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Search suggestions for "62-53-3".

  1. CEBS Data Related to Aniline (62-53-3) https://cebs.niehs.nih.gov/cebs/test_article/62-53-3


171 results found for "62-53-3".

  1. TR-130: Aniline Hydrochloride (CASRN 142-04-1) 3.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr130.pdf

    0 BIOASSAY OF ANILINE HYDROCHLORIDE FOR POSSIBLE CARCINOGENICITY CAS No. 142-04-1 ... Institutes of Health BIOASSAY OF ANILINE HYDROCHLORIDE FOR POSSIBLE ...

  2. Aniline hydrochloride: Target Organs and Levels of Evidence for... 57KB

    https://ntp.niehs.nih.gov/data/tr/100s/tr130levels

    7 Aniline hydrochloride: Target Organs and Levels of Evidence for TR-130 Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN 142-04-1) Chemical (Study Title) ...

  3. Abstract for TR-130 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr130

    Aniline Hydrochloride for Possible Carcinogenicity CASRN: 142-04-1 Chemical Formula: C6H7N . HCl Molecular Weight: 129.589 Synonyms/Common Names: benzenamine hydrochloride; aniline ...

  4. Spleen - Adipocyte Metaplasia - Nonneoplastic Lesion Atlas 288KB

    https://ntp.niehs.nih.gov/atlas/nnl/immune-system/spleen/AdipocyteMetaplasia

    It has been reported in the red pulp of rats exposed to some aromatic amines (e.g., aniline, aniline hydrochloride, para-chloroaniline) and in rats with splenic mesenchymal ...

  5. TOX-73: Diazoaminobenzene (CASRN 136-35-6) 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox073.pdf

    ... The structure of the chemical is a combination of benzene and aniline, both of which are ... a tube) to determine if the chemical breaks down into benzene or aniline in the body. ...

  6. RoC Background Document for Diazoaminobenzene; Nov. 22, 2002 1.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/daab_rg2_public_correct_no_app_508.pdf

    ... known human carcinogen benzene and to the animal carcinogen aniline. Human Exposure Use. ... Production. DAAB may be produced by reaction of aniline with isoamyl nitrate or by ...

  7. TR-351: para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in... 12.2MB

    https://ntp.niehs.nih.gov/go/tr351

    ... mg/kg p-chloro- aniline hydrochloride in water by gavage, 5 days per week for 103 weeks. ... There was some evidence of carcinogenic activity of p-chloro- aniline hydrochloride for ...

  8. RoC Profile: Diazoaminobenzene; 15th RoC 2021 129KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diazoaminobenzene.pdf

    Diazoaminobenzene is metabolized to benzene and to the known ro- dent carcinogen aniline; ... to rats and mice, benzene and aniline were detected in blood, benzene was ...

  9. Abstract for TR-278 63KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr278

    Abstract 2,6-Xylidine is a chemical intermediate used principally in the production of dyes. It is also a component of tobacco smoke, a degradation product of aniline-based ...

  10. Use of Toluidine in the Manufacture of Dyes 253KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/otolconsultant_report_508.pdf

    ... These dyes were originally produced in the 19 th century, from the oxidation of commercial aniline. At that time, aniline contained significant amounts of o- and p-toluidines. ...

  11. Abstract for TR-289 70KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr289

    plastics and synthetic rubber), phenol (phenolic resins), cyclohexane (nylon), aniline, maleic anhydride (polyester resins), alkylbenzenes (detergents), chlorobenzenes, and ...

  12. RoC Background Document for Nitrobenzene; Sept. 19, 2002 1.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nbpub_no_appendices_508.pdf

    ... Summary Introduction Nitrobenzene is a nitro aromatic hydrocarbon used to produce aniline. ... The primary use of nitrobenzene is in the manufacture of aniline, an intermediate in the ...

  13. TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf

    ... It is also a com- ponent of tobacco smoke, a degradation product of aniline-based ... environment through the degradation of aniline-based pesti- cides such as CGA 17020 ...

  14. RoC Background Document for 4,4'-Thiodianiline; March 27, 2002 1.1MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/tdapub_no_appendices_508.pdf

    ... Production. TDA probably is prepared by reaction of aniline with sulfur. United States ... Aniline and dapsone, on the other hand, caused tumors of the spleen. Some similarity in ...

  15. Abstract for TOX-73 64KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox073

    ...3-diphenyl-1-triazene; DPT; N-(phenylazo)aniline Report Date: September 2002 Full Report ... that it would be metabolized into aniline and benzene; therefore, metabolism and ...

  16. Spleen - Adipocyte Metaplasia 314KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/spleen/admetap/spleen-adipocyte-metaplasia-pdf_508.pdf

    It has been reported in the red pulp of rats exposed to some aromatic amines (e.g., aniline, aniline hydrochloride, para-chloroaniline) and in rats with splenic mesenchymal ...

  17. TR-360: N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and... 10.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr360.pdf

    ... the draft Technical Report on N,N-dimethyl- aniline on March 13,1989, are listed below. ... Popp commented that the lesions reported were very typical of the aniline class of ...

  18. Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf

    ... OR chloro-ortho toluidine OR aniline OR ((manufacture OR manufacturing OR ... OR chloro-ortho toluidine OR aniline OR ((manufacture OR manufacturing OR ...

  19. RoC Profile: Nitrobenzene; 15th RoC 2021 133KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrobenzene.pdf

    ... (1) reduction of the nitro group to form aniline, followed by ring oxidation to form ... Nitrobenzene can be reduced to aniline under anaer- obic conditions (by bacteria in the ...

  20. TOX-43: o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9... 5.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox043.pdf

    ... TOXICITY The major toxic effect of aniline and its aromatic amine and chlorinated ... Aniline derivatives are only effective as methemoglobin-inducing agents in vivo, and it ...

  21. RoC Monograph: ortho-Toluidine; July 2014 2.4MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/otoluidine_508.pdf

    ... the same one assessed by Hanley et al. (2012) for exposure to ortho-toluidine and aniline. ... Workers were exposed to aniline, which is an animal carcinogen; however, exposure levels ...

  22. TR-171: 2,4-Dimethoxyaniline Hydrochloride (CASRN 54150-69-5... 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr171.pdf

    ... SUMMARY A bioassay for the possible carcinogenicity of 2,4-dimethoxy- aniline HC1 was ... IN RATS TREATED WITH 2,4-DIMETHOXY- ANILINE HC1 C-l APPENDIX D SUMMARY OF THE ...

  23. TR-189: p-Chloroaniline (CASRN 106-47-8) 3.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr189.pdf

    ... the carcinogenicity of p-chloro- aniline for Fischer 344 rats or B6C3Fl mice. viii ... SUMMARY FOR B6C3Fl MICE--p-CHLORO- ANILINE FEEDING EXPERIMENT 11 ANALYSES OF THE ...

  24. TR-211 Carcinogenesis Studies of C.I. Acid Orange 10 (CASRN 1936... 7.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr211.pdf

    ... a metabolite of C.I. Acid Orange 10 (aniline) had been shown to be carcinogenic at ... First synthesized in 1878 by Baum, C.I. Acid Orange 10 can be made by diazotizing aniline ...

  25. TR-418: p-Nitroaniline (CASRN 100-01-6) in B6C3F1Mice (Gavage... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr418.pdf

    ... when previous p$rp studies o f aniline and substituted anilines used the dietary route. ... These responses are similar to those observed with aniline and substituted aniline ...

  26. RoC Concept: ortho-Toluidine 318KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/otolconcdocroc8-30-12_508.pdf

    ... (1) magenta manufacturing, (2) aniline manufacturing and processing (3) ... methylaniline), ortho-aminoazotoluene, aniline, 4-chloro-ortho-toluidine, nitrobenzene, ...

  27. Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf

    ... occupation, from which evolved the term aniline cancer. 46 The textile dye, chemical, and ... Aniline is a key intermediate in the manufacturing of dyes. Aniline, however, was not ...

  28. RoC Profile: 4,4'-Methylenedianiline and Its Dihydrochloride... 141KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylenedianiline.pdf

    Physical and chemical properties of 4,4'-methylenedi aniline are listed in the following ... 96% 4,4'-methylenedianiline, 3% other isomeric amines, and traces of aniline (ATSDR 1998). ...

  29. RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf

    ... of the Bladder Among Workers in Aniline Factories (Studies and Reports, Series F, No. 1). ... antigens and blastomogenic activity of aniline dyes. (In Russian). Gig. Trud. Prof. ...

  30. RoC Profile: Basic Red 9 Monohydrochloride; 15th RoC 2021 121KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/basicred9.pdf

    increased incidence of cancer in magenta workers was attributable to exposure to magenta or to one or more of its interme- diates and impurities, such as o-toluidine or aniline. ...

  31. Minutes: BSC TRRS; Oct. 18, 2001 79KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2001/oct/trrs18oct2001mins_508.pdf

    ... The proposed conclusions to the report were: Diazoaminobenzene is metabolized to the known carcinogens benzene and aniline. Some toxic effects associated with aniline (Heinz body ...

  32. Spleen - Fibrosis - Nonneoplastic Lesion Atlas 292KB

    https://ntp.niehs.nih.gov/atlas/nnl/immune-system/spleen/Fibrosis

    Goodman DG, Ward JM, Reichardt WD. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine ...

  33. Spleen - Fibrosis 442KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/spleen/fibrosis/spleen-fibrosis-pdf_508.pdf

    ... References: Goodman DG, Ward JM, Reichardt WD. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine ...

  34. ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf

    ... Lipids 44.0 (3.4) 9.404 (4.2) Aniline Food additive; Manufacturing; Personal ... original LLNA evaluation (ICCVAM 1999), aniline and nickel sulfate, were obtained from ...

  35. Protocol: Evaluation of Human Cancer Studies on Exposure to ortho... 518KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/ortho-toluidineprotocol_508.pdf

    ... general, (2) magenta manufacturing, (3) aniline---based dye manufacturing, (4) production ... toluidine OR chloro---ortho toluidine OR aniline OR ((manufacture OR manufacturing OR ...

  36. Minutes: BSC TRRS; April 18, 1988 4.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/apr/88apr18trrsmins_508.pdf

    ... sensitivity to aniline toxicity was based on differences in a single erythrocyte enzyme . ... carcinogenicity and other effects for the aniline compounds to be a useful addition. or. ...

  37. RoC Profile: 4,4'-Thiodianiline; 15th RoC 2021 129KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/thiodianiline.pdf

    ... However, no uses of either 4,4'-thiodianiline or mordant yellow 16 since the early 1990s have been reported. Production 4,4'-Thiodianiline is prepared by reaction of aniline with ...

  38. RoC Profile: Benzene; 15th RoC 2021 110KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf

    ... (12%), nitrobenzene (used to produce aniline and other chemicals) (5%), detergent alkylate (linear alkylbenzene sulfonates) (3%), and chlorobenzenes and other products (5%). ...

  39. TR-225: D & C Red No. 9 (CASRN 5160-02-1) in F344 Rats and B6C3F1Mice... 7.1MB

    https://ntp.niehs.nih.gov/go/tr225

    ... should be expanded to note that aniline and para-chloroaniline also induce such lesions. ... In reports on the bioassay of aniline (NCI, 1978), azobenzene (NCI, 1979), and ...

  40. TR-233: 2-Biphenylamine Hydrochloride (CASRN 2185-92-4) in F344... 8.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr233.pdf

    ... with splenic hemangiosarcomas. Aniline is a classic example, producing ... J. 119; 52P-53P; 1970.1 He commented on Dr. Williams' statement about aniline a n d a n n ...

  41. Presentation: The Murine Local Lymph Node Assay: BrdU-ELISA 889KB

    https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/6-strickland.pdf

    ... Traditional LLNA Sensitizers (n = 32) Traditional LLNA Nonsensitizers (n = 11) 3-Aminophenol Aniline Benzoquinone 4-Chloroaniline 5-Chloro-2-methyl-4- isothiazolin-3-one Cinnamic ...

  42. RoC Profile: Acetaldehyde; 15th RoC 2021 176KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf

    ... Acetaldehyde has been used in the manufacture of aniline dyes, plastics, and synthetic rubber, to silver mirrors, and to harden gelatin fibers. It has also been used in the ...

  43. TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf

    ... chloride Trade names: Aniline Green; Benzal Green; Benzaldehyde Green; ... chloride Trade names: Aniline Green; Benzal Green; Benzaldehyde Green; ...

  44. Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

    ... confirm negative results) reported for aniline, 4-chloroaniline, streptomycin sulfate, ... as the "gold standard", three compounds (aniline, nickel sulfate, neomycin sulfate) were ...

  45. RoC Background Document: p-Chloro-o-toluidine and its Hydrochloride... 2.6MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/chloro-o-toluidine_508.pdf

    ... 2-Amino-5-chlorotoluene hydrochloride Aniline, 4-chloro-2-methyl-, hydrochloride Azanil ... biphenyls, aniline, a-toluidine, 4,4' -methylenedianiline, and p-chloro-o-toluidine. ...

  46. Captafol/o-Nitrotoluene Expert Panel Report Part A - Peer Review... 138KB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/o_nitrotolouene_reportparta_508.pdf

    ... were employed in the department with o-toluidine and aniline exposure for > 10 years." . ... The authors concluded that o-toluidine was more likely than aniline to be responsible for ...

  47. Minutes: BSC RoC; Oct. 14, 2003 1.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2003/rocmin101403.pdf

    ... is metabolized to benzene, a known human carcinogen, and to aniline, an animal carcinogen. ... Benzene metabolites, including phenol, hydroquinone glucoronide, muconic acid, and aniline ...

  48. Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf

    ... 50-00-0 Y 1A 1 1 1A Tetrachlorosalicylanilide* 1154-59-2 Y 1A 1A 1 1A/1B Aniline* 62-53-3 Y 1B 1B NC 1B Chlorpromazine 50-53-3 N 1B 1 NC 1B Cinnamic alcohol 104-54-1 Y 1B ...

  49. TR-160: 2,4,5-Trimethylaniline (CASRN 137-17-7) 3.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr160.pdf

    ... acid and the various aniline moieties, including 2,4,5-trimethylanilin... Time on Species, Sex, Initial No. aniline in Diet (b) Study and Test Group Animals ...

  50. Peer Review Report: RoC Peer Review; Dec. 12-13, 2013 287KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/december/peerreviewrpt20131213_508.pdf

    ... well characterized. The most common co-exposure was to aniline; however, the exposure levels were much lower for aniline than for o-toluidine, and the subcohorts exposed to ...

 
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