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TR-236: D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1Mice... 6.4MB
https://ntp.niehs.nih.gov/go/tr236
OF D-MAN NITOL (CAS NO. 69-65-8) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY) U.S. ... ON THE CARCINOGENESIS BIOASSAY OF D-MANNITOL (CAS NO. 69-65-8) IN F344/N RATS AND B6C3F1 ...
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D-Mannitol: Target Organs and Levels of Evidence for TR-236 54KB
https://ntp.niehs.nih.gov/data/tr/200s/tr236levels
8 D-Mannitol: Target Organs and Levels of Evidence for TR-236 Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study) Chemical (Study ...
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Abstract for TR-236 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr236
6abs Abstract for TR-236 Carcinogenesis Bioassay of D-Mannitol in F344/N Rats and B6C3F1 Mice (Feed Study) CASRN: 69-65-8 Chemical Formula: C6H14O6 Molecular Weight: 182.17 Report ...
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TR-238: Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1Mice... 11.2MB
https://ntp.niehs.nih.gov/go/tr238
... Mice fed ziram were housed in the same room as mice fed eugenol (CAS No. 97-534) for the first year of the study and with mice fed D- mannitol (CAS No. 69-65-8) for the entire ...
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Developmental Neurotoxicity Screening Assay Chemical List | National... 429KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... (paracetamol) Neg Control 62571-86-2 DTXSID1037197 Captopril Neg Control 69-65-8 DTXSID1023235 D-Mannitol Neg Control 486-56-6 DTXSID1047576 Cotinine Neg Control 132-98-9 ...
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TR-223 Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344... 6.8MB
https://ntp.niehs.nih.gov/go/tr223
... feeding stud- Table 8. For the first 9 months of the two-year ies of mannitol and ziram. ... No other chemicals were then on studies of mannitol (CAS No. 69-65-8) and test in that ...
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TR-227: Gum Arabic (CASRN 9000-01-5) in F344 Rats and B6C3F1Mice... 4.0MB
https://ntp.niehs.nih.gov/go/tr227
... was 85.5% pure based on an assay for mannitol as compared with a glucose standard. ... OXIDATION Modification of USP Assay for Mannitol (USP, 1970): Samples were dis- solved in ...
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TR-235: Zearalenone (CASRN 17924-92-4) in F344/N Rats and B6C3F1Mice... 6.8MB
https://ntp.niehs.nih.gov/go/tr235
... Rat5 and Mice: temperature 23" t 3°C; uncontrolled humidity D-Mannitol. stannous ... air changed I5 times per hour Rats: D-mannitol, ziram, propyl gallate Mice: propyl ...
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TR-240: Propyl Gallate (CASRN 121-79-9) in F344/N Rats and B6C3F1Mice... 6.9MB
https://ntp.niehs.nih.gov/go/tr240
... D-Mannitol, stannous chloride, ziram, ethyl acrylate, allyl isothiocyanate, zearalenone ... of fluorescent light per day Rats: D-Mannitol, ziram, zearalenone Mice: Zearalenone ...
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TR-224: Tara Gum (CASRN 39300-88-4) in F344 Rats and B6C3F1Mice... 3.7MB
https://ntp.niehs.nih.gov/go/tr224
... were titrated by periodate oxidation using a modification of the USP assay for mannitol. ... Modification o f USP Assay f o r Mannitol (USP XVIII, 1970) Samples were d i s s o ...
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TR-234: Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and... 11.0MB
https://ntp.niehs.nih.gov/go/tr234
... in Same Room ethyl acrylate. eugenol. n-mannitol: Chemical/Vehicle Mixture Preparation ... Rats: ethyl acrylate, eugenol. o-mannitol: Mice: ethyl acrylate. eugenol, o-mannitol; ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence N No Evidence P Clear Evidence P Clear Evidence TR-236 12/16/81 D-mannitol 69-65-8 N No Evidence N No Evidence N No Evidence N No Evidence TR-235 12/16/81 ...
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TOX-83: Toxicity Studies of o-Chloropyridine (CASRN 109-09-1... 3.9MB
https://ntp.niehs.nih.gov/go/tox083
... plate incorporation method in TA100 only with S9 and no, or greatly reduced, mutagenicity when glutathione, thiourea, D-mannitol, or pyridine N-oxide was added to the test mixture. ...
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TR-341: Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr341
... Blue 1 Eugenol Stannous chloride o-Mannitol Ziram Propyl gallate Zearalenone HC Blue ... Blue 1 Eugenol Stannous chloride o-Mannitol Ziram Propyl gallate Zearalenone HC Blue ...
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CERHR Monograph: Hydroxyurea 3.6MB
https://ntp.niehs.nih.gov/go/hu_monograph
... tion, examined the ef fects of d-mannitol, a specific scavenger of hydroxyl free ... [purity not given] (positive control group), 550 mg/kg bw d-mannitol, or saline. ...
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TR-345: Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1... 25.2MB
https://ntp.niehs.nih.gov/go/tr345
... Blue 1 Eugenol Stannous chloride D-Mannitol Ziram Propyl gallate Zearalenone ... 1/40 Stannous chloride 2/50 3/50 5/50 o-Mannitol 3/50 0/50 3/50 Ziram 2/50 1150 2/50 ...
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TR-299: C.I. Disperse Blue 1 (A commercial dye containing approximatel... 15.0MB
https://ntp.niehs.nih.gov/go/tr299
... C ytembena Eugenol Stannous chloride Mannitol Ziram Propyl gallate Zearalenone HC Blue ... Cytembena Eugenol Stannous chloride Mannitol Ziram Propyl gallate Zearalenone HC Blue ...
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TR-271: HC Blue No. 1 (CASRN 2784-94-3) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr271
... Cytembena Eugenol Stannous chloride Mannitol Ziram Propyl gallate Zearalenone HC Blue ... Reserpine Cytembena Eugenol Stannous chloride Mannitol Ziram Propyl gallate Zearalenone HC ...
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TR-259: Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1Mice... 12.2MB
https://ntp.niehs.nih.gov/go/tr259
... day; 15 room air changes per hour First study: eugenol, allyl isothiocyanate. and D-mannitol Second and third studies: none First study: same as single dose study Second study: ...
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TR-293: HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl... 8.0MB
https://ntp.niehs.nih.gov/go/tr293
... 1140 Stannous chloride 0/50 0/50 0/50 Mannitol 0/50 0/50 0/50 Ziram 0/50 0/50 0/50 ... 9/40 0/40 Stannous chloride 4/50 1150 Mannitol 14/50 0/50 Ziram 7/50 0/50 Propyl ...
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Study Reports 1.0MB
https://ntp.niehs.nih.gov/publications/reports
... 1983 Technical Report TR-236 PDF (6.43 MB) Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Technical Report TR-235 PDF ...
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Technical Reports 862KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1983 Technical Report TR-236 PDF (6.43 MB) Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Technical Report TR-235 PDF ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-236 PDF (6.43 MB) Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity ...
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TR-364: Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344... 11.2MB
https://ntp.niehs.nih.gov/go/tr364
... 1140 2/40 Stannous chloride 1/50 1/50 D-Mannitol 2/49 2/49 Ziram 1/50 1/50 Propyl gallate ... HC Blue No. 2 (2.1. Disperse Blue 1 D-Mannitol 2/44 2/49 0150 2/44 2/49 0150 Ziram ...
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Monograph: Antimony Trioxide; Appendices; Aug. 15, 2018 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_appendices_revised.pdf
... cell death exposed to SbCl 3 alone Hashemzaei et al. 2015 Primary rat hepatocytes Mannitol, a ROS scavenger ROS lipid peroxidation MMP cell death exposed to SbCl 3 ...
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TR-221: Locust Bean Gum (CASRN 9000-40-2) in F344 Rats and B6C3F1Mice... 3.2MB
https://ntp.niehs.nih.gov/go/tr221
... Modification of (J.S.P. Assay for Mannitol (OSP, 1970) Samples were dissolved in 25 ... TIT RATION BY PERI OP ATE OXIDATION Modification of U . S . P. Assay for Mannitol. (USP , ...
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
... If blood agar medium is not suited for the test, mannitol salt agar medium shall be used. ... respectively, and incubated at 35-37°C. Mannitol Sodium Chloride Agar Medium Any dried ...
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Monograph: Antimony Trioxide; Appendices; Nov. 29, 2017 1.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_appendices.pdf
... Ûcell death exposed to SbCl 3 alone Hashemzaei et al. 2015 Primary rat hepatocytes Mannitol, a ROS scavenger Ü ROS Ü lipid peroxidation Û MMP Ücell death exposed to SbCl 3 ...
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TR-229: Guar Gum (CASRN 9000-30-0) in F344 Rats and B6C3F1Mice... 4.0MB
https://ntp.niehs.nih.gov/go/tr229
... Batch 01 (Karl Fisher) 7 . 3 + 0 . 1 ( & )% Batch 02 (Karl Fisher) 4.94 + 0.02 ( 6 )% D. TITRATION BY PERIODATE OXIDATION Modification of U. S. P. Assay for Mannitol (USP, 1970). ...
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TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.5MB
https://ntp.niehs.nih.gov/go/tr326
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl Isothiocyanate Zearalenone D-Mannitol 1,1,1,2-Tetrachloroethane Ziram Bis(2-chloro-1methylethy1)ether Propyl Gallate ...
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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/go/tr417
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl Isothiocyanate Zearalenone D-Mannitol 1,1,1,2-Tetrachloroethane Ziram Bis(2chloro-1-Methylethy1)ether Propyl Gallate ...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/go/tr444
... 233 2-Biphenylamine Hydrochloride 234 Allyl Isothiocyanate 235 Zearalenone 236 D-Mannitol 237 1,1,1,2-Tetrachloroethane 238 Ziram 239 Bis(2-chloro-1-methy1ethyl)ether 240 ...
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TR-324: Boric Acid (CASRN 10043-35-3) in B6C3F1Mice (Feed Studies... 6.5MB
https://ntp.niehs.nih.gov/go/tr324
... Initial attempts to extract and titrate boric acid with stand- ard alkali as a complex with glycerol or mannitol failed because the feed complexes ren- dered the boric acid ...
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TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB
https://ntp.niehs.nih.gov/go/tr359
... 233 2-Biphenylamine Hydrochloride 234 Allyl Isothiocyanate 235 Zearalenone 236 D-Mannitol 238 Ziram 239 Bis(2-chloro-l-methylethyl)ether 240 Propyl Gallate 242 Diallyl ...
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TR-409: Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies... 9.6MB
https://ntp.niehs.nih.gov/go/tr409
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl Isothiocyanate Zearalenone D-Mannitol 1,1,1,2-Tetrachloroethane Ziram Bis(2chloro-1-methylethy1)ether Propyl Gallate ...
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TR-410: Naphthalene (CASRN 91-20-3) in B6C3F1Mice (Inhalation... 8.6MB
https://ntp.niehs.nih.gov/go/tr410
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl hthiocyanate Zearalenone D-Mannitol 1,1,1,2-Tetrachloroethane Ziram Bis(2chloro-1methylethyl)ether Propyl Gallate Diallyl ...
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TR-323: Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N... 9.8MB
https://ntp.niehs.nih.gov/go/tr323
... 233 2-Biphenylamine Hydrochloride 234 Allyl Isothiocyanate 235 Zearalenone 236 D-Mannitol 237 1,1,1,2-Tetrachloroethane 238 Ziram 239 Bis(2-chloro-1 -methy lethy l)ether 240 ...
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TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr329
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl Isothiocyanate Zearalenone D-Mannitol 1,1,1,2-Tetrachloroethane Ziram Bis(2-chloro-1-methylethy1)ether Propyl Gallate ...
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TR-334: 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats... 9.0MB
https://ntp.niehs.nih.gov/go/tr334
... Ephedrine Sulfate Zearalenone Chlorinated Paraffins (Clz, 60%chlorine) D-Mannitol Decabrornodiphenyl Oxide Marine Diesel Fuel and J P - 5 Navy Fuel ...
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TR-399: Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats... 8.7MB
https://ntp.niehs.nih.gov/go/tr399
... Chlorendic Acid 4-Vinylcyclohexene o-Phenylphenol 3-Chloro-2-methylpropene 236 D-Mannitol 309 Decabromodiphenyl Oxide 238 237 Ziram 1,1,1,2-Tetrachloroethane 311 310 ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/go/tr413
... 233 2-Biphenylamine Hydrochloride 234 Allyl Isothiocyanate 235 Zearalenone 236 D-Mannitol 237 1,1,1,2-Tetrachloroethane 238 Ziram 239 Bis(2-chloro-1-Methylethy1)ether 240 ...
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RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/lead-public_508.pdf
... than did the hydroxyl radical scavengers, mannitol and 5,5- dimethyl-1-pyrroline-1-oxide. ... catalase, and glutathione, and was potentiated by superoxide dismutase and mannitol. ...
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TR-321: Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and... 10.6MB
https://ntp.niehs.nih.gov/go/tr321
... Pentachloroethane 2-Biphenylamine Hydrochloride Allyl Isothiocyanate Zearalenone D-Mannitol 1,1,1 ,Z-Tetrachloroethane Ziram Bis(2-chloro-1 methylethylkther Propyl Gallate ...
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TR-332: 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats... 10.3MB
https://ntp.niehs.nih.gov/go/tr332
... 311 Tetrachloroethylene (Inhalation) 235 Zearalenone 312 n-Butyl Chloride 236 D-Mannitol 314 Methyl Methacrylate 237 1,1,1,2-Tetrachloroethane 315 Oxytetracycline ...
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TR-337: Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/go/tr337
... 311 Tetrachloroethylene (Inhalation) 235 Zearalenone 312 n-Butyl Chloride 236 D-Mannitol 314 Methyl Methacrylate 237 1,1,1,2-Tetrachloroethane 315 Oxytetracycline ...
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TR-338: Erythromycin Stearate (CASRN 643-22-1) in F344/N Rats... 10.0MB
https://ntp.niehs.nih.gov/go/tr338
... Fuel and J P - 5 Navy Fuel 235 Zearalenone 311 Tetrachloroethylene (Inhalation) 236 D-Mannitol 312 n-Butyl Chloride 238 Ziram 314 Methyl Methacrylate 239 Bis(2-chloro-1-methy1ethyl...
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TR-339: 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats... 11.1MB
https://ntp.niehs.nih.gov/go/tr339
... 311 Tetrachloroethylene <Inhalation) 235 Zearalenone 312 n-Butyl Chloride 236 D-Mannitol 314 Methyl Methacrylate 237 1,1 ,1 ,2-Tetrachloroethane 315 Oxytetracycline ...
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TR-387: dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats... 10.4MB
https://ntp.niehs.nih.gov/go/tr387
... Agar 231 Stannous Chloride 232 Pentachloroethane 233 2-Biphenylamine Hydrochloride 234 Allyl Isothiocyanate 235 Zearalenone 236 D-Mannitol 237 l,l,l,Z-Tetrachloroethane 238 Ziram ...
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TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB
https://ntp.niehs.nih.gov/go/tr400
... 234 Allyl Isothiocyanate 235 Zearalenone 307 Ephedrine Sulfate 236 D-Mannitol 308 ChlorinatedPariffins (Clb 60% chlorine) 309 Decabromodiphenyl Oxide 237 ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal... 1.3MB
https://ntp.niehs.nih.gov/go/tr518
... Magnetic Field Promotion Malonaldehyde, Sodium Salt Manganese Sulfate Monohydrate D-Mannitol Marine Diesel Fuel and JP-5 Navy Fuel Melamine 2-Mercaptobenzothiazole Mercuric ...