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TR-097: Titanium Dioxide (CASRN 13463-67-7) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr097.pdf
Report Series No. 97 BIOASSAY OF TITANIUM DIOXIDE FOR POSSIBLE CARCINOGENICITY CAS ... Institutes of Health BIOASSAY OF TITANIUM DIOXIDE FOR POSSIBLE CARCINOGENICITY ...
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Titanium dioxide: Target Organs and Levels of Evidence for TR... 56KB
https://ntp.niehs.nih.gov/data/tr/000s/tr097levels
3 Titanium dioxide: Target Organs and Levels of Evidence for TR-097 Bioassay of Titanium Dioxide for Possible Carcinogenicity (CASRN 13463-67-7) Chemical (Study Title) CASRN Peer ...
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Abstract for TR-97 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr097
Bioassay of Titanium Dioxide for Possible Carcinogenicity CASRN: 13463-67-7 Chemical Formula: O2Ti Molecular Weight: 79.865 Report Date: 1979 Full Report PDF Abstract Titanium ...
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Abstract for TR-399 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr399
.../Common Names: Titanium ferrocene; biscyclopentadienyltitanium dichloride;dichlorodi-p-cyclopentadienyltitanium; dichlorobis(h5-2,4-cyclopentadien-1-yl)titanium; ...
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TR-399: Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats... 8.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr399.pdf
... APPENDIX E Analysis of Tissue Residues for Titanium in the Gavage Studies ...... Molecular Weight: 248.99 Synonyms:Titanium ferrocene; biscyclopentadienyltitanium ...
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Lung - Keratinizing Cyst - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/lung/KeratinizingCyst
Keratinizing cysts are typically seen in rats after inhalation exposure to particulate material (e.g., talc, titanium dioxide), though they are also seen in rats exposed by gavage ...
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TOX-74: Cellulose Insulation 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox074_rev.pdf
... (talc), potassium aluminum silicate hydroxide (muscovite), and titanium dioxide (rutile). ... Rats received CI, titanium dioxide (particle controls), or sterile saline (controls). BAL ...
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RoC Background Document: Metallic Nickel and Certain Nickel Alloys... 1.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/ni_no_appendices_508.pdf
......... 49 pure nickel, stainless steel, nickel-titanium alloy, and pure titanium ...... 56 culture medium after ...
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Abstract for TOX-74 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox074
(talc), potassium aluminum silicate hydroxide (muscovite), and titanium oxide (rutile). ... Rats received CI, titanium dioxide (particle controls), or sterile saline (controls). BAL ...
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Lung - Keratinizing Cyst 384KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/lung/keracyst/lung-keratinizing-cyst-508.pdf
Comment: Keratinizing cysts are typically seen in rats after inhalation exposure to particulate material (e.g., talc, titanium dioxide), though they are also seen in rats exposed ...
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Public Comment: Carbon black; Robert MCunney; RoC; Jan. 19, 2012 1.3MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/mccunney20120227.pdf
... Subjects with occupational exposure to carbon black, 9 titanium dioxide, industrial talc ... has also been observed in a range of PSPs with low toxicity, such as titanium dioxide. ...
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Public Comment: Carbon black; Jimmy Boyd; RoC; Jan. 19, 2012 1.3MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/boyd20120227.pdf
... Subjects with occupational exposure to carbon black, 9 titanium dioxide, industrial talc ... has also been observed in a range of PSPs with low toxicity, such as titanium dioxide. ...
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RoC Profile: Cupferron; 15th RoC 2021 165KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cupferron.pdf
In analytical laboratories, cupferron is a reagent used for quantitative determination of vana- dates and titanium and the colorimetric determination of aluminum (NCI 1978, HSDB ...
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Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot... 491KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf
turbine aircraft engines); (2) magnetic alloys with aluminum, copper, nickel (Ni) or titanium; (3) high strength steels; (4) electro-deposited alloys; (5) as a component oflithium ...
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NCTR SOT Presentations; SOT; March 19-23, 2023 289KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/pressctr/ntp_news/2023/sot_nctr_508.pdf
... Abstract Number: 2000, Oral Presentation Title: Effect of Food-Grade Titanium Dioxide on DNA Methylation in Human Cells National Center for Toxicological Research (NCTR) ...
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Background Document: RoC: Cobalt-Tungsten Carbide: Powders and... 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/hardmetalsbd20100408_508.pdf
... Ta(Nb)C: tantalum niobium carbide TiC: titanium carbide TLV: threshold limit value ... with other metallic carbides such as titanium carbide or tantalum carbide; see Table ...
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Public Comment: Carbon black (Attachment); Sarah Amick; RoC;... 92KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/amickattach_508.pdf
... Carbon Black, Titanium Dioxide, and Talc at 63, available at http://monographs.iarc.fr/ENG/Monographs/vol93/mono93.pdf (IARC 2010 Monograph). 4 International Carbon Black ...
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TR-098: dl-Menthol (CASRN 89-78-1) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr098.pdf
... Rats Feed Studies (CAS 13463-67-7) titanium dioxide (CAS 119-53-9) benzoin (CAS ... fed dl-menthol, together with those fed titanium dioxide and those fed benzoin, were ...
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Presentation: Cobalt and Certain Cobalt Compounds Studies in... 539KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/presentations/experimentalanimals_508.pdf
... Cobalt metal (nanoparticle) and nickel implants induced tumors in rats . Titanium dioxide, silicon dioxide, and PVC implants did not induce tumors, although they have the same ...
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RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf
... after implantation of substances (e.g., titanium dioxide and silicon diox- ide) with the ... Other metals, such as nickel, tungsten, iron, aluminum, and titanium, may also be used in ...
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Public Comment: Carbon black; Patrick Beatty; RoC; Jan. 19, 2012 118KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/beatty20120227.pdf
... This effect is not restricted to carbon black but is also seen in other "inert" particulates such as titanium dioxide and talc. The existence of airborne concentrations of carbon ...
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Public Comment: Carbon black; Sarah Amick; RoC; Jan. 19, 2012 167KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/amick20120228.pdf
... Community Right-to-Know; Titanium Dioxide, 53 Fed. Reg. 23106, 23111 (1988), which concluded that titanium dioxide is not a carcinogen despite lung overburden rat study results. ...
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Minutes: BSC Nano. Working Group; June 24, 2005 235KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2005/nwgminutes20050624_508.pdf
... and phototoxicity studies of titanium dioxide (TIO2), zinc oxide (ZNO), and quantum dots . ... Initial NTP focus areas: single and multi-walled nanotubes, fullerene C60, titanium ...
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TR-138: Sulfisoxazole (CASRN 127-69-5) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr138.pdf
... 89-78-1) dl-menthol (CAS 13463-67-7) titanium dioxide Gavage Studies (CAS 108-60-1) ... phenol At week 48, the rats fed titanium dioxide, dl-menthol, or benzoin were ...
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Mining Potential Chemical Co-exposures from Consumer Product... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2021/20210126-iccvam-cop-isaacs-508.pdf
... Reduced rank relative to overall population Potentially lower exposure for the demographic Most Prevalent Single Chemicals e.g., titanium dioxide has a higher prevalence rank for ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf
... The pulvules also contain starch, gelatin, silicone, titanium dioxide, iron oxide, and ... II II-3 methylcellulose, titanium dioxide, polyethylene glycol, and yellow iron oxide. ...
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CERHR Monograph: Methylphenidate 11.6MB
https://ntp.niehs.nih.gov/ntp/ohat/stimulants/methylphenidate/methylphenidatemonograph.pdf
... lactose,. magnesium. stearate,. mineral.oil,.povidone.titanium.dioxide,.and.zein. ...oxide,.sugar.spheres,.talc,.titanium. dioxide,.triethyl.citrate,.and/or.yellow.iron.oxide. ...
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TR-100: Cupferron (CASRN 135-20-6) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr100.pdf
... It also finds application as a quantitative reagent for vanadates and titanium and for the colori- metric estimation of aluminum (Windholz, 1976). The chelating properties of ...
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TR-204: Benzoin for Possible Carcinogenicity (CASRN119-53-9) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr204.pdf
... dimethyl terephthalate (CAS 1346-67-7) titanium oxide Gavage Studies (CAS 108-60-1) ... dimethyl terephthalate (CAS 1346-67-7) titanium oxide Gavage Studies (CAS 108-60-1) ...
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TR-121: Dimethyl Terephthalate (CASRN 120-61-6) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr121.pdf
... (CAS 119-53-9) benzoin (CAS 13463-67-7) titanium dioxide (CAS 89-78-1) dl-menthol Gavage ... (CAS 119-53-9) benzoin (CAS 13463-67-7) titanium dioxide (CAS 89-78-1) dl-menthol 10 ...
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Minutes: BSC; Dec. 13, 1996 288KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/december/19961213_bsc_508.pdf
... as a possible indicator for study, he noted that two of the highest production volume inorganics have been subjects of two- year studies, - carbon black and titanium dioxide. ...
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TR-191: Technical Grade Bis(2-chloro-1-methylethyl) ether (CASRN... 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr191.pdf
... (CAS 120-61-6) dimethyl terephthalate (CAS 89-78-1) dl-menthol (CAS 13463-67-7) titanium dioxide Gavage Studies (CAS 127-69-5) sulfisoxazole (CAS 7446-34-6) selenium sulfide ...
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TR-194: Selenium Sulfide (Gavage) (CASRN 7446-34-6) 4.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr194.pdf
... (CAS 119-53-9) benzoin (CAS 13463-67-7) titanium dioxide (CAS 89-78-1) dl-menthol (CAS ... (CAS 119-53-9) benzoin (CAS 13463-67-7) titanium dioxide (CAS 89-78-1) dl-menthol (CAS ...
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RoC Profile: Diesel Exhaust Particulates; 15th RoC 2021 151KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dieselexhaustparticulates.pdf
... O, Bellmann B, Koch W, Levsen K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel-engine exhaust, carbon- black, and titanium-dioxide. ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
... such as nickel, tungsten, iron, aluminum, and titanium may also be used in implants. ... The most common metal components consist of either cobalt chrome or titanium (Novick ...
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Minutes: BSC Nano. Working Group; March 15, 2006 160KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2006/minutesnwg20060315_508.pdf
... physicochemical characteristics of metals oxides in sunscreens. o Evaluate dermal penetration of metal oxides in sunscreens. o Evaluate photocarcinogenicity of titanium oxide. . ...
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TR-421: Talc (CASRN 14807-96-6)(Non-Asbestiform) in F344/N Rats... 16.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr421.pdf
... the relatively more inert particles like titanium dioxide and talc (Saffiotti andStinson, ... In 2-year inhalation studies o f titanium dioxide (Lee e? af., 1985), chromium dioxide ...
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Peer Review Panel Report: Validation Status of the LLNA (2008... 6.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2008.pdf
... used as cosmetic ingredients (e.g., titanium dioxide) and aluminum compounds ... used as cosmetic ingredients (e.g., titanium dioxide) and aluminum compounds ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
... uranium, radium, vanadium, mercury, titanium, tungsten, nickel, antimony, copper, ... fully adjusted model: above and titanium dioxide, acrylic fibers, polyethylene, ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
... nickel(2+) tank cars) ) Nickel titanate; Nickel titanium oxide 12653-76-8 NiTiO 154.61 I< Nickel titanate; Nickel titanium oxide (NiTi03) 12035-39-1 M0778 Ni03Ti; NiTi03 ...
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Minutes: BSC; April 13, 2011 257KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf
... carbon nanotubes, fullerenes, and titanium dioxide, as well as newer, emerging ENMs ... example, NIOSH recently issued recommendations for titanium dioxide and carbon nanotubes. ...
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TOX-33: 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox33.pdf
... Functional group titration by nitro 0 reduction with titanium (III) chloride followed by ... Functional group titration by nitro reduction with titanium (III) chloride followed by ...
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Peer Review Panel Report: Updated Validation Status of the LLNA... 807KB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2009.pdf
... materials (chemically characterized extracts), and nanomaterials (e.g., titanium oxide). ... Nanomaterials (e.g., titanium oxide) The Panel viewed that available data for substances ...
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RoC Profile: Certain Glass Wool Fibers (Inhalable); 15th RoC... 235KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/glasswoolfibers.pdf
... These modifiers include oxides of aluminum, titanium, zinc, magnesium, lithium, barium, calcium, sodium, and potassium. Glass wool products consist of individual fibers, which have ...
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Background Document: RoC: Glass Wool Fibers; 2010 3.7MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf
... These modifiers include oxides of aluminum, titanium, zinc, magnesium, lithium, barium, ... × 3 i.t. 24 mo 0/12 Gross et al. 1970 Titanium dioxide (granular dust as control) 0 0 1 ...
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TOX-91: Abrasive Blasting Agents Administered by Inhalation to... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox091_508.pdf
... as respirable quartz, arsenic, beryllium, cadmium, lead, chromium, manganese, nickel, titanium, silver, and vanadium. 4 They do not consider the potential risks of exposure to ...
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TR-361: Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage... 7.2MB
https://ntp.niehs.nih.gov/go/tr361
... No deaths occurred in 42 rats exposed to titanium dioxide-hexachloroethane compared with 7/42 in the group exposed to zinc-hexachloroethane. It is not clear if hexachloroethane ...
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TR-203: Phenol for Possible Carcinogenicity (CASRN108-95-2) 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr203.pdf
... bioassays conducted under this contract were 8/50 (16%) for benzoin (CAS 119-53-9), 14/49 (29%) for titanium dioxide (CAS 1309-63-3), and 14/49 (29%) for dl-menthol (CAS 89-78-1). ...
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TR592: Dietary Zinc (CASRN 5263-02-5) In Sprague Dawley Rats... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr592_508.pdf
... As a weak metal, zinc is typically alloyed with other metals (e.g., aluminum, copper, titanium, and magnesium) to increase its strength. Industry consumption of zinc in 2002 was ...
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TOX-44: o-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride... 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox044.pdf
... Karl Fischer ana lysis indicated 0.021% ± 0.003% water. Functional group titration, by nitro reduction wit h titanium (III) chloride followed by back titration with standardized ...