Skip to Main Navigation Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

We welcome your feedback!

Contact us with your comments.

QUICK TIPS
 
of 5

Refine

  • Categories
  • Content Type
  • Reports and Publications
  • Years
  • Formats

Search suggestions for "75-05-8".

  1. CEBS Data Related to Acetonitrile (75-05-8) https://cebs.niehs.nih.gov/cebs/test_article/75-05-8


248 results found for "75-05-8".

  1. TR-447: Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1Mice... 14.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr447.pdf

    7 TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACETONITRILE (CAS NO. 75-05-8) IN F344/N RATS AND B6C3F, MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...

  2. Abstract for TER91039 60KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter91039

    9abs Abstract for TER91039 Inhalation Development Toxicology Studies: Acetonitrile in Rats CASRN: 75-05-8 Chemical Formula: C2H3N Molecular Weight: 41.0527 Report Date: February ...

  3. Abstract for TR-447 68KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr447

    Abstract for TR-447 Toxicology and Carcinogenesis Studies of Acetonitrile in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 75-05-8 Chemical Formula: C2H3N Molecular ...

  4. Target Organs and Levels of Evidence for TR-447 57KB

    https://ntp.niehs.nih.gov/data/tr/400s/tr447levels

    Target Organs and Levels of Evidence for TR-447 Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Chemical ...

  5. Minutes: BSC TRRS; June 21, 1994 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1994/june/trrs21june1994mins_508.pdf

    Number Long-Term Studies Ace tonitrile 75-05-8 Inhalation......J. R. Bucher, NIEHS, introduced the toxicology and carcinogenesis studies of acetonitrile ...

  6. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    Test Chemicals Test Chemical CAS # Molecular Weight Supplier Product Code Purity (%) Acetaminophen 103-90-2 151.20 SIGMA A7085 99 Acetonitrile 75-05-8 41.05 SIGMA A3396 99.5 ...

  7. Studies on Historical Control Reports for NIH-07 Feed 312KB

    https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf

    Rats Fischer344 Inhalation Air Acetonitrile Rats Fischer344 Inhalation Air ... Mice B6C3F1 Inhalation Air Acetonitrile Mice B6C3F1 Inhalation Air Chloroprene ...

  8. Presentation: Application of Peptide Reactivity for Screening... 2.5MB

    https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/8-boverhoff.pdf

    Chemical-Protein Reactivity, Metabolism and Skin Sensitization Readout for Direct Peptide Reactivity Assay (DPRA): Peptide Depletion Test chemical dissolved in acetonitrile. Test ...

  9. Nomination Background: 1-Butyl-3-methylimidazolium chloride ... 1.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ionic_liquids_508.pdf

    ... and 69 ºC. It is soluble in acetone, acetonitrile, ethyl acetate, isopropyl alcohol, ... Koel (2000) Soluble in: acetone, acetonitrile, ethyl acetate (hot), isopropyl ...

  10. Predicting human developmental toxicity of pharmaceuticals using... 510KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf

    ... On the fourth day, the media was removed and added to acetonitrile to make a 40% acetonitrile solution, as outlined in the Sample preparation section below. hES cell viability ...

  11. Application of Non-animal Test Methods and Defined Approaches... 22.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/immunotox/it/niceatm-it-report-june2020-final-wappx-508.pdf

    ... collected in a single successful assay run with all compounds initially dissolved at 100 mM in acetonitrile (DCOIT, BBIT, MIT, OIT), water (CMIT/MIT), or acetonitrile:water (BIT). ...

  12. TR-544: Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats... 7.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr544.pdf

    ... and carcinogenesis studies of dibromo- acetonitrile received public review by the National ... methanol from rat stomach or from rat or mouse liver was monoglutathionyl acetonitrile. ...

  13. Adrenal Gland, Cortex, X-Zone - Atrophy - Nonneoplastic Lesion... 298KB

    https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/CortexX-Zone-Atrophy

    ... National Toxicology Program. 1996. NTP TR-447. Toxicology and Carcinogenesis Studies of Acetonitrile (CAS No. 79-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, ...

  14. TOX-84: Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8... 5.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox084_508.pdf

    ... of phthalan by nitrogen monoxide in acetonitrile with N-hydroxyphthalimide as the ... was used to determine the presence of acetonitrile, GC/MS was used for chloroform, and ...

  15. TR-325: Pentachloronitrobenzene (CASRN 82-68-8) in B6C3F1Mice... 6.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr325.pdf

    ... The method of analysis involved a n acetonitrile extraction of the dosed feed and gas ... Plates: Silica Gel 60 F-254,25 mm thick System 2 Solvent: Acet0ne:acetonitrile (1: 1) ...

  16. TR-562: Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats... 6.4MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr562.pdf

    ... The purities of acetonitrile:water:phosphoric acid (70:30:0.1) extracts of lots 007-090200 ... and/or canadaline only in the acetonitrile:water:phosphoric acid (70:30:0.1) extract. ...

  17. Adrenal Gland, Cortex, X-Zone - Atrophy 412KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/cxzatrophy/adrenal-gland-cortex-xzone-atrophy-pdf_508.pdf

    ... National Toxicology Program. 1996. NTP TR-447 Toxicology and Carcinogenesis Studies of Acetonitrile (CAS No. 79-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). ...

  18. TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox059.pdf

    ... The residue was redissolved in acetonitrile for HPLC spectral analyses. Purified samples ... Prior to solvent extraction, 26 nmol 9-chloroanthracene dissolved in 250 µL acetonitrile ...

  19. TR-238: Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1Mice... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr238.pdf

    ... This lot of ziram also contained an acetonitrile- insoluble impurity (see Appendix E, ... Ultraviolet, 254 nm Solvent: 45% acetonitrile in water Flow: 1.5 ml/ min Results: ...

  20. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... NHK Assay (µg/mL) Acetaminophen 103-90-2 99 Sigma 8.1 4.7-1000 7.7 11.8-4000 Acetonitrile 75-05-8 99.5 Sigma 8.4 118-100000 7.9 8.12-200000 Acetylsalicylic acid 50-78-2 99.5 Sigma ...

  21. Validation of the Electrophilic Allergen Screening Assay (EASA... 1.3MB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-gordon-poster.pdf

    ... Benzyl cinnamate Pos/Pos/Pos Neg/Pos/Pos Neg/Pos/Pos Neg/Pos/Pos Pos Neg/Neg NC = negative control, PC = positive control, ACN = acetonitrile, TC = test chemical, SS = solvent ...

  22. TR-177: 4'-(Chloroacetyl)-acetanilide (CASRN 140-49-8) 3.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr177.pdf

    ... High pressure liquid chroma- tography (HPLC) indicated the presence of one peak with a shoulder at a shorter retention time using one solvent system [i.e., acetonitrile in 0.1 M ...

  23. TR-341: Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1Mice... 10.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr341.pdf

    ... on a pBondapak Cts column with a water:acetonitrile (88:12) mo- bile phase at a flow rate ... with a pBondapak Cts column, a water:acetonitrile (70:30) mobile phase at a flow rate of ...

  24. TR-367: Phenylbutazone (CASRN 50-33-9) in F344/N Rats and B6C3F1Mice... 10.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr367.pdf

    ... The sus- pensions were extracted with acetonitrile and analyzed by high-performance liquid ... system of aqueous 1% (v/v) acetic acid: acetonitrile with 1% (v/v) acetic acid (65:35). ...

  25. TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf

    ... stored for 14 ples were extracted with acetonitrile, and the days in the dark in sealed ... bottles) were extracted with 100 ml of acetonitrile by shaking for 15 minutes on a ...

  26. TOX-73: Diazoaminobenzene (CASRN 136-35-6) 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox073.pdf

    ... An isocratic mobile phase of acetonitrile was used at a flow rate of 1.0 mL/minute. The ... ammonium acetate (1.5% weight/volume):acetonitrile (40:60); flow rate 0.75 mL/minute ...

  27. TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

    ... μL of acetonitrile and extracted with hexane. Tissue samples (0.1-0.3 g) were prepared similarly to blood samples except tissues were homogenized prior to acetonitrile ...

  28. RR-12: Synthetic Turf/Recycled Tire Crumb Rubber: Characterization... 761KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr12_508.pdf

    ... phase A) and 0.1% formic acid in acetonitrile (mobile phase B) with the following ... for 2 minutes with 10% B. Samples were diluted 1:2 in acetonitrile and run in triplicate. ...

  29. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... Evidence P Clear Evidence SE Some Evidence SE Some Evidence TR-447 06/21/94 Acetonitrile 75-05-8 EE Equivocal Evidence NE No Evidence NE No Evidence NE No Evidence TR-446 06/21/...

  30. Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf

    ... and extracted by a solution of N,O-bis(trimethylsilyl) trifluoroacetamide in acetonitrile. ... by the FDA, the diethyl ether/hexane extract is partitioned with acetonitrile. ...

  31. TR-485: Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology... 12.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr485.pdf

    ... 10 mg/L. Oxymetholone was extracted with a mixture of dimethyl formamide and acetonitrile. ... a mobile phase of acetonitrile:water:ammonium dihydrogen phosphate (550:500:5.75 v/v/wt). ...

  32. TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf

    ... the iso- cratic pump, containing water:acetonitrile (90:10), was used to backflush the ... was washed with water:acetonitrile (95:5) for 1.5 minutes at 1 mL per minute to waste. ...

  33. TR-593: NTP Technical Report on the Toxicology and Carcinogenesis... 7.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr593_508.pdf

    ... acetate (0.39%), 2-butanone (0.51%), acetonitrile (0.24%), and acetic acid (0.12%), ... 3-methyl-2-4-pen-tanedione, ethyl acetate, acetonitrile, and acetic acid was analyzed. ...

  34. TOX-32: Methylene bis(thiocyanate), (CASRN 6317-18-6) 3.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox32.pdf

    ... and a very slight trace Impurity 0 using an acetone :hexane (60 :40) solvent system and a major spot and a trace impurity using a toluene : acetonitrile (96 :4) solvent system . ...

  35. RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf

    ... Mobile phases, 0.1% formic acid in water (A), and 0.1% formic acid in acetonitrile (B), ... 64-19-7 60.05 Acetone 67-64-1 58.08 Acetonitrile 75-05-8 41.05 Acetophenone 98-86-2 ...

  36. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ... collect in charcoal tube, extract with acetonitrile HPLC/fluorescence detection 0.080 μg/... to cyclohexane, clean up, exchange to acetonitrile HPLC/ultraviolet (UV) spectrometry 250 ...

  37. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... or sold by TVC member companies, with acetonitrile extractable concentrations of BPA as ... and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and ...

  38. Nomination Background: Isoamyl acetate (CASRN: 123-92-2) 205KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/isoamylacetate_508.pdf

    ... Mutagen., 19 (Suppl. 21):2-141 Zimmermann, F.K., Mayer, V.W., Scheel, I., & Resnick, M.A. (1985) Acetone, methyl ethyl ketone, ethyl acetate, acetonitrile and other polar aprotic ...

  39. Final Report Developing Experimental Approaches for the Evaluation... 705KB

    https://ntp.niehs.nih.gov/ntp/meetings/2004/nanotoxworkshop_508.pdf

    ... Characterization of stability a. Description of methodology, e.g., "1 g was suspended in 4 mL of acetonitrile, vortexed, and analyzed using a ..." b. Estimation of the half-life of ...

  40. TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf

    ...lorobenzalmalononitrile 0/50 0/50 0/50 Acetonitrile 0/48 0/48 0/48 2-Chloroacetophenone 3/...lorobenzalmalononitrile 0/48 0/48 0/48 Acetonitrile 0/48 0/48 0/48 2-Chloroacetophenone 1/...

  41. GMM-10: Genetically Modified Model Report on Diispropylcarbodiimide... 380KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm10_508.pdf

    ... It is flammable; soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide, and tetrahydrofuran; and reacts with water to form 1,3-diisopropylurea. ...

  42. TR-347: d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1Mice... 9.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr347.pdf

    ... in hexane was extracted with acetonitrile; the extract was analyzed by gas ... specific-phosphorus detedor. (c) Acetonitrile extracts of d-limonene were acid ...

  43. Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf

    ... Major Major Major Minor Minor NL Ethyl acetate [with 2-ethyl-2-methyloxirane for Ridgway] 141-78-6 8857 Major Major Major Minor ? NL Acetonitrile* 75-05-8 6342 Major Major Major ? ...

  44. TR-569: Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine... 7.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr569_508.pdf

    ... NFV is very soluble in methanol, ethanol, 2-propanol, propylene glycol, and acetonitrile, ... The mobile phase (1 mL/minute) was held at 5% acetonitrile:95% water for 5 minutes and ...

  45. TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf

    ... plastic containers at room rier, after extraction with acetonitrile, centri- temperature. ... The stability of 8- water:acetonitrile (55:45) was used. 8-Methoxy- methoxypsoralen in ...

  46. TR-366: Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1Mice... 14.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr366.pdf

    ... at 280 nm, a pBondapak C l 8 col- umn, and a solvent system of water:acetonitrile (955). ... with a Brownlee RP-18 column and a mobile phase of water:acetonitrile (95:5). ...

  47. TR-523: Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats... 10.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr523.pdf

    ... It is flammable; soluble in chloroform, methylene chloride, acetonitrile, dioxane, ... The mobile phase was acetonitrile at a flow rate of 0.75 mL/minute (Method 1). The ...

  48. TOX-83: Toxicity Studies of o-Chloropyridine (CASRN 109-09-1... 3.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox83_508.pdf

    ... CA), an isocratic mobile phase of acetonitrile:Milli-Q ® water:glacial acetic acid ... Phenomenex, Inc., Torrance, CA) using acetonitrile and water, both containing 0.1% TFA. ...

  49. TOX-34: 1-Nitropyrene (CASRN 5522-43-0) 1.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox034.pdf

    ... The extract was then reconstituted in 70:30 acetonitrile:water, sonicated, vortexed, and ... an d reconstituted in a solution of acetonitrile containing 9-nitrophenanthrene, which ...

  50. DART-08: Modified One-Generation Study of Bisphenol AF (CASRN... 5.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/dart/dart08_508.pdf

    ... The optimal extraction solvent was determined to be acidified acetonitrile (99:1, acetonitrile:acetic acid, v:v). Bisphenol AF, NTP DART 08 13 Prior to study start, the stability ...

 
of 5