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TR-031: Tolbutamide (CASRN 64-77-7) 2.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr031.pdf
1 BIOASSAY OF TOLBUTAMIDE FOR POSSIBLE CARCINOGENICITY CAS NO. 64-77-7 NCI-CG-TR-31 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National Institutes of ...
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Tolbutamide: Target Organs and Levels of Evidence for TR-031 56KB
https://ntp.niehs.nih.gov/data/tr/000s/tr031levels
6 Tolbutamide: Target Organs and Levels of Evidence for TR-031 Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7) Chemical (Study Title) CASRN Peer Review Date ...
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Abstract for TR-31 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr031
1abs Abstract for TR-31 Bioassay of Tolbutamide for Possible Carcinogenicity CASRN: 64-77-7 Chemical Formula: C12H18N2O3S Molecular Weight: 270.3512 Synonyms/Common Names: ...
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Abstract for TR-51 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr051
Abstract Tolzamide is an oral hypoglycemic agent of the arylsulfonylurea type, similar to tolbutamide, chlorpropamide, and acetohexamide. A bioassay of the hypoglycemic drug ...
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Abstract for TR-50 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr050
Acetohexamide is an oral hypoglycemic agent of the arylsulfonyl-urea group with a potency between that of tolbutamide and chlorpropamide. A bioassay of acetohexamide for possible ...
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Human stem-cell derived intestinal organoids as a tool to evaluate... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_10_Patrik Lundquist_GutModels2023_508.pdf
... Haloperidol Glucoronidation CYP2D6 2.7 To be determined Diclofenac CYP2C9 5.9 4OH-diclofenac Tolbutamide CYP2C9 0 None (so far) Caffeine CYP1A2 0 None detected Nicotine CYP2A6 0 ...
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TR-051: Tolazamide (CASRN 1156-19-0) 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr051.pdf
... arylsulfonylurea type, similar to tolbutamide, chlorpropamide, and acetohexamide. It is approximately five times more potent than tolbutamide in the human diabetic and was ...
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TR-007: Phenformin (CASRN 114-86-3) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr007.pdf
... L-tryptophan 1-buty1-3-(p-tolylsulfonyl)urea; tolbutamide 4,4'-sulfonyldianiline ... 1-buty1-3-(p-tolylsulfonyl)urea; tolbutamide 4,4'-sulfonyldianiline ...
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TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf
... The effect was demonstrated by hepatic metabolism of tolbutamide (measuring plasma ... NTP TOX 67 inhibitor of tolbutamide hydroxylase activity in human liver ...
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TR-045: Chlorpropamide (CASRN 94-20-2) 2.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr045.pdf
... Structurally, it is a derivative of tolbutamide in which chlorine is substituted for the ... l-butyl-3-(p-tolylsulfonyl)urea (tolbutamide) (CAS 64-77-7) 5-(4-chlorophenyl)-6-eth...
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TR-050: Acetohexamide (CASRN 968-81-0) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr050.pdf
... group with a potency between that of tolbutamide and chlorpropamide (Jackson, 1969). ...(p-tolylsulfonyl)urea (toIbutamide) (CAS 64-77-7) 4-chloro-N-((propylamino)carbonyl)benzen...
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TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf
... (0.2 mg), paclitaxel (20 μM) CYP2C9 d Tolbutamide hydroxylation Phosphate buffer (0.1 M), NADPH (1 mM), microsomal protein (0.2 mg), tolbutamide (240 μM) CYP2C19 b ...
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TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf
... (0.2 mg), paclitaxel (20 μM) CYP2C9 d Tolbutamide hydroxylation Phosphate buffer (0.1 M), NADPH (1 mM), microsomal protein (0.2 mg), tolbutamide (240 μM) CYP2C19 b ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... N No Evidence P Clear Evidence N No Evidence P Clear Evidence TR-031 09/26/77 Tolbutamide 64-77-7 N No Evidence N No Evidence N No Evidence N No Evidence TR-030 09/26/77 ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... Oral Rat or Mouse LD50 (mg/kg) 104 Tolbutamide 1.81 9.62 2601.1 105 21 Theophylline ... 109 Frusemide 2.33 7.86 2599.8 104 Tolbutamide 1.81 9.62 2601.1 346 50 Potassium I ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 2 103 18 Nicotine 54-11-5 290.45 1.79 50.3 0.31 24.3 0.15 162.26 0.31 104 Tolbutamide 64-77-7 489.39 1.81 NA NA 2601.1 9.62 270.38 9.62 105 21 Theophylline 58-55-9 329.75 1.83 ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1977 Technical Report TR-031 PDF (2.39 MB) Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7) 1977 Technical Report TR-030 PDF (2.99 MB) Bioassay of ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-031 PDF (2.39 MB) Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7) 1977 Long-Term Carcinogenicity TR-030 PDF (2.99 MB) Bioassay ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 1977 Technical Report TR-031 PDF (2.39 MB) Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7) 1977 Technical Report TR-030 PDF (2.99 MB) Bioassay of ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf
... Fluoxetine and norfluoxetine also are inhibitors of CYP2C enzymes, which metabolize diazepam, warfarin, tolbutamide, and phenytoin, and of CYP3A4, which metabolizes ...
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TR-535: 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr535.pdf
... J. Pharmacol. 85, 121-126. Back, D.J., Tjia, J.F., Karbwang, J., and Colbert, J. (1988). In vitro inhibition studies of tolbutamide hydroxylase activity in human liver microsomes ...
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TR-357: Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and... 12.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr357.pdf
... Proc. 42:1707-1710. 31. Gold, B.; Mirvish, S.S. (1977) N-Nitroso de- rivatives of hydrochlorothiazide, niridazole, and tolbutamide, Toxicol. Appl. Pharmacol. 40:131- 136. 32. ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
... levels and a prolonged sleep time Tolbutamide Metabolism is greater in males than ... Not present. 2C8 Retinol metabolism. 2C9/10 Hexobarbital, tolbutamide metabolism. 2C18 ...
