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369 results found for "70-18-8".

  1. TOX-31: Isoprene (CASRN 78-79-5) 7.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox031.pdf

    ... F-1 Appendix G Tissue Glutathione Concentration Analyses . . . . . . . . . . . . . . . . . ... In addition to histopathology, evaluations included clinical pathology, tissue glutathione ...

  2. TR-563: Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice... 11.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr563.pdf

    ... 161 APPENDIX G Liver Glutathione Data ......Reduced and oxidized glutathione levels were generally increased in 75 and 150 mg/kg males ...

  3. RoC Background Document: Thiotepa; Nov. 18-19, 1996 2.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/thiotepa1_508.pdf

    ... Figure 6-1 Reactions of Thiotepa with Glutathione (GSH) ...... 31 7.0 ... Diglutathionyl thiotepa 2-Aminoethyl glutathione Tepa is extremely soluble in water, and ...

  4. RoC Monograph: 1-Bromopropane; September 2013 1.9MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

    ... (mutations and DNA damage), oxidative stress, glutathione depletion, and immunomodulation. ... Glutathione is an important cellular defense mechanism, and its reduction can lead to ...

  5. RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf

    ... uptake and subsequent processing ofTFE-glutathione conjugates by renal ~-lyase (Miller and ... The first step in the metabolism ofTFE involves glutathione conjugation in the liver. The ...

  6. Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf

    ... 1178 Sulfotransferases 1178 UDP-Glucuronosyltransferases 1179 Glutathione S-Transferases and Glutathione 1181 Conjugates Biomonitoring Aromatic Amines, HAAs, and Their 1182 ...

  7. Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf

    ... Styrene-7,8-oxide can be metabolized by epoxide hydrolase to the glycol or by glutathione S-transferase to glutathione conjugates. Styrene glycol is further metabolized to ...

  8. TR-544: Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats... 7.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr544.pdf

    ... APPENDIX G Glutathione-S-Transferase Activity . . . . . . . . . . . . . . . . . . . . . . ... Because the molar ratio of glutathione consumed to dibromoacetonitrile undergoing reaction ...

  9. RoC Monograph: Trichloroethylene; January 2015 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/monographs/finaltce_508.pdf

    ... (DCVC), S-(1,2-dichlorovinyl)glutathione (DCVG), and NAcDCVC .........11 Figure 1-2. Glutathione-dependent Metabolic Pathways of ...

  10. Mechanistic and Other Relevant Data; Amy Wang; RoC; Jan. 24,... 1.5MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/presentations/mechanistic_508.pdf

    Sb(III) is highly reactive to sulfhydryl groups (thiols) Glutathione (GSH) Antimony Compounds Are Electrophilic Glutathione reductase . Antimony compounds can interact with ...

  11. TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 10.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr509.pdf

    ... Tissues and plasma from dosed rats were examined for malondi- aldehyde and glutathione ... (primarily via the addition of glutathione across their electrophilic C-C double ...

  12. RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf

    ......... 49 6.3 Glutathione Depletion ......Ethylene oxide is eliminated by hydrolysis and by conjugation with glutathione, and ...

  13. Minutes: BSC; March 13, 1990 1.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1990/march/19900313-14bsc_minutes_508be.pdf

    3 (2) Mechanisms of Mutagenesis by Glutathione 3 (3) B11e Ac1ds as Ind1cators and ... inside the red blood cell. (2) Mechanisms of Mutagenesis by Glutathione -- Dr. ...

  14. RoC Profile: 1-Bromopropane; 15th RoC 2021 194KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf

    ... reactions catalyzed by cytochrome P450 (pri- marily CYP2E1) and glutathione conjugation. ... This metabolite is produced in humans by conjugation of 1-bromopropane with glutathione, ...

  15. RoC Background Document: Chlorozotocin (CZT); Nov. 18-19, 1996 1.6MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/chlorozotocin1_508be.pdf

    ... Products and Their Subsequent Glutathione Adducts ......of CENUs and is catalyzed by a glutathione-dependent enzyme. 6.1.1 Chemical ...

  16. Presentation: Application of Peptide Reactivity for Screening... 2.5MB

    https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/8-boverhoff.pdf

    - Evaluated reactivity toward glutathione, or 3 synthetic peptides (cysteine, ... potency and peptide depletion to glutathione and cysteine and lysine peptides - ...

  17. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ... or as glutathione (GSH), cysteine, glucuronic acid, and sulfate conjugates. ... oxygen obtained through ring hydroxylation, hydration, and glutathione conjugation. ...

  18. 15th RoC: Acronyms 58KB

    https://ntp.niehs.nih.gov/ntp/roc/content/acronyms_508.pdf

    FANC Fanconi anemia complementation group proteins FDA Food and Drug Administration, United States G guanine GERD gastro-esophageal reflux disease GSH glutathione GST glutathione ...

  19. Peer Review Report: RoC Peer Review; Aug. 12, 2014 198KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2014/august/sep_report20140812_508.pdf

    ... and there is little support for glutathione conjugation as a relevant metabolic pathway. ... The presumed mode of action via glutathione conjugation is based on flawed research. ...

  20. TR-421: Talc (CASRN 14807-96-6)(Non-Asbestiform) in F344/N Rats... 16.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr421.pdf

    ... increased glutathione Minoralterationsattributed t o talcexposurewere reductase. ... for rats and dehydrogenase, glutathione reductase, total nucleated mice were ...

  21. TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf

    ... were collected for induction of glutathione, cytochromes P450 and P450 2E1, and DNA ... and an exposure-related decrease in glutathione content in the liver of females; these ...

  22. Background Document: RoC: o-Nitrotoluene ; 2010 1.5MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/o-nt-final_508.pdf

    ... The next most abundant metabolite was S-(o-nitrobenzyl) glutathione, which accounted for ... erythrocytes PGST: placental glutathione S-transferase ppb: parts per billion ...

  23. RoC Background Document: Isoprene; Dec. 2-3, 1998 2.2MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/isoprene_oneapp_508.pdf

    ... Detoxification of these intermediates may occur by hydrolysis catalyzed by epoxide hydrolase or conjugation with glutathione catalyzed by glutathione-S-transferase. The diepoxide ...

  24. Integrating KMD/TK Data with MoA and Other Information in a Weight... 686KB

    https://ntp.niehs.nih.gov/iccvam/meetings/kmd-symp-2020/ppt/12-clewell-508.pdf

    ... Depletion of glutathione (Acetaminophen) 8 Examples of Potential Supporting Evidence for ... to toxicodynamic changes . e.g., glutathione depletion, nuclear receptor activation . ...

  25. TOX-38: Sodium Selenate and Sodium Selenite (CASRNs 13410-01... 1.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox038.pdf

    ... Glutathione depletion by buthionine [S,R] sulfoximine treatment depressed 75 Se-selenite uptake and transfer to the body, suggesting that glutathione is involved in the ...

  26. CERHR Monograph: 1-Bromopropane 1.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf

    ... GC gas chromatography gd gestation day GLP Good Laboratory Practices GSH glutathione GST glutathione S-transferase h hour HCFC hydrochlorofuorocarbon 2,5-HD 2,5-hexanedione HSDB ...

  27. Final RoC Background Document for Formaldehyde 5.8MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf

    ... circulation because it is rapidly metabolized by glutathione-dependent formaldehyde dehydrogenase and S-formyl-glutathione hydrolase to formic acid, which is excreted in the ...

  28. TOX-62: WY-14,643 (CASRN 50892-23-4) 2.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox062.pdf

    ... catalase and decreased activity of glutathione peroxidase (Lazarow, 1981; Furukawa et ... Effects of Peroxisome Proliferators on Glutathione and Glutathione-Related Enzymes in Rats ...

  29. Public Comment: Pulegone Christie Harman; RoC; Sept. 20, 2013 126KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/harman20131018_508.pdf

    ... glutathione and glucuronic acid conjugation, minimizing further transformation to menthofuran and subsequent reactive metabolites (Chen et al., 2003b). Glutathione-depletin...

  30. Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf

    ... which can then conjugate with glutathione (GSH), forming mercapturic acid derivatives. ... which can then conjugate with glutathione (GSH), forming mercapturic acid ...

  31. Background Document: RoC: Captafol; 2010 1.1MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf

    ... and a promoter of preneoplastic glutathione S- transferase placental form positive ... In the presence of sulfhydryl compounds, such as glutathione and cysteine, captafol is ...

  32. Background Document: RoC: Styrene; 2010 4.3MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf

    ... which can be detoxified by glutathione conjugation or conversion to styrene ... Glutathione depletion as a result of styrene exposures has been reported to be associated ...

  33. Abstract for TOX-31 66KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox031

    In addition to histopathology, evaluations included clinical pathology, tissue glutathione analyses, forelimb and hindlimb grip strength analyses, and sperm motility and vaginal ...

  34. RoC Profile: Styrene-7,8-oxide; 15th RoC 2021 144KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styreneoxide.pdf

    Styrene oxide can be me- tabolized by epoxide hydrolase to form the glycol or by glutathione S-transferase to glutathione conjugates. Styrene glycol is further me- tabolized to ...

  35. TOX-44: o-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride... 1.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox044.pdf

    ... TOXICITY REPORT NUMBER 44 Placental glutathione S-transferase (PGST)-positive foci of ... Carbonium Ion; (J) S-(o-Aminobenzyl) Glutathione; (K) S-(o-Aminobenzyl)-N-acetylcysteine ...

  36. Acronyms & Abbreviations 80KB

    https://ntp.niehs.nih.gov/support/acronyms

    ...deoxy-5-fluoro-3'-thiacytidine) G Guanine Gav-Dea Gavage Death GST Glutathione S-transferase GST-P+ Glutathione S-transferase placental form positive GSTT1 Glutathione ...

  37. RoC Profile: Tetrafluoroethylene; 15th RoC 2021 132KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrafluoroethylene.pdf

    processing of tetrafluoroethylene-glutathione conjugates by renal b-lyase (Anders et ... 1988. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. ...

  38. CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB

    https://ntp.niehs.nih.gov/ntp/ohat/styrene/styrene_monograph.pdf

    ... glucose-6-phosphate.dehydrogenase GSH glutathione h hour(s) HHE Health.Hazard.Evaluation ...eading.to.formation.of.hippuric.acid),.glutathione.conjugation.of.styrene.oxide,.and. ...

  39. TOX-15: t-Butyl Perbenzoate (CASRN 614-45-9) 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox015.pdf

    ... in blood, stomach contents, and liver homogenates, or in the presence of glutathione. ... buffer (pH 7.4), with and without 5 mM glutathione; and liver microsomes and soluble ...

  40. TR-532: Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats... 7.2MB

    https://ntp.niehs.nih.gov/go/tr532

    ... carbon dioxide while reac- tion with reduced glutathione (GSH) produces carbon monoxide. ... X=halogen atom; GSH=reduced glutathione; GSSG=oxidized glutathione; ...

  41. CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf

    ... Laboratory Practice GSH ......glutathione GST ......glutathione-S-transferase h......hour(s) HBSS ...

  42. TR-500: Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation... 8.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr500.pdf

    ... These intermediates are then excreted in the urine as glutathione, cysteine, glucuronic ... Glutathione conjugation of naphthalene metabolites plays an important role in ...

  43. Abstract for TR-510 88KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr510

    were collected for induction of glutathione, cytochromes P450 and P450 2E1, and DNA ... and an exposure-related decrease in glutathione content in the liver of females; these ...

  44. TR-582: Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr582_508.pdf

    ... undergo oxidation, hydrolysis, and reactions with glutathione and cellular macromolecules. ... The involvement of glutathione in the detoxification of vinylidene chloride was consistent ...

  45. TOX-47: Methacrylonitrile 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox047.pdf

    ... formation in rats. 1-Cyano-1-methoxyloxirane interacts with reduced glutathione, presumably via glutathione transferases, resulting in the formation of 1-(S-glutathionyl)-2-propa...

  46. TR-564: 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1... 9.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr564.pdf

    ... Lee et al. (2007a) observed S-propyl glutathione in livers of BALB/c mice following a single oral dose of 1,000 mg/kg 1-bromo- propane, with maximum levels of S-propyl glutathione ...

  47. Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf

    ... diet showed dose-related increases in glutathione S-transferase placental form ... A few rats died during the experiment, possibly due to surgery. Glutathione S-transferase ...

  48. TR-549: Bromochloroacetic Acid (CAS 5589-96-8) in F344/N Rats... 20.0MB

    https://ntp.niehs.nih.gov/go/tr549

    ... et al., 1997) catalyzed by glutathione-S-transferase zeta (GST-.) (Tong et al., 1998a). ... During GST-.-mediated oxygenation of dihaloacetates to glyoxylate, glutathione is required ...

  49. RoC Profile: Isoprene; 15th RoC 2021 158KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf

    These intermediates may be detoxified by hydrolysis (catalyzed by epoxide hydrolase) or conjugation with glu- tathione (catalyzed by glutathione S-transferase). The diepoxide ...

  50. RoC Profile: Naphthalene; 15th RoC 2021 147KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf

    ... into dihydrodiols, (2) conjugation by glutathione transferases, and (3) spontaneous ... including glutathione, cysteine, glucuronic acid, and sulfate conjugates (NTP 2002). ...

 
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