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RoC Profile: Bromodichloromethane; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromodichloromethane.pdf
Administration of bromodichloro methane by stomach tube caused benign and malig- nant ... In 2009, bromodichloro- methane was available from 18 suppliers worldwide, including 11 ...
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TR-350: Tribromomethane (Bromoform) (CASRN 75-25-2) in F344/N... 11.8MB
https://ntp.niehs.nih.gov/go/tr350
... Tribromo- methane induced trifluorothymidine (Tft) resistance in mouse L5178Y cells with ... tribromo- 0,100, or 200 mgkg tribromo- methane in corn oil, 5 d/wk methane in corn oil, ...
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Abstract for TR-186 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr186
4,4'-bis(dimethylamino) diphenylmethane; Tetra base; Methane base; Michler's base; Michler's hydride; Michler's methane Report Date: 1979 Full Report PDF Abstract ...
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Abstract for TR-110 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr110
Bioassay of Iodoform for Possible Carcinogenicity CASRN: 75-47-8 Chemical Formula: C H I3 Synonyms/Common Names: triiodo-methane Report Date: 1978 Full Report PDF Abstract ...
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Abstract for TR-536 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr536
Toxicology and Carcinogenesis Studies of Bis(2-chloroethoxy)methane in F344/N Rats and ... bis(beta;-chloroethyl) acetal; methane, bis(2-chloroethoxy)-; ...
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TR-536: bis(2-Chloroethoxy)methane (CASRN 111-91-1) in Male F344... 9.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr536.pdf
STUDIES OF BIS(2-CHLOROETHOXY)METHANE (CAS No. 111-91-1) IN F344/N RATS AND ... STUDIES OF BIS(2-CHLOROETHOXY)METHANE (CAS No. 111-91-1) IN F344/N RATS AND ...
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RoC Profile: Nitromethane; 15th RoC 2021 136KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitromethane.pdf
the rela- tionship between human cancer and exposure specifically to nitro- methane. ... Metabolism of nitro- methane by rat liver microsomes resulted in formation of only trace ...
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TR-306: Dichloromethane (Methylene Chloride) (CASRN 75-09-2)... 13.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr306.pdf
... of each sex were f~xposed to dichloro- methane at concentrations of 525-8,400 ppm 6 ... In industry, dichloro- methane is used as a solvent in paint removers, degreasing agents, ...
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TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB
https://ntp.niehs.nih.gov/go/tr426
... final mean body weights o f groups receiving dichloro- methane in 2.5 or 5 mL corn oilkg. ... compared to rats receiving dichloro- methane in 2.5 mL corn oilkg (1/50), but was' not ...
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TR-321: Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and... 10.6MB
https://ntp.niehs.nih.gov/go/tr321
... the draft, Technical Report on bromodichloro- methane on August 19,1986, are listed below. ... the hepatotoxicity of bromodichloro- methane administered as a single oral dose in ...
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GMM-05: Genetically Modified Model Report on Bromodichloromethane... 1.6MB
https://ntp.niehs.nih.gov/go/gmm05
... Bromodichloro- methane was nominated to the NTP by the United States Environmental ... Bromodichloro- methane as a halogenated organic molecule is included in the trihalomethane ...
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TR-386: Tetranitromethane (CASRN 509-14-8) in F344/N Rats and... 12.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr386.pdf
... 0,2, or 5 ppm tetranitro- 0,0.5,or 2 ppm tetranitro- 0,0.5,or 2 ppm methane, 6 h/d. 5 &wk methane, 6 h/d, 5 d/wk methane, 6 Wd, 5 d/wk methane, 6 Wd, 5 diwk Body weights in ...
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TR-282: Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats... 9.0MB
https://ntp.niehs.nih.gov/go/tr282
... (greater than 98% pure), a trihalo- methane formed after chlorination of water ... in which chlorodibromo- methane was being given in a microencapsulated form in feed. ...
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TR-106: Trichlorofluoromethane (CASRN 75-69-4) 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr106.pdf
... TRICHLOROFLUORO- METHANE CHRONIC STUDY RATS 25 GROWTH CURVES FOR TRICHLOROFLUOROMETHANE CHRONIC STUDY MICE 32 SURVIVAL COMPARISONS OF TRICHLOROFLUORO- METHANE CHRONIC STUDY MICE ...
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Agenda: BSC TRRS; Nov. 19, 2009 31KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2009/november/agenda111909.pdf
Feed, male and female F344/N rats and B6C3F1 mice Bis(2-chloroethoxy) methane [111-91-1] TR 536 Used as a solvent and as the starting agent in the production of fungicides and ...
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RoC Background Document: Isoprene; Dec. 2-3, 1998 2.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/isoprene_oneapp_508.pdf
... The large quantities of non-methane hydrocarbons (NMHCs) emitted by vegetation, especially ... Since they compete directly with methane for hydroxyl radicals, they may indirectly affect ...
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RoC Profile: Dichloromethane; 15th RoC 2021 148KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichloromethane.pdf
... Source: HSDB 2009. and as an extraction solvent for spice oleoresins, hops, and caffeine in coffee (NTP 1986). However, due to health concerns, dichloro- methane's use as an ...
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Historical Controls: Pathology Tables by All Routes/Vehicles... 224KB
https://ntp.niehs.nih.gov/ntp/historical_controls/historicalratesgmm_508.pdf
... p53 Females, 6 months Bromodichloro- methane Sodium bromate Diisopropyl- carbodiimide ... (1.0%) p53 Males, 6 months Bromodichlor- methane Sodium bromate Dichloroacetic acid ...
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RoC Profile: Isoprene; 15th RoC 2021 158KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf
... 10 ppbC. Isoprene accounts for less than 10% of non-methane hydro- carbons in ambient air. ... 1997. Characterization of non-methane hydrocarbons in the rural southeast United States. ...
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RoC Profile: Coke-Oven Emissions; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cokeovenemissions.pdf
... About 20% to 35% of the initial coal charge is emitted as gases and vapors, most of which are collected in by-product coke production. Coke-oven gas includes hydrogen, methane, ...
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RoC Profile: Hexachloroethane; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hexachloroethane.pdf
... It has also been used as a component of fire-extinguishing fluids, an additive in combustible liquids (ignition suppressant), and an inhibitor of the explosiveness of methane and ...
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RoC Profile: Tetranitromethane; 15th RoC 2021 125KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetranitromethane.pdf
... Occupational exposure to tetranitro- methane presumably occurred during the manufacture and use of trinitro toluene (TNT) (NTP 1990). During the early part of World War I, a high ...
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Minutes: BSC TRRS; March 23, 1984 492KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1984/mar/84mar23trrsmins_508.pdf
i n o g e n i c i t y was observed f o r female B6C3F1 mice, s i n c e chlorodibromo- methane caused an increased i n c i d e n c e o f h e p a t o c e l l u l a r adenomas and an ...
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TR-461: Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1Mice... 21.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr461.pdf
... pressure is 27,8 mm Hg at 20" C. Nitro- methane is soluble in alcohol, ether, ... on the carcinogenicity of nitro- methane in experimental animals was found inthe ...
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TR-569: Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr569_508.pdf
... Viramune ® 3-isoquinoline carboxamide] methane sulfonate Trade name: Viracept ® With ... Viramune ® 3-isoquinoline carboxamide] methane sulfonate Trade name: Viracept ® ...
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TR-186: 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine (CASRN 101... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr186.pdf
... f -bis(dimethylamino) diphenylmethane; tetra base; methane base; Michler's base; Michler f s hydride; and Michler's methane, 4,4*-Methylenebis(N,N-dimethyl)benzenamine is an ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf
... Methane, propionalde- hyde, and four unknown impurities were detected in various exposure system samples. Methane and pro- pionaldehyde were detected in all generator flask samples ...
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TR-110: Iodoform (CASRN 75-47-8) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr110.pdf
... The Chemical Abstracts Service (CAS) Ninth Collective Index (1977) name for this compound is triiodo-methane. In the past, iodoform was used by humans chiefly as a topical ...
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TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr288.pdf
... impurities that was commonly observed had the s a m e r e t e n t i o n time as methane. ... The average concentration was 0.67% by area. Analysis of propane and methane standards ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
... 180 oc to 200 °C, giving elemental nickel, carbon oxides, hydrogen, methane, and water. ... and absence ofUV light, methyl methane sulfonate (MMS), and buthionine sulfoxamine (BSO). ...
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TR-148: 1-Phenyl-2-thiourea (CASRN 103-85-5) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr148.pdf
... Thin-layer chromatography was performed utilizing two solvent systems (chloroformrdichloro- methane:ethyl acetate:formic acid and chloroform:acetone). Each plate showed only one ...
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TR-532: Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats... 7.2MB
https://ntp.niehs.nih.gov/go/tr532
... exposure of F344 rats to bromodichloro- methane on gestation days 8 or 9 was associated ... Miscellaneous Lesions: Exposure to bromodichloro- methane resulted in significant ...
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TR-086: 1,2-Dibromoethane (CASRN 106-93-4) 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr086.pdf
... (79-00-5); tetrachloroethylene (127-18-4); car- bon disulfide (75-15-0); hexachloroethane (67-72-1); trichlorofluoro- methane (75-69-4); and carbon tetrachloride (56-23-5). ...
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TR-392: Chlorinated Water (CASRNs. 7782-50-5 and 7681-52-9) and... 75.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr392.pdf
... trihalomethanes - chloroform, chlorodibromomethane, bromodichloro- methane, and bromoform. ... Toxicology and carcinogenesis Studies of Tribromo- methane (Bromoform) (CAS No. 75-25-2) ...
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TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB
https://ntp.niehs.nih.gov/go/tr385
... 1 pp m = 3 .891 mg/m 3 Synon ym: Bromo methane PHYSICAL AND CHEMICAL PROPERTIES though a ... dimethyl bromide, dichloro- methane, and the halogenated ethanes (Simmon et a ...
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TR-528: 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and... 5.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr528.pdf
... However, because nitro- methane is slightly soluble in water and evaporates at about the ... 10, 30, or 70 mg/L nitro- methane; or 0, 4.5, 9.0, or 18.0 mg/L 1,2,3-trichloro- propane. ...
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TR-285: C.I. Basic Red 9 Monohydrochloride (Pararosaniline) ... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr285.pdf
... Basic fuchsin is a mixture of three closely related 4,4',4''-triaminotriaryl- methane dyes ... 106 organic and 3. Bannister, D.; Elliott, J . (1983) Triphenyl- methane and related dyes. ...
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GMM-09: Genetically Modified Model Report on Dicyclohexylcarbodiimide... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm09_508.pdf
... dichlorodicyanobenzoquinone in dichloro- methane to produce a mixture that can be evaporated and heated in sodium hydroxide to yield dicyclohexylcar- bodiimide (Furumoto, 1971b). ...
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TR-279: Amosite Asbestos (CASRN 12172-73-5) in F344/N Rats (Feed... 36.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr279.pdf
... Faint traces of methylazoxymethane and azoxy- details are given in Table 4. methane were detected by high-performance liquid chromatography (Fiala et al., 1976). Animals were to ...
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TR-447: Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1Mice... 14.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr447.pdf
... the presence of a catalyst (e.g., Ag, Cu, MOO, or ZnS); orthe reaction o f cyanogen chloride with methane, ketones,ethanol, alkylene epoxides, and paraffins or olefins (WHO, 1993). ...
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TR-549: Bromochloroacetic Acid (CAS 5589-96-8) in F344/N Rats... 20.0MB
https://ntp.niehs.nih.gov/go/tr549
... For example, increasing the pH from 6 to 8 increases trihalo- methane formation, decreases trihaloacetate formation, and has little effect on mono- and dihaloacetate levels. ...
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TOX-14: p-Chloro-a,a,a-Trifluorotoluene (CASRN 98-56-6) 2.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox014.pdf
... The column used was a 10% SP-1000 on 80/100 Supelcoport ® (2 mm x 1.8 m) with an argon/10% methane carrier gas at a flow rate of 30 ml/min. 14 CHLORO-α α α α, , , ,α α α ...
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TR-450: Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and... 21.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr450.pdf
... PRODUCTION , USE, AND HUMAN EXPOSURE Tetrafluoroethylene is generally produced by the pyrolysis of chlorodifluoromethane or trifluoro- methane (IARC, 1979; Hawley, 1981; Material ...
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TR-554: 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr554.pdf
... rats were administered doses of 5-(hydroxymethyl)-2-furfural (300 mg/kg) or azoxy- methane (5 mg/kg) by gavage, and the colons were examined 30 days later (Zhang et al., 1993). ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
... distinct cardiotoxins, bis(2-chloroethoxy) methane (CEM) and ephedrine/caffeine (E/C). ... cardiotoxins, bis(2-chloroethoxy) methane (CEM) and ephedrine/caffeine (E/C), and ...
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TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf
... In rats and fish, DIM, LTR, and 1-(3- hydroxymethyl)-indolyl-3-indolyl-methane were detected in the liver following oral administration of indole-3-carbinol; the parent ...
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TR-251: Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate... 8.9MB
https://ntp.niehs.nih.gov/go/tr251
... Prepared within 2 hours of dosing 14-0.y Studies Polycarbonate Rats: 2-3 per cage; Mice: 5 per cage Diphenyl methane diisocyanate Toluene diisocyanate was dissolved in corn oil at ...
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TR-567: Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1... 6.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr567.pdf
... incorporation, but to increase the rate of DNA excision repair processes following treatment of cells with ultraviolet radiation or methyl methane- sulfonate (Rhee et al., 1991). ...
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RoC Background Document: Phenolphthalein; Oct. 30-31, 1997 2.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/phenolphthalein1_508.pdf
... Bis(4-hydroxyphenyl)[2- (phenoxysulfonyl)phenyl]methane: Isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfonphthalein). ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... TR-536 11/19/09 bis(2-Chloroethoxy)methane 111-91-1 NE No Evidence NE No Evidence NE ... Evidence TR-106 03/06/78 Trichlorofluoro-methane 75-69-4 IS Inadequate Experiment IS ...