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TR-022: Dieldrin (CASRN 60-57-1) 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr022.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 22 1978 BIOASSAY OF DIELDRIN FOR POSSIBLE CARCINOGENICITY CAS No. 60-57-1 NCI-CG-TR-22 U.S. DEPARTMENT OF ...
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TR-021: Aldrin and Dieldrin (CASRN 309-00-2) (CASRN 60-57-1) 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr021.pdf
Technical Report Series No. 21 BIOASSAYS OF ALDRIN and DIELDRIN FOR POSSIBLE CARCINOGEN ICITY CAS No's. 309-00-2 and 60-57-1 NCI-CG-TR-21 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND ...
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Dieldrin: Target Organs and Levels of Evidence for TR-022 56KB
https://ntp.niehs.nih.gov/data/tr/000s/tr022levels
2 Dieldrin: Target Organs and Levels of Evidence for TR-022 Bioassay of Dieldrin for Possible Carcinogenicity (CASRN 60-57-1) Chemical (Study Title) CASRN Peer Review Date Route/...
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Abstract for TR-21 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr021
1abs Abstract for TR-21 Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity Substances: Aldrin (CASRN 309-00-2) Dieldrin (CASRN 60-57-1) Report Date: 1978 Full Report PDF ...
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Abstract for TR-22 60KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr022
2abs Abstract for TR-22 Bioassay of Dieldrin for Possible Carcinogenicity CASRN: 60-57-1 Chemical Formula: C12H8Cl6O Molecular Weight: 380.9122 Report Date: 1978 Full Report PDF ...
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Abstract for TR-17 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr017
product of dieldrin. Although it has never been produced commercially, photodieldrin was selected for testing in 1969 because it was a photochemical conversion product of dieldrin. ...
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Aldrin: Target Organs and Levels of Evidence for TR-021 59KB
https://ntp.niehs.nih.gov/data/tr/000s/tr021levels
Aldrin: Target Organs and Levels of Evidence for TR-021 Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) Chemical (Study Title) CASRN ...
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Abstract for TR-12 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr012
Endrin is an organochlorine pesticide having a structural characteristic of the cyclodiene group, which includes aldrin (CAS No. 309-00-2), dieldrin (CAS No. 60-57-1), chlordane ...
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Abstract for TR-9 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr009
Abstract Heptachlor is a member of the cyclodiene group of chlorinated insecticides (aldrin, dieldrin, endrin, chlordane, heptachlor, and endosulfan) that was developed in the 15 ...
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Abstract for TR-8 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr008
Chlordane is a member of the cyclodiene group of chlorinated insecticides, which includes aldrin, dieldrin, endrin, heptachlor, and endosulfan. It was introduced in 1945 and was ...
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TR-017: Photodieldrin (CASRN 13366-73-9) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr017.pdf
... V SUMMARY A bioassay of dieldrin-free photodieldrin (synthesized by Gulf South Research ... Groups of 50 rats of each sex were initially administered photo- dieldrin at one of two ...
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RoC Profile: Chlorendic Acid; 15th RoC 2021 124KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorendicacid.pdf
insecticides such as heptachlor, chlordane, endosulfan, endrin, and dieldrin (NTP 1987). ... chlordane, heptachlor, aldrin, dieldrin, isodrin, and endrin and their metabolites. ...
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PBPK Modeling to Predict Chemical Distribution in Brain and Adipose... 159KB
https://ntp.niehs.nih.gov/sites/default/files/2024-01/Unnikrishnan-SOT_2024_abstract-508.pdf
... chemicals like mono(2- ethylhexyl) phthalate, dieldrin and bisphenol A were studied. ... from the model were within 2-fold of the experimental data for acetaminophen and dieldrin. ...
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TR-012: Endrin (CASRN 72-20-8) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr012.pdf
... C I of the cyclodiene group, which includes aldrin (CAS 309-00-2), dieldrin (CAS 60-57-1), chlordane (CAS 57-74-9), heptachlor (CAS 76-44-8), and endosulfan (CAS 115-29-7). ...
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PowerPoint Presentation 925KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/knudsenposter.pdf
... Chemical TC-CytoBurst MTC Activity * LEC-o/c REP1, REP2 oc-var sq / total LEC-cv REP1, REP2 cv-var sq / total comment Dieldrin 17.44 10 negative NA 0.14 NA 0.24 Aldrin 23.18 10 ...
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TR-304: Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1Mice... 14.6MB
https://ntp.niehs.nih.gov/go/tr304
... endrin, and dieldrin) (Murphy, marily as chemical intermediates in the manu- 1980). ... LDso = 335 mg/kg; dieldrin, LDso = 46 mglkg; heptachlor, LDso =100 mg/kg) (Murphy, 1980). ...
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TR-008: Chlordane (CASRN 57-74-9) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr008.pdf
... insecticides, which includes aldrin, dieldrin, endrin, heptachlor, and endosulfan. ... controls taken from tests performed on dieldrin, chlordane, heptachlor, dichlorvos, and ...
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TR-009: Heptachlor (CASRN 76-44-8) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr009.pdf
... of chlorinated insecticides (aldrin, dieldrin, endrin, chlordane, heptachlor, and ... taken from tests performed on aldrin, dieldrin, chlordane, heptachlor, dichlorvos, and ...
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TR-437: Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats... 15.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr437.pdf
... such as heptachlor,chlordane,aldrin,dieldrin,endrin,and mirex (Bell et al., 1 9 7 9 ) . ... such as heptachlor, aldrin, and dieldrin (NCI, 1977a,1978); and because ...
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PBPK Modeling to Predict Chemical Distribution in Brain and Adipose... 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Unnikrishnan-poster.pdf
... of Cmax were compared with observed data for a few chemicals including benzo[a]pyrene, diazepam, trichloroethylene, deltamethrin, acetaminophen, bisphenol A and dieldrin. . ...
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TR-501: p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344... 13.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr501.pdf
... was seen in female rats exposed to 50 ppm p,pN-dichlorodiphenyl sulfone and 1 ppm dieldrin in feed compared to female rats exposed to 1 ppm dieldrin alone (Street et al., 1971). ...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
... OR dichlorvos[tiab] OR dieldrin[tiab] OR diesel[tiab] OR ...phenyl-dichloroethylene OR dichlorvos OR dieldrin OR diesel OR diethylstilbestrol OR ...
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Presentation: Suspected Modes of Action Affected by Pesticides... 599KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/alavanja-508.pdf
... Among 679 Male Applicators in the AHS Pesticide Exposed Total n Exposed n OR (95% CI) Dieldrin Never Ever 649 20 31 6 1.0 (ref) 5.6 (1.9-16.6) Carbon tetrachloride/ Carbon ...
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TR-004: Dimethoate (CASRN 60-51-5) 2.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr004.pdf
... plus the matched controls for the studies of aldrin, chlordane, dichlorvos, dieldrin, and heptachlor; these studies overlapped the dimethoate feeding study for at least a year. ...
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TR-010: Dichlorvos (CASRN 62-73-7) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr010.pdf
... for the studies of aldrin, dieldrin, chlordane, dichlorvos, dimethoate, and heptachlor. ... of chlordane (20 males, 20 females), dieldrin (20 males, 20 females), aldrin (20 ...
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TR-033: Tetrachlorvinphos (CASRN 961-11-5) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr033.pdf
... Mice receiving tetrachlorvinphos were maintained in a room housing mice administered dieldrin (CAS 60-57-1) or malathion (CAS 121-75-5), together with their respective matched ...
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TR-035: Methoxychlor (CASRN 72-43-5) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr035.pdf
... It may also substitute in some cases for aldrin, dieldrin, chlordane and hepta- chlor, all of which have had their registrations cancelled (Ouellette and King, 1976). According to ...
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Literature Search Results: Systematic Review of Long-term Neurological... 260KB
https://ntp.niehs.nih.gov/ntp/ohat/sarin/literature_results_508.pdf
... J Pharmacol Exp Ther 313(3): 1082-1089. Burchfiel J, Duffy F, Sim V. 1976. Ersistent effects of sarin and dieldrin upon primate electroencephalogram. Toxicol Appl Pharmacol 35: ...
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RoC Profile: Hexachlorobenzene; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hexachlorobenzene.pdf
... N. 2003. Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: β-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene. ...
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Captafol/o-Nitrotoluene Expert Panel Report Part A; RoC expert... 162KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/captafol_report_parta_508.pdf
... P19, L 15, Insert "The authors did not examine correlations between captafol and each of the three components that showed elevated ORs (1,3-dichloropropene, dieldrin and ...
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TR-038: Aroclor (CASRN 27323-18-8) 1.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr038.pdf
... housed in the same room as rats treated with aflatoxin B1 (CAS 1162-65-8), lead (II) acetate (CAS 301-04-2), hexachlorophene (CAS 70-30-4), or dieldrin (CAS 60-57-1) in the feed. ...
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RoC Profile: Dichlorodiphenyltrichloroethane; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichlorodiphenyltrichloroethane.pdf
... Eur J Cancer Prev 10(2): 153-156. Snedeker SM. 2001. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin. Environ Health Perspect 109(Suppl 1): 35-47. Wolff MS, ...
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TR-024: Malathion (CASRN 121-75-5) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr024.pdf
... Mice receiving malathion were maintained in a room housing mice fed tetrachlorvinphos (CAS 961-11-5) and dieldrin (CAS 60-57-1), together with their respective matched controls. E. ...
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In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity... 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Kreutz-poster.pdf
... Fluoxa str obin Te mbotrione Tri-allate MGK He ptachlor e pox ide B C hlorpyr ifos Dieldrin Flufe na ce t Chlor pr omazine hydrochlor ide Ethoprop A zinphos -me thy l A bame ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... N No Evidence E Equivocal Evidence N No Evidence N No Evidence TR-022 11/28/77 Dieldrin 60-57-1 N No Evidence N No Evidence NT Chemical Not Tested in Species/Sex NT Chemical Not ...
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TR-069: Azinphosmethyl (CASRN 86-50-0) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr069.pdf
... lindane, chlordane, dimethoate, tetra- chlorvinphos (CAS 961-11-5), malathion, dieldrin (CAS 60-57-1), photodieldrin (CAS 13366-73-9), and captan, constituting a total of 140 males ...
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TR-070: Parathion (CASRN 56-38-2) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr070.pdf
... In mice, the matched controls from the current bioassay of parathion were combined with matched controls from bioassays of azinphosmethyl, chlordane, dieldrin (CAS 60-57-1), ...
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TR-014: Lindane (CASRN 58-89-9) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr014.pdf
... Biometrika j32(3): 679-682, 1975. Thorpe, E. and Walker, A. I. T., The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, ...
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Public Comment: Methyl isobutyl ketone; Steven Risotto; RoC;... 379KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/risotto20131018_508.pdf
... Toxicologic Pathol 28:788-798 (2000) Kolaja KL et al. Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats. Fundam Appl Toxicol 29:219-228 ...
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TR-228: Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr228.pdf
8 CARCINOGENESIS BIOASSAY OF VINYLIDENE CHLORIDE (CAS NO. 75-35-4) IN F344 RATS AND B6C3FJ MICE (GAVAGE STUDY) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... DDD 72-54-8 Pesticide Metabolite environmental contaminant 8.00E+06 - 3.91E+03 2.00E+01 - 9.77E-03 5.71E-05 - 2.79E-08 97% Sigma Powder Dieldrin 60-57-1 Pesticide environmental ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... DDD 72-54-8 Pesticide Metabolite environmental contaminant 8.00E+06 - 3.91E+03 2.00E+01 - 9.77E-03 5.71E-05 - 2.79E-08 97% Sigma Powder Dieldrin 60-57-1 Pesticide environmental ...
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Minutes: BSC; April 6, 1994 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/april/19940406bscmins_508.pdf
... Agency for Toxic Substances and Disease Registry has derived "minimum risk levels" for arsenic, dieldrin, nickel, 1,2-dichloroethane and 2,4-dichlorophenol from immune endpoints . ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 230.5 63 4 Diazepam 0.16 2.49 709.1 207 Dieldrin 0.18 0.12 45.7 64 Bendiocarb 0.18 0.8 ... 44.0 241 Sodium azide 0.71 0.69 44.9 207 Dieldrin 0.18 0.12 45.7 179 Acrolein 0.047 0.82 ...
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Background Document: RoC: Captafol; 2010 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf
... Specifically, the authors did not examine correlations between captafol and each of the three compounds that showed elevated ORs (1,3- dichoropropene, dieldrin, and ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1978 Technical Report TR-022 PDF (1.47 MB) Bioassay of Dieldrin for Possible Carcinogenicity (CASRN 60-57-1) 1978 Technical Report TR-021 PDF (5.18 MB) Bioassays of Aldrin ...
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TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf
... organic pollutants: DDT-aldrin-dieldrin-endrin-chlordane, heptachlor-hexachlorob... organotropism of dichlorobiphenyl (DCB), Dieldrin, and hexachlorobenzene (HCB) in rats. ...
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TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox103_508.pdf
... 1 Mirex a <0.01 1 Methoxychlor a <0.05 1 Dieldrin a <0.01 1 Endrin a <0.01 1 Telodrin a ... a <0.01 - 4 Methoxychlor a <0.05 - 4 Dieldrin a <0.01 - 4 Endrin a <0.01 - 4 Telodrin ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 0.67 63 4 Diazepam 439-14-5 45.56 0.16 709.1 2.49 535.3 1.88 284.76 2.49 207 Dieldrin 60-57-1 68.56 0.18 45.7 0.12 38.1 0.1 380.9 0.12 64 Bendiocarb 22781-23-3 40.19 0.18 178.6 ...
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DART-07: Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy... 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/dart/dart07_508.pdf
... 1 Mirex b <0.01 1 Methoxychlor b <0.05 1 Dieldrin b <0.01 1 Endrin b <0.01 1 Telodrin b ... 1 Mirex a <0.01 1 Methoxychlor a <0.01 1 Dieldrin a <0.01 1 Endrin a <0.01 1 Chlordane a ...