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TR-124: Piperonyl Sulfoxide (CASRN 120-62-7) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr124.pdf
Institute CARCINOGENESIS Technical Report Series NO. 124 BIOASSAY OF PIPERONYL SULFOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 120-62-7 NCI-CG-TR-124 U.S. DEPARTMENT OF HEALTH, ...
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Piperonyl sulfoxide: Target Organs and Levels of Evidence for... 57KB
https://ntp.niehs.nih.gov/data/tr/100s/tr124levels
5 Piperonyl sulfoxide: Target Organs and Levels of Evidence for TR-124 Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity (CASRN 120-62-7) Chemical (Study Title) CASRN ...
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Abstract for TR-124 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr124
4abs Abstract for TR-124 Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity CASRN: 120-62-7 Chemical Formula: C18H28O3S Molecular Weight: 324.4822 Synonyms/Common Names: ...
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BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf
... ER TA Agonist Activity 1,2 ER TA Antagonist Activity 1,3 Solvent Dimethyl sulfoxide 67-68-5 Sigma- Aldrich Corp D8418 99.9% - - Agonist Reference Standard 17β-estradiol 50-28-2 ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... sulfoxide [DMSO]): 1% (v/v) DMSO (CASRN 67-68-5) diluted in tissue culture media B-7 ... [DMSO]): 1% v/v dilution of DMSO (CASRN 67-68-5) diluted in tissue culture media E2 ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... Compounds Gerberick Dimethylsulfoxide - 67-68-5 78.13 0.57 Liquid Sulfur Compounds ... et al. (2005) Dimethyl sulfoxide 67-68-5 AOO + + 72 25 2.70 50 2.30 100 3.90 ...
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Recommended Performance Standards for the LLNA 2.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf
Recommended Performance Standards: Murine Local Lymph Node Assay Interagency Coordinating Committee on the Validation of Alternative Methods National Toxicology Program ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds The Results of an Independent Peer Review Evaluation ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products ...
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Minutes: SACATM; June 18, 2010 287KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/2010/june/minutes20100618.pdf
Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) June 17 - 18, 2010 I. LOCATION OF BACKGROUND MATERIALS/PRESENTATIONS AND FREQUENTLY USED ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
NIH Publication No: 03-4503 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... NR 50 b Interlaboratory reproducibility c (mg/ml) (mg/ml) Dimethylsulphoxide 67-68-5 44.06 18.36 Propylene glycol 57-55-6 36.27 25.40 Acetone 67-64-1 18.41 14.74 Ethanol 64-17-5 ...
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Minutes: BSC; Nov. 30-Dec. 1, 2010 984KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/novdec/minutes20101201.pdf
National Toxicology Program Board of Scientific Counselors November 30 - December 1, 2010 National Institute of Environmental Health Sciences Research Triangle Park, NC Table of ...
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TR-136: Aldicarb (CASRN 116-06-3) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr136.pdf
6 BIOASSAY OF ALDICARB FOR POSSIBLE CARCINOGENICITY CAS No. 116-06-3 NCI-CG-TR-136 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National Institutes of ...
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TOX-36: Pesticide/Fertilizer Mixtures 5.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox036.pdf
6 N T P Technical Report on Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F, Mice National Toxicology Program Post Office ...
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Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf
Independent Scientific Peer Review Panel Report Evaluation of the LUMI-CELL ® ER (BG1Luc ER TA) Test Method May 2011 Interagency Coordinating Committee on the Validation of ...
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BALB/c 3T3 NRU Cytotoxicity Test Method: ICCVAM Recommended Protocol 345KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/ivcyto-balbc.pdf
ICCVAM-Recommended Test Method Protocol BALB/c 3T3 NRU Cytotoxicity Test Method Originally published as Appendix C1 of "ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity ...
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NHK 3T3 NRU Cytotoxicity Test Method: ICCVAM Recommended Protocol 378KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/ivcyto-nhk.pdf
ICCVAM-Recommended Test Method Protocol Normal Human Keratinocyte NRU Cytotoxicity Test Method Originally published as Appendix C2 of "ICCVAM Test Method Evaluation Report: In ...
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Presentation: Conducting and Interpreting the Murine Local Lymph... 495KB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/4-woolhiser.pdf
Toxicology & Environmental Research and Consulting Conducting and Interpreting the Murine Local Lymph Node Assay (LLNA) Mike Woolhiser, Ph.D. Science & Technology Leader, TERC The ...
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RoC Profile: Nitrilotriacetic Acid; 15th RoC 2021 135KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrilotriaceticacid.pdf
Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Nitrilotriacetic Acid CAS No. 139-13-9 Reasonably anticipated to be a human carcinogen First listed ...
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Agency Response to ICCVAM Recommendations on LUMI-CELL Test Method 880KB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/transmitfeb12/doi-response-508.pdf
United States Department of the Interior U.S. GEOLOGICAL SURVEY 1220 I Sunrise Valley Drive Reston, VA 20192 t(g©m:ovm: ~ ~ JUL - 9 2012 ~ In Reply, Refer to: MS 953 08 12000556 ...
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RoC Profile: Hydrazobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazobenzene.pdf
Hydrazobenzene CAS No. 122-66-7 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as 1,2-diphenylhydrazine H ...
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RoC Profile: 4,4'-Methylenebis(2-chloroaniline); 15th RoC 2021 143KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylenebis_chloroaniline.pdf
2-chloroaniline) CAS No. 101-14-4 Reasonably anticipated to be a human carcinogen First listed in the Third Annual Report on Carcinogens (1983) Also known as methylene-bis-ortho-ch...
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Expert Panel Evaluation of the Validation Status of In Vitro... 1.1MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/expertpanfinalrpt/panelrpt1102.pdf
Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional ...
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BG1 Luc ER TA Agonist Protocol (Appendix B of ICCVAM BRD) 411KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c2-appxb.pdf
... team. 5.2 Controls Controls for the ER agonist protocol are as follows: Vehicle control (dimethyl sulfoxide [DMSO]): 1% (v/v) DMSO (CASRN 67-68-5) diluted in tissue culture media. ...
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RoC Profile: Azacitidine; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/azacitidine.pdf
Azacitidine CAS No. 320-67-2 Reasonably anticipated to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) Also known as 5-azacytidine, 5-azaC, or Vidaza ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... NA NA Heterocyclic compounds; Lactones; Sulfur compounds NA NA Dimethyl sulfoxide NA 67-68-5 78.13 0.57 Liquid NA Sulfur compounds Manufacturing; Pharmaceuticals 2,4-Dinitro- ...
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ICCVAM Recommended Protocol for the LUMI-CELL ER Agonist Assay 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/ivsdocs/lumiag12mar09.pdf
... are as follows: 273 Vehicle control (dimethyl sulfoxide [DMSO]): 1% (v/v) DMSO (CASRN 67-68-5) diluted in 274 tissue culture media. 275 Reference standard (17β-estradiol [E2]): ...
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ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test... 14.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/at-tmer-complete.pdf
ICCVAM TEST METHOD EVALUATION REPORT IN VITRO CYTOTOXICITY TEST METHODS FOR ESTIMATING STARTING DOSES FOR ACUTE ORAL SYSTEMIC TOXICITY TESTING Interagency Coordinating Committee ...
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TR-321: Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and... 10.6MB
https://ntp.niehs.nih.gov/go/tr321
PROGRAM Technical Report Series No. 321 4 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE (CAS NO. 75-27-4) IN F344/N RATS AND B6C3Fi MICE (GAVAGE STUDIES) U.S. ...
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ICCVAM Recommended Protocol: Test Chemical Solubility for Neutral... 242KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invidocs/phiiiprot/solphiii.pdf
Solubility Determination Phase III - Validation Study September 24, 2003 TEST METHOD PROTOCOL for Solubility Determination In Vitro Cytotoxicity Validation Study Phase III ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
Methods for Estimating Acute Oral Systemic Toxicity Background Review Document Volume 2 of 2 Prepared by The National Toxicology Program (NTP) Interagency Center for the Evaluation ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation ...
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BG1Luc ER TA Agonist Protocol: Appendix C of ICCVAM BRD 369KB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c3-appxc.pdf
... Controls for the ER antagonist protocol are as follows: Vehicle control (dimethyl sulfoxide [DMSO]): 1% v/v dilution of DMSO (CASRN 67-68-5) diluted in tissue culture media. ...
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ICCVAM Recommended Protocol for the LUMI-CELL ER Antagonist Assay 1.4MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/ivsdocs/lumiantag12mar09.pdf
... 295 Vehicle control (dimethyl sulfoxide [DMSO]): 1% v/v dilution of DMSO (CASRN 67-68-5) 296 diluted in tissue culture media. 297 Ral/E2 reference standard for range finder ...
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TR-296: Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr296.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRAKIS(HYDR0XYMETHYL)PHOSPHONIUM SULFATE (THPS) (CAS NO. 55566-30-8) AND TETRAKIS(HYDR0XYMETHYL)PHOSPHONIUM CHLORIDE (THPC) (CAS NO. ...
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RoC Monograph: Trichloroethylene; January 2015 4.6MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/finaltce_508.pdf
RepoRt on CaRCinogens MonogRaph on tRiChloRoethylene ROC MONOGRAPH 05 JANUARY 2015 Report on Carcinogens Monograph on Trichloroethylene RoC Monograph 05 January 2015 National ...
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TR-333: N-Phenyl-2-naphthylamine (CASRN 135-88-6) in F344/N Rats... 9.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr333.pdf
3 TOXICOLOGY AND CARCINOGENESIS STUDIES O F N-PHENY L-2-NAPHTHYLAMINE (CAS NO. 135-88-6) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...
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TOX-18: Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) 4.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox018.pdf
National Toxicology Program Toxicity Report Series Number 18 NTP Technical Report on Toxicity Studies of JM:ethyl Ethyl Ketone Peroxide (CAS No. 1338-23-4) in Dim.ethyl Phthalate ...
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TR-313: Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro... 13.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr313.pdf
3 ("1- <~ -.,~ J'~.l~Vdl0.~ TOXICOLOGY AND CARCINOGEl'fESIS STUDIES OF MIRE X (1, la,2,2,3,3a,4,5,5,5a,5 b,6- Dodecac hlorooctahydro-1 ,3,4- metheno-lH- cyclo buta[cd]pentalene) ...
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TR-358: Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage... 8.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr358.pdf
8 TOXICOLOGY AND CARCINOGENESIS STUDIES OF OCHRATOXIN A (CAS NO. 303-47-9) IN F344/N RATS (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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LLNA BrdU-ELISA Test Method: ICCVAM Recommended Protocol 272KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llna-brdu-elisa.pdf
2-Bromodeoxyuridine-ELISA Test Method (LLNA: BrdU-ELISA), a Nonradioactive Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and ...
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LLNA:DA Test Method: ICCVAM Recommended Protocol 279KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llna-da.pdf
DA A Nonradioactive Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products Originally published as Appendix B of "ICCVAM Test ...
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Update Protocol for the LLNA 656KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llnaupdated.pdf
Updated Protocol for the Murine Local Lymph Node Assay Originally published as Appendix A of "Recommended Performance Standards: Murine Local Lymph Node Assay" NIH Publication No. ...
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ICCVAM Recommended Protocol: BALB/c 3T3 Neutral Red Uptake Assay 424KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invidocs/phiiiprot/3t3phiii.pdf
BALB/c 3T3 Neutral Red Uptake Cytotoxicity Assay Phase III - Validation Study November 4, 2003 TEST METHOD PROTOCOL for the BALB/c 3T3 Neutral Red Uptake Cytotoxicity Test A Test ...
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ICCVAM Recommended Protocol: NHK Neutral Red Uptake Assay 413KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invidocs/phiiiprot/nhkphiii.pdf
the NHK Neutral Red Uptake Cytotoxicity Assay Phase III - Validation Study: November 4, 2003 TEST METHOD PROTOCOL for the NHK Neutral Red Uptake Cytotoxicity Test A Test for Basal ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
Submission of XDS's LUMI-CELL ER High-Throughput System for Screening Estrogen-Like Chemicals for Review by ICCVAM Presented By: Xenobiotic Detection Systems Inc. 1601 E. Geer ...
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TOX-54: 1,4-Butanediol (CASRN 110-63-4) 577KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox054.pdf
4 NTP Summary Report on the Metabolism, Disposition, and Toxicity of 1,4-Butanediol (CAS No. 110-63-4) Richard D. Irwin, Ph.D., Study Scientist National Toxicology Program Post ...