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TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf
8bit NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF INDOLE-3-CARBINOL (CASRN 700-06-1) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES ...
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Abstract for TR-584 80KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr584
Abstract for TR-584 Toxicology Studies of Indole-3-carbinol in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley ...
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Target Organ and Levels of Evidence for TR-584 60KB
https://ntp.niehs.nih.gov/data/tr/500s/tr584levels
Target Organ and Levels of Evidence for TR-584 Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies ...
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Minutes: TR Panel; May 22, 2014 273KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/minutes20140522_508.pdf
VII. Draft NTP Technical Report on Indole-3-Carbinol (TR-584) ......was used for Green Tea Extract, Indole-3-Carbinol, and CIMSTAR 3800. She discussed and ...
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TR Panel: Actions; TRs 583, 584, 585, 586; May 22, 2014 86KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/actionstrsep20140522_508.pdf
Indole---3---carbinol The Panel voted (4 yes, 2 no, 0 abstentions) to accept, as written, the draft NTP conclusions, no evidence of carcinogenic activity of indole---3---carbinol ...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 15KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont_2013_by_list_of_studies_508.pdf
Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage ... Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan ...
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P08: Statisitical Analysis of Primary Tumors for Mice (20209... 159KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20209_tables/04_f1_m3_p08.pdf
(GAVAGE CORN OIL) 20006-04 -- Indole-3-carbinol (GAVAGE CORN OIL) 20007-06 -- Kava ... extract (GAVAGE WATER) 20006-04 -- Indole-3-carbinol (GAVAGE CORN OIL) 20007-06 -- Kava ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 59KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/hiscont2013_hsd_gavage_cornoil_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Report List of Studies B6C3F1 Mice; Aug... 18KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-list-of-studies-mice.pdf
Species Strain Sex Route Vehicle Chemical Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil Pentabromodiphenyl Ether Mixture ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 162KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/micegavcornoil2013_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 260KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/path_micegavcornoil2014_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: List of Studies for Mice; Studies started... 8KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_list20150700_508.pdf
Mice B6C3F1 Male and Female Gavage Corn oil Ginkgo biloba extract Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil ...
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Historical Controls: Report List of Studies HSD Rats; Aug. 2016 17KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-list-of-studies-hsd-rats.pdf
Species Strain Sex Route Vehicle Chemical Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan Sprague- Dawley Male and Female Inhalation Air ...
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Historical Controls: Studies on 2014 Reports 20KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014_studylist_508.pdf
Mice B6C3F1 Male and Female Gavage Corn oil Ginkgo biloba extract Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil Kava ...
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Historical Controls: Report List of Studies HSD Rats; April 2019 10KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hclist_20190400.pdf
Male and Female Perinatal and postnatal Feed 2-Hydroxy-4-methoxybenzophenone Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan Sprague- ...
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Uterus - Hyperplasia, Stromal - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/uterus/HyperplasiaStromal
Abstract: https://ntp.niehs.nih.gov/go/9771 National Toxicology Program. 2014. NTP TR-584. Toxicology Studies of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and B6C3F1 Mice ...
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Historical Controls: Report List of Studies B6C3F1/N Mice; April... 10KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hclist_20190400.pdf
2-Hydroxy-4-methoxybenzophenone Mice B6C3F1/N Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1/N Male and Female Inhalation Air Metal Working Fluids: CIMSTAR 3800 ...
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P08: Statistical Analysis of Primary Tumors for Male & Female... 180KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20523_tables/04_f1_m3_p08.pdf
ALL ROUTES 60311-06 -- Cobalt (INHALATION AIR) 99031-04 -- Ginkgo biloba extract (GAVAGE CORN OIL) 20203-04 -- Green Tea Extract (GAVAGE WATER) 20006-04 -- Indole-3-carbinol ...
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Uterus - Hyperpalsia, Stromal 264KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/uterus/hypstr/uterus-hyperplasia-stromal-pdf-508.pdf
NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/9771 National Toxicology Program. 2014. NTP TR-584. Toxicology Studies of Indole-3-Carbinol (CAS No. 700-06-1...
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Agenda: TR Peer Review; May 22, 2014 194KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/agenda2014522_508.pdf
Peer-review comments Panel . Panel discussion Dr. Carpenter Draft NTP Technical Report on Indole-3-Carbinol (TR-584) Study scientist: Dr. Michael Wyde, NIEHS/DNTP Study ...
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Historical Controls: All Routes and Vehicles for Harlan Sprague... 149KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20190400.pdf
03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Battelle Northwest 051047203 01/17/... 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol Battelle Northwest 051047203 01/17/...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 70KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_hsdrats_allroutes_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Pathology Tables by Route/Vehicle for Harlan... 69KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_hsdrats_byroute_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 196KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014mice_all_routes_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: By Route and Vehicle for Mice; Studies started... 285KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_rte20150700_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Southern Research Institute ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Southern Research Institute ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 435KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-mice-by-route.pdf
Battelle Columbus Laboratory 052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol ... Battelle Columbus Laboratory 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 93KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-rats-all-routes.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 143KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-rats-by-route.pdf
03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Female Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol NOTE: The text on page 2 ...
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Historical Controls: By Route and Vehicle for Mice; April 2019 664KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hcrpt_rte20190400.pdf
Battelle Columbus Laboratory 052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol ... Battelle Columbus Laboratory 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol ...
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Historical Controls: By Route and Vehicle for Harlan Sprague... 464KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_rte20190400.pdf
03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Female Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol NOTE: The text on page 2 ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
No Evidence NE No Evidence NE No Evidence NE No Evidence TR-584 05/22/14 Indole-3-Carbinol 700-06-1 NE No Evidence SE Some Evidence CE Clear Evidence NE No Evidence TR-583 05/22/...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 276KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_mice_allroutes_508.pdf
... 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Route/Vehicle for B6C3F1... 950KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_mice_byroute_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Route/Vehicle for B6C3F1... 684KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014mice_byroute_508.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 124KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_allrte20150700.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 179KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-mouse-all-routes.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/...
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Historical Controls: All Routes and Vehicles for Mice; April... 189KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hcrpt_allrte20190400.pdf
04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/... 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 05/05/...
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Presentation: Adverse Outcome Pathway (AOP) for Sustained Aryl... 822KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/simon-508.pdf
AHR activation is considered to be the initial key event for dioxin-induced tumor . However, many ligands activate the AHR and do not produce tumors, e.g. indole-3-carbinol in ...
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Lymph node - Lymphatic Sinus, Ectasia - Nonneoplastic Lesion... 288KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/LymphaticSinusEctasia
Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/ National Toxicology Program. 2004. Short-Term Bioassay of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and ...
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Lymph Node - Lymphatic Sinus, Ectasia 575KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/lymph_node/lsectasia/lymph-node-lymphatic-sinus-ectasia-pdf_508.pdf
.../pmc/articles/PMC1892634/ National Toxicology Program. 2004. Short-Term Bioassay of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 2016 Technical Report TR-584 PDF (4.13 MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 2016 Technical Report TR-584 PDF (4.13 MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-584 PDF (4.13 MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies ...
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TR-595: Sprague Dawley (Hsd:Sprague Dawley SD) Rats Exposed to... 5.6MB
https://ntp.niehs.nih.gov/go/tr595
... tris(chloroisopropyl) phosphate, indole-3-carbinol, perfluorooctanoic acid, dietary ... studies with three brain sections (indole-3-carbinol, perfluorooctanoic acid, and dietary ...
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All Past Events 1004KB
https://ntp.niehs.nih.gov/events/past
... Review Meeting: Green Tea Extract, Indole-3-Carbinol, CIMSTAR 3800, and ... NTP Technical Reports Peer Review Meeting: Green Tea Extract, Indole-3-Carbinol, CIMSTAR ...
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Minutes: BSC; Dec. 9-10, 2014 270KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2014/dec/bsc_dec2014_minutes_508.pdf
... acid (BDCA, TR-583), indole-3-carbinol (TR-584), green tea extract ... Indole-3-carbinol is a dietary supplement. The panel voted (4 yes, 2 no, 0 abstentions) to ...
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TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf
... indoles (e.g., indole-3-carbinol found in cruciferous vegetables), dietary flavonoids (e.g., quercetin, kaempferol), and heme degradation products (e.g., bilirubin/biliverdin). ...
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TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf
... indoles (e.g., indole-
3-carbinol found in cruciferous vegetables), dietary flavonoids (e.g., quercetin, kaempferol), and heme degradation products (e.g., bilirubin, biliverdin). ...
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TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr529.pdf
... indoles (e.g., indole-
3-carbinol found in cruciferous vegetables), dietary flavonoids (e.g., quercetin, kaempferol), and heme degradation products (e.g., bilirubin/biliverdin). ...
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TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf
... indoles (e.g., indole-3-
carbinol found in cruciferous vegetables), dietary flavonoids (e.g., quercetin, kaempferol), and heme degra- dation products (e.g., bilirubin/biliverdin). ...