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Search suggestions for "64-86-8".

  1. CEBS Data Related to Colchicine (64-86-8) https://cebs.niehs.nih.gov/cebs/test_article/64-86-8


46 results found for "64-86-8".

  1. Testis, Germ Cell - Exfoliation - Nonneoplastic Lesion Atlas 287KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/GermCell-Exfoliation

    esters and microtubule inhibitors such as colchicine and the fungicide carbendazim. ... exhibit differential sensitivity to the microtubule disruptors carbendazim and colchicine. ...

  2. Testis, Germ Cell - Exfoliation 687KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/testis/gcexfol/testis_germ_cell-exfoliation_508.pdf

    esters and microtubule inhibitors such as colchicine and the fungicide carbendazim. ... exhibit differential sensitivity to the microtubule disruptors carbendazim and colchicine. ...

  3. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    56-75-7 323.14 FLUKA 23275 > 99 Citric Acid 77-92-9 192.10 SIGMA C0759 98 Colchicine 64-86-8 399.45 FLUKA 27650 > 98 Cupric Sulfate Pentahydrate 7758-99-8 249.70 SIGMA C7631 ...

  4. Developmental Neurotoxicity Health Effects Innovation Program... 3.4MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/december/presentations/13behl_bsc_508.pdf

    ... Objective 1: Building on DNTP's Past Experience Aschner et al., 2017 & Mundy 2015 5- FU Paraquat Rotenone Colchicine Valproic acid Lead acetate BDE-99 , BDE-47, EHDP ...

  5. The Development of a 96-well Plate-Based Model of the Human Intestinal... 2.3MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_09_Bill Thelin_GutModels2023_508.pdf

    ... Compound (Mechanism) Diarrhea Incidence Clinical Cmax RepliGut® (TEER IC 15 ) Bortezomib (Proteosome Inh) 77% 1.3E-06 0.01 Colchicine (Microtubule Inh) 96% 1.8E-08 0.04 Afatinib ...

  6. ICCVAM Background Review Document (Vol 1): In Vitro Cytotoxicity... 16.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol1_nov2006.pdf

    ... biphasic concentration-responses in the range finder tests for aminopterin and colchicine. ... This effect with colchicine was very reproducible across laboratories in the NHK NRU test, ...

  7. Developmental Neurotoxicity Assessment Using In Vitro Assays 6.8MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2022/20220125-iccvam-cop-hogberg-508.pdf

    ... tert-Butylphanyldipheny1phospha!e Colchicine Valinomycin Bis(tributyhin)oxide ... BMC. CUrYaP: 13.24 11M Hill: 13.18 11H Colchicine Valinomycin Bis(tributyhin)oxide ...

  8. TR-578: Ginkgo biloba Extract (CASRN 90045-36-6) in F344/N Rats... 7.9MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr578_508.pdf

    ... ginkgolide B. HPLC/MS analysis for the presence of colchicine using the colchicine standard from Sigma-Aldrich resulted in no observable peak of colchicine in the test material. ...

  9. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... Assay (µg/mL) pH in NHK Medium b Concentrations Tested in NHK Assay (µg/mL) Colchicine 64-86-8 > 98 Fluka 8.2 0 7.7 0.0014-0.10 Cupric sulfate pentahydrate 7758-99-8 99.7 Sigma ...

  10. TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr415.pdf

    ... activity o f the drugs colcemid, colchicine, and 16 Polysorbate SO, NTP TR 415 ... cellular uptake o f radiolabeled colchicine, so theauthors concluded polysorbate 80 ...

  11. TOX-28: Tetrachlorophthalic Anhydride (CASRN 117-08-8) 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox028.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  12. CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf

    ... Plug-positive females were given colchicine 26 h after the hCG and were killed 5 h later. ... Plugged females were given colchicine 24 h after hCG to arrest zygote development at ...

  13. TR-352: N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats... 27.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr352.pdf

    ... Examination of tibial and sural nerves showed microscopic evidence of shrinkage and loss of myelinated fibers, myelin retraction, and corru- gated myelin sheaths. [3H]Colchicine ...

  14. TOX-55: trans-1,2-Dichloroethylene (CASRN 156-60-5) 3.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox055.pdf

    ... sacrifice, the animals received an intraperitoneal injection of colchicine in saline. ... sacrifice, the animals received an intraperitoneal injection of colchicine in saline. ...

  15. Report of 2006 ICCVAM Peer Panel Meeting on In Vitro Cytotoxicity... 1.3MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/atpanelrpt06/atpanelrpt.pdf

    ... The Panel asked whether something other than mechanism of action contributed to the unusual concentration-response curves for aminopterin and colchicine. The Draft BRD should ...

  16. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... hydroxide 0.000049 0.12 44.0 6 Colchicine 0.000054 0.015 6.0 133 Cytochalasin D ... chloride 0.00046 0.021 5.1 6 Colchicine 0.000054 0.015 6.0 2 Actinomycin D ...

  17. CERHR Monograph: Hydroxyurea 3.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf

    ... injected with 500 mg/kg bw hydroxyurea [purity not given], 500 mg/kg bw hydroxyurea11 mg/kg bw colchicine, or 1 mg/kg bw colchicine. Three untreated animals were used as controls. ...

  18. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... Triphenyltin hydroxide 76-87-9 0.02 0.000049 44.0 0.12 245.9 0.67 367.03 0.12 6 Colchicine 64-86-8 0.02 0.000054 NA NA 6.0 0.015 399.48 0.015 7 Ouabain 630-60-4 0.04 0.000072 NA NA ...

  19. TR-603: Black Cohosh Root Extract (CASRN 84776-26-1) Administered... 3.1MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-12/tr603_508.pdf

    ... Another compound, colchicine, is also associated with development of megaloblastic anemia resulting from a functional cobalamin deficiency, 115; 177 and colchicine is a ...

  20. OECD Guidance Document 129: Using Cytotoxicity Tests to Estimate... 1.4MB

    https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd129.pdf

    ... compound Citric acid 77-92-9 796 400 5929 Organic compound; Carboxylic acid Colchicine 64-86-8 0.034 0.007 15 (mouse) Organic compound; Polycyclic compound Cupric sulfate ...

  21. Minutes: MPRP; Oct. 1-2, 2012 559KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf

    ... J, Botkin C, Knutsen T. 1978. Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP- 16-213 and VM-26) in mice. ...

  22. TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox35.pdf

    ... (BrdUrd) tablets (Boehringer Mannheim), colchicine (Eli Lilly), Hoechst 33258 (American ... before kill time, each animal was injected intraperitoneally with 2 mg1kg colchicine . ...

  23. TR-458: Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats ... 12.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr458.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  24. TR-486: Isoprene (CASRN 78-79-5) in F344/N Rats (Inhalation Studies... 11.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr486.pdf

    ... Two hours before sacrifice, the animals received an intraperitoneal injection of colchicine in saline. At the time of colchicine injection, peripheral blood samples for ...

  25. ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test... 14.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/at-tmer-complete.pdf

    ... The Panel asked whether something other than mechanism of action contributed to the unusual concentration-response curves for aminopterin and colchicine. The Draft BRD should ...

  26. RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf

    ... Immediately after, mice were injected i.p. with lead nitrate in saline at concentrations of 10, 20, or 40 mg/kg b.w. Mice were injected i.p. with colchicine 22 hours after BrdU ...

  27. TR-350: Tribromomethane (Bromoform) (CASRN 75-25-2) in F344/N... 11.8MB

    https://ntp.niehs.nih.gov/go/tr350

    ... killed, the mice received an intraperitoneal injection of 2 mg/kg colchicine (in saline). ... the mice received a n intraperitoneal in- jection of 2 mg/kg colchicine (in saline). ...

  28. TR-382: Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1Mice... 11.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr382.pdf

    ... killed, the mice received an intraperitoneal injection of 2 mg/kg colchicine (in saline). ... killed, the mice received a n intraperitoneal injection of 2 mg/kg colchicine (in saline). ...

  29. TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr402.pdf

    ... the mice received an intraperitoneal (IP) injection of 2 mg/kg colchicine in saline. ... Two hours prior to sacrifice, the mice received an IP injection of 2 mg/kg colchicine in ...

  30. TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection o f colchicine ... before sacrifice, the mice received an intraperitoneal injection o f colchicine in saline. ...

  31. TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf

    ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  32. TR-473: Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1Mice... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr473.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  33. TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr475.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  34. TR-482: Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1... 27.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr482.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  35. CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

    ... Females with vaginal plugs were treated with colchicine to prevent the first embryonic ... The 90-day-old mice were s.c. injected with 5 mg/kg bw colchicine and killed 5 hr later. ...

  36. TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf

    ... Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine ... exposure day, at the time of colchicine injection (necessary for Abs and SCE analyses). ...

  37. TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB

    https://ntp.niehs.nih.gov/go/tr385

    ... with a 50 mg bromodeoxyuridine (BrdU) tablet (McFee et al., 1983), and two hours prior to sacrifice, the mice received an IP injection of 2 mg/kg colchicine (in saline). ...

  38. TR-601: Di(2-ethylhexyl) Phthalate Administered in Feed to Sprague... 4.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr601_508.pdf

    ... Two hours before sacrifice, the animals received an intraperitoneal injection of colchicine in saline. The animals were euthanized 18 hours after BrdU dosing. One or both femurs ...

  39. TR-434: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 21.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr434.pdf

    ... injection of 2 mgkg colchicine (in saline). Peripheral blood smears for micronucleus analysis were prepared at the time of colchicine injection and processed as described below. ...

  40. TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf

    ... they decline in number during subsequent nuclear divisions due to cell death.) Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  41. TR-490: Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1Mice... 10.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr490.pdf

    ... decline in number during subsequent nuclear divisions due to cell death.) Two hours before sacrifice, the animals received an intraperitoneal injection of colchicine in saline. ...

  42. Draft TR-601: Di(2-ethylhexyl) Phthalate (CASRN 117-81-7) Administered... 3.6MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr601_508.pdf

    ... Two hours before sacrifice, the animals received an intraperitoneal 9 injection of colchicine in saline. The animals were euthanized 18 hours after BrdU dosing. One 10 or both ...

  43. TR-457: Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats... 18.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr457.pdf

    ... they decline in number during subsequent nuclear divisions due to cell death.) Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  44. TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf

    ... decline in number during subsequent nuclear divisions due to cell death.) Two hours before sacrifice, the animals received an intraperitoneal injection of colchicine in saline. ...

  45. TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats... 16.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr470.pdf

    ... they decline in number during subsequent nuclear divisions due to cell death.) Two hours before sacrifice, the mice received an intraperitoneal injection of colchicine in saline. ...

  46. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf

    ... J, Botkin C, Knutsen T. 1978. Tera- togenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice. ...

 
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