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Search suggestions for "58-08-2".

  1. CEBS Data Related to Caffeine (58-08-2) https://cebs.niehs.nih.gov/cebs/test_article/58-08-2
  2. CEBS Data Related to Bitter orange Extract Mixture (BITTERORANGE... https://cebs.niehs.nih.gov/cebs/search?data=all&q=BITTERORANGE
  3. Report on Carcinogens Aspirin, phenacetin, and caffeine https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/phenacetinandanalgesicmixtures.pdf


105 results found for "58-08-2".

  1. Abstract for RACB84044 61KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84044

    4abs Abstract for RACB84044 Caffeine: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water CASRN: 58-08-2 Chemical Formula: C8H10N4O2 Molecular ...

  2. Abstract for RACB81078 60KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb81078

    Abstract for RACB81078 Caffeine: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water CASRN: 58-08-2 Chemical Formula: C8H10N4O2 Molecular ...

  3. TR-067: a Mixture of Aspirin, Phenacetin, and Caffeine (CASRN... 3.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr067.pdf

    OF A MIXTURE OF ASPIRIN, PHENACETIN, AND CAFFEINE FOR POSSIBLE CARCINOGENICITY CAS No. ... OF A MIXTURE OF ASPIRIN, PHENACETIN, AND CAFFEINE FOR POSSIBLE CARCINOGENICITY ...

  4. Aspirin, phenacetin, and caffeine: Target Organs and Levels of... 57KB

    https://ntp.niehs.nih.gov/data/tr/000s/tr067levels

    6 Aspirin, phenacetin, and caffeine: Target Organs and Levels of Evidence for TR-067 Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity (CASRN ...

  5. Abstract for RACB94006 80KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb94006

    6abs Abstract for RACB94006 Reproductive Toxicity of Caffeine Administered by Gavage to Sprague-Dawley Rats CASRN: 58-08-2 Chemical Formula: C8H10N4O2 Molecular Weight: 194.19 ...

  6. Abstract for TR-67 66KB

    https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr067

    Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity Substances: Aspirin mixture with Phenacetin and Caffeine (CASRN 8003-03-0) Aspirin (CASRN ...

  7. Nomination Background: d-Pseudoephedrine (CASRN: 90-82-4) 388KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ephedrinealkaloids_508.pdf

    stimulants, such as caffeine (guarana), as well as salicin, diuretics, and cathartics. Ephedra-containing performance enhancers often contain caffeine and other ingredients, ...

  8. Abstract for TR-473 77KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr473

    tea (Thea sinensis) and chocolate and is structurally related to caffeine and theobromine. ... of its relationship to purines such as caffeine, 1-methyl-3-hydroxyguanine, and ...

  9. Abstract for TR-243 66KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr243

    and fungicides, as a solvent for waxes, fats, resins, and oils, as an anesthetic for medical and dental use, and as an extractant for spice oleoresins and for caffeine from coffee. ...

  10. Abstract for TR-306 65KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr306

    The use of dichloromethane as an extraction solvent for spice oleoresins, hops, and caffeine from coffee has been approved by the U.S. Food and Drug Administration. Dichloromethane ...

  11. TR-473: Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1Mice... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr473.pdf

    ... tea (Thea sinensis) and chocolate and is structurally related to caffeine and theobromine. ... of its relationship to purines such as caffeine, 1-methyl-3-hydroxyguanine, and ...

  12. Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

    ... Reliability of FETAX Studies on Caffeine......Assessment of FETAX Studies on Caffeine ......7-32 Figure 6 ...

  13. Presentation: Mechanisms of Acute Toxicity 2.4MB

    https://ntp.niehs.nih.gov/iccvam/meetings/at-wksp-2015/session4/1-wilson-508.pdf

    Agent Toxicity ranking LD50 (/kg bw) GHS Cat Caffeine ? ? ? Arsenic ? ? ? Aspirin ? ? ? ... Agent Toxicity ranking LD50 (/kg bw) GHS Cat Caffeine 4 130-320 mg 3 Arsenic 3 46 mg 2 ...

  14. Trichloroethylene: Target Organs and Levels of Evidence for TR... 57KB

    https://ntp.niehs.nih.gov/data/tr/000s/tr002levels

    heat exchange liquid, diluent in paints and adhesives, caffeine extractant, textile processing, solvent in production of color additives for food, cosmetics, drugs (HSDB 1990). ...

  15. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    246.31 FLUKA 19012 100.2 Cadmium II chloride 10108-64-2 183.31 FLUKA 20899 99.8 Caffeine 58-08-2 194.20 FLUKA 27600 99.9 Carbamazepine 298-46-4 236.30 SIGMA C4024 > 99 Carbon ...

  16. Reproductive Abstracts 202KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive RACB81078 Caffeine Caffeine (CASRN: 58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When ...

  17. Nomination Background: p-Synephrine (CASRN: 94-07-5) 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bitterorange_508.pdf

    ... Similarly, studies of supplements containing synephrine plus caffeine are also controversial. The combination of synephrine and caffeine (in other herbs such as guarana and maté) ...

  18. Appendix C: Overview of human studies: Non-cancer health outcome 881KB

    https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_c_508.pdf

    ... More than 25 studies examine impacts of doses of melatonin, caffeine, and various other ... pregnancy history; smoking; alcohol; caffeine; marital status; parity; hours worked; ...

  19. Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf

    ... phenobarbital) and dietary factors (high fat, low calcium, caffeine). HCA mixtures. ... Table 4-18. Colon tumors produced in female F344 rats orally exposed to PhIP, caffeine, ...

  20. Study Abstracts 375KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive RACB81078 Caffeine Caffeine (CASRN: 58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When ...

  21. Slide 1 2.8MB

    https://ntp.niehs.nih.gov/iccvam/meetings/kmd-symp-2020/ppt/06-boobis-508.pdf

    ... 10 Effects of furafylline on caffeine kinetics Furafylline (90 mg p.o.) [Furafylline] (mg/l) 0 1 2 0 2 4 8 4 8 12 Time (days) [Caffeine] (mg/l) 11 Point of departure NOAEL ...

  22. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... (30% to 35%), methylxanthines such as caffeine and theobromine (2.5% to 4.0%), proteins ... from 250 to 300 mg tea solids, composed of 30% to 42% catechins and 3% to 6% caffeine 2 . ...

  23. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... (30% to 35%), methylxanthines such as caffeine and theobromine (2.5% to 4.0%), proteins ... from 250 to 300 mg tea solids, composed of 30% to 42% catechins and 3% to 6% caffeine 2 . ...

  24. NTP at the SOT; March 6, 2005 308KB

    https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf

    ... Necrosis and Sudden Death of Rats Exposed to a Combination of Ephedrine and Caffeine 829 Ortel, Tomas Adhesion-molecule Changes in 2-Butoxyethanol (BE) Fisher F344 Rat ...

  25. Human stem-cell derived intestinal organoids as a tool to evaluate... 5.4MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_10_Patrik Lundquist_GutModels2023_508.pdf

    ... Haloperidol Glucoronidation CYP2D6 2.7 To be determined Diclofenac CYP2C9 5.9 4OH-diclofenac Tolbutamide CYP2C9 0 None (so far) Caffeine CYP1A2 0 None detected Nicotine CYP2A6 0 ...

  26. Public Comment on 81 FR 42718: C. Elegans Models for Developmental... 2.0MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/hunt-81fr42718.pdf

    ... sodium arsenite, sodium fluoride, caffeine, valproic acid, sodium borate or DMSO in ... fluoride, sodium borate, valproic acid, caffeine and DMSO. Sodium borate was found to be ...

  27. RoC Profile: Dichloromethane; 15th RoC 2021 148KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichloromethane.pdf

    ... Source: HSDB 2009. and as an extraction solvent for spice oleoresins, hops, and caffeine in coffee (NTP 1986). However, due to health concerns, dichloro- methane's use as an ...

  28. Predicting human developmental toxicity of pharmaceuticals using... 510KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf

    ... Aspirin 1.805 (Blacklock et al., 2001) Caffeine 4.4 (Benowitz, 1990) Diphenhydramine ... and only ascorbic acid and caffeine are false positives for teratoge- nicity (Table 5). ...

  29. TOWARD VALIDATION OF A HUMAN IN... 1.1MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf

    ... TER 0.001 Ascorbic Acid Pharmaceutical NON 300 Aminopterin Pharmaceutical TER 0.009 Caffeine Pharmaceutical NON 300 Busulfan Pharmaceutical TER 2 Diphenhydramine Pharmaceutical ...

  30. DEVELOPMENT OF A TARGETED BIOMARKER... 3.4MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/palmerposter.pdf

    ... Compound Human Effect hES Cells iPS Cells Teratogenicity Potential (μM) Prediction Teratogenicity Potential (μM) Prediction Ascorbic Acid NON >300 NON >300 NON Caffeine NON >300 ...

  31. A BIOMARKER BASED DEVELOPMENTAL ... 919KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-sot.pdf

    ... Compound Human Effect Prediction hESC iPSC Ascorbic Acid NON NON NON Caffeine NON NON NON Diphenhydramine NON NON NON Doxylamine NON NON NON Folic Acid NON NON NON Isoniazid NON ...

  32. Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf

    ... levels including acetaminophen, imipramine, clozapine, caffeine, and theophylliine. 230 The 3-N-demethylation of caffeine is catalyzed by P450 1A2, and the urinary ratios among ...

  33. Comparison of devTOX quickPredict Assay With Other Methods 1.0MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf

    ... Busulfan 49.6 N/A N/A D DT DT (1) DT (2,4) DT (6) n.d. DT (1; High, 2) DT (Strong, 5) DT DT Caffeine 9.3 7.7 325 C NON NON (1) DT (2,4) DT (4) DT (3,8) NON (1), DT (Weak, 5) DT (6) ...

  34. NTP Monograph on Health Effects of Low-Level Lead Appendix C... 1.2MB

    https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixc_final_508.pdf

    ... job status, alcohol intake, serum creatinine, hemoglobin, hematocrit, and caffeine intake. ... models Adjusted for age, BMI, sex, caffeine use, and race Regression coefficient of ...

  35. TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf

    ... Cancer Res., 32 (1972), 2686-2695. 5. Kakunaga, T. "Caffeine Inhibits Cell Transformation ... Several reports have indicated that treatment with caffeine following exposure to UV light ...

  36. RoC Profile: Propylthiouracil; 15th RoC 2021 126KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/propylthiouracil.pdf

    ... on Cancer. pp. 91-125. Ly A, Drewnowski A. 2001. PROP (6-n-propylthiouracil) tasting and sensory responses to caffeine, sucrose, neohesperidin dihydrochalcone and chocolate. ...

  37. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... of the RC (acetonitrile, p-aminophenol, caffeine, coumarin, dimethyl-formamide, mercury ... and for two chemicals (p-aminophenol and caffeine), the predicted LD50 values differed ...

  38. RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf

    ... Effects of Sodium Saccharin and Caffeine on the Urinary Bladder of Rats Treated with ... Life Time Occupation, Smoking, Caffeine, Saccharine, Hair Dyes and Bladder Carcinogenesis. ...

  39. Comparison of the Stemina devTOX quickPredict system with other... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf

    ... Butylparaben NON n.d. n.d. NON (12) n.d. DT (14) n.d. n.d. 0.62 n.d. NON N/A 110 n.d. Exposure (Daston) Rodent Caffeine NON │ DT C NON (1) DT (2,4) DT (4) DT (3,8) DT (5) NON (1) ...

  40. RoC Profile: Phenacetin and Analgesic Mixtures Containing Phenacetin... 129KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenacetinandanalgesicmixtures.pdf

    ... Gann 70: 29-36. Johansson SL. 1981. Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). ...

  41. RoC Background Document: Trichloroethylene (TCE); Oct. 30-31... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/trichl_tce1997_2apps_508.pdf

    ... natural fats and oils, spices, hops, and caffeine (from coffee), but FDA banned these uses ... and dental use, and as an extractant for spice oleoresins and for caffeine from coffee. ...

  42. ICCVAM Background Review Document (Vol 1): In Vitro Cytotoxicity... 16.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol1_nov2006.pdf

    ... Sodium compound; Fluorine compound Caffeine 192 MEIC, RC (outlier), TESS, NTP, HPV ... In the 50< LD 50 ≤300 category, four substances (haloperidol, caffeine, copper sulfate ...

  43. RoC Profile: Trichloroethylene; 15th RoC 2021 237KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichloroethylene.pdf

    ... from spices and hops, and to re- move caffeine from coffee; as an anesthetic and ... natural fats and oils, spices, hops, or caffeine (from coffee) since the FDA imposed ...

  44. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... 7.8 2.35-800 Cadmium II chloride 10108-64-2 99.8 Fluka 8.1 0.135-5 7.7 0.337-100 Caffeine 58-08-2 99.9 Fluka 8.3 1.6-5000 7.8 3.25-10000 Carbamazepine 298-46-4 > 99 Sigma 8.0 ...

  45. Presentation: Fundamentals of QSAR Modeling: Basic Concepts and... 7.7MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2016/tropsha-508.pdf

    ... Carbamazepine ‘Distant biological neighbors ’Close chemical neighbors => Chemical similarity works better Caffeine ’Close biological neighbors ‘Distant chemical neighbors => ...

  46. 15th RoC: Appendix B 103KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_b.pdf

    ... Br J Cancer 45:332-336. Nakanishi K, Hirose M, Ogiso T, Hasegawa R, Arai M, Ito N. 1980. Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with ...

  47. Minutes: BSC; Aug. 18, 2005 1.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf

    ... Bucher said the NTP is developing methodology to study the pathological and functional aspects of cardiotoxicity using model compounds including ephedra, caffeine, and ...

  48. TR-093: 3-Amino-9-ethylcarbazole Hydrochloride (CASRN 132-32... 6.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr093.pdf

    ... (CAS 8003-03-0) aspirin: phenacetin: caffeine (APC) The high-dose male and female ... (CAS 8003-03-0) aspirin: phenacetin: caffeine (APC) Male and female high-dose mice ...

  49. TR-394: Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1Mice... 14.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr394.pdf

    ... 5,350 ppm phenazone, 1,020 ppm caffeine, a mixture of apair of these drugs, or a ... received phenacetin, phenazone, and combina- tions of phenacetin, phenazone, and caffeine. ...

  50. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... Clofibric acid 2.61 5.82 1249.3 112 48 Caffeine 2.64 0.99 192.3 264 Chloral hydrate 2.65 ... Diethyl phthalate 5.52 38.7 8601.5 285 Caffeine sodium benzoate 5.67 2.54 859.4 286 ...

 
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