) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for ...
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CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB
https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf
Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP) November 2006 NIH Publication No. 06 - 4476 iii Table of ConTenTs ...
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TR-314: Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and... 11.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr314.pdf
4 /~ t.,~f_ TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL METHACRYLATE (CAS NO. 80-62-6) IN F344/N RATS AND B6C3Ft MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
Episkin(tm), EpiDerm(tm), and Rat Skin Transcutaneous Electrical Resistance (TER) In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals Background ...
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RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000 1.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf
Steroidal Estrogens December 13 - 14, 2000 Meeting of the NTP Board of Scientific Counselors Report on Carcinogens Subcommittee Prepared for the: U.S. Department of Health and ...
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CERHR Monograph: Hydroxyurea 3.6MB
https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf
National Toxicology Program U.S. Department of Health and Human Services Center for The Evaluation of Risks To Human Reproduction NTP-CERHR MoNogRaPH oN THE PoTENTial HuMaN ...
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TR-485: Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology... 12.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr485.pdf
OF OXYMETHOLONE (CAS NO. 434-07-1) IN F344/N RATS AND TOXICOLOGY STUDIES OF OXYMETHOLONE IN B6C3F MICE 1 (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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Draft DART-06: Modified One-Generation Study of 2-Ethylhexyl... 2.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart06_508.pdf
Ethylhexyl p-Methoxycinnamate 4 (CASRN 5466-77-3) Administered in Feed to 5 Sprague Dawley (Hsd:Sprague Dawley ® SD ® ) 6 Rats with Prenatal, Reproductive Performance, 7 and ...
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DART-06: Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnam... 5.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart06_508.pdf
eThylhexyl P-meThoxyciNNam aTe (caSRN 5466-77-3) aDmiNiSTeReD iN feeD To SPRaGue Dawley (hSD:SPRaGue Dawley ® SD ® ) RaTS wiTh PReNaTal, RePRoDucTive PeRfoRmaNce, aND SubchRoNic ...
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Public Comment: Ruth Danzeisen of Cobalt Development Institute... 1.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/publiccomm/cdi20150708.pdf
the Cobalt Development Institute 8 July 2015 18 Jeffries Passage, Guildford, Surrey, GU1 4AP, United Kingdom Tel: +44 1483 578877 e-mail: info@thecdi.com Fax: +44 1483 567042 ...
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DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart05_508.pdf
hyDRoxy-4-meTho xybeNzoPheNoNe (caSRN 131-57-7) aDmiNiSTeReD iN feeD To SPRaGue Dawley (hSD:SPRaGue Dawley ® SD ® ) RaTS wiTh PReNaTal aND RePRoDucTive PeRfoRmaNce aSSeSSmeNTS iN ...
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RoC Monograph: 1-Bromopropane; September 2013 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf
1-BRoMopRopane ROC MONOGRAPH 01 SEPTEMBER 2013 Report on Carcinogens Monograph on 1-Bromopropane RoC Monograph 01 September 2013 National Toxicology Program Public Health Service ...
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Draft DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxyben... 3.3MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart05_508.pdf
Hydroxy-4-methoxybenzophenone 4 (CASRN 131-57-7) Administered in Feed to 5 Sprague Dawley (Hsd:Sprague Dawley ® SD ® ) 6 Rats with Prenatal and Reproductive 7 Performance ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
NIH Publication No: 03-4503 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters DMAE Aceglutamate [3342-61-8] DMAE p-Acetamidobenzoate [281131-6] and [3635-74-3] DMAE Bitartrate [5988-51-2] ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
Chemical Information Review Document for Artificial Butter Flavoring and Constituents Diacetyl [CAS No. 431-03-8] and Acetoin [CAS No. 513-86-0] Supporting Nomination for ...
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ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf
i Corrositex ® : An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals The Results of an Independent Peer Review Evaluation Coordinated by the ...
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TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf
NTP TechNical RePoRT oN The Toxicology aNd caRciNogeNesis sTudies of 2-hydRoxy- 4-meThoxybeNzoPheNoNe (casRN 131-57-7) admiNisTeRed iN feed To sPRague dawley (hsd:sPRague dawley ® ...
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RoC Profile: Nitrosamines; 15th RoC 2021 374KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrosamines.pdf
N-Nitrosamines: 15 Listings R 1 N R 2 N O Generic N-nitrosamine structure N-Nitrosamines are a class of chemical compounds with the general structure shown above. The essential ...
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TR-220: C.I. Acid Red 14 (CASRN 3567-69-9) in F344/N Rats and... 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr220.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 220 CARCINOGENESIS BIOASSAY OF C. I. ACID RED 14 (CAS NO. 3567-69-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDY) U.S. ...
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TR-361: Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage... 7.2MB
https://ntp.niehs.nih.gov/go/tr361
61 {* / &' , $ W ' . , . * > J * . , , TOXICOLOGY AND CARCINOGENESIS STUDIES OF HEXACHLOROETHANE (CAS NO. 67-72-1) IN F344/N RATS (GAVAGE STUDIES) U.S. DEPARTMENT O F HEALTH AND H ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
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TR-338: Erythromycin Stearate (CASRN 643-22-1) in F344/N Rats... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr338.pdf
8 TOXICOLOGY AND CARCINOGENESIS STUDIES OF ERYTHROMYCIN STEARATE (CAS NO. 643-22-1) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...
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TR-452: 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) (CASRN... 31.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr452.pdf
NATIONAL TOXICOLOGY PROGRAM Technical.Report Series No. 452 ~t~wcts ~ t~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,2-BIS(BROMOMETHYL)-I,3-PROPANEDIOL (FR-1138 ®) (CAS NO. ...
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TOX-79: Genistein (CASRN 446-72-0) 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox079.pdf
National Toxicology Program x Toxicity Report Series Number 79 NTP Technical Report on the Reproductive Dose Range-Finding Toxicity Study of Genistein (CAS No. 446-72-0) ...
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TR-247: L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr247.pdf
7 CARCl NOG EN ESlS BIOASSAY OF L-ASCORBIC ACID (VITAMIN C) (CAS NO. 50-81-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
CADMIUM FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by Integrated ...
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CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB
https://ntp.niehs.nih.gov/ntp/ohat/styrene/styrene_monograph.pdf
Styrene February 2006 NIH Publication No. 06 - 4475 iii Table of ConTenTs Preface......
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Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf
FINAL Report on Carcinogens Background Document for Selected Heterocyclic Amines: PhIP, MeIQ, and MeIQx September 19, 2002 Prepared for the: U.S. Department of Health and Human ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
HTML NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review ...