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Abstract for TER96003 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter96003
Developmental Toxicity Evaluation of Melatonin Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 CASRN: 73-31-4 Chemical Formula: C13H16N2O2 ...
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Monograph: Night Shift Work and Light at Night; August 24, 2018 6.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph20180824.pdf
... workers Circadian disruption: Primarily melatonin and clock gene expression Human ... Circadian disruption: Primarily melatonin and clock gene expression Experimental ...
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Mechanistic and Other Relevant Data; Stan Atwood; ROCPRP; Oct... 1017KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/08atwood_rocprp_508.pdf
Outline: Mechanistic Data ↓ Oncostatic activity ↑ Tumor promotion 6.2: Melatonin & Clock genes Focus: breast cancer Circadian disruption Biological effects Cancer . Melatonin . ...
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NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf
... regulators of the circadian timing system (e.g., cortisol and melatonin) (see Figure 1). ... the adrenal gland, melatonin from the pineal gland) (Honma 2018, Brown and Azzi 2013). ...
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Appendix A: Overview of human studies: Cancer, biomarkers, and... 1.8MB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_a_508.pdf
... of circadian disruption, primarily measurement of 6-sulfatoxymelatonin (aMT6s), the primary urinary metabolite of melatonin and surrogate of circulating melatonin levels. ...
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Evidence Integration; Ruth Lunn; ROCPRP; Oct. 5, 2018 1015KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/09lunn_rocprp_508.pdf
NSW Melatonin Human cross-sectional Exposure Outcome Evidence stream Confidence of the ... Evidence stream Confidence Assessment Melatonin Breast cancer Human & animal ...
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Appendix B: Overview of experimental animal studies: Carcinogenicity 208KB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_b_508.pdf
of carcinogenicity such as nocturnal melatonin and its metabolite, ... Studies on blindness and physiological melatonin are also not reported although they may ...
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Research Concept: Shift Work; 2014 756KB
https://ntp.niehs.nih.gov/ntp/roc/concept_docs/2014/shiftworkconcept_508.pdf
and wavelength) can suppress nighttime melatonin production by the pineal gland and studies suggesting that decreased melatonin levels may play a role in breast cancer ...
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Abstract for TR-71 60KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr071
L-Tryptophan is an essential amino acid for humans, and a precursor of the neurohormones serotonin (5-hydroxytryptamine) and melatonin (N-acetyl-5-methoxytryptamine), and the B ...
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Monograph: Summary of NTP Cancer Hazard Conclusions: Exposure... 870KB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal_summary20210400_508.pdf
... regulators of the circadian timing system (e.g., cortisol and melatonin) (see Figure 1). ... the adrenal gland, melatonin from the pineal gland) (Honma 2018, Brown and Azzi 2013). ...
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TR-489: Magnetic Field Promotion (DMBA Initiation) in Sprague... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr489.pdf
... Study . . . . . . 101 APPENDIX D Melatonin Analyses . . . . . . . . . . . . . . . . ... for changes in SECOND 13-WEEK STUDY pineal gland and serum melatonin concentrations. ...
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TOX-58: 60-Hz Magnetic Fields 1.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox058.pdf
... In addition, magnetic field exposure was not associated with a significant reduction in serum melatonin or pineal gland melatonin concentration, or pineal gland activity of ...
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Public Comment: Shiftwork involving light at night; Robert Wagner... 34KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/wagner20120208.pdf
While we are aware of the IARC report and others linking shiftwork to melatonin ... breast cancer growth by the nocturnal melatonin signal and the consequences of its ...
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Introduction and Exposure Studies of Circadian Disruption; Ruth... 1.5MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/04lunn_rocprp_508.pdf
... nucleus Circadian rhythms Melatonin and clock genes Circadian Regulation SCN ... Other clock gene entrainers include cortisol and other glucocorticoids Melatonin and clock ...
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RoC Protocol: Electric Light; May 7, 2018 472KB
https://ntp.niehs.nih.gov/ntp/roc/protocols/electric-light_508.pdf
... effects on circadian disruption and melatonin suppression, and animal models and human ... workers Circadian disruption: Primarily melatonin and clock gene expression Electric ...
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Shift Work at Night, Artificial Light at Night, and Circadian... 114KB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/shortbios20160310_508.pdf
Blask's research has focused on the circadian control and therapeutics of cancer by melatonin as well as the consequences of the circadian disruption of melatonin production by ...
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Session Abstract 265KB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/session_abstract20160311_508.pdf
... One of the most important circadian humoral factors is the pineal hormone melatonin, which transmits time information (via peak and duration of melatonin production) to many organs ...
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Peer Review Report: Draft Report on Carcinogens Monograph on... 316KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2018/october/peerreview20181005_508.pdf
... Key roles are played by melatonin and clock genes. Environmental exposures that disrupt ... The effectiveness of LAN in inducing melatonin suppression depends on light wavelength and ...
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Appendix D: Overview of experimental animal studies: Non-cancer... 157KB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_d_508.pdf
including activity, body temperature, melatonin and corticosterone levels, and ... these studies with the exception of melatonin, which was only measured in light studies. ...
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Abstract for TR-489 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr489
Additional animals were evaluated for changes in pineal gland and serum melatonin ... were evaluated for pineal gland and serum melatonin concentrations at 4, 8, or 12 weeks. ...
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Public Comment: Shiftwork involving light at night; Stephen Pauley... 57KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/pauley20120220.pdf
...ne
by
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et
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Melatonin-Depleted
Blood
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Premenopausal
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Exposed
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Light
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Night...
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Cancer Studies in Experimental Animals; Gloria Jahnke; ROCPRP... 488KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/07jahnke_rocprp_508.pdf
Mice and Rats - Nocturnal animals, most active at night - Most produce melatonin during ... studies measured additional biological effects and/or had co-exposures to melatonin . ...
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Objectives and Methods; Ruth Lunn; ROCPRP; Oct. 5, 2018 952KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/01lunn_rocprp_508.pdf
... or day shift CD: melatonin, clock genes expression Biological effects Human experimental studies or reviews LAN Standard lighting conditions CD: melatonin: clock genes ...
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TR-488: 60-HZ Magnetic Fields in F344/N Rats and B6C3F1Mice ... 20.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr488.pdf
... In a series of studies, no effects of 200 mG exposure on nocturnal melatonin concentra- ... magnetic fields may suppress nocturnal melatonin concentrations in rodents (Wilson et ...
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Appendix C: Overview of human studies: Non-cancer health outcome 881KB
https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_c_508.pdf
... The primary measurements studied were melatonin and cortisol level relation to circadian ... More than 25 studies examine impacts of doses of melatonin, caffeine, and various other ...
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Abstract for TOX-58 60KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox058
In addition, magnetic field exposure was not associated with a significant reduction in serum melatonin or pineal gland melatonin concentration, or pineal gland activity of ...
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NTP Review of Shift Work at Night, Light at Night, and Circadian... 110KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/shiftwork
... Such exposure has been shown to cause circadian disruption (as evident by melatonin ... part by decreased levels of the hormone melatonin; normal melatonin levels are important ...
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Abstract for Cancer Hazard Assessment: Night Shift Work and Light... 61KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/shiftwork/abstract
... The animal studies demonstrate that melatonin suppression (a biomarker of circadian ... Studies in humans demonstrate that exposure to LAN causes melatonin suppression. NTP final ...
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Actions: ROCPRP; Oct. 5, 2018 483KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2018/october/actions20181005_508.pdf
... certain lighting conditions cause (1) melatonin suppression and other types of circadian ... of recognized carcinogens, and (3) melatonin suppression in humans. 'Certain lighting ...
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Brain- Nonneoplastic Lesion Atlas 311KB
https://ntp.niehs.nih.gov/atlas/nnl/nervous-system/brain
... nucleus Angiotensin II Pineal gland PI Circadian rhythms Subventricular zone Melatonin Neural lobe, pituitary NLP Kidney water transfer; uterine contraction Kidney tubules; ...
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RoC Profile: Ultraviolet-Radiation-Related Exposures; 15th RoC... 169KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ultravioletradiationrelatedexposures.pdf
... UVA has been found to react with melatonin, a hormone that helps to regulate sleep-wake cycles. Although the photoproducts of mel- atonin have not been identified, melatonin has ...
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Minutes: BSC TRRS; March 11, 1998 624KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1998/mar/trrs11march1998mins_508.pdf
... He discussed studies that report EMF can block melatonin inhibition of cell growth and lower nocturnal melatonin levels in rodents. Dr. Boorman summarized the findings from a ...
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Brain - Introduction 915KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/nervous/brain/brain-introduction_508.pdf
... nucleus Angiotensin II Pineal gland PI Circadian rhythms Subventricular zone Melatonin Neural lobe, pituitary NLP Kidney water transfer; uterine contraction Kidney tubules; ...
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Monograph: Night Shift Work and Light at Night; Appendix A: Literature... 199KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph_appa.pdf
... PubMed: (corticosterone[tiab] OR cortisol[mh] OR cortisol[tiab] OR melatonin[mh] OR melatonin[tiab] OR "body temperature"[mh] OR body-temperature*[tiab]) A.2.6 ...
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TR-071: L-Tryptophan (CASRN 73-22-3) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr071.pdf
... and a precursor of the neurohormones serotonin (5-hydroxytryptamine) and melatonin (N-acetyl-5-methoxytrypt- amine), and the B vitamin nicotinic acid (Orten and Neuhaus, 1975). ...
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Human Breast Cancer Studies; Pam Schwingl; ROCPRP; Oct. 5, 2018 2.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/05schwingl_rocprp_508.pdf
... space station photos** to develop a Melatonin Suppression Index from blue light . 1 ... Circadian-effective metric (melatonin suppression index**) (1 study) . Self-reported ...
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RoC Background Document: Ultraviolet (UV) Radiation, Broad Spectrum... 3.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/uv_no_appendices_508.pdf
... UVA has been found to alter the molecular structure of melatonin, a hormone that helps ... photoproducts; moderate phototoxicity of melatonin has been predicted (Kim et al. 1999). ...
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Literature Search Results: Systematic Review of Fluoride Exposure... 768KB
https://ntp.niehs.nih.gov/ntp/ohat/fluoride/literature_results20200916_508.pdf
... Fluoride 37: 7-12. Jain A, Mehta VK, Chittora RA, Mahdi A, Bhatnagar M. 2015. Melatonin ... brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. ...
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Minutes: BSC; April 17, 1996 335KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/april/19960417_bsc_508.pdf
... 17, 1996 with melatonin and cancer cell growth, free radicals and magnetic fields, calcium and cell signaling, kinases and magnetic fields, and melatonin, light and breast cancer. ...
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Minutes: BSC; April 6, 1994 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/april/19940406bscmins_508.pdf
... In research on electromagnetic fields (EMF), studies are underway on general toxicological characterization, developmental toxicity and effects on melatonin levels . Chronic ...
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Minutes: BSC; May 14, 1997 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1997/may/bsc_mins1997may14_508.pdf
... include tamoxifen, water disinfection byproducts, pesticides, TCDD, and melatonin . ... metabolism and secretion of melatonin as part of the effort to evaluate ...
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Monograph: Night Shift Work and Light at Night; Appendix C: Transmerid... 1.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph_appc.pdf
... discrimination between exposed and unexposed along relevant axis (melatonin suppression). ... Non-peak sleep (not sleeping during nocturnal melatonin peak (going to sleep after 2:00 ...
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RoC Handbook Appendix: Standard Search Strings; July 26, 2023 450KB
https://ntp.niehs.nih.gov/.../2023-08/Standard_Search_Strings_for_Literature_Database_Searches_for_Preparing_Report_on_Carcinogens_Monographs_2023_final_508.pdf
... Hormones[MH] or "Thyroid Hormones" OR Melatonin[MH] OR Endocrine Disruptors[MH] OR ... AND hormones) OR "Thyroid Hormones" OR melatonin OR (endocrine AND disruptors) OR ...
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Minutes: BSC; June 21-22, 2012 191KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2013/june/minutes20130625_508.pdf
... a dose response, with the simplest biological mechanism having to do with melatonin. ... Stevens agreed, providing examples of how melatonin expression might be studied. Also, he ...
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RR-01: Systematic Literature Review on the Effects of Fluoride... 7.2MB
https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr01_508.pdf
... R, Mahdi AA, Bhatnagar M. 2015. Melatonin ameliorates fluoride induced ... Jain A, Mehta VK, Chittora R, Mahdi AA, Bhatnagar M. 2015. Melatonin ameliorates fluoride ...
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Notice: BG1Luc4E2 Cells Are Being Renamed VM7Luc4E2 Cells 1.1MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/bg1luc/bg1luc-vm7luc-june2016-508.pdf
... Mol Endocrinol. 2003;17:792- 803. 32. Baldwin WS, Travlos GS, Risinger JI, Barrett JC. Melatonin does not inhibit estradiol-stimulated proliferation in MCF-7 and BG-1 cells. ...
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TR-596: B6C3F1/N Mice Exposed to Whole-body Radio Frequency Radiation... 4.3MB
https://ntp.niehs.nih.gov/go/tr596
... G, Krstic D, Cvetkovic T, Pavlovic V. Melatonin reduces oxidative stress induced by ... damage in the kidney induced by 900-MHz-emitted mobile phone: Protection by melatonin. ...
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Minutes: BSC; Sept. 10-11, 2003 500KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf
... lens optical quality, micronuclei frequency, DNA strand breaks in brain cells, urinary metabonomic profiles, and excretion of melatonin metabolites. Board Discussion Dr. ...
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Predicting human developmental toxicity of pharmaceuticals using... 510KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf
... J. Pediatr. 131, S30-S39. Tan, D., Manchester, L., Reiter, R., Plummer, B., Hardies, L., Weintraub, S., Vijayalaxmi, Shepherd, A., 1998. A novel melatonin metabolite, cyclic ...
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TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf
... Gastrin IL-1$ Ornithine decarboxylase Thyroid hormones c-Ras Tyrosine kinase Melatonin c-ErbA Terminal deoxynucleotidyltransferase Phosphoenolpyruvate carboxykinase ...