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RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
FINAL Report on Carcinogens Background Document for Lead and Lead Compounds May 8, 2003 Prepared for the: U.S. Department of Health and Human Services Public Health Service ...
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RoC Profile: Lead and Lead Compounds; 15th RoC 2021 190KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lead.pdf
Lead and Lead Compounds CAS No. 7439-92-1 (Lead) No separate CAS No. assigned for lead compounds as a class Reasonably anticipated to be human carcinogens First listed in the ...
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NTP Monograph on Health Effects of Low-Level Lead 12.9MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
Toxicology Program NTP NTP Monograph Health Effects of Low-Level Lead June 2012 THIS PAGE LEFT INTENTIONALLY BLANK NTP MONOGRAPH ON HEALTH EFFECTS OF LOW-LEVEL LEAD June 13, 2012 ...
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NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/appendicesathrue_final_508.pdf
NTP Monograph on Health Effects of Low-Level Lead THIS PAGE LEFT INTENTIONALLY BLANK NTP MONOGRAPH ON HEALTH EFFECTS OF LOW-LEVEL LEAD June 13, 2012 APPENDIX A: HUMAN STUDIES OF ...
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TR-151: Lead Dimethyldithiocarbamate (CASRN 19010-66-3) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr151.pdf
Report Series NO. 151 BIOASSAY OF LEAD DIMETHYLDITHIOCARBAMATE FOR POSSIBLE ... National Institutes of Health BIOASSAY OF LEAD DIMETHYLDITHIOCARBAMATE FOR POSSIBLE ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix A... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixa_final_508.pdf
APPENDIX A: HUMAN STUDIES OF NEUROLOGICAL EFFECTS OF LEAD CONSIDERED IN DEVELOPING ... Monograph on Health Effects of Low-Level Lead 2 Study Description Population Age (yr) ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixe_final_508.pdf
E: HUMAN STUDIES OF REPRODUCTIVE AND DEVELOPMENTAL EFFECTS OF LEAD CONSIDERED IN ... Monograph on Health Effects of Low-Level Lead 208 Study Description Population Age (yr) ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix C... 1.2MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixc_final_508.pdf
C: HUMAN STUDIES OF CARDIOVASCULAR EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS ... Monograph on Health Effects of Low-Level Lead 146 Study Description Population Age (yr) ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix B... 873KB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixb_final_508.pdf
LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix B: Human Studies of Immune Effects of Pb Considered in Developing Conclusions NTP Monograph on Health Effects of Low-Level Lead ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix D... 543KB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixd_final_508.pdf
LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix D: Human Studies of Renal Effects of Pb Considered in Developing Conclusions NTP Monograph on Health Effects of Low-Level Lead ...
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Lead dimethyldithiocarbamate: Target Organs and Levels of Evidence... 56KB
https://ntp.niehs.nih.gov/data/tr/100s/tr151levels
5 Lead dimethyldithiocarbamate: Target Organs and Levels of Evidence for TR-151 Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CASRN 19010-66-3) Chemical ...
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Minutes: MPRP; Nov. 17-18, 2011 236KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2011/november/minutes20111118.pdf
Overview of the Evaluation of Low-Level Lead ......Draft NTP Monograph on Health Effects of Low-Level Lead Peer Review Panel Meeting November ...
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Health Effects of Low-level Lead 67KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/lead
36443 Health Effects of Low-level Lead Lead in water and image of child Topic Overview CASRN: 7439-92-1 Status: Evaluation completed Background Information Although reductions in ...
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Abstract for RACB94009 65KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb94009
Abstract for RACB94009 Reproductive Toxicity of in Lead Acetate Trihydrate in ... The potential effects of lead acetate trihydrate on the Sprague-Dawley rat reproductive ...
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Abstract for RACB84059 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84059
9abs Abstract for RACB84059 Lead Acetate Trihydrate: Reproduction and Fertility Assessment ... Lead Acetate Trihydrate (PbA) is used in manufacturing other lead salts, in the textile ...
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Abstract for RACB82102 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb82102
2abs Abstract for RACB82102 Lead Acetate Trihydrate: Reproduction and Fertility Assessment ... Lead Acetate Trihydrate (PbA) was evaluated in this follow-up study as a possible ...
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Actions on Lead Monograph: MPRP; Nov. 17-18, 2011 103KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2011/november/actionsleadmonograph_508.pdf
Actions on Draft NTP Monograph on Health Effects of Low-Level Lead Peer Review Panel ... 2011, to peer review the draft NTP Monograph on Health Effects of Low-Level Lead (Pb). ...
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Abstract for TR-151 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr151
1abs Abstract for TR-151 Bioassay of Lead Dimethyldithiocarbamate for Possible ... Full Report PDF Abstract The lead salt of bis(dimethyldithiocarbamic) acid is used ...
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Minutes: BSC RoC; Oct. 14, 2003 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2003/rocmin101403.pdf
Neutrons ......4 Lead and Lead Compounds ......
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Comment: Antimony Trioxide (Attachment); Caroline Braibant, Geert... 9.7MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/braibant_attach2.pdf
Registrant's Identity: Campine NV Lead Registrant of Diantimony trioxide- JS ATO- ... trioxide EC no.: 215-481-4 < 0.1 % (w/w) lead monoxide EC no.: 215-267-0 < 0.25 % (w/w) ...
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Minutes: BSC; May 10, 2010 200KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/may/minutes20100510.pdf
APPROACH FOR THE EVALUATION OF LOW-LEVEL LEAD...... 19 PRESENTATION OF ... Dr. Carney, the first lead discussant, said he was surprised that only two human exposure ...
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Minutes: BSC; June 21-22, 2012 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/june/bscminutes20120622_508.pdf
Monograph on Health Effects of Low-Level Lead ......B. BSC Discussion Dr. Lisa Minor, first lead reviewer, considered the modification of the ...
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Abstract for TR-86 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr086
Abstract 1,2-Dibromoethane, a volatile saturated brominated hydrocarbon, is used principally as a lead scavenger in tetra-alkyl lead gasoline and antiknock preparations but also as ...
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Documents Provided to the NTP Board of Scientific Counselors... 55.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf
... monograph Kyla W. Taylor, Ph.D., Project Lead John R. Bucher, Ph.D. Andrew A. Rooney, ... Manager Christopher A. Sibrizzi, M.P.H., Lead Work Assignment Manager Contributors ...
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Minutes: BSC; Dec. 6, 2007 262KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2007/december/bsc_mins2007dec06_508.pdf
......... 25 VII. Review of Lead and Cadmium for the Center for the ......... 27 Lead......
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... for Lead and Copper: Improvements (LCRI) The U.S. Environmental Protection Agency (EPA) is proposing revisions to the National Primary Drinking Water Regulation (NPDWR) for lead ...
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Abstract for TR-389 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr389
Abstract Sodium azide is a white crystalline solid used in the manufacture of the explosive lead azide. It is the principal chemical used to generate nitrogen gas in automobile ...
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Esophagus - Ulcer - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/esophagus/Ulcer
Esophageal erosions, ulcers, and necrosis are frequently the result of gavage accidents. Such trauma can lead to perforation, periesophageal abscesses, and fibrosis. An erosion is ...
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NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf
... for the two exposure scenarios that can lead to circadian disruption- persistent night ... Role Collaborator Affiliation Co-project leads Ruth M. Lunn, DrPH NIEHS, DNTP, ORoC ...
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Carpels Antimony Trioxide public comment 545KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/publiccomm/carpels20180110_508.pdf
I. Introduction Campine 1 is in the lead and antimony business for more than 100 years. ... of ATO in masterbatches, we recycle lead acid batteries (including antimonial lead) ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB
https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf
... 2014. Speciation and phytoavailability of lead and antimony in a small arms range soil ... A, Regina IS. 2012. Antimony, arsenic and lead distribution in soils and plants of an ...
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Salivary Gland, Duct - Concretion - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Duct-Concretion
They may be seen with atrophy. Concretions or foreign bodies can lead to duct dilation, inflammation, and fibrosis. Recommendations: A concretion in a salivary duct should be ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
... Cadmium is generally the by-product of processing sulfide ores for zinc, lead, and copper ... a commercial grade that has a purity of about 98% with lead, zinc, and iron as impurities. ...
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Monograph: Summary of NTP Cancer Hazard Conclusions: Exposure... 870KB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal_summary20210400_508.pdf
for two exposure scenarios that can lead to circadian disruption: persistent night ... Collaborators Role Collaborator Affiliation Co-project leads Responsible for execution and ...
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Comment: National Toxicological Program (NTP) Board of Scientific... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/05_kennedy_bsc_508.pdf
Asbestos was linked to cancer in the 1930's . Asbestos was removed from intra oral bandages in 1980 . Lead was introduced for the model A Ford in 1929 . Lead was removed from ...
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Abstract for TR-55 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr055
Although the major use of 1,2-dichloroethane is as an intermediate in the synthesis of vinyl chloride, the compound also finds application as a constituent in lead-containing ...
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Protocol to Evaluate the State of the Science for Transgenerational... 855KB
https://ntp.niehs.nih.gov/ntp/ohat/transgenerational/protocol201506_508.pdf
early life exposures can lead to disease outcomes much later in life (Barker et al. 2002). ... by two screeners (one of which will be the project lead, who will screen all references). ...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
... AROMATIC HYDROCARBON EXPOSURE Project co-leads: Andrew A. Rooney Ph.D., Integrated Health ... from prolonged exposure to stimuli can lead to chronic inflammation, long-term ...
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Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf
... Role Collaborator Affiliation Project lead Responsible for execution and coordination ... other forms of inorganic antimony that might lead to exposure to antimony(III) trioxide. ...
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Highlights From 2020 OECD WNT Meeting (ICCVAM Public Forum 2020... 284KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2020/ppt/15-oecd-hall-508.pdf
USG National Coordinator for the OECD TG Programme (hall.wanda@epa.gov) 2 No. Title Lead 2 ... NEW PROJECTS APPROVED 3 No. Title Lead Outcome of Evaluation 1 Bioelution Test Method EC ...
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TR-581: Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr581_508.pdf
... hexahydrate may lead the reader to conclude that the exposure concentrations were based on the heptahydrate or hexahydrate form, respectively. This may further lead a reader to ...
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FDA Update: ICCVAM Public Forum 2015 301KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/fda-iccvampubforum-2015-508.pdf
FDA-ICCVAM 3Rs A. Jacobs May 27, 2015 Tox21 activities in the past year . CDER was the lead center until 2014 . CFSAN and the FDA Foods program took over as the lead in 2014 . ...
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Human Cancer Studies; Suril Mehta; RoC; Jan. 24, 2018 644KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/presentations/humancancerstudies_508.pdf
Potential confounders among lung cancer risk factors - Occupational: arsenic, lead, ... Potential confounders among stomach cancer risk factors - Occupational: lead, asbestos - ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... 77-09-8 see Phenolphthalein 77-78-1 see Dimethyl Sulfate 78-00-2 (tetraethyl lead) see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see Trichloroethylene 79-06-1 see ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
In addition, cancer at the injection site was observed in rats following administration of chromium compounds (calcium chromate, lead chromate, basic lead chromate, zinc chromate, ...
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Agenda: ICCVAM 2016 Public Forum 82KB
https://ntp.niehs.nih.gov/sites/default/files/iccvam/meetings/iccvam-forum-2016/iccvampf-2016-05-25-agendav6.pdf
2016 (9:00 AM - 3:00 PM) Time Agenda Item Leads 9:00 AM 1. Welcome and Introductions ... 2 Time Agenda Item Leads 2:00 PM 6. Public Comments (20 min) Written Comments Submitted . ...
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Inflammation-based Atherosclerosis Associated with Environmental... 66KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/ongoing/atherosclerosis
The extent to which environmental exposures ultimately lead to adverse health effects ... contribute to inflammation that leads to atherosclerosis and to evaluate key ...
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Tooth, Ameloblast - Atrophy - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/tooth/Ameloblast-Atrophy
Focal atrophy of ameloblasts can lead to enamel hypoplasia, which is difficult to assess ... Atrophy can lead to squamous metaplasia of ameloblasts, characterized by loss of the ...
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Bone - Physeal Dysplasia - Nonneoplastic Lesion Atlas 292KB
https://ntp.niehs.nih.gov/atlas/nnl/musculoskeletal-system/bone/PhysealDysplasia
the physis can lead to physeal thickening and dysplasia (Figure 1 image opens in a pop-up window ); this is an example of decreased cartilage resorption. This leads to a ...
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Skeletal Muscle- Nonneoplastic Lesion Atlas 277KB
https://ntp.niehs.nih.gov/atlas/nnl/musculoskeletal-system/skeletal-muscle
Responses of skeletal muscle to insult and stimulation represent a robust constellation of mixed reactions. Stimulation can lead to hypertrophy, while disuse can result in atrophy; ...
