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TOX-29: Cupric Sulfate (CASRN 7758-99-8) 7.7MB
https://ntp.niehs.nih.gov/go/tox029
... Study of Cupric Sulfate. .. 62 Results of Copper Staining of Liver and Kidney Sections ... Weight 249.68 Synonyms Chalcanthite Copper sulfate Bluestone Blue vitriol Roman ...
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Abstract for TOX-29 64KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox029
Synonyms/Common Names: Chalcanthite; copper sulfate; cupric sulfate pentahydrate; ... Because copper salts are found in human water supplies, toxicity studies of cupric sulfate ...
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Abstract for TR-88 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr088
Full Report PDF Abstract 1H-Benzotriazole is an anticorrosive chemical used primarily on copper, but also on iron, steel, cadmium, chromium, zinc, and silver-nickel alloys. A ...
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TR592: Dietary Zinc (CASRN 5263-02-5) In Sprague Dawley Rats... 2.0MB
https://ntp.niehs.nih.gov/go/tr592
... Zinc, NTP TR 592 v Table 5. Zinc and Copper Concentrations in Blood of Rats in the ... based on the potential for elevated zinc intakes to interfere with copper absorption 10 . ...
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Abstract for TR-172 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr172
Sodium diethyldithiocarbamate is a chelating agent used primarily in the analytical determination of copper, arsenic, nickel, and other metals. Other applications include the ...
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TR-430: C.I. Direct Blue 218 (CASRN 28407-37-6) in F344/N Rats... 16.0MB
https://ntp.niehs.nih.gov/go/tr430
... dye containing approximately 60% copper complex of 3,3'-[(3,3'-dihydro~[1,l'-biph... Major Component of C.I. Direct Blue 218 A copper complex of 3,3'-[(3,3'-dihydroxy[l,l'-bip...
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Abstract for TR-552 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr552
It is also a by-product in the industrial synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. Propargyl alcohol is used as a reactant/...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/cadmium_508.pdf
... Cadmium is generally the by-product of processing sulfide ores for zinc, lead, and copper ... CdS 144.47 0.13 mg/100 g Cadmium-copper 7364-06-0 Cd.Cu varies with n.g. alloy ...
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RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/lead-public_508.pdf
... In worldwide metal use, lead ranks behind only iron, copper, aluminum, and zinc. Its ... smelters) to 200 μg/m 3 (storage-battery plants and brass, bronze, and copper foundries). ...
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Poster Abstracts: Collaborative Workshop on Aquatic Models and... 2.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/aquatictox-2014/aquatictox-posterabstracts-508.pdf
M. Chernick, K.W.H. Kwok, W. Dong, M. Ware, N. Zheng, D.E. Hinton 5 Copper Nanoparticles and or Ionic Copper (II) Causes Neurotoxicity and Cardiotoxicity in Zebrafish Embryos E. ...
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Pancreatic islets - Metaplasia, Hepatocyte - Nonneoplastic Lesion... 281KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pancreatic-islets/MetaplasiaHepatocyte
While it may be an incidental finding in rats, hepatocyte metaplasia can be induced by peroxisome proliferators, by methyl-deficient diets, and experimentally by copper ...
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TR-462: Molybdenum Trioxide (CASRN 1313-27-5) in F344 Rats and... 25.6MB
https://ntp.niehs.nih.gov/go/tr462
... . . . . . . . . . . 229 APPENDIX I Liver Copper Analysis . . . . . . . . . . . . . . . . ... counts or motility, o r liver copper concentrations between control an d exposed rats. ...
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RoC Background Document: Beryllium Compounds; Dec. 16-17, 1999 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
......... 11 2.1.2 Beryllium-copper alloy ......beryllium-aluminum alloy beryllium-copper alloy beryllium-nickel alloy beryl ore ...
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Shawn Jeter | National Institute of Environmental Health Sciences 398KB
https://www.niehs.nih.gov/research/atniehs/dtt/assoc/opo/staff/shawn
ME et al (1997) Comparative pulmonary absorption, distribution, and toxicity of Copper Gallium Diselenide, Copper Indium Diselenide, and Cadmium Telluride in Sprague-Dawley rats. ...
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Abstract for TR-430 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr430
...halnedisulfonato]](8-)]]di-, tetrasodium; copper, [tetrahydrogen-3,3'-[(3,3'-dihydroxy-4,4... Full Report PDF Abstract C.I. Direct Blue 218 is a copper chelated dye used for cellulose, ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 599KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/references/antimonyreferences_508.pdf
... Update of cancer incidence among workers at a copper/nickel smelter and nickel refinery. ... Arsenic exposure and mortality: a case- referent study from a Swedish copper smelter. ...
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RoC Profile: Arsenic and Inorganic Arsenic Compounds; 15th RoC... 152KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/arsenic.pdf
Occupational exposure to inorganic arsenic compounds, especially in mining and copper ... in complex minerals containing copper, lead, iron, nickel, cobalt, and other met- als. ...
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RoC Background Document: Metallic Nickel and Certain Nickel Alloys... 1.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/ni_no_appendices_508.pdf
... The most important alloying constituents are iron, chromium, copper, and molybdenum. There ... 0.47% manganese, 0.46% silicon, 0.24% copper, 0.11% cobalt, 0.10% phosphorus, 0.03% ...
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Endocrine, Pancreatic Islets, Metaplasia Hepatocyte 620KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/pancreatic_islets/metaplas/pancreatic_islets-metaplasia-hepatocyte_508.pdf
While it may be an incidental finding in rats, hepatocyte metaplasia can be induced by peroxisome proliferators, by methyl-deficient diets, and experimentally by copper ...
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RoC Profile: Beryllium and Beryllium Compounds; 15th RoC 2021 149KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/berylliumandberylliumcompounds.pdf
... Beryllium-copper alloy usually contains 4.0% to 4.25% beryllium by weight. It has a melt- ... addition of just 2% beryllium to copper forms alloys that are six times stronger ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
... scrap, and through the refining of other metals, such as copper and platinum (IARC, 1990). ... to decrease impurities such as antimony, cobalt, arsenic, zinc, copper, iron, and lead. ...
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Public Health Impact 1.4MB
https://ntp.niehs.nih.gov/media/impact
... for Lead and Copper: Improvements (LCRI) In December 2023, the U.S. Environmental Protection Agency (EPA) requested comment on the proposed the Lead and Copper Rule ...
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RoC Profile: Cupferron; 15th RoC 2021 165KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/cupferron.pdf
and is used to separate and precipitate metals such as copper, iron, va- nadium, and thorium. It is used to separate tin from zinc and to sep- arate copper and iron from other metals. ...
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Validation of an In Vitro Gastrointestinal Digestion and Co-culture... 19.2MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_06_Sayes_GutModels2023_508.pdf
... of copper, lead, and glyphosate on neuronal cells. Journal of Hazardous Materials Advances. 2023 Aug 1;11:100355. Dose-response curves related to glyphosate, copper nitrate, ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
... The two false positive compounds were copper chloride and zinc sulfate. The LLNA ... The two false positive compounds were copper chloride and zinc sulfate. All six of the ...
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Comment:Peer Review Report Draft of RoC Monograph on Cobalt;... 975KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/publiccomm/cdi20150708.pdf
... which is a very low figure by comparison to other metals such as copper and aluminium. ... News April 2015) whereas refined copper is ~25million mta and aluminium is ~40million mta. ...
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NTP at the SOT; 2007 433KB
https://ntp.niehs.nih.gov/ntp/meetings/2007/ntpsot20070329_508.pdf
Min Song ssion Toxicogenomics I: Liver: Transcriptome Changes in HepG2 Cells Exposed to Copper: GO Analysis and Hierarchical Clustering (J. H. Freedman) 750-124 Matthew Stout ...
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TR-088: 1H-Benzotriazole (CASRN 95-14-7) 3.5MB
https://ntp.niehs.nih.gov/go/tr088
... corrosive chemical used primarily on copper, but also on iron, 1H-BENZOTRIAZOLE ... In the electronics industry, it is used to treat packing materials for copper electronic ...
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TR-428: Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5... 19.9MB
https://ntp.niehs.nih.gov/go/tr428
... The effect of dietary manganese on the content of manganese, iron, copper, and zinc in ... Tissues examined in metal concentration analyses for copper, iron, manganese, and zinc ...
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TR-552: Toxicology and Carcinogenesis Studies of Propargyl Alcohol... 1.4MB
https://ntp.niehs.nih.gov/go/tr552
... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ... synthesis of butynediol from acetylene and formaldehyde with copper acetylide as catalyst. ...
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Abstract for TR-462 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr462
... sperm counts or motility, or liver copper concentrations between control and exposed rats. ... There were significant increases in liver copper concentrations in female mice exposed to ...
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Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot... 491KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf
The primary uses of Co metal are: (1) high temperature, corrosion-resistant superalloys (e.g., used in turbine aircraft engines); (2) magnetic alloys with aluminum, copper, nickel ...
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Revised Draft RoC Monograph Cobalt: RoC Peer Review; July 22... 3.0MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt.pdf
... most often found in ores associated with copper or nickel, but may also be a by-product ... reported to EPA (TRI 2014d) include gold, copper, and nickel ore mining, hazardous waste ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
... most often found in ores associated with copper or nickel, but may also be a by-product ... to EPA (USEPA 2014d) include gold, copper, and nickel ore mining, hazardous waste ...
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RoC Profile: Thiourea; 15th RoC 2021 126KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/thiourea.pdf
... for engraving metal surfaces, as an isomerization catalyst in the conversion of maleic to fumaric acid, in copper-refining electrolysis, in electroplating, and as an an- tioxidant. ...
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RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf
... (Continued) C. 1. Direct Brown 95, copper, 116071-86-61 y MR FR MM TR-108 GL7375000 ... The benzidine moiety is not complexed in this copper complex. C. I. Direct Brown 154, I ...
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CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/go/soy_monograph
... phosphorous, magnesium, zinc, manganese, copper, iodine, sodium selenate, potassium, ... phosphorous, magnesium, zinc, manganese, copper, iodine, selenium sodium, potassium, ...
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RoC Protocol: Methods for Preparing the Draft RoC Monograph on... 520KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/protocols/cobalt_508.pdf
... These scenarios have been identified including gold, copper, or nickel ore mining, ... of cobalt in lung tissue from deceased copper smelter workers with and without lung ...
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Draft RoC Monograph Cobalt: RoC Peer Review; July 22, 2015 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph.pdf
... most often found in ores associated with copper or nickel, but may also be a by-product ... reported to EPA (TRI 2014d) include gold, copper, and nickel ore mining, hazardous waste ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/leadappendixe_final_508.pdf
... 7-15 years old living in Silesia, near copper smelters; Year=1995; Male=52% Range 7-15 ... 7-15 years old living in Silesia, near copper smelters; Year=1995; Male=52% Range 7-15 ...
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Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf
... FETAX Solution, stock solutions, or test solutions should not contact brass, copper, lead, ... ascorbic acid, copper sulfate, monosodium glutamate, sodium acetate, and sodium arsenate. ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/acrylamide/acrylamide_monograph.pdf
... In this method, acrylonitrile is hydrated with a fi xed copper catalyst. Unreacted ... Concentrations of aqueous solutions range from 40 to 50%. Copper is often added at ...
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Presentation: Predicting Acute Toxicity Hazard in the Absence... 1.9MB
https://ntp.niehs.nih.gov/iccvam/meetings/at-wksp-2015/session3/2-tunkel-508.pdf
... Chlorophyll Direct Blue 86 >5,000 mg/kg C.I. Pigment Green 7 2,000 mg/kg Chemicals . Dicopper chloride trihydroxide . Copper sulfate pentahydrate . Dicopper oxide LD 50 299-2,006 ...
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Antimony Trioxide public comment 1.0MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/publiccomm/mostafa20180109_508.pdf
... J Hazard Mater 307 (2016): 336-43. Martin, W. A., L. S. Lee, and P. Schwab. "Antimony Migration Trends from a Small Arms Firing Range Compared to Lead, Copper, and Zinc." Sci Total ...
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Draft RoC Monograph Cobalt Appendix: RoC Peer Review; July 22... 1.7MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph_appen.pdf
... students with no occupational hx with metals) of the copper- belt, Province of Katanga. ... (reported in a series of publications) of copper smelter workers exposed to cobalt and ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
... uses of wood treated with chromated copper arsenate (pres- sure-treated wood) that ... to be used in residential settings cannot be treated with chromated copper arsenate. ...
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15th RoC: Appendix F 165KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_f.pdf
... and Its Hydrochloride chromated copper arsenate (CCA) see Arsenic and Inorganic ... estrogens see Estrogens, Steroidal copper-beryllium alloy see Beryllium and ...
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TR-197: Selenium Sulfide (Dermal Study) (CASRN 7446-34-6) 2.4MB
https://ntp.niehs.nih.gov/go/tr197
... cells; as a constituent in alloys in copper and steel; as vulcanizing agents in ... Instrument: Debye-Scherrer camera with filtered copper radiation, 50 kv, and 30 mamp. ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... LLNA test when metal salts, including nickel and copper salts, are applied to the skin. ... LLNA test when metal salts, including nickel and copper salts, are applied to the skin. ...
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RoC Profile: Lead and Lead Compounds; 15th RoC 2021 190KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lead.pdf
... In worldwide metal use, lead ranks behind only iron, copper, alu- minum, and zinc (Howe ... 3 at storage-battery plants and brass, bronze, and copper foundries (Froines et al. 1990). ...
