Brain - Cholesterol Clefts - Nonneoplastic Lesion Atlas 286KB

https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/brain/CholesterolClefts

(arrow) consisting of gliosis, macrophages, and crystalline-shaped cholesterol clefts. ... spaces formerly occupied by cholesterol crystals, often referred to as cholesterol clefts. ...

Brain - Cholesterol Clefts 324KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/nervous/brain/chclefts/brain-cholesterol_clefts_508.pdf

Cholesterol clefts Figure Legend: Figure 1 Cholesterol clefts in a male B6C3F1 mouse from a chronic study. Comment: A mature degenerate focus is represented in Figure 1 (arrow) ...

Abstract for TR-60 64KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr060

Phenesterin, an experimental anticancer agent, is a steroidal alkylating agent composed of the carboxylic acid ester of cholesterol and an aryl nitrogen mustard. A bioassay of ...

Pituitary Gland, Rathke's Cleft - Dilation - Nonneoplastic Lesion... 294KB

https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pituitary-gland/Rathke'sCleft-Dilation

Cholesterol clefts (arrow, Figure 1 image opens in a pop-up window and Figure 2 image ... Hemorrhage or cholesterol clefts within the dilated Rathke's cleft should not be diagnosed ...

Abstract for TR-565 70KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr565

Treatment claims also include lowering cholesterol levels; reducing insulin resistance; reducing the growth of cancer cells in breast, cervical, and prostate gland cancers; and ...

Pituitary Gland, Rathke's Cleft - Dilation 857KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/pituitary/rcdilat/pituitary-gland-rc-dilation-pdf_508.pdf

material with cholesterol clefts (arrow) present at the edge of the dilated cleft. ... proteinaceous material and the cholesterol clefts (arrow) at the edge of the ...

Presentation: Developing AOPs from PPAR Activation Leading to... 738KB

https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/nepelska-508.pdf

4 PPAR activation Hormone synthesis ƒ¢ cholesterol transport ƒ¢ Hormone levels ƒ¢ ... ƒœ embryonic and foetal development ƒœ cholesterol uptake and transport ƒœ represent a ...

RoC Profile: Estrogens, Steroidal; 15th RoC 2021 161KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/estrogenssteroidal.pdf

Steroidal estrogens are cholesterol derivatives comprising a group of structurally ... structurally related hormone molecules derived from the cholesterol molecule (IARC 1979a). ...

Bone marrow - Infiltration Cellular, Histiocyte - Nonneoplastic... 292KB

https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte

variable amounts of cellular debris, cholesterol clefts, or pigment (e.g., hemosiderin) ... Increased numbers of pale-staining vacuolated histiocytes containing cholesterol crystals ...

TOX-62: WY-14,643 (CASRN 50892-23-4) 2.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox062.pdf

... a chemical that was developed by the pharmaceutical industry to lower serum cholesterol. ... that contain a variety of enzymes involved in metabolism of lipids and cholesterol. ...

CERHR Monograph: Soy Infant Formula 122.6MB

https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf

... function, reproductive endpoints, cholesterol, diabetes mellitus, and cognitive function. ... system endpoints, cholesterol, diabetes mellitus, and cognitive function (Figure 2). ...

TOX-93: Toxicity Study of Chitosan (CASRN 9012-76-4) Administered... 2.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox093_508.pdf

... The 9% male and female rats had significantly decreased cholesterol values (26% to 48%), ... and moisture, as well as reduced levels of phosphorous, cholesterol, and triglycerides. ...

RR-08: In Vivo Repeat Dose Biological Potency Study of Triphenyl... 1.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr08_508.pdf

... for which BMD values could be obtained were serum HDL (high-density lipoprotein) cholesterol levels, absolute liver weights, relative liver weights, and serum cholesterol levels. ...

Minutes: BSC; Nov. 30-Dec. 1, 2010 984KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/novdec/minutes20101201.pdf

... NTP Testing Program Research Concept: Cholesterol and Lipid Modulating Agents: ... XXV. NTP Testing Program Research Concept: Cholesterol and Lipid Modulating Agents: ...

Bone Marrow - Infiltration Cellular, Histiocyte 565KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilhi/bone_marrow-infiltration_cellular_histiocyte_508.pdf

Increased numbers of pale-staining vacuolated histiocytes containing cholesterol crystals ... variable amounts of cellular debris, cholesterol clefts, or pigment (e.g., hemosiderin) ...

RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf

... Two of these studies involved surgical implantation of saccharin-containing cholesterol ... On the other hand, two studies in which saccharin-containing cholesterol pellets were ...

National Institute of Environmental Health Sciences: NIEHS-05 152KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-05

Although serum cholinesterase activity was significantly decreased and total cholesterol ... High density lipoprotein (HDL) cholesterol concentration was also significantly increased ...

TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf

... concentration and decreased bile acid, cholesterol, and phospholipid concentrations. ... In the 3-month study, elevated serum cholesterol and phospholipid concentrations were ...

TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf

... Serum cholesterol levels were increased by doses of600 mg/kg or more in male rats and 900 ... Serum cholesterol levels were increased in male mice at doses of 900 mg/kg or more, ...

TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf

... Cholesterol levels i n 1v00 and 2 5 , O O O ppm females and triglyceride levels in 25,OOO ... leukocyte count and differential Ui" cholesterol and triglyceride P d a q m e rm0l)acr ...

TR-496: Fumonisin B1(CASRN 116355-83-0) in F344/N Rats and B6C3F1Mice... 33.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr496.pdf

... The concen- trations of creatinine, cholesterol, triglycerides, and total bile acids, as ... Cholesterol and total bile acid concentrations and alanine aminotrans- ferase and alkaline ...

TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf

... concentration and decreased bile acid, cholesterol, and phospholipid concentrations. ... In the 3-month study, elevated serum cholesterol and phospholipid concentrations were ...

Abstract for TOX-99 69KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox099

concentration and decreased bile acid, cholesterol, and phospholipid concentrations. ... In the 3-month study, elevated serum cholesterol and phospholipid concentrations were ...

Uterus - Hemorrhage - Nonneoplastic Lesion Atlas 287KB

https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/uterus/Hemorrhage

It is often associated with mononuclear cell leukemia in F344 rats. When chronic hemorrhage occurs, hemosiderin-laden macrophages, cholesterol clefts, dystrophic calcification or ...

Characterizing, Navigating, and Modeling the Chemical Space 17.4MB

https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2017/fourches-508.pdf

Follow on C 33 H 35 FN 2 O 5 0D/1D 2D 3D PDB code = 1HWK Competitive inhibitor of HMG-CoA reductase in liver Lower blood cholesterol LIPITOR (atorvastatin) World's best-selling ...

TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf

... Serum levels of triglycerides, cholesterol, and albumin showed dose-related decreasing ... to controls, and cholesterol and albumin levels were lower than those of controls. ...

Abstract for TOX-95 75KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox095

At week 14, cholesterol was significantly increased in the 100 mg/kg or greater males and ... findings (LOEL = 10 mg/kg) including increased cholesterol and alanine aminotransferase. ...

TOX-49: 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) 3.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox049.pdf

... Decreases in serum concentrations of total protein and cholesterol could also have been ... creatinine, total protein, albumin, cholesterol, alanine aminotransferase, alkaline ...

Uterus - Hemorrhage 243KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/uterus/hemorr/uterus-hemorrhage-pdf-508.pdf

It is often associated with mononuclear cell leukemia in F344 rats. When chronic hemorrhage occurs, hemosiderin-laden macrophages, cholesterol clefts, dystrophic calcification or ...

Abstract for DART-08 153KB

https://ntp.niehs.nih.gov/publications/reports/dart/dart08

... BPAF exposure related changes included significant decreases in serum cholesterol ... Clinical chemistry Male NA None ↓ Cholesterol, bile acids ↓ Cholesterol, bile acids ...

Bone marrow - Inflammation - Nonneoplastic Lesion Atlas 297KB

https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation

Intracellularly, pigment (hemosiderin) or cholesterol clefts may be seen. Occasionally, granulomatous inflammation is associated with lipid vacuoles that are usually smaller than ...

Poster: 3-Month Toxicity Studies of Tetravelent and Pentavalent... 1.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/posters/roberts_sot20190300.pdf

Exposure to vanadium may occur via ingestion . Vanadyl sulfate is sold as a dietary supplement for diabetes and high cholesterol . Sodium metavanadate was selected for study as a ...

Adrenal Gland, Cortex - Vacuolization, Cytoplasmic - Nonneoplastic... 294KB

https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/Cortex-VacuolizationCytoplasmic

In many cases, the vacuoles have been shown to represent accumulations of various lipids or cholesterol. Cortical vacuolization can occur as a spontaneous, age-related change ...

Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas 290KB

https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis

With more severe or chronic congestion of the vasculature, macrophages sometimes containing pigment and/or cholesterol clefts may be seen around the dilated vasculature. A ...

TR-407: C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and... 15.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr407.pdf

... cystic degeneration in males and by granulomas and cholesterol pigmentation in females. ... lesions (including pigmentation, cholesterol in the mesenteric nodes) and the ...

TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf

... concentrations; and decreased globulin, cholesterol, and triglyceride concentrations. In PFHxSK males, globulin, cholesterol, and triglyceride concentrations were decreased. ...

Abstract for RR-08 62KB

https://ntp.niehs.nih.gov/publications/reports/rr/rr08

for which BMD values could be obtained were serum HDL (high-density lipoprotein) cholesterol levels, absolute liver weights, relative liver weights, and serum cholesterol levels. ...

National Institute of Environmental Health Sciences: NIEHS-06 152KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-06

liver weight, increased serum high-density lipoprotein cholesterol concentration, increased serum total cholesterol concentration, increased serum lowdensity lipoprotein ...

Abstract for TOX-96 85KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox096

... concentrations; and decreased globulin, cholesterol, and triglyceride concentrations. In PFHxSK males, globulin, cholesterol, and triglyceride concentrations were decreased. ...

Ovary - Atrophy - Nonneoplastic Lesion Atlas 294KB

https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/Atrophy

These findings may include interstitial cell hyperplasia, necrosis of follicular epithelium, increased numbers of cystic follicles, accumulation of pigment or lipid, cholesterol ...

Bone Marrow - Angiectasis 710KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/angiect/bone_marrow-angiectasis_508.pdf

With more severe or chronic congestion of the vasculature, macrophages sometimes containing pigment and/or cholesterol clefts may be seen around the dilated vasculature. A ...

RoC Profile: Isoprene; 15th RoC 2021 158KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf

The iso- prene analogue isopentenyl pyrophosphate is a building block of cholesterol synthesis, and levels of exhaled isoprene correlate with cholesterol synthesis (IARC 1994, ...

TOX-22: N,N-Dimethylformamide (CASRN 68-12-2) 1.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox022.pdf

... Serum cholesterol levels were increased at all exposure concentrations. Relative liver ... Dr. Klaassen noted the increased serum cholesterol levels and wondered whether cholesterol ...

TOX-42: 1,3-Diphenylguanidine (CASRN 102-06-7) 1.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox042.pdf

... Lower total serum protein, cholesterol, triglyceride, and creatinine concentrations were ... albumin, total and direct bilirubin, cholesterol, triglycerides, alkaline phosphatase ...

Abstract for TOX-97 125KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox097

... dehydrogenase); decreased globulin and cholesterol concentrations; and increased total ... No effect ↓ [a] No effect ↑ No effect ↑ ↑ Cholesterol ↓ No effect ↓ ↑ ↓ No ...

TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf

... liver, mild anemia, increases in serum cholesterol concentrations, and decreases in serum ... leukocyte count C//n/ca/chem/stry: cholesterol and triglycerides Polybrominated ...

TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf

... Cholesterol concentrations were signif- icantly decreased in 200 and 400 mg/kg males and ... creatinine, total protein, albumin, cholesterol, triglycerides, alanine ...

TOX-95: Toxicity Studies of Myristicin (CASRN 607-91-0) Administered... 3.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox095_508.pdf

... At week 14, cholesterol was significantly increased in the 100 mg/kg or greater males and ... findings (LOEL = 10 mg/kg) including increased cholesterol and alanine aminotransferase. ...

Integrating Bayesian Approaches with PBPK Modeling in a Human... 2.1MB

https://ntp.niehs.nih.gov/iccvam/meetings/popvar-2022/ppt/05_chou_508.pdf

EFSA (2018) Serum cholesterol 1.8 PFOS Human PBPK model UF1, interspecies uncertainty ... EFSA guidance value (EFSA, 2018) based on the endpoint of elevated cholesterol levels in ...

National Institute of Environmental Health Sciences: NIEHS-04 152KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-04

liver weight, increased serum total cholesterol concentration, decreased serum albumin/globulin ratio, and increased serum high-density lipoprotein cholesterol concentration. ...