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Abstract for TR-42 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr042
Full Report PDF Abstract 5-Azacytidine, a synthetic analogue of cytidine, has been used as an investigational anticancer drug in the United States since 1970. A bioassay of ...
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RoC Profile: Nitrosourea Chemotherapeutic Agents; 15th RoC 2021 215KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrosoureachemotherapeuticagents.pdf
(methyl-CCNU, semustine), and chlorozotocin - degrade to form the 2-chloroethyl carbonium ion, which is a strong electrophile capable of alkylating guanine, cytidine, and adenine. ...
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RoC Profile: Azacitidine; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/azacitidine.pdf
... Properties Azacitidine is a pyrimidine analogue of cytidine that exists at room ... CD. 1988. Carcinogenicity and haemoglobin synthesis induction by cytidine analogues. ...
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RoC Background Document: Strong Inorganic Acid Mists Containing... 2.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/sulfuric_acid_mists1_2apps_508.pdf
... to enhance the depurination rate of DNA and the deamination rate of cytidine (IARC, 1992). ... are known to enhance the depurination rate of DNA and the deamination rate of cytidine. ...
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RoC Profile: Strong Inorganic Acid Mists Containing Sulfuric... 150KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/stronginorganicacidmists.pdf
acid is most likely related to the genotoxicity of low-pH environments, which are known to increase the rates of depurination of DNA and deamina- tion of cytidine (IARC 1992a). ...
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RoC Background Document: Azacitidine; Nov. 18-19, 1996 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/azacitidine1_508.pdf
... Summary: Metabolism and distribution of 5-AzaC are similar in humans, mice, and dogs. Enzymes involved in metabolism include cytidine deaminase and uridine-cytidine kinase. ...
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TR-042: 5-Azacytidine (CASRN 320-67-2) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr042.pdf
... (CAS 320-67-2; NCI C01569), a synthetic analogue of cytidine, has been used as an investigational anticancer drug in the United States since 1970 (Von Hoff et al. , 1976). ...
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TR-569: Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr569_508.pdf
... (3TC) is an (-)enantiomer analogue of cytidine. 3TC is a white-to-off-white crystalline ... Erickson-Viitanen, S. (2002). DPC 817: A cytidine nucleoside analog with activity against ...
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Minutes: BSC; Sept. 23, 1982 738KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1982/september/bsc_mins19820923_508.pdf
... TABLE 34 (Continued) RECOMMENDATION CHEMICAL CASE No. - (Priority) REMARKS 9) Cytidine 65-46-3 No testing Concur with CEC recommendation for possible study through research ...
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GMM-16: Genetically Modified Model Report on Study of Mixtures... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm16_508.pdf
... (3TC) is an (-) enantiomer analogue of cytidine. 3TC is a white to off-white crystalline solid, with a solubility of approximately 70 mg/mL in water at 20° C (PDR, 2010a). ...
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CERHR Monograph: Hydroxyurea 3.6MB
https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf
... The study authors concluded that deoxycytidylic acid was the cytidine compound with the greatest protective ef fect and that protective ef fects were greater for cytidine than for ...
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TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf
... Cancer Res.. 31 U97D, 1434-1439- 4. Baird, W.M., P.W. Melera, and R.K. Boutwell. "Acrylamide Gel Electrophoresis Studies of the Incorporation of Cytidine-3H Into Mouse Skin RNA at ...
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RoC Monograph: Human Immunodeficiency Virus Type 1; August 2016 2.2MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/hiv_final201608_508.pdf
... of activation-induced cytidine deaminase (AID) (Epeldegui et al. 2010; He et al. 2006). ... expression of activation induced cytidine deaminase in peripheral blood ...
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RoC Monograph Peer Review: Human Immunodeficiency Virus Type... 2.1MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_hiv.pdf
... of activation-induced cytidine deaminase (AID) (Epeldegui et al. 2010a, He et al. 2006). ... expression of activation induced cytidine deaminase in peripheral blood ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
... the conversion of phosphoethanolamine to cytidine diphosphate ethanolamine was the ... with the phosphoethanolamine and cytidine diphosphate ethanolamine were decreased ...
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RoC Background Document for Diethanolamine; March 22, 2002 1.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/deapub_no_appendices_508.pdf
... HO Ethanolamine ADP OH NH 2 Phosphorylethanolamine O P O + CTP OH PP i H 2 N O HO P O Cytidine diphosphate ethanolamine (CDP-ethanolamine) HO O P O O CH 2 Cyto sine + ...
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RoC Background Document for Hepatitis B Virus; June 11, 2003 2.8MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hbv_rg2public_508.pdf
... Lamivudine is a pyrimidine derivative in the "unnatural" L-configuration (Torresi and Locarnini 2000). Lamivudine is the negative enantiomer of a dideoxy analogue of cytidine and ...
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RoC Monograph: Epstein-Barr Virus; August 2016 2.0MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/ebv_final201608_508.pdf
... Moreover, malarial infection has been shown to directly increase the number of germinal center translocations occurring via deregulation of activation-induced cytidine deaminase, ...
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TR-368: Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1Mice... 13.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr368.pdf
... Bio- chimie 64:775-781. 83. Podger, D.M.; Grigg, G.W. (1986) Enhance- ment of frameshift mutagenesis in Salmonella typhimurium derivatives of hisC3076 by 5-aza- cytidine and other ...
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Draft RoC Monograph Epstein-Barr virus (EBV): RoC Peer Review... 1.5MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/december/ebv_peer_draft_monograph.pdf
... or policy 37 translocations occurring via deregulation of activation-induced cytidine deaminase, an enzyme responsible for class switch recombination and somatic ...
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RoC Monograph Peer Review: Epstein-Barr Virus; Dec. 2015 1.6MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_ebv.pdf
... Moreover, malarial infection has been shown to directly increase the number of germinal center translocations occurring via deregulation of activation-induced cytidine deaminase, ...
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TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf
... Lymphomas of the T-cells are much less common, and lymphomas arising from the thymus are uncommon. With phenolphthalein, 1,3-butadiene, and 2',3'-dideoxy- cytidine (ddC) (Sanderset ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
... Life Sci. 29, 1797-1802. Barrio, J.R., Secrist, J.A., III, and Leonard, N.J. (1972). Fluorescent adenosine and cytidine derivatives. Biochem. Biophys. Res. Commun. 46, 597-604. ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf
...//dx.doi.org/10.1080/15257770601112697 16. Backman J, Sjoholm R, Kronberg L. Characterization of the adducts formed in the reactions of glycidamide with thymidine and cytidine. ...
