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Presentation: Incorporating Population Variability and Susceptible... 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2015/wetmore-508.pdf
... Time (min) Ln Concentration (µM) 0 20 40 60
80
0.0 0.2 0.4 0.6 0.8 1.0 UGT1A1 UGT1A9 Time ... Time (min) Ln Concentration (uM) 0 20 40 60
80
-0.4 -0.2 0.0 0.2 0.4 0.6 UGT1A4 Time (min) ...
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Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf
... Median 7.83 Lower Quartile 0.00 Upper Quartile 36.70 Distribution of Chemical C ss (µM) > 2 0 0 > 5 0 - 2 0 0 > 1 0 - 5 0 > 2 - 1 0 > 0 . 5 - 2 0 - 0 . 5 0 20 40 60
80
0 20 40 60 ...
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Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf
... Diclofenac - 30 μg Liver Compartment Time (hr) [Diclofenac] (ng/mL) LC/MS/MS Human Hepatocytes Simulated Blood 0 20 40 60
80
0 50000 100000 150000 Diclofenac - 30 μg Human ...
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TR-021: Aldrin and Dieldrin (CASRN 309-00-2) (CASRN 60-57-1) 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr021.pdf
... 60 74 0 37-38 FEMALE Matched-Control 10 0 111-112 Low-Dose 50 30 80 0 32 High-Dose 50 60 80
0 32-33 a All animals were approximately 35 days of age when placed on study. ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... Harmful if swallowed. Irritating to eyes, respiratory system, skin. Antipyrene 11.6 9.56 1799.7 188.25 60-80-0 A5882 N/A Irritant. Dimethyl 114 38.3 2800.1 73.11 68-12-2 D8654 ...
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TR-275: 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07... 14.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr275.pdf
... mg mg/kg(a) (b) Initial (c) Final Change (percent) (percent) MALE (d)O 20 30 40 60
80
0 114. 172 226 339 4.42 5/5 5/5 5/5 5/5 5/5 (e) 415 172.6 ± 6.8 215.2 ± 8.4. 175.2 ± ...
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TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf
... Risk (%) 100 0 100 200 300 400 0 20 40 60
80
0 100 200 300 400 0 20 40 60 80 28 wks. ... (%) 100 0 50 100 150 200 250 300 0 20 40 60
80
0 50 100 150 200 250 300 0 20 40 60 80 44 ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... NA 1879.3 27.6 68.09 27.6 300 Antipyrine 60-80-0 2183.70 11.6 1799.7 9.56 1699.9 9.03 ... 2.78 NA NA 647 2.78 300 Antipyrine 60-80-0 2183.70 11.6 1799.7 9.56 1699.9 9.03 ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... 350% +2 std dev 300% 300% 250% 250% 200% 150% 200% 150% 100% 100% 50% 50% 0% 0 20 40 60 80
0% 8/17/03 11/25/03 3/4/04 6/12/04 Number of assays Date % Ratio % Ratio DMSO QC DMSO QC ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... 350% +2 std dev 300% 300% 250% 250% 200% 150% 200% 150% 100% 100% 50% 50% 0% 0 20 40 60 80
0% 8/17/03 11/25/03 3/4/04 6/12/04 Number of assays Date % Ratio Number of Assays Date ...
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TR-524: Photocarcinogenesis Study of Glycolic Acid and Salicylic... 17.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr524.pdf
... Control Cream GA 4% GA 10% SA 2% SA 4% % Mice with Lesions Weeks on Study 18 23 28 33 38 43 48 53 Female Mice, 0.3 MED/Day Lesions / Mouse 100 20 40 60
80
0 5 10 15 20 % Mice with ...
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TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE ...
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TR-459: t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and... 25.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr459.pdf
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