Background Document: RoC: Cobalt-Tungsten Carbide: Powders and... 1.9MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/hardmetalsbd20100408_508.pdf

Report on Carcinogens Background Document for Cobalt-Tungsten Carbide: Powders and Hard ... Blank RoC Background Document for Cobalt-Tungsten Carbide: Powders and Hard Metals 3/16/09 ...

Cobalt-Tungsten Carbide Powders and Hard Metals Expert Panel... 6.5MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_panelreportparta_508.pdf

A - Peer Review of the Draft Background Document on Cobalt-Tungsten Carbide Powders and Hard Metals The Report on Carcinogens (RoC) expert panel for cobalt-tungsten carbide powders ...

Cobalt-Tungsten Carbide Powders and Hard Metals Expert Panel... 700KB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_panelreportpartb_508.pdf

for Cobalt-Tungsten Carbide Powders and Hard Metals and Scientific Justification for the Recommendation The Report on Carcinogens (RoC) expert panel for cobalt-tungsten carbide ...

Agenda: RoC Cobalt-Tungsten Carbide Powders and Hard Metals Expert... 111KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_agenda20081210.pdf

Report on Carcinogens (RoC) Cobal t-Tungsten Carbide Powders and Hard Metal s Expert Panel ... Zan Persichetti - Extrude Horne Corp . Dr. John Schell, International Tungsten Industry ...

RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf

That Release Cobalt Ions In Vivo and Cobalt-Tungsten Carbide: Pow- ders and Hard Metals. ... Cobalt-tungsten carbide was first listed in the Twelfth Report on Carcinogens. The pro- ...

Roster: RoC Cobalt-Tungsten Carbide Powders and Hard Metals Expert... 120KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_roster20081210.pdf

Report on Carcinogens (RoC) Cobalt-Tungsten Carbide Powders and Hard Metals Expert Panel Roster December 9 th -10 th , 2008 Max Costa, Ph.D., Chair Steven Markowitz, M.D. New York ...

Report on Carcinogens (RoC) Expert Panel Meeting: Cobalt-Tungsten... 60KB

https://ntp.niehs.nih.gov/events/past/2000s/2008/panel_2008-12-09

Report on Carcinogens (RoC) Expert Panel Meeting: Cobalt-Tungsten Carbide Powders and Hard ... Report on Carcinogens (RoC) Expert Panel Meeting: Cobalt-Tungsten Carbide Powders and Hard ...

Comment: Toxicology and Carcinogenesis Studies of Sodium Tungstate... 143KB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/publiccomm/lemus20210318_trprp_508.pdf

International Tungsten Industry Association Submitted electronically via US NTP portal ... 599 Dear Sir/Madam, The International Tungsten Industry Association (ITIA) is ...

TR-599: Sodium Tungstate Dihydrate in Sprague Dawley (Hsd:Sprague... 4.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr599_508.pdf

... Clinical Examinations, Tungsten Concentrations, and Pathology ... D-1 Appendix E. Tungsten Concentration Determination ......

Draft TR-599: Sodium Tungstate Dihydrate (CASRN 10213-10-2) in... 3.4MB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr599_508.pdf

... 4 Clinical Examinations, Tungsten Concentrations, and Pathology ... D-1 42 Appendix E. Tungsten Concentration Determination ......

Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate... 552KB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/presentations/02sodiumtungstate_behlv2_508.pdf

2, 2021 Background 1 .Tungsten is present naturally in the environment and can enter waterways through weathering of rocks and soil .Hence, tungsten was nominated for study ...

Minutes: BSC; June 21-22, 2010 364KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/june/minutes20100622.pdf

the 12 th Report on Carcinogens: Cobalt- Tungsten Carbide: Powders and Hard Metals ... Risks to Human Reproduction CoWC cobalt-tungsten carbide: powders and hard metals DERT ...

NTP Response to BSC Peer Review Comments on the Draft Substances... 324KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/response062110bsc2011.pdf

Roster of Attending Members 3 Cobalt-Tungsten Carbide: Powders and Hard Metals 4 BSC ... substances were reviewed: cobalt-tungsten carbide: powders and hard metals, ...

DOI Update: ICCVAM Public Forum 2014 342KB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2014/7-doi-alternativetestingmethodactivities-rattnerf.pdf

of Non-toxic Shot lead replacements: steel bismuth-tin copper-clad iron tungsten-bronze tungsten-iron tungsten-matrix tungsten-nickel-iron tungsten-polymer ...

Research Concept: Cobalt; 2014 690KB

https://ntp.niehs.nih.gov/ntp/roc/concept_docs/2014/cobalt_508.pdf

Two cobalt compounds, 'cobalt sulfate' and 'cobalt-tungsten carbide: powders and hard ... and classified 'cobalt metal without tungsten carbide' and 'cobalt sulfate and other ...

Revised Draft RoC Monograph Cobalt: RoC Peer Review; July 22... 3.0MB

https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt.pdf

... Cobalt is used in alloys or composites, such as cobalt-tungsten carbide, and in ... Two cobalt-containing substances, 'cobalt sulfate' and 'cobalt-tungsten carbide: powders ...

Draft RoC Monograph Cobalt: RoC Peer Review; July 22, 2015 2.8MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph.pdf

... Cobalt is used in alloys or composites, such as cobalt-tungsten carbide, and in ... Two cobalt-containing substances, 'cobalt sulfate' and 'cobalt-tungsten carbide: powders ...

Response to Expert Panels' Peer-Review Comments on Background... 354KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/responseexpertpanelreport2011.pdf

Comments 7 References 8 Cobalt-Tungsten Carbide: Powders and Hard Metals 9 ... Panels' Peer-Review Comments Cobalt-Tungsten Carbide: Hard Metals and Powders 9 ...

Minutes: BSC; July 7, 2009 399KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/july/minutes20090724.pdf

......... 49 Tungsten Oxide ......for these two nominations and cobalt-tungsten carbide powders and hard metals will be ...

Abstract for TR-581 92KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr581

been raised about the occurrence of occupational disease, i.e. hard metal disease, associated with exposure to cobalt and its compounds, including cobalt metal-tungsten carbide. ...

Dept. of the Interior Alternative Test Method Activities (ICCVAM... 1.5MB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2019/12-leet-doi_508.pdf

... Registration of Non-toxic Shot Lead shot replacements: iron (steel) iron-tungsten bismuth-tin copper-clad iron corrosion-inhibited copper tungsten-bronze tungsten-iron ...

RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB

https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf

... Cobalt is used in alloys or composites, such as cobalt-tungsten carbide, and in ... Two cobalt-containing substances, cobalt sulfate' and cobalt-tungsten carbide: powders and ...

Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot... 491KB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf

... of Co and tungsten carbide, and is not seen in workers exposed only to Co. This finding is consistent with in vitro results indicating that Co and tungsten carbide ...

Agenda: BSC; June 21-22, 2010 84KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/june/agenda20100621.pdf

Gloria Jahnke, NIEHS/NTP Dr. Novak 12:15 PM LUNCH 1:00 - Glass Wool Fibers (continued) 3:00 BREAK 3:30 - Cobalt-Tungsten Carbide: Powders and Hard Metals . Public Comments . BSC ...

ICCVAM 2018 Public Forum Presentation: Dept. of the Interior... 1.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2018/12-doi.pdf

... Shot Lead shot replacements: iron (steel) iron-tungsten bismuth-tin copper-clad iron corrosion-inhibited copper tungsten-bronze tungsten-iron tungsten-matrix ...

Presentation: Cobalt and Certain Cobalt Compounds Human Cancer... 479KB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/presentations/humancancerstudies_508.pdf

exposed to "other" cobalt, not including tungsten carbide Wild et al. 2000 Historical ... 1 exposed case "Cobalt alone" (w/o tungsten carbide) not controlled for other ...

15th RoC: Appendix F 174KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

... Co/WC see Cobalt-Related Exposures, Cobalt-Tungsten Carbide: Powders and Hard Metals ... see Cobalt-Related Exposures, Cobalt-Tungsten Carbide: Powders and Hard Metals ...

Draft RoC Monograph Cobalt Appendix: RoC Peer Review; July 22... 1.7MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph_appen.pdf

... 1.6 µg/g Powder processing- 28.5 Tungsten carbide production- 2.1 Sintering- 4.1 ... of cobalt at secondary cobalt facilities processing tungsten carbide scrap raw materials. ...

Presentation: Cobalt and Certain Cobalt Compounds: Properties... 908KB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/presentations/humanexposure_508.pdf

Pigments, driers, catalysts, adhesives . Animal diets Cemented carbides and bonded diamonds . Tungsten carbides ("hard metals") . Steel with microdiamonds impregnated into surface ...

Revised Draft RoC Monograph Cobalt Appendix: RoC Peer Review... 1.7MB

https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt_append.pdf

... 1.6 µg/g Powder processing- 28.5 Tungsten carbide production- 2.1 Sintering- 4.1 ... of cobalt at secondary cobalt facilities processing tungsten carbide scrap raw materials. ...

RoC Profile: 4,4'-Methylenedianiline and Its Dihydrochloride... 141KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylenedianiline.pdf

... including the determination of tungsten and sulfates, as a cor- rosion inhibitor, as an antioxidant and curative agent in rubber, and to prepare azo dyes (IARC 1986, ATSDR 1998). ...

TOX-5: Cobalt Sulfate Heptahydrate CASRN 10026-24-1 2.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox005.pdf

... production of alloys, and in the tungsten carbide hard metal industry (Kazant- zis, 1981). ... Cobalt is used in the cemented tungsten carbide industry and is thought to be responsible ...

SOT Annual Meeting: NIEHS and NTP Activitie; March 7-11, 2010 281KB

https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/sot_49_activities.pdf

... AM-8:50 AM, Ballroom F (Convention Center) Informational Session Impact of Tungsten and Tungsten Alloys on Health Risk Chairpersons Palur G. Gunasekar and Michelle J. Hooth ...

RoC Background Document: Metallic Nickel and Certain Nickel Alloys... 1.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/ni_no_appendices_508.pdf

... na na Fe-Cr-Ni na Cobalt chromium nickel tungsten alloy na na Co-Cr-Ni-W na solid 316L na ... 46.8% cobalt, 19.63% chromium, 13.76% tungsten, 3.78% iron, 2.21% magnesium, 1.39% ...

Completed RoC Evaluations 119KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc

... RoC Review of Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo Cobalt-Tungsten Carbide Powders and Hard Metals Reasonably anticipated to be a human carcinogen ...

15th RoC: Glossary 200KB

https://ntp.niehs.nih.gov/ntp/roc/content/glossary_508.pdf

... tar a thick black liquid produced by distilling coal cobalt-tungsten carbide hard metal a composite of tungsten carbide particles with a metallic cobalt powder as a binder, ...

Listed Substances; 15th RoC 2021 76KB

https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

... Compounds That Release Cobalt Ions In Vivo (see Cobalt-Related Exposures) Cobalt-Tungsten Carbide: Powders and Hard Metals (see Cobalt-Related Exposures) p-Cresidine Cumene ...

Minutes: BSC; Oct. 26, 2004 769KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/october/bscmins2004oct26_508.pdf

... The International Tungsten Industry Association, which represents 48 companies producing and consuming tungsten, submitted comments on tungsten trioxide in which they clarified the ...

TR-581: Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1... 9.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr581_508.pdf

... with exposure to cobalt and its compounds, including cobalt metal-tungsten carbide. ... Production and Use Cobalt metal is widely used in the production of cemented tungsten-coba...

Minutes: BSC; Sept. 10-11, 2003 500KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf

... glycidamide, 4-phenylcyclohexene, tungsten 5. Nanoscale materials - nanocrystalline ... The International Tungsten Industry Association, which represents 48 companies producing ...

TOX-05: Cobalt Sulfate Heptahydrate in F344/N Rats and B6C3F1... 2.7MB

https://ntp.niehs.nih.gov/sites/default/files/2023-08/tox05_508.pdf

... production of alloys, and in the tungsten carbide hard metal industry (Kazant- zis, 1981). ... Cobalt is used in the cemented tungsten carbide industry and is thought to be responsible ...

NTP 2014: Current Directions & Evolving Strategies 3.3MB

https://ntp.niehs.nih.gov/ntp/pubs/currentdirections2014_508.pdf

... Researchers at NIOSH are using artificial human lung fluids to study the persistence of tungsten oxide fibers formed during the processing of tungsten-containing ores and assessing ...

RoC Profile: Ionizing Radiation; 15th RoC 2021 246KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ionizingradiation.pdf

... porcelain teeth, gemstones activated by neutrons, and thoriated tungsten welding rods. ... non- silica optical glass, and thoriated tungsten filaments, and as a cata- lyst. ...

15th RoC: Acronyms 58KB

https://ntp.niehs.nih.gov/ntp/roc/content/acronyms_508.pdf

... capsid antigen VOC volatile organic chemical vol. volume v/v volume-volume ratio WC tungsten carbide WHO World Health Organization wt. weight XPA xeroderma pigmentosum ...

Appendices A-G; 15th RoC 2021 448KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

... Co/WC see Cobalt-Related Exposures, Cobalt-Tungsten Carbide: Powders and Hard Metals ... see Cobalt-Related Exposures, Cobalt-Tungsten Carbide: Powders and Hard Metals ...

TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 13.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr471.pdf

... production of alloys, and in the tungsten carbide hard metal industry (Kazantzis, 1981). ... ele- ments such as nickel, arsenic, or tungsten; adverse respiratory effects (such as ...

TOX-89: Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2... 2.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox089_508.pdf

... in a hair dye under the conditions of usage was studied by Wolfram and Maibach 20 . ... Varco J, Wallace P, Wolfram L. Hair preparations In: Kroschwitz J, Howe-Grant M, editors. ...

TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 9.0MB

https://ntp.niehs.nih.gov/sites/default/files/2023-08/tr471_508.pdf

... production of alloys, and in the tungsten carbide hard metal industry (Kazantzis, 1981). ... ele- ments such as nickel, arsenic, or tungsten; adverse respiratory effects (such as ...

Acronyms & Abbreviations 80KB

https://ntp.niehs.nih.gov/support/acronyms

... capsid antigen VOC Volatile organic chemical vol. Volume v/v Volume-volume ratio WC Tungsten carbide WET BED Wet Bedding WHO World Health Organization Wrng-Sex Wrong Sex wt. ...

Peer Review Report: Draft Report on Carcinogens (RoC) Monograph... 236KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2015/july/sepreport20150722_508.pdf

... adhesives, and animal diets), and in tungsten-carbide hard metals and bonded diamonds. ... not control for co-exposures other than tungsten carbide, suggesting that the odds ratio ...