INVITTOX Protocol for the EPISKIN Test 2.9MB

https://ntp.niehs.nih.gov/iccvam/methods/dermal/epiderm/epiddocs/epidderm_invittox-508.pdf

... The precipitated formazan is extracted overnight by using acidified isopropanol (0.85 ml), ... 1 flask extraction solution of isopropanol acid (ready to use) ~I ___ specific ...

ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf

... Acyclic NA (2.2) 82.232 (2.3) Isopropanol 5, 6 Cosmetics; Disinfectant; Food ... range between 1.8 and 2.5 include salicylic acid, hexane, chlorobenzene, and isopropanol. ...

ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf

... Acyclic NC (2.2) 56.328 (1.9) Isopropanol * Cosmetics; Disinfectant; Food ... Because the majority (five) of the seven tests, had SI values < 1.6, isopropanol is ...

RoC Profile: Diethyl Sulfate; 15th RoC 2021 129KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diethylsulfate.pdf

A retrospec- tive cohort study of morbidity and mortality among 355 ethanol and isopropanol production workers found a significant excess of laryn- geal cancer (4 deaths) (Lynch et ...

RoC Profile: 2,2-Bis(bromomethyl)-1,3-propanediol (Technical... 119KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bis_bromomethyl_propanediol.pdf

... It is soluble in water and benzene, very soluble in acetone, isopropanol, and methanol, and slightly soluble in carbon tetrachloride and xylenes (HSDB 2009). Physical and chemi- ...

Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

... HCl 614-39-1 271.79 SIGMA-ALDRICH 222968-25G 99.7 2 Propanol (Isopropyl alcohol) 67-63-0 60.10 SIGMA I0398 > 99.9 DL Propranolol 350-60-90 295.80 SIGMA P0884 100 Propylparaben ...

RoC Profile: Dichlorodiphenyltrichloroethane; 15th RoC 2021 155KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichlorodiphenyltrichloroethane.pdf

... chlorobenzene, cyclohexanone, ethanol, ethyl ether, gasoline, isopropanol, kerosene, morpholine, peanut oil, pine oil, tetralin, and tributyl phosphate (IARC 1974, HSDB 2009). ...

Captafol/o-Nitrotoluene Expert Panel Report Part A; RoC expert... 162KB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/captafol_report_parta_508.pdf

... g/cm 3 at 20°C b Solubility water water acetone benzene dimethylsulfoxide isopropanol methyl ethyl ketone toluene xylene slightly soluble in most organic solvents 1.4 mg/...

Background Review Document: In Vitro Test Methods for Assessing... 2.4MB

https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf

... The precipitated formazan is extracted overnight by using acidified isopropanol (0.85 ml), ... 1 flask extraction solution of isopropanol acid (ready to use) 1 flask negative ...

Peer Review Report: Draft NTP Monograph on Systematic Review... 468KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2019/february/peerreview20190204_508.pdf

... The only exception was the Bansal 2009 study, which was the only study to use isopropanol as the vehicle; she was not convinced that isopropanol would not alter sarin absorption. ...

Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf

... Glycerol 56-81-5 N N/A NC NC NC 4-Hydroxybenzoic acid 99-96-7 N N/A NC NC NC Isopropanol 67-63-0 N N/A NC NC NC Lactic acid 50-21-5 N N/A NC NC NC 4-Nitrobenzyl bromide 100-11-8 ...

ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB

https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf

... ORGBA NC NC NC NC 8 Isopropanol NORG NC NC NC N/A 11 2-Phenylethanol ... The precipitated formazan is extracted overnight by using acidified isopropanol (0.85 ml), ...

Presentation: The Murine Local Lymph Node Assay: BrdU-ELISA 889KB

https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/6-strickland.pdf

... Diethyl phthalate Dimethyl isophthalate Glycerol Hexane 2-Hydroxypropyl methacrylate Isopropanol Lactic acid Methyl salicylate Propylene glycol Salicylic acid Sulfanilamide ...

Presentation: The Murine Local Lymph Node Assay: DA 1010KB

https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/7-salicru.pdf

... 1-Bromobutane Chlorobenzene Diethyl phthalate Dimethyl isophthalate Hexane Isopropanol Lactic acid Methyl salicylate Nickel (II) chloride Propylparaben Salicylic acid ...

TOX-3: Acetone (CASRN 67-64-1) 2.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox003.pdf

... metabolized to ketones), such as isopropanol, sec-butanol, and n-hexane, and the ... Samples were mixed with isopropanol as an internal Acetone, NTPTOX 3 16 standard and ...

Validation of the Electrophilic Allergen Screening Assay (EASA... 1.3MB

https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-gordon-poster.pdf

... Benzyl alcohol Pos/Neg/Pos Pos/Neg/Pos Neg/Neg/Neg Neg/Neg/Neg Neg Pos-Neg/Neg Glycerol Neg/Neg/Neg Neg/Neg/Neg Neg/Neg/Neg Neg/Neg/Neg Neg Neg/Neg Isopropanol Neg/Neg/Neg Neg/Neg/...

CERHR Monograph: Potential Human Reproductive and Developmental... 1.0MB

https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/2-bromopropane/2bp_monograph.pdf

... 2-BP metabolite concentrations (isopropanol, acetone, bromide, parent) in urine was ... assay indicated that parent and isopropanol are not detectable in urine, suggesting ...

TR-177: 4'-(Chloroacetyl)-acetanilide (CASRN 140-49-8) 3.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr177.pdf

... utilizing two solvent systems (i.e., benzene:isopropanol and chloroform:dioxane). ... utilizing two solvent systems (i.e., acetone:chloroform and benzene:isopropanol). ...

Reproducing the ITS-2 Model Using R 472KB

https://ntp.niehs.nih.gov/iccvam/methods/immunotox/its-os/its2_r_version-508.pdf

... 0.939476 0.027764 0.000313 0.032447 67-63-0 0.977885 0.016434 0.000304 0.005376 ... 0.939476 0.027764 0.000313 0.032447 67-63-0 0.977885 0.016434 0.000304 0.005376 ...

TR-181: Michler's Ketone (CASRN 90-94-8) 3.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr181.pdf

... Thin-layer chromatography was performed utilizing two solvent systems (i.e., 5 isopropanol and benzene:methanol). Each plate was visualized with visible and ultraviolet light and ...

TR-210: 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1Mice... 6.5MB

https://ntp.niehs.nih.gov/go/tr210

... The gas samples were discharged into 15-ml test tubes containing 1.0 ml isopropanol. Aliquots of the mixed isopropanol solutions were injected directly into a Varian 600-D gas ...

Application of Non-animal Test Methods and Defined Approaches... 22.2MB

https://ntp.niehs.nih.gov/iccvam/methods/immunotox/it/niceatm-it-report-june2020-final-wappx-508.pdf

... stop cock . Dimethyl sulfoxide (DMSO) . Isopropanol . Acetone . Benchtop vortex mixer . ... steps 2.1.1-2.1.3, make a 100 mM solution using isopropanol as the solvent. Vortex to mix. ...

TOX-89: Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2... 2.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox089_508.pdf

... 6 days per week [a mixture of Natrosol ® 250HR (2.0%), Tween 80 (2.0%), sodium sulfite (0.05%), deionized water (82.95%), and isopropanol (10.0%) was used as the vehicle] 1 . ...

Prospective and Retrospective Evaluation of the Eye Irritation... 344KB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/formulationreport_2021_fd-508.pdf

... The inserts were incubated with 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyl-tetrazolium bromide dye, rinsed with Dulbecco's phosphate-buffered saline, and incubated with isopropanol ...

TR-206: 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats... 7.0MB

https://ntp.niehs.nih.gov/go/tr206

... The gas samples were discharged into 15-ml test tubes containing 1.0 ml isopropanol. Aliquots of the mixed isopropanol solutions were injected directly into a Varian 600-D gas ...

Recommended Performance Standards for the LLNA 2.2MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf

... 90 1 45-100 NC +/+ +/+ 14 Chlorobenzene 108-90-7 Liq AOO NA 1 NA NA -/- -/* 15 Isopropanol 67-63-0 Liq AOO NA 1 NA NA -/- -/+ 16 Lactic acid 50-21-5 Liq DMSO NA 1 NA NA -/- -/* 17 ...

RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf

... Analytical Conc.(μg/mL) Acetone - 67-64-1 101.4 Ethanol FN03251502 64-17-5 103.4 Isopropanol - 67-63-0 102.2 Methanol - 67-56-1 102.3 Chemical and Physical Characterization of ...

ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf

... Isobutanol 78-83-1 Alcohol Solvent; Chemical intermediate; Flavor ingredient Isopropanol 67-63-0 Alcohol Solvent; Aerosol formulations (ingredient) N-Lauroylsarcosine, sodium ...

OECD Test Guideline 429: Skin Sensitisation: Local Lymph Node... 291KB

https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-tg429-2010.pdf

... 90 1 45-100 NC +/+ +/+ 14 Chlorobenzene 108-90-7 Liq AOO 25 1 NA NA -/- -/* 15 Isopropanol 67-63-0 Liq AOO 50 1 NA NA -/- -/+ 16 Lactic acid 50-21-5 Liq DMSO 25 1 NA NA -/- -/* 17 ...

Update on NICEATM Computational Resources 6.6MB

https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2021/ppt/2021_sacatm_s4-1_kleinstreuer_v2_508.pdf

le\ NTP National Toxicology Program Update on NICEATM Computational Resources SACATM September 28-29, 2021 Nicole Kleinstreuer Acting NICEATM Director Resources High-Quality Data ...

Background Document: RoC: Captafol; 2010 1.1MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf

... ] (calculated from molar volume) Solubility water acetone benzene dimethylsulfoxide isopropanol methyl ethyl ketone toluene xylene slightly soluble in most organic solvents 1.4 mg/...

Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

... References Comment Isopropanol// Isopropyl alcohol// 2-Propanol 67-63-0 alkanol// aliphatic secondary alcohol solvent// cosmetics// body rubs// pharmaceutic aid (solvent)// ...

ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf

... liquid I* undiluted 99.9% Fisher 4 3 2 69.2 1 I R41 Balls et al. (1995) Isopropanol 67-63-0 liquid S undiluted 99.9% Fisher 1 2 1.6 23.3 2A 1 II I R36 R41 Balls et al. ...

ICCVAM Test Method Evaluation Report: Ocular Hazard Testing Strategy... 4.3MB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/amcp/tmer-all.pdf

... Isopropanol, for extraction B-31 ICCVAM AMCP Evaluation Report . MTT Addition Medium is ... Isopropanol, reagent-grade 3.4 Solutions Follow the manufacturer's recommendations with ...

TR-427: Turmeric Oleoresin (CASRN 8024-37-1) (Major Component... 16.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr427.pdf

... The oleoresin may contain no more than 14 Turmeric Oleoresin, NTP TR 427 30 ppm o f acetone or chlorinated solvents, and no more than50 ppm methanol, ethanol, or isopropanol ...

GMM-15: Genetically Modified Model Report on Senna (Feed Studies... 4.0MB

https://ntp.niehs.nih.gov/ntp/htdocs/gmm_rpts/gmm15_508.pdf

... GC for residual volatiles detected methanol and isopropanol, both at levels below their ... GC for residual volatiles detected methanol and isopropanol, both at levels below their ...

TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf

... raphy on silica gel plates with a mobile phase of either to1uene:pdioxane:isopropanol:ammoni- um hydroxide (20:30:30:15) ( s y s t e m 1) or methylethy1ketone:glacial ...

TR-301: ORTHO-Phenylphenol (CASRN 90-43-7) Alone and with 7,12... 15.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr301.pdf

... isopropanol was added. This solution was allowed to stand overnight at room temperature. The resulting pale yellow crystalline flakes were washed four times with 25 ml isopropanol. ...

TOX-54: 1,4-Butanediol (CASRN 110-63-4) 577KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox054.pdf

... The first trap was maintained at 0 C by an ice-water bath; the second was maintained at -60 C by an isopropanol and dry ice bath. The second two traps each contained 500 mL of 1 N ...

TR-344: Tetracycline Hydrochloride (CASRN 64-75-5) in F344/N... 10.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr344.pdf

... with a 100 mM sodium EDTA:isopropanol (1: 1) solvent system; visuali- zation was by ultraviolet light at 254 nm, am- monium hydroxide, and a boric acidsulfuric acid spray reagent. ...

TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf

... Of the five vehicles examined, penetration followed the order propylene glycol = isopropyl alcohol > mineral oil > diisopropyl adipate > polyethylene glycol 400. Isopropanol ...

Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf

... Identified in Room Air but NOT Butter Flavoring Isopropyl alcohol; 2-Propanol; Isopropanol 67-63-0 3776 NL Major Major Major Major NL Propane 74-98-6 6334 NL Major Major Major ...

TOX-14: p-Chloro-a,a,a-Trifluorotoluene (CASRN 98-56-6) 2.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox014.pdf

... in 10 ml of a mixed solvent (1:1 water/isopropanol), and the absorbance determined using ... 14 A-5 Figure 4 U.V. Spectra 1:1 water/isopropanol solution of CTFT and α-CD molecular ...

ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf

... chloride - 57077-36-8 176.69 2.54 - Carboxylic Acids Gerberick Isopropanol Isopropyl alcohol, 2- Propanol 67-63-0 60.10 0.82 Liquid Alcohols Gerberick Isopropyl dicyandiamide - ...

Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

... 125 NA NA 88.12 125 128 10 2- Propanol 67-63-0 10038.37 167 5842.7 97.2 NA NA 60.11 97.2 ... NA NA 197.39 28.8 128 10 2- Propanol 67-63-0 10038.37 167 5842.7 97.2 NA NA 60.11 97.2 ...

ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB

https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf

... NP Botham et al. (1995) hydrogen peroxide - NP 1996 Submission isopropanol - 3.6 Barratt ... (isostearic acid; n -butyl propionate; isopropanol; phenethyl bromide; 2- phenylethanol; o ...

Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf

... NA NA 21.8 5450 N NA NA (RIFM 2007) Isopropanol AOO 10 25 50 1.7 1.1 1.0 NC NC N CBA NA ... 0 NA NA 70866 18 NA NA - (RIFM 2007) Isopropanol NA NA NA NA NA 0 6897 NA NA NA NA - ...

TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox103_508.pdf

... content determined that acetonitrile, isopropanol, and ethyl acetate were not present at ... content determined that acetonitrile, isopropanol, and ethyl acetate were not present at ...

ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

... 8.3 67-1000 7.5 47-10000 2-Propanol 67-63-0 > 99.9 Sigma 8.5 1011-50000 7.7 ... of Lethaliy f acid; Amide 2-Propanol 67-63-0 5843 60.10 Organic compound; Alcohol > ...

RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf

... tumors in di-isopropanol-nitrosamine- treated F344 rats and newborn C57BL and ICR mice. ... tumors in di-isopropanol-nitrosamine-treated F344 rats and newborn C57BL and ICR mice. ...