TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf

... Serum levels of thy- roxine (T4)and/or triiodothyronine (T3)were significantly decreased ... The toxicity of ETU in rats was demonstrated by reduction in serum triiodothyronine (T3) ...

TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf

... and decreased thyroxine and triiodothyronine concentrations of male and female ... Triiodothyronine concentrations were increased in exposed male and female mice, and ...

Abstract for TR-457 80KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr457

Hypothyroidism, evidenced by decreased serum triiodothyronine and thyroxine concentrations ... There were no differences in triiodothyronine, thyroxine, or thyroid-stimulating hormone ...

TR-457: Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats... 18.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr457.pdf

... De- creased serum triiodothyronine and thyroxine concen- trations and increased ... There were, however, no differences in tri- reverse triiodothyronine concentrations of ...

TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf

... Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free ... Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free ...

TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf

... Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free ... Thyroid Stimulating Hormone (A, B), Triiodothyronine (C, D), Thyroxine (E, F), and Free ...

TR-516: 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and... 9.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr516.pdf

... tions; serum thyroxine and triiodothyronine concentra- tions were decreased, and ... -70° C until analyzed for triiodothyronine, thyroxine, and thyroid stimulating ...

TR-372: 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325... 12.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr372.pdf

... Serum triiodothyronine (T3) and thyroxin (T4) concentrations in females receiving 330 ppm ... samples for changes in triiodothyronine (T3), thyroxin ( T 4 ) , and thyrotropin (TSH). ...

TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

... for Plasma Free and Total Thyroxine, Triiodothyronine, and Thyroid Stimulating Hormone ... and 25 mg/kg/day groups, and total triiodothyronine (T3) was significantly decreased in ...

TR-461: Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1Mice... 21.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr461.pdf

... The absolute liver weight of male mice in serum triiodothyronine, thyroxine, 'and free ... Reagents for triiodothyronine, thyroxine, and free thyroxine assays were obtained ...

TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 22.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr558.pdf

... respective vehicle controls; total triiodothyronine (T ) and thyroid 3 stimulating ... A 4 decrease in triiodothyronine concentration also occurred in all dosed groups at the ...

ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

... Panel SSE Error sum of squares T3 Triiodothyronine T4 Thyroxine TA Transcriptional ... = Relative binding aff nity; T3 = Triiodothyronine; T4 = Thyroxine. a Substances in ...

National Institute of Environmental Health Sciences: NIEHS-10 155KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-10

significantly decreased total thyroxine concentration, increased absolute liver weight, increased relative liver weight, and decreased total triiodothyronine concentration. ...

Abstract for TR-244 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr244

Levels of porphyrin tended to decrease gradually, primarily in mice, following cessation of exposure. The significant decreases in serum thyroxine (T4) and triiodothyronine (T3) in ...

TR-458: Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats ... 12.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr458.pdf

... There was.also a mild decrease in triiodothyronine concentrations in the 24,OOO ppm ... Hormone ossoys: thyroid-stimulating hormone, triiodothyronine(6 and 15 months and study ...

TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf

... those of vehicle controls and serum triiodothyronine (T 3 ) and thyroid stimulating ... by thyrotrophin releasing hormone (TRH), TSH itself, T 4 , and triiodothyronine (T 3 ). ...

Abstract for TR-447 68KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr447

Clinical pathology findings included nonresponsive, normocytic, normochromic anemia in 1,600 ppm males and females and in 800 ppm females, and decreased triiodothyronine (T3) ...

TR-517: Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and... 10.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr517.pdf

... Serum concentrations of thyroxine and triiodothyronine were significantly reduced in 1,000 ... thyroid stimulating hormone (TSH), triiodothyronine (T 3 ), and thyroxine (T 4 ). 25 ...

TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf

... levels and increases in serum total triiodothyronine (T 3 ) and thyroid stimulating 7 ... thyroid gland by thyrotrophin releasing hormone, TSH itself, T 4 , and triiodothyronine. ...

TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf

... There were no significant differences observed in serum free T 4 , total triiodothyronine ... thyroid gland by thyrotrophin releasing hor- mone, TSH itself, T 4 , and triiodothyronine. ...

National Institute of Environmental Health Sciences: NIEHS-07 155KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-07

In female rats, the effects included significantly decreased reticulocyte count, increased large unstained cell count, decreased total triiodothyronine concentration, increased ...

TR-578: Ginkgo biloba Extract (CASRN 90045-36-6) in F344/N Rats... 7.9MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr578_508.pdf

... There were no significant decreases in the levels of triiodothyronine or total thyroxine. ... stimulating hormone and total triiodothyronine using a Packard Cobra II gamma ...

Abstract for TR-388 72KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr388

... The principal toxic effects of ethylene thiourea involved the thyroid gland. Serum levels of thyroxine (T4) and/or triiodothyronine (T3) were significantly decreased in rats ...

TR-526: a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 9.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr526.pdf

... There were dose-dependent increases in serum triiodothyronine concentrations at 14 and 31 ... thyroid gland by thyrotrophin releas- ing hormone, TSH itself, T 4 , and triiodothyronine. ...

TR-530: a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl ... 13.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr530.pdf

... Serum total triiodothyronine (T 3 ) exhibited a treatment-related increase at the 14-, ... Radioimmunoassays were performed for thyroid stimulating hormone (TSH), triiodothyronine, ...

TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf

... There were no effects on triiodothyronine or thyroid stimulating hor- mone levels in any ... stimulating hormone (TSH), total triiodothyronine (T 3 ), and free thyroxine (T 4 ) ...

Abstract for TOX-67 70KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox067

... and decreased thyroxine and triiodothyronine concentrations of male and female ... Triiodothyronine concentrations were increased in exposed male and female mice, and ...

Abstract for TOX-77 69KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox077

Free and total serum thyroxine (T4) were significantly decreased in the 10 and 25 mg/kg/day groups, and total triiodothyronine (T3) was significantly decreased in the 25 mg/kg/day ...

Abstract for TR-516 77KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr516

The thyroid hormone data indicated that rats administered 2-methylimidazole developed alterations in thyroid hormone concentrations; serum thyroxine and triiodothyronine ...

Abstract for TR-558 90KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr558

... groups in both sexes compared to their respective vehicle controls; total triiodothyronine (T3) and thyroid stimulating hormone (TSH) concentrations were generally unaffected. ...

Abstract for TR-372 66KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr372

... Serum triiodothyronine (T3) and thyroxin (T4) concentrations in females receiving 330 ppm or more and T4 concentrations in males receiving 170 ppm or more were significantly lower ...

Abstract for TR-390 68KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr390

... Decreases in serum triiodothyronine (T3) values were observed in exposed females, and decreases in mean thyroxin (T4) concentrations in exposed males and females; no significant ...

Abstract for TR-517 70KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr517

... Water consumption by exposed rats was generally similar to that by controls throughout the study. Serum concentrations of thyroxine and triiodothyronine were significantly reduced ...

Abstract for TR-461 77KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr461

... On day 23, transient decreases in serum triiodothyronine, thyroxine, and free thyroxine were observed in male rats exposed to 375 ppm or greater and female rats exposed to 750 or ...

Abstract for TR-525 75KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr525

... There were no significant differences observed in serum free T4, total triiodothyronine (T3), or thyroid stimulating hormone (TSH) at 14 weeks. At both 31 and 53 weeks, there were ...

TR-248: 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552... 9.5MB

https://ntp.niehs.nih.gov/go/tr248

... 4 Figure 5 Structure of Triiodothyronine . . . . . . . . . . . . . . . . . . ... cant structural resemblance to triiodothyronine (TJ) (Figure 5) and thyroxine (T4). ...

Abstract for TR-521 77KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr521

... At 14 weeks, there were significant decreases in serum total and free thyroxine (T4) levels and increases in serum total triiodothyronine (T3) and thyroid stimulating hormone ...

Abstract for TR-559 71KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr559

... There were no effects on triiodothyronine or thyroid stimulating hormone levels in any dosed groups evaluated at the 14-, 31-, and 53-week interim evaluations. There were increases ...

Abstract for TR-529 71KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr529

... Thyroid hormone concentrations Serum total thyroxine (T4), free T4, and total triiodothyronine (T3) concentrations in the 3,000 µg/kg group were significantly lower than those in ...

TR-390: 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82... 12.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr390.pdf

... Decreases in serum triiodothyronine (T3) values were observed in exposed females, and ... alanine aminotransferase (KT), triiodothyronine (T3), thyroxine (TJ, and thyroid ...

TOX-71: Malachite Green Chloride and Leucomalachite Green (CASRNs... 2.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox071.pdf

... stimulating hormone (TSH), triiodothyronine (T 3 ), and thyroxine (T 4 ) concentrations. ... thyroid-stimulating hormone (TSH), triiodothyronine (T 3 ), and thyroxine (T 4 ) for ...

Abstract for TR-520 76KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr520

... In the 550 and 1,000 ng/kg rats, total thyroxine (T4) and free T4 were significantly lower than vehicle controls and serum triiodothyronine (T3) and thyroid stimulating hormone ...

Abstract for TR-578 78KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr578

... There were no significant decreases in the levels of triiodothyronine or total thyroxine. Mean body weights of 300 mg/kg males and females were less (10% or more) than those of the ...

TOX-65: 3,3',4,4'-Tetrachloroazobenzene 2.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox065.pdf

... All clinical chemistry endpoints except total triiodothyronine, total thyroxine, and ... Total triiodothyronine, total thyroxine, and thyroid-stimulating hormone concentrations ...

TOX-66: 3,3',4,4'-Tetrachloroazoxybenzene 3.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox066.pdf

... All clinical chemistry endpoints except total triiodothyronine, total thyroxine, and ... Total triiodothyronine, total thyroxine, and thyroid-stimulating hormone concentrations ...

Abstract for TR-526 77KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr526

... At 14, 31, and 53 weeks, there were dose-dependent reductions in total serum and free thyroxine concentrations. There were dose-dependent increases in serum triiodothyronine ...

Abstract for TOX-97 125KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox097

... No effect ↓ ↓ ↓ ↓ ↓ ↓ Total triiodothyronine ↓ No effect ↓ No effect ↑ ... No effect Free thyroxine ↓ No effect Total triiodothyronine No effect ↑ Testosterone ...

CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB

https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

... inhibit.the.actions.of.triiodothyronine.(T3).or. its. binding. to.TRs. (83, ... Food intake and maternal serum levels of triiodothyronine, thyroxine, and ...

TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf

... Increased serum triiodothyronine (T3) and T3/T4 (total thyroxine) ratios were measured in ... Levels of serum thyroid stimulating hormone (TSH), total triiodothyronine (T3), and free ...

Abstract for TR-458 72KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr458

... In female rats, a decreased hematocrit value occurred at 15 months in the 24,000 ppm group. There was also a mild decrease in triiodothyronine concentrations in the 24,000 ppm ...