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TR-346: Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344... 8.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr346.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLOROETHANE (ETHYL CHLORIDE) (CAS NO. 75-00-3) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN ...
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Abstract for TR-346 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr346
Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 75-00-3 Chemical Formula: C2H5Cl Molecular Weight: ...
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Target Organs and Levels of Evidence for TR-346 58KB
https://ntp.niehs.nih.gov/data/tr/300s/tr346levels
Target Organs and Levels of Evidence for TR-346 Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation ...
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TR-068: Hexachloroethane (CASRN 67-72-1) 3.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr068.pdf
the results of the bioassay of hexa- chloroethane conducted for the Carcinogenesis ... SUMMARY A bioassay for possible carcinogenicity of technical-grade hexa- chloroethane was ...
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RoC Profile: Hexachloroethane; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hexachloroethane.pdf
Administration of hexa- chloroethane by stomach tube caused liver cancer (hepatocellular ... the rela- tionship between human cancer and exposure specifically to hexa- chloroethane. ...
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Minutes: BSC TRRS; Oct. 3, 1988 964KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/oct/88oct3-4trrsmins_508.pdf
Inhalation 1 (Ethyl Bromide) Chloroethane Inhalation (Ethyl Chloride) ... r a t s i n a companion study o f chloroethane asking why the analogous findings ...
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TR-361: Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage... 7.2MB
https://ntp.niehs.nih.gov/go/tr361
... and carcinogenesis studies of hexa- chloroethane received public review by the National ... and below 60"C is a patented method for producing hexa- chloroethane (Archer, 1979). ...
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TOX-4: 1,2-Dichloroethane (Ethylene Dichloride) (CASRN 107-06... 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox004.pdf
... (Symons et al., 1975) measured 1,2-di- chloroethane concentrations of 0-6 ug/liter in ... Spreafico et al. (1980) observed that 1,2-di- chloroethane administered to rats by gavage ...
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TR-027: 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr027.pdf
... are the potential of 1,1,2,2-tetra- chloroethane for causing liver damage as well as ... 1,1,2,2-tetra- chloroethane for administration to treated animals in the chronic studies. ...
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TR-232 Carcinogenesis Studies of Pentachloroethane (CASRN 76... 7.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr232.pdf
... The low- est published lethal concentrations of penta- chloroethane, administered by ... The technical-grade penta- chloroethane was considered to be representa- tive of the ...
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TOX-45: Renal Selected Halogenated Ethanes 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox045.pdf
... These range from the singly halogenated chemi cals chloroethane (NTP, 1989a) and ... exposed to bromoethane (NTP, 1989b) or chloroethane (NTP, 1989a) and a weaker response to ...
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TR-363: Bromoethane (Ethyl Bromide) (CASRN 74-96-4) in F344/N... 10.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr363.pdf
... in female rats in a companion study of chloroethane, asking why the analogous findings ... Both chloroethane (NTP, 1989)and 1,2-dibromo- ethane (NTP unpublished results) were evalu- ...
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TR-237 Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr237.pdf
... I , ] , 1,2-tetra- per volume basis chloroethane to corn oil on a weight per volume ... rats administered 1, I , 1 ,2-tetra- chloroethane at the doses used in this bioassay, ...
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TR-461: Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1Mice... 21.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr461.pdf
... such as metal degreasers and aerosol propellants such as 1,1, I -tri- chloroethane. ... I-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Ozone 16/50 ...
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TR-065: Chloropicrin (CASRN 76-06-2) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr065.pdf
... rats intubated with 1 ,1 ,2 ,2-tetra- chloroethane (79-34-5), allyl chloride (107-05-1), ... mice intubated with 1,1,2,2-tetra- chloroethane (79-34-5), chloroform (67-66-3), ...
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TR-055: 1,2-Dichloroethane (CASRN 107-06-2) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr055.pdf
... (Sykes and Klein, 1957) . . Atmospheric contamination with 1,2- di chloroethane and subsequent inhalation may result following use of the compound in the field as a soil fumigant. ...
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TR-003: 1,1,1-Trichloroethane (CASRN 71-55-6) 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr003.pdf
... The design of the carbon tetrachloride study (positive control) was essentially the same as that of 1,1,1-tri chloroethane. The high dose for male rats was 74 mg/kg and the high ...
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TR-073: Allyl Chloride (CASRN 107-05-1) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr073.pdf
... were housed in the same room with rats intubated with chloroform (67-66-3); carbon tetrachloride (56-23-5); 1,1,2,2-tetra- chloroethane (79-34-5); and 1,2-dibromoethane (106-93-4). ...
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TR-002: Trichloroethylene (CASRN 79-01-6) 19.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr002.pdf
... (<5 ppm) or 1,1,1,2-tetra- chloroethane (<2 ppm) were indicated by gas ... following 17 compounds: 1,1,2,2-tetra- chloroethane, chloroform, 3-chloropropene, ...
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TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf
... Hydrochloride 1/50 0/50 1/50 Chloroethane 0/50 0/50 0/50 Hexachlorocyclopentadie... Hydrochloride 0/50 2/50 2/50 Chloroethane 0/49 2/49 2/49 Hexachlorocyclopentadie...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... No. CAS No. Analytical Conc. (μg/mL) Bromomethane LB22203 74-83-9 2030 Chloroethane LB55667 75-00-3 2029 Chloromethane LB64986 74-87-3 2063 Dichlorodifluoromethane LB68837 ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... P Clear Evidence NE No Evidence NE No Evidence NE No Evidence TR-346 10/03/88 Chloroethane 75-00-3 EE Equivocal Evidence EE Equivocal Evidence IS Inadequate Experiment P Clear ...
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TR-447: Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1Mice... 14.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr447.pdf
... I-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Overall ... I-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Overall ...
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TR-243: Trichloroethylene (Without Epichlorohydrin) (CASRN 79... 7.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr243.pdf
... TCE may also be used as a chain terminator in polyvinyl chloride production and as an intermediate in the production of penta- chloroethane (Kirk-Othmer, 1963 and 1979; IARC, 1979; ...
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TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 13.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr471.pdf
... Hydrochloride 4/50 1/50 5/50 Chloroethane 0/50 0/50 0/50 Hexachlorocyclopentadie... Hydrochloride 11/50 11/50 Chloroethane 8/36 8/36 Hexachlorocyclopentadiene ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf
... 0/46 l-Epinephrine Hydrochloride 1/50 Chloroethane 0/50 Hexachlorocyclopentadiene 0/48 ... 1/48 l-Epinephrine Hydrochloride 0/50 Chloroethane 0/50 Hexachlorocyclopentadiene 0/50 ...
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TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr475.pdf
... l-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Ozone 1/50 ... Hydrochloride 10/50 0/50 2/50 11/50 Chloroethane 11/50 2/50 0/50 13/50 ...
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TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/2023-08/tr471_508.pdf
... l-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Ozone 18/42 ... l-Epinephrine Hydrochloride Chloroethane Hexachlorocyclopentadiene Ozone 4/50 ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... TR-346 PDF (8.74 MB) Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1989 Technical ...
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TR-156: p,p'-Ethyl-DDD (CASRN 72-56-0) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr156.pdf
... The dichlorodiphenyl-tri-chloroethane analog, p,p'-DDT, has also been reported to induce hepatomas in various strains of mice (international Agency for Research on Cancer, 1974), ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... TR-346 PDF (8.74 MB) Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1989 Technical ...
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TR-273: Trichloroethylene (CASRN 79-01-6) in Four Strains of... 16.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr273.pdf
... thane, NCI, 1978b; l,l,a-tri- chloroethane, NCI, 1978c;tetrachloroethylene, NCI, 1977;pentachloroethane, NTP, 19831, the survival of the rats was compromised by the dose regimen. ...
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TR-392: Chlorinated Water (CASRNs. 7782-50-5 and 7681-52-9) and... 75.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr392.pdf
... Gas chromatography indicated that the known possible impurities, hexa- chloroethane and hexachlorobenzene, were not present at concentrations greater than 0.01%. P R E P A R A T I ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-346 PDF (8.74 MB) Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1989 Long-Term ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... In addition, seven of the candidate substances (bisphenol A, 1,1-dichloro-bis[4- chlorophenyl]ethylene, dichlorodiphenyltri- chloroethane, di-(2-ethylhexyl)phthalate, ...
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TR-385: Methyl Bromide (CASRN 74-83-9) in B6C3F1Mice (Inhalation... 7.3MB
https://ntp.niehs.nih.gov/go/tr385
... Research Triangle Park, NC. 53 References National Toxicology Program (NTP) (1989b). Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CAS No. 75-00-3) in ...
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TR-462: Molybdenum Trioxide (CASRN 1313-27-5) in F344 Rats and... 25.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr462.pdf
... Hydrochloride 4/50 1/50 5/50 Chloroethane 0/50 0/50 0/50 Hexachlorocyclopentadie... Hydrochloride 11/50 5/50 15/50 Chloroethane 3/50 2/50 5/50 Hexachlorocyclopentadie...
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TR-384: 1,2,3-Trichloropropane (CASRN 96-18-4)in F344 Rats and... 5.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr384.pdf
... as the parent compound, tetrachloroethylene, 1,1,2,2- tetra-chloroethane, and CO 2 . ... 391 Tris(2-chloroethyl) Phosphate 346 Chloroethane 392 Chlorinated Water and ...
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RoC Monograph: 1-Bromopropane; September 2013 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf
... The majority of these molecules (bromoform [tribromomethane], chlorodibromomethane, chloroethane, chlorofluoromethane, 2-chloro-1,1,1,-trifluoroethane, 1,2- dichloropropane, methyl ...
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TR-347: d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1Mice... 9.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr347.pdf
... of Health, Bethesda, MD. 51. National Toxicology Program (NTP) (1983) Toxicology and Carcinogenesis Studies of Penta- chloroethane in F344/N Rats and B6C3F1 Mice (Gavage Studies). ...
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TR-210: 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1Mice... 6.5MB
https://ntp.niehs.nih.gov/go/tr210
... Not detected at limit of 0.01% Methylene Bromide + 0.14 0.14 0.14 1-Bromo,2-Chloroethane 1,2-Dibromoethane 99.4 99 3 99.4 2-Chloroethanol 0.01 0.04 0.03 Broino form 0.03 ...
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TR-573: Styrene-acrylonitrile trimer in F344/N Rats (Perinatal... 5.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr573_508.pdf
... (Equivocal Evidence) Glioma 0/50 0/47 1/50 (2%) TR 346: 2-Year Inhalation Study of Chloroethane 0 ppm 15,000 ppm Male Malignant Astrocytoma 0/50 1/50 (2%) Malignant ...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf
... Nitrofurantoin Dichlorvos Benzyl Alcohol Tetracycline Hydrochloride Roxarsone Chloroethane D-Limonene a-Methyldopa Sesquihydrate Pentachlorophenol Tribromomethane ...
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TR-389: Sodium Azide (CASRN 26628-22-8) in F344 Rats (Gavage... 8.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr389.pdf
... 342 Dichlorvos 343 Benzyl Alcohol 344 Tetracycline Hydrochloride 345 Roxarsone 346 Chloroethane 347 D-Limonene 348 a-Methyldopa Sesquihydrate 349 Pentachlorophenol 350 ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr413.pdf
... 344 Tetracycline Hydrochloride 381 d-Cawone 345 Roxarsone 382 Furfural 346 Chloroethane 385 Methyl Bromide 347 D-Limonene 386 Tetranitromethane 348 @-Methyldopa ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... p-Chloroaniline Hydrochloride Chlorobenzene Chlorodibromomethane Chloroethane 2-Chloroethanol 3-Chloro-2-Methylpropene Chloroprene 1-Chloro-2-Propanol TR No. 394 ...
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TR-387: dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats... 10.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr387.pdf
... 343 344 345 346 Benzyl Alcohol Tetracycline Hydrochloride R m r s o n e Chloroethane 367 368 369 370 Phenylbutazone Nalidixic Acid Alpha-Methylbenzyl Alcohol Benzofuran ...
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TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf
... Dihydrochloride 345 Roxarsone 391 Tris(2-chloroethyl) Phosphate 346 Chloroethane 392 Chlorinated Water and Chloraminated Water 347 D-Limonene 393 Sodium Fluoride ...
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TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf
... 371 3-72 373 TdUene 3,Y-Dimethcnybenzidine Dihydmchloride Sucdnic Anhydride 346 347 chloroethane D-Limonene 374 375 V i Toluene Gl)CidOl 348 349 350 ~-McthyldOpa Sesquihydrate ...
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TR-390: 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82... 12.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr390.pdf
... Hydrochloride 368 Nalidixic Acid 345 Roxarsone 369 Alpha-Methylbenzyl Alcohol 346 Chloroethane 370 Benzofuran 347 D-Limonene 371 Toluene 348 &Methyldopa Sesquihydrate 372 ...