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TR592: Dietary Zinc (CASRN 5263-02-5) In Sprague Dawley Rats... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr592_508.pdf
aNd caRciNogeNesis sTudy of dieTaRy ZiNc (casRN 5263-02-5) iN sPRague dawley ... and Carcinogenesis Study of Dietary Zinc (CASRN 5263-02-5) in Sprague Dawley ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
Wood Dust December 13 - 14, 2000 Meeting of the NTP Board of Scientific Counselors Report on Carcinogens Subcommittee Prepared for the: U.S. Department of Health and Human Services ...
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RoC Profile: Wood Dust; 15th RoC 2021 313KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/wooddust.pdf
National Toxicology Program, Department of Health and Human Services Report on Carcinogens, Fifteenth Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc ...
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Abstract for TR-592 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr592
Zinc[1] in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Study) CASRN: 5263-02-5 Chemical Formula: C2H6O12Zn5 Molecular Weight: 549.0074 Synonyms/Common Names: Zinc ...
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Abstract for TR-581 92KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr581
1abs Abstract for TR-581 Toxicology Studies of Cobalt Metal in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/...
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Pancreatic islets - Necrosis - Nonneoplastic Lesion Atlas 285KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pancreatic-islets/Necrosis
Necrosis of beta cells in pancreatic islets has been associated with zinc deficiency and with xenobiotics that bind zinc. Affected beta cells are typically shrunken and ...
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Peer Review Report: TRPRP; July 13, 2017 156KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2017/july/panel_report20170713.pdf
VI. Draft NTP Technical Report on Dietary Zinc (TR592) ......Ludewig concurred. VI. Draft NTP Technical Report on Dietary Zinc (TR592) A. Presentation ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
... Cadmium is generally the by-product of processing sulfide ores for zinc, lead, and copper ... a commercial grade that has a purity of about 98% with lead, zinc, and iron as impurities. ...
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Minutes: BSC RoC; Dec. 13-15, 2000 205KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/minutes20001213.pdf
Summary Minutes - December 13-15, 2000 NTP Board of Scientific Counselors Report on Carcinogens Subcommittee SUMMARY MINUTES of the National Toxicology Program Board of Scientific ...
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TOX-74: Cellulose Insulation 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox074_rev.pdf
... silver, sodium, tellurium, thallium, titanium, vanadium, yttrium, zinc, and zirconium. ... calcium, copper, iron, lithium, magnesium, manganese, sodium, titanium, and zinc. ...
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RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
... In worldwide metal use, lead ranks behind only iron, copper, aluminum, and zinc. Its ... age, the chemical form of lead, and minerals in the diet (e.g., iron, calcium, and zinc). ...
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CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB
https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf
... ZnT-1......zinc.transporter-1 µg......DEHP.may.exacerbate.zinc.and. vitamin. E. deflciencies,. which. are.not.uncommon.in.preter...
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Abstract for TR-88 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr088
Abstract 1H-Benzotriazole is an anticorrosive chemical used primarily on copper, but also on iron, steel, cadmium, chromium, zinc, and silver-nickel alloys. A bioassay of ...
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Actions on the Draft NTP Technical Reports Peer Reviewed on July... 513KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2017/july/actions20170713_508.pdf
Reports on dietary zinc, 2,3-butanedione, and p-chloro-α,α,α- trifluorotoluene. ... Technical Report TR 592: Dietary Zinc The Panel voted to accept unanimously (6 yes, 0 no, ...
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Abstract for TR-454 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr454
Nickel sulfate hexahydrate is used in nickel plating, as a mordant in dyeing and printing textiles, as a blackening agent for zinc and brass, and in the manufacture of organic ...
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Public Comment: Carbon black (Attachment); Sarah Amick; RoC;... 92KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/amickattach_508.pdf
1400 K Street, NW · Washington, DC 20005 · tel (202) 682-4800 · fax (202) 682-4854 · www.rma.org Dr. Ruth Lunn, Director Office of the RoC DNTP, NIEHS, P.O. Box 12233, MD ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
... Both copper and zinc tissue concentrations decreased (P < 0.001) with subacute and ... The authors noted that decrease in zinc and copper concentrations might affect the ...
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Abstract for TER89143 and TER90043 62KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter89143
43abs Abstract for TER89143 and TER90043 Inhalation Developmental Toxicology Studies: Gallium Arsenide in Rats and Mice CASRN: 1303-00-0 Chemical Formula: AsGa Molecular Weight: ...
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Background Document: RoC: Cobalt-Tungsten Carbide: Powders and... 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/hardmetalsbd20100408_508.pdf
... coldstream process and the zinc process, and the finer tungsten carbide and cobalt powders that result are ready to use to make new hard metals. The zinc process is considered the ...
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Abstract for RR-04 59KB
https://ntp.niehs.nih.gov/publications/reports/rr/rr04
4abs Abstract for RR-04 Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives Report Date: October 2017 Full Report PDF Abstract Background ...
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RoC Background Document: Silica, Crystalline (Respirable Size... 1.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/silica_no_app_508.pdf
FINAL Report on Carcinogens Background Document for Silica, Crystalline (Respirable Size) December 2 - 3, 1998 Meeting of the NTP Board of Scientific Counselors Report on ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
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Abstract for TR-428 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr428
8abs Abstract for TR-428 Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 10034-96-5 Chemical ...
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Abstract for TOX-74 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox074
4abs Abstract for TOX-74 Toxicity Study Report on the Atmospheric Characterization, Particle Size, Chemical Composition, and Workplace Exposure Assessment of Cellulose Insulation ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
Intrabronchial implantation of zinc chro- mate or strontium chromate also caused bronchial ... lead chromate, basic lead chromate, zinc chromate, or strontium chromate) by ...
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Comment: Meat-related exposures (OHAT1); Shalene McNeill, The... 67KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_1ohat20161007.pdf
Comparison of complementary feeding strategies to meet zinc requirements of older ... pureed meat (beef and gravy), iron--- and zinc---fortified infant cereal (IZFC), or ...
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RoC Background Document: Beryllium Compounds; Dec. 16-17, 1999 5.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
... silicate beryllium sulfate beryllium oxide beryllium phosphate beryllium zinc silicate. ... Beryllium and Beryllium Compounds Compound Zinc beryllium silicate BeO 4 SiZn CASRN ...
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Pancreatic Islets - Necrosis 584KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/pancreatic_islets/necrosis/pancreatic_islets-necrosis_508.pdf
Comments: Necrosis of beta cells in pancreatic islets has been associated with zinc deficiency and with xenobiotics that bind zinc. Affected beta cells are typically shrunken and ...
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DOT Update: ICCVAM Public Forum 2015 265KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/dot-iccvampubforum-2015-508.pdf
Pipeline and Hazardous Material Administration (PHMSA) Department of Transportation AN ICCVAM UPDATE Presented at the Public Forum, NIH Natcher Center, MD May 27, 2015 Steve Hwang, ...
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RoC Profile: Silica, Crystalline (Respirable Size); 15th RoC... 136KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/silica.pdf
Silica, Crystalline (Respirable Size) CAS No.: none assigned Known to be a human carcinogen First listed in the Sixth Annual Report on Carcinogens (1991) Also known as crystalline ...
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New Approach Methodologies for Exposure from EPA's ExpoCast Project... 2.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2019/september/presentations/2-3-isaacs.pdf
New Approach Methodologies for Exposure from EPA's ExpoCast Project Kristin Isaacs National Exposure Research Laboratory Office of Research and Development, United States ...
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TR-428: Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5... 19.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr428.pdf
... The effect of dietary manganese on the content of manganese, iron, copper, and zinc in ... Tissues examined in metal concentration analyses for copper, iron, manganese, and zinc ...
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TR-492: Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and... 23.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr492.pdf
... erythrocytosis and in- creased zinc protoporphyrin/heme ratios in exposed groups of rats. ... an erythrocytosis and in- creased zinc protoporphyrin/heme ratios in male and female mice. ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB
https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf
... body activation analysis of cobalt, iron, rubidium, selenium, zinc, antimony and cesium. ... antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins. ...
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Mountaintop Removal Mining: Impacts on Health in the Surrounding... 66KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/mining
780611 Mountaintop Removal Mining: Impacts on Health in the Surrounding Community Landscape of mining mountain tops Topic Overview Status: Evaluation completed Background ...
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Cobalt-Tungsten Carbide Powders and Hard Metals Expert Panel... 6.5MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_panelreportparta_508.pdf
... Interactions with zinc finger proteins, which are involved in DNA binding and ... In addition, the p53 protein is another zinc-dependent transcription factor involved in ...
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Formaldehyde Expert Panel Report Part B - Recommendation for... 406KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/fa_partb.pdf
B Formaldehyde Expert Panel Report Part B - Recommendation for Listing Status for Formaldehyde and Scientific Justification for the Recommendation The Report on Carcinogens (RoC) ...
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Public Comment: Carbon black; Robert MCunney; RoC; Jan. 19, 2012 1.3MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/mccunney20120227.pdf
February 27, 2012 Dr. Ruth Lunn, Director Office of the RoC DNTP, NIEHS, P.O. Box 12233,MD K2-14 Research Triangle Park, NC 27709 By e-mail to: lunn@niehs.nih.gov and overnight ...
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NTP Monograph on Health Effects of Low-Level Lead 12.9MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
... Wide Range Achievement Test-Revised ZPP zinc protoporphyrin NTP Monograph on Health ... Pb can also impair heme formation by inhibit- ing ferrochelatase such that zinc is used in ...
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RoC Profile: Beryllium and Beryllium Compounds; 15th RoC 2021 149KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/berylliumandberylliumcompounds.pdf
... phosphate, beryllium silicate, or zinc beryllium silicate by intravenous ... Beryllium zinc sulfate was formerly used as an oxygen-dominated phosphor in lu- minescent ...
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TOX-30: Dibutyl Phthalate (CASRN 84-74-2) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox030.pdf
... Testicular zinc concentrations were lower in the 40,000 ppm group than in the controls, a ... Testicular zinc concentrations were lower in the 20,000 and 40,000 ppm groups than in the ...
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Abstract for TR-137 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr137
7abs Abstract for TR-137 Bioassay of Diazinon for Possible Carcinogenicity CASRN: 333-41-5 Chemical Formula: C12H21N2O3PS Molecular Weight: 304.3489 Synonyms/Common Names: ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
impact Public Health Impact The public impact of NTP's work can be measured through its use by other agencies, often to support the establishment of regulations or guidelines to ...
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Abstract for TR-238 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr238
CASRN: 137-30-4 Chemical Formula: C6H12N2S4Zn Molecular Weight: 305.82 Synonyms/Common Names: zinc dimethyldithiocarbamate Report Date: April 1983 Full Report PDF Abstract A ...
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DOT PHMSA Update: ICCVAM Public Forum 2017 243KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2017/03p-hwang-dot-508.pdf
Pipeline and Hazardous Material Administration (PHMSA) Department of Transportation AN ICCVAM UPDATE Presented at the Public Forum, NIH Natcher Center, MD May 23, 2017 Steve Hwang, ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... (C.I.) see Basic Red 9 Monohydride basic zinc chromate see Chromium Hexavalent Compounds ... Zanosar see Streptozocin zeolites see Erionite zinc beryllium silicate see Beryllium and ...
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CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf
... as iron, calcium, phosphorous, magnesium, zinc, manganese, copper, iodine, sodium ... as iron, calcium, phosphorous, magnesium, zinc, manganese, copper, iodine, selenium ...
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RoC Review of Antimony Trioxide 92KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/antimonyt
Sb203 RoC Review of Antimony Trioxide The recent Report on Carcinogens is now available. Composite image of a sofa on fire with antimony trioxide chemical formula Topic Overview ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
... Acetoin is prepared from diacetyl by partial reduction with zinc and acid. It is also ... to diacetyl in air and forms a solid dimer on standing or treatment with granulated zinc. ...
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Public Comment: Carbon black; Jimmy Boyd; RoC; Jan. 19, 2012 1.3MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/boyd20120227.pdf
___... PLEASE REPLY TO: February 27, 2012 Jimmy W. Boyd ...
