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TR-451: Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1... 27.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdf
... O N THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF NICKEL OXIDE (CAS NO. 1313-99-1) IN F344/... Public Health Service National Institutes o f Health 2 Nickel Oxide, NTP TR 451 ...
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TR-453: Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and... 17.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr453.pdf
STUDIES OF NICKEL SUBSULFIDE (CAS NO. 12035-72-2) IN F344/N RATS AND B6C3Fl M I C E ... ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF NICKEL SUBSULFIDE (CAS NO. 12035-72-2) IN ...
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TR-454: Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344... 19.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr454.pdf
TOXICOLOGY AND CARCINOGENESIS STUDIES OF NICKEL SULFATE HEXAHYDRATE (CAS NO. 10101-97-0) ... ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF NICKEL SULFATE HEXAHYDRATE (CAS NO. ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
NICKEL COMPOUNDS FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the ... NOl-ES-25346 1 NTP Report On Carcinogens 1998 Background Document For Nickel Compounds ...
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RoC Background Document: Metallic Nickel and Certain Nickel Alloys... 1.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/ni_no_appendices_508.pdf
FINAL Report on Carcinogens Background Document for Metallic Nickel and Certain Nickel Alloys December 13 - 14, 2000 Meeting of the NTP Board of Scientific Counselors Report on ...
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RoC Profile: Nickel Compounds and Metallic Nickel; 15th RoC 2021 170KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nickel.pdf
Nickel Compounds and Metallic Nickel Introduction Nickel compounds and metallic nickel have many industrial and com- mercial applications, including use in stainless steel and ...
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Abstract for TR-451 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr451
Abstract for TR-451 Toxicology and Carcinogenesis Studies of Nickel Oxide in F344/N Rats ... Names: Bunsenite; C.I. 77777; green nickel oxide; mononickel oxide; nickel monoxide; ...
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Abstract for TR-454 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr454
Abstract for TR-454 Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate in .../Common Names: Blue salt; hexahydrate, nickel (2+) salt; nickel monosulfate ...
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Abstract for TR-453 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr453
Abstract for TR-453 Toxicology and Carcinogenesis Studies of Nickel Subsulfide in F344/N ... Synonyms/Common Names: Heazlewoodite; nickel subsulphide; nickel sulfide (3:2); ...
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Minutes: BSC RoC; Dec. 13-15, 2000 205KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/minutes20001213.pdf
Methyleugenol ......7 . Metallic Nickel and Nickel Alloys ...
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Target Organs and Levels of Evidence for TR-451 59KB
https://ntp.niehs.nih.gov/data/tr/400s/tr451levels
of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Nickel ...
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Target Organs and Levels of Evidence for TR-453 59KB
https://ntp.niehs.nih.gov/data/tr/400s/tr453levels
Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Nickel ...
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Target Organs and Levels of Evidence for TR-454 59KB
https://ntp.niehs.nih.gov/data/tr/400s/tr454levels
Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in ... Route/Exposure Levels Study Laboratory Nickel sulfate hexahydrate 10101-97-0 11/29/1994 ...
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Minutes: BSC TRRS; Nov. 29, 1994 179KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1994/nov/trrs29nov1994mins_508.pdf
......5 Nickel Oxide 1313-99-1 Inhalation ......7 Nickel Subsulfide 12035-72-2 Inhalation ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
... NA Not available NC Not calculated Ni Nickel NICEATM National Toxicology Program ... the LLNA: DA can be used for testing metal compounds, with the exception of nickel. ...
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Abstract for TR-172 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr172
Sodium diethyldithiocarbamate is a chelating agent used primarily in the analytical determination of copper, arsenic, nickel, and other metals. Other applications include the ...
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Abstract for TR-88 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr088
Abstract 1H-Benzotriazole is an anticorrosive chemical used primarily on copper, but also on iron, steel, cadmium, chromium, zinc, and silver-nickel alloys. A bioassay of ...
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Abstract for TR-494 83KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494
an additive in the kraft pulping process in the paper industry, a catalyst in the isomerization of vegetable oils, an accelerator in nickel electroplating, and as a bird repellant. ...
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TOX-94: Toxicity Studies of 1020 Long Multiwalled Carbon Nanotubes... 2.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox094_508.pdf
... Table 2. Postexposure Lung Weights, Nickel Concentrations and Burdens, and 1020 Long ... Table 7. Postexposure Lung Weights, Nickel Concentrations and Burdens, and 1020 Long ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... NA Not available NC Not calculated Ni Nickel NICEATM National Toxicology Program ... with the accuracy of the LLNA: BrdU-ELISA. One exception would be nickel compounds. ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
... the LLNA appeared useful for the testing of metal compounds, with the exception of nickel. ... (2) metals, with the exception of nickel; (3) substances tested in aqueous ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
... Cadmium is also used in nickel-cadmium (Ni-Cd) batteries (electrode material), fungicides, ... Other consumer products include nickel-cadmium (nicad) batteries and cadmium-plated ...
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Studies on Historical Control Reports for NIH-07 Feed 312KB
https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf
nitrite Rats Fischer344 Inhalation Air Nickel oxide 2 Species Strain Route Vehicle Chemical Rats Fischer344 Inhalation Air Nickel subsulfide Rats Fischer344 Inhalation Air ...
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Presentation: Cobalt and Certain Cobalt Compounds Human Cancer... 479KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/presentations/humancancerstudies_508.pdf
- Occupational: asbestos, chromium, nickel, arsenic, soot, tar or radon. - ... et al. 2005 Incidence cohort of Norwegian nickel refinery workers in one refinery ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
Treated Mustard Gas 2-Naphthylamine Neutrons (see Ionizing Radiation) Nickel Compounds (see Nickel Compounds and Metallic Nickel) Radon (see Ionizing Radiation) Silica, ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
Chrome platers are exposed to soluble chromium(VI) compounds and possibly to nickel. ... Chrome platers are exposed to soluble chromium(VI) compounds and possibly to nickel. ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
... found in ores associated with copper or nickel, but may also be a by-product of zinc, ... Cobalt is used in nickel-cadmium, nickel-metal hydride, and lithium-ion battery ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB
https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf
... arsenic, and metals (lead, cadmium, nickel, mercury, thallium, and uranium) in urine ... Update of cancer incidence among workers at a copper/nickel smelter and nickel refinery. ...
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Draft RoC Monograph Cobalt: RoC Peer Review; July 22, 2015 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph.pdf
... found in ores associated with copper or nickel, but may also be a by-product of zinc, ... Cobalt is used in nickel-cadmium (Ni-Cd), nickel-metal hydride (Ni-MH), and lithium- ion ...
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DOI Update: ICCVAM Public Forum 2014 342KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2014/7-doi-alternativetestingmethodactivities-rattnerf.pdf
tungsten-iron tungsten-matrix tungsten-nickel-iron tungsten-polymer tungsten-tin-bismuth tungsten-tin-iron tungsten-tin-iron-nickel Bottom Line - many shot types registered ...
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Background Document: RoC: Cobalt-Tungsten Carbide: Powders and... 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/hardmetalsbd20100408_508.pdf
... to any "IARC carcinogen" (PAHs, silica, nickel compounds, chromium compounds, or cobalt ... of metallic tungsten with cobalt and nickel has been reported to cause tumors at the ...
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Revised Draft RoC Monograph Cobalt: RoC Peer Review; July 22... 3.0MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt.pdf
... found in ores associated with copper or nickel, but may also be a by-product of zinc, ... Cobalt is used in nickel-cadmium, nickel-metal hydride, and lithium-ion battery ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... National Toxicology Program (NTP). 1996. Toxicology and Carcinogenesis Studies of Nickel ... NTP Technical Report on the Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN ...
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TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox35.pdf
... chloride 11 .2 1 .125 3 .75 11 .25 37.5 Nickel 0 .5 0 .204 0 .68 2 .04 6 .8 Phenol 3 .27 ... With the exception of three metals (cadmium, chromium, and nickel) for which the maximum ...
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Appendix C; 15th RoC 2021 46KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_c.pdf
Methyl tert-butyl ether (MTBE) 1634-04-4 Ninth RoC 1998 Rodent cancer data were not sufficient. https://ntp.niehs.nih.gov/ntp/newhomeroc/other_ background/mtbe1_508.pdf Nickel ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... hydrochloride) see Procarbazine and Its Hydrochloride 373-02-4 (nickel acetate) see Nickel and Nickel Compounds 434-07-1 see Oxymetholone 443-48-1 see Metronidazole ...
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Draft RoC Monograph Cobalt Appendix: RoC Peer Review; July 22... 1.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph_appen.pdf
... conc. a Thomassen et al. (1999) Russia Nickel refinery workers 346 7.8 White and Dyne ... Nickel and cobalt production workers And age-matched healthy workers unexposed to Co Mean ...
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Revised Draft RoC Monograph Cobalt Appendix: RoC Peer Review... 1.7MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt_append.pdf
... f 10.8 (Thomassen et al. 1999) Russia Nickel refinery workers 346 7.8 (White and Dyne ... Nails conc. (Bencko et al. 1986) Czech Republic. Nickel and cobalt production workers And ...
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Peer Review Panel Report: Validation Status of the LLNA (2008... 6.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2008.pdf
... appears to be useful for the testing of metal compounds, with the exception of nickel. ... tool for metals, with the exception of nickel, which produces variable responses. ...
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Abstract for TOX-94 73KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox094
amount of residual nickel catalyst (0.52% by weight). The average L-MWNT-1020 nanotube length was 2,600 nm and the average width was 15.3 nm. Because nickel was shown to be ...
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Federal Agency Response to ICCVAM Recommendations on the LLNA 1.1MB
https://ntp.niehs.nih.gov/iccvam/methods/immunotox/transmitjune10/fda-response.pdf
LLNA: BrdU-ELlSA can be used for testing nickel compounds based on its ability to ... The LLNA: DA can be used for testing metal compounds, with the exception of nickel. FDA ...
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RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf
... Cobalt is one of a group of metals (transition metals, like iron and nickel) that promote ... In the cohort studies, hard-metal (Moulin et al. 1998, Wild et al. 2000) and nickel-refine...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... For example, nickel salts and streptomycin were each considered negative in the LLNA because most of the LLNA responses were negative (8/10 tests for nickel salts; 4/5 tests for ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... certain types of test substances, such as nickel salts, mixtures, high-molecular weight ... Chemicals and substances included in these tests (e.g., nickel, rubber, and fragrance ...
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Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot... 491KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf
magnetic alloys with aluminum, copper, nickel (Ni) or titanium; (3) high strength ... carcinomas and erythrocytosis in rats following intrarenal injection of nickel subsulfide. ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
.../other_ background/mtbe1_508.pdf Nickel alloys Tenth RoC 2000 Human data were ... and Inorganic Arsenic Compounds metallic nickel see Nickel Compounds and Metallic Nickel ...
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TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 13.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr471.pdf
... combination with other ele- ments such as nickel, arsenic, or tungsten; adverse ... arsenic and nickel in the French plant and tungsten carbide in the Swedish facility. ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... LLNA test when metal salts, including nickel and copper salts, are applied to the skin. ... page C-22) that a LLNA false negative for nickel sulfate is " . . . as unsurprising as it ...
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TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/2023-08/tr471_508.pdf
... combination with other ele- ments such as nickel, arsenic, or tungsten; adverse ... arsenic and nickel in the French plant and tungsten carbide in the Swedish facility. ...
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RoC Background Document: Beryllium Compounds; Dec. 16-17, 1999 5.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
... alloy beryllium-copper alloy beryllium-nickel alloy beryl ore bertrandite chrysoberyl ... Ni, Fe, and Co 11133-98-5 NR NR NR 870-980 NR NR NR toxic fumes of BeO Beryllium-nickel ...
