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TR-289: Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1Mice... 16.4MB
https://ntp.niehs.nih.gov/go/tr289
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 289 . ? * * L M A N V e "ce L - TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZENE (CAS NO. 71-43-2) IN F344/N RATS AND B6C3F1 ...
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GMM-08: Genetically Modified Model Report on Benzene (Gavage... 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm08_508.pdf
aNd caRciNoGeNesis sTudy of BeNzeNe (casRN 71-43-2) iN GeNeTically Modified haPloiNsufficieNT P16 iNk4a / P19 aRf Mice (GavaGe sTudy) NTP GMM 08 OCTOBER 2007 NTP REPORT ON THE ...
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RoC Profile: Benzene; 15th RoC 2021 110KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf
Benzene CAS No. 71-43-2 Known to be a human carcinogen First listed in the First Annual Report on Carcinogens (1980) Carcinogenicity Benzene is known to be a human carcinogen based ...
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Abstract for TR-289 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr289
Abstract for TR-289 Toxicology and Carcinogenesis Studies of Benzene in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 71-43-2 Chemical Formula: C6H6 Molecular Weight: 78.11 ...
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Transgenic model evaluation II (Benzene): Target Organs and Levels... 58KB
https://ntp.niehs.nih.gov/data/gmm/gmm08levels
Transgenic model evaluation II (Benzene): Target Organs and Levels of Evidence for GMM-08 GMM-08 Toxicology and Carcinogenesis Study of Benzene (CASRN 71-43-2) in Genetically ...
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Abstract for GMM-8 67KB
https://ntp.niehs.nih.gov/publications/reports/gmm/gmm08
Abstract for GMM-8 Toxicology and Carcinogenesis Study of Benzene in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study) CASRN: 71-43-2 Chemical Formula: C6H6 ...
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Target Organs and Levels of Evidence for TR-289 59KB
https://ntp.niehs.nih.gov/data/tr/200s/tr289levels
Target Organs and Levels of Evidence for TR-289 Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study ...
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RoC Profile: Diazoaminobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diazoaminobenzene.pdf
diazoaminobenzene is me- tabolized to benzene, a known human carcinogen, and (2) ... Benzene was listed in the First Annual Report on Carcinogens in 1980 based on human ...
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Abstract for TR-61 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr061
Full Report PDF Abstract Pentachloronitrobenzene (PCNB), a halogenated benzene derivative and agricultural pesticide, was selected for bioassay by the National Cancer Institute ...
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RoC Background Document for Diazoaminobenzene; Nov. 22, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/daab_rg2_public_correct_no_app_508.pdf
... is metabolized to the known human carcinogen benzene and to the animal carcinogen aniline. ... DAAB is predicted to be a carcinogen because it is metabolized to benzene and aniline. ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
...... 19 Project 1: Benzene ADME in Genetically Diverse Mouse Strains...... 21 Project 2: Benzene ADME Phenotype and Haplotype Association ...
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Abstract for TR-127 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr127
Full Report PDF Abstract 5-Nitro-o-anisidine, a tri-substituted benzene derivative used as an intermediate in the synthesis of dyes, was selected for bioassay by the National ...
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TOX-73: Diazoaminobenzene (CASRN 136-35-6) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox073.pdf
... The structure of the chemical is a combination of benzene and aniline, both of which are ... a tube) to determine if the chemical breaks down into benzene or aniline in the body. ...
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Minutes: BSC TRRS; Aug. 28, 2006 1.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2006/aug/trrs28aug2006mins_508.pdf
Benzene ......The motion was approved unanimously (7 yes, 0 no, 0 abstention votes). Benzene Dr. June ...
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Abstract for TR-542 78KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr542
isopropylbenzol; (1-methyl/ethyl)benzene; 2-phenylpropane Report Date: February ... reaction process that uses acidic catalysts to alkylate benzene with propylene. ...
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RoC Concept: Cumene 251KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/cumeneconcdocroc8-30-12_508.pdf
isopropylbenzene) is an alkylated benzene found in fossil fuels, such as blended ... Cumene is structurally similar to benzene, toluene, styrene, xylene, and ethylbenzene. It ...
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RoC Profile: 1,4-Dichlorobenzene; 15th RoC 2021 149KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichlorobenzene.pdf
Administration of 1,4-dichloro- benzene by stomach tube caused benign and malignant liver ... soluble in chloroform, carbon disulfide, benzene, and ether; and very sol- uble in ethanol ...
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Minutes: BSC; Oct. 28, 1983 699KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1983/minutesbsc19831028_508.pdf
Larry G. ~art, (919) 541-3971; FTS 629-3971. Contents Technical Report CAS No. Page Number Benzene 71-43-2 1 1,3-Butadiene 106-99-0 3 Phosphate Tris(2-ethylhexyl) 78-42-2 5 ...
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RoC Profile: Nitrobenzene; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrobenzene.pdf
In mice, inhalation exposure to nitro- benzene caused benign and malignant lung tumors ... to occur when nitrobenzene is ingested, and the latter when nitro- benzene is inhaled. ...
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TR-466: Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr466.pdf
... spread human exposure and because of its structural similarity to benzene and toluene. ... There was some evidence of carcinogenic activity of ethyl- benzene in female B6C3F 1 mice ...
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TOX-7: 1,2,4,5-Tetrachlorobenzene (CASRN 95-94-3) 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox007.pdf
... 215.9 Synonyms: s-tetrachlorobenzene; benzene tetrachloride ABSTRACT Toxicology studies ... 215.9 Synonyms: s-tetrachlorobenzene; benzene tetrachloride I. INTRODUCTION Chemical ...
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Protocol for a Systematic Review of Traffic-Related Air Pollution... 1.3MB
https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/protocol_20160616_508.pdf
... 8 mobile source air toxics as key: benzene, 1,3-butadiene, formaldehyde, ... pollution include: benzene, diesel exhaust and polycyclic aromatic hydrocarbons (PAHs). ...
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RoC Review of Cumene 71KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/cumene
Primary Uses or Exposures An alkylated benzene that is a natural component of petroleum and can also be synthesized from propylene and benzene. Used primarily to produce phenol and ...
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Minutes: BSC; Nov. 2008 308KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/november/minutes_final.pdf
41 IX. Predicting Hepatocarcinogenic Potential of Alkoxypropenyl Benzene ...... IX. Predicting Hepatocarcinogenic Potential of Alkoxypropenyl Benzene Derivatives using ...
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TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB
https://ntp.niehs.nih.gov/go/tr371
... metabolism of benzene and the alkylben- zenes was excellent, although some discussion on the area of toluene's (and xylene's) modifying the metabolism of benzene would enhance ...
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RoC Profile: Toluene Diisocyanates; 15th RoC 2021 156KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/toluenediisocyanates.pdf
Also known as TDI; 1,3-diisocyanatomethyl benzene; isocyanic acid, methyl-m-phenylene ... They decompose in water, but are very soluble in acetone and benzene, and are mis- cible ...
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Minutes: BSC TRRS; July 27, 1984 719KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1984/july/84jul27trrsmins_508.pdf
L a r r y G. Hart, (919) 541-3971; FTS 629-3971. CONTENTS Technical Report CAS No. Benzene 71-43-2 C h r y s o t i l e Asbestos 12001-29-5 1,3-Dichloropropene (Telone I I @ ) ...
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Abstract for TOX-73 64KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox073
it would be metabolized into aniline and benzene; therefore, metabolism and disposition ... The only volatile metabolite detected in the breath was benzene, and all the metabolites ...
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TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox35.pdf
... 0 .01 Arsenic 30 .6 0 .27 0 .9 2 .7 9 Benzene 5 .0 0 .375 1 .25 3 .75 12 .5 Cadmium 0 ... Arsenic tdoxide' 30 .6 0 .27 0 .9 2 .7 9 Benzene 71-43-2 5 .0 0 .375 1 .25 3 .75 12 .5 ...
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Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
... to a variety of chemicals, including benzene, toluene, ethylbenzene, and various ... workers might also have been exposed to benzene. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 ...
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Abstract for TR-534 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr534
CASRN: 1321-74-0 Chemical Formula: C10H10 Molecular Weight: 130.189 Synonyms/Common Names: Benzene, diethenyl-(9CI); diethenylbenzene; divinyl benzene; divinylbenzene-HP (high ...
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TR-261: Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1Mice... 10.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr261.pdf
... FIGURES Figure 1 Metabolism of Chloro benzene. . . . . . . . . . . . . . . . . . . . . . . ... of chlorobenzene as comparable to benzene, based on structure and rodent toxicity, ...
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Abstract for TR-250 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr250
This compound is practically insoluble in water but is miscible in alcohol and ether and soluble in benzene and chloroform. Toxicology and carcinogenesis studes of benzyl acetate ...
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Re-envisioning Toxicity Assessment @NTP (ICCVAM Public Forum... 2.8MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2019/04-casey-ntp_508.pdf
Types of Programs at NTP .Single Agents - e.g., Arsenic, Benzene .Agent Classes - e.g. PAHs, PFAS Types of Programs at NTP .Single Agents - e.g., Arsenic, Benzene .Agent Classes - ...
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RoC Profile: Coke-Oven Emissions; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cokeovenemissions.pdf
aromatic hydrocarbons (PAHs), nitrosa- mines, coal tar, arsenic compounds, and benzene. ... Coke-oven emissions are defined as the benzene-soluble fraction of total particulate ...
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TR-366: Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1Mice... 14.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr366.pdf
... between hydroquinone and benzene lent support for changing the conclusion for female rats to clear evidence of carcinogenic activity, since benzene is a potent leukemogen. Dr. ...
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Abstract for TOX 30 77KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox030
dibutyl ester; benzene-o-dicarboxylic acid di-n-butyl ester; o-benzenedicarboxylic acid dibutyl ester; butyl phthalate; n-butyl phthalate; DBP; dibutyl 1,2-benzene dicarboxylate; ...
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RoC Profile: Hydrazobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazobenzene.pdf
slightly soluble in benzene and deuterated dimethyl sulfoxide, insoluble in acetic acid, and practically insoluble in water (HSDB 2009). Hydrazo- benzene is stable under normal ...
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RoC Profile: Lindane, Hexachlorocyclohexane (Technical Grade... 155KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lindane.pdf
α isomer is practically insolu- ble in water but soluble in chloroform and benzene. The β isomer is very slightly soluble in water and slightly soluble in chloroform and benzene. ...
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Abstract for TR-26 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr026
CASRN: 1836-75-5 Chemical Formula: C12H7Cl2NO3 Molecular Weight: 284.0973 Synonyms/Common Names: 2,4-dichloro-1-(4-nitrophenoxy)-benzene; 2,4-dichlorophenyl-p-nitrophenyl ether; ...
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TR-534: Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr534.pdf
... Formula: C 10 H 10 Molecular Weight: 130.189 Synonyms: Benzene, diethenyl-(9CI); diethenylbenzene; divinyl benzene; divinylbenzene-HP (high purity); divinylbenzene (m- and ...
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Abstract for TOX-82 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox082
...)-benzene (9CI); 1-allyl-4-methoxybenzene; 3-(p-methoxyphenyl)propene; 4-allylanisole; 4-allyl-1-methoxybenzene; chavicol methyl ether; esdragol; 1-methoxy-4-(2-propenyl)-benzene; ...
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Abstract for TR-124 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr124
CASRN: 120-62-7 Chemical Formula: C18H28O3S Molecular Weight: 324.4822 Synonyms/Common Names: 1,2-(Methylenedioxy)-4-(2-(octylsulfinyl)propyl) benzene Report Date: 1979 Full Report ...
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Abstract for TR-184 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr184
CASRN: 1836-75-5 Chemical Formula: C12H7Cl2NO3 Molecular Weight: 284.0973 Synonyms/Common Names: 2,4-dichloro-1-(4-nitrophenoxy)-benzene, 2,4-dichlorophenyl-p-nitrophenyl ether, ...
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RoC Profile: 4-Dimethylaminoazobenzene; 15th RoC 2021 183KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylaminoazobenzene.pdf
... It is practically insoluble in water, but is soluble in alcohol, benzene, chloroform, ... and ingestion. 4-Dimethyl- aminoazo benzene was a component of brilliantine, which ...
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RoC Profile: Styrene; 15th RoC 2021 252KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styrene.pdf
among exposed workers, and there was po- tential confounding by co-exposure to benzene. ... polymer content, aldehydes, peroxides (as H 2 O 2 ), benzene, sulfur, and chlorides. ...
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Abstract for TOX-07 62KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox007
CASRN: 95-94-3 Chemical Formula: C6H2Cl4 Molecular Weight: 215.9 Synonyms/Common Names: s-Tetrachlorobenzene; benzene tetrachloride Report Date: January 1991 Full Report PDF ...
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Abstract for TR-35 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr035
CASRN: 72-43-5 Chemical Formula: C16H15Cl3O2 Molecular Weight: 345.651 Synonyms/Common Names: 1,1'-(2,2,2-trichloroethylidene)bis (4-methoxy)-benzene; 1,1,1-trichloro-2,2'-bis(p-me...
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RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf
... and ethanol Soluble in diethyl ether, benzene, and carbon tetrachloride Very soluble in ... procedures. 40 CFR 80.55-Sec. 80.55 Measurement methods for benzene and 1 ,3-butadiene. ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
Aristolochic Acids Arsenic and Inorganic Arsenic Compounds Asbestos Azathioprine Benzene Benzidine (see Benzidine and Dyes Metabolized to Benzidine) Beryllium and Beryllium ...
