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15 results found for "75-44-5".

  1. Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf

    ... Lung injury was induced by phosgene and mustard via several processes, including free ... Ketene is as acutely toxic to the lungs as phosgene (Wooster et al., 1946). 35 Chemical ...

  2. RoC Profile: Captafol; 15th RoC 2021 155KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/captafol.pdf

    ... Cap- tafol will not burn, but when heated to decomposition, it emits toxic fumes, including nitrogen oxides, sulfur oxides, phosgene, and chlo- rine (IPCS 1993). Physical and ...

  3. TOX-41: 1,1,1-Trichloroethane (CASRN 71-55-6) 2.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox041.pdf

    ... It can also be oxidized at high temperatures to yield phosgene. PRODUCTION, USE, AND HUMAN EXPOSURE 1,1,1-Trichloroethane is used as an industrial solvent, especially for the cold ...

  4. TR-582: Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr582_508.pdf

    ... Hydrochloric acid, formaldehyde, and phosgene concentrations were measured in atmosphere ... Formaldehyde and phosgene were measured in atmosphere samples collected on silica ...

  5. TOX-56: Carisoprodol (CASRN 78-44-4) 3.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox056.pdf

    ... When heated, carisoprodol emits hazardous fumes (Lewis, 1993). PRODUCTION, USE, AND HUMAN EXPOSURE Carisoprodol is produced by reacting phosgene with 2-methyl-2-propyl-1,3-propaned...

  6. TOX-83: Toxicity Studies of o-Chloropyridine (CASRN 109-09-1... 3.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox83_508.pdf

    ... poses a slight fire hazard, and when exposed to heat can release toxic phosgene gas 1; 4 . ... A third patented process reacts 2-hydroxypyridine with phosgene in the presence of an ...

  7. TR-273: Trichloroethylene (CASRN 79-01-6) in Four Strains of... 16.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr273.pdf

    ... into products such as hydrogen chloride, phosgene, carbon monoxide, and chlorine peroxide. ... instantly to phosgene and/or hydrogen chloride, chlorine, and dichloroacetyl chloride. ...

  8. Background Document: RoC: Captafol; 2010 1.1MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf

    ... Captafol will not burn, but when heated to decomposition, it emits toxic fumes such as nitrogen oxides, sulfur oxides, phosgene, and chlorine (WHO 1993). The physical and chemical ...

  9. TOX-101: Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered... 6.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox101_508.pdf

    ... This concentration was chosen on the basis of limited exposure data and because diazomethane is thought to have a similar mechanism of action to that of phosgene. 13 These animal ...

  10. TR-321: Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and... 10.6MB

    https://ntp.niehs.nih.gov/go/tr321

    ... The authors hypothesize t h a t the trihalomethanes, like chloroform, are metabolized to a phosgene-like intermediate, although this intermediate has not been isolated for ...

  11. TR-312: n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and... 15.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr312.pdf

    ... Ther- mal decomposition may produce phosgene. It can react vigorously with oxidizing materials (Merck, 1983; Sedivec and Flek, 1976; Oettingen, 1955; Sax, 1984). n-Butyl chloride ...

  12. TOX-3: Acetone (CASRN 67-64-1) 2.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox003.pdf

    ... 74. Kubic, V.L.; Anders, M.W. (1980) Metabo- lism of carbon tetrachloride to phosgene. ... B.; Whittaker, N.F.; Krishna, G. (1977) Phosgene: A metabolite of chloroform. Biochem. ...

  13. TR-440: Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15... 16.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr440.pdf

    ... Species comparison o f acute inhalation estimation from incomplete observations. J. Am. toxicity o f ozoneand phosgene. J. Toxicol.Environ.Stat. Assoc. 53, 457-481. Health 19, ...

  14. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... Examples of such toxicity is the production of phosgene by the oxidative metabolism of chloroform and the acute liver necrosis seen after carbon tetrachloride exposure. Such ...

  15. Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf

    ... is converted to a reactive intermediate (phosgene) an order of magnitude faster by ... dechlorination of chloroform to phosgene, - activation of ethyl carbamate to ...

 
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