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Search suggestions for "75-87-6".

  1. CEBS Data Related to Chloral (75-87-6) https://cebs.niehs.nih.gov/cebs/test_article/75-87-6


80 results found for "75-87-6".

  1. TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox059.pdf

    the Toxicity and Metabolism Studies of Chloral Hydrate (CAS No. 302-17-0) Administered ... the Toxicity and Metabolism Studies of Chloral Hydrate (CAS No. 302-17-0) Administered ...

  2. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF CHLORAL HYDRATE (AD ... NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF CHLORAL HYDRATE (AD ...

  3. TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORAL HYDRATE (CAS ... NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORAL HYDRATE (CAS ...

  4. Abstract for TOX-59 68KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox059

    Abstract for TOX-59 Toxicity and Metabolism Studies of Chloral Hydrate Administered by ... Full Report PDF Abstract Chloral hydrate is widely used as a sedative and a hypnotic in ...

  5. Abstract for TR-502 71KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr502

    Toxicology and Carcinogenesis Studies of Chloral Hydrate in B6C3F1 Mice (Gavage Studies) ... Full Report PDF Abstract Chloral hydrate is used medically as a sedative or hypnotic and ...

  6. Abstract for TR-503 67KB

    https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr503

    Abstract for TR-503 Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and ... Full Report PDF Abstract Chloral hydrate is used medically as a sedative or hypnotic and ...

  7. TR-502: Data 56KB

    https://ntp.niehs.nih.gov/data/tables/tr/500s/tr502

    7 TR-502: Data TR-502 Chloral Hydrate Pathology Tables - Male Mice Summary of Lesions in Regimen E Pathology Tables - Female Mice Summary of Lesions in Regimen A Summary of Lesions ...

  8. TR-503: Data 56KB

    https://ntp.niehs.nih.gov/data/tables/tr/500s/tr503

    9 TR-503: Data TR-503 Chloral Hydrate (Feed Restriction) Pathology Tables - Male Mice Summary of the Incidence of Neoplasms Historical Incidence of Hepatocellular Neoplasms Summary ...

  9. Minutes: BSC TRRS; May 18, 2000 94KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2000/may/trrs18may2000mins_508.pdf

    Minutes Technical Report CAS # Route Page Number Chloral Hydrate 302-17-0 Gavage 1 (Feed Restriction) Sulfone Chloral Hydrate 302-17-0 Gavage 3 Indium Phosphide 22398-80-7 ...

  10. Target Organs and Levels of Evidence for TR-502 57KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr502levels

    Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Chloral hydrate ...

  11. Target Organs and Levels of Evidence for TR-503 57KB

    https://ntp.niehs.nih.gov/data/tr/500s/tr503levels

    Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary ... Route/Exposure Levels Study Laboratory Chloral hydrate 302-17-0 05/18/2000 Gavage 0, 25, ...

  12. RoC Monograph: Trichloroethylene; January 2015 4.6MB

    https://ntp.niehs.nih.gov/ntp/roc/monographs/finaltce_508.pdf

    .........30 2.7.4. Chloral Hydrate (CH) ......Chloral also is a major oxidative metabolite but has low systemic levels due to rapid ...

  13. RoC Background Document: Trichloroethylene (TCE); Oct. 30-31... 3.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/trichl_tce1997_2apps_508.pdf

    ... Trichloroacetic Acid ...... 37 6.3.3.2 Chloral Hydrate ......(3) N- (hydroxyacetyl)aminoethanol, (4) chloral, (5) trich1oroethano1, (6) ...

  14. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    C4024 > 99 Carbon tetrachloride 56-23-5 153.82 SIGMA-ALDRICH 289116-100ml > 99.5 Chloral hydrate 302-17-0 165.40 SIGMA C8383 100.1 Chloramphenicol 56-75-7 323.14 FLUKA 23275 > ...

  15. Nomination Background: Wireless Communication Devices (CASRN... 153KB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/wireless051999_508.pdf

    antibiotic with no carcinogenicity study data - with a high priority ; c) a study on chloral hydrate, an important hypnotic used in pediatric medicine, using the p53 hemizygous ...

  16. RoC Concept: Trichloroethylene 729KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/tce_revised_concdocroc12-31-13_508.pdf

    ... cytochrome P450, primarily via CYP2E1 to chloral or TCE oxide and (2) conjugation with ... Downstream metabolites of the oxidation pathway include chloral hydrate, trichloroethanol ...

  17. Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

    ... processes : the reaction of chloral hydrate with calcium carbonate (or sodium ... TCA can be derived from the treatment of chloral hydrate with fuming nitric acid ...

  18. Peer Review Report: RoC Peer Review; Aug. 12, 2014 198KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2014/august/sep_report20140812_508.pdf

    ... The main pathway is through chlorine migration to form chloral and chloral hydrate, which are reduced by alcohol dehydrogenase to form trichloroethanol (TCOH), which is further ...

  19. RoC Profile: Acetaldehyde; 15th RoC 2021 176KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf

    ... is used primarily as a chemical intermediate in the pro- duction of acetic acid, pyridine and pyridine bases, peracetic acid, pentaerythritol, butylene glycol, and chloral. ...

  20. Minutes: BSC; April 6, 1994 2.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/april/19940406bscmins_508.pdf

    ... Allaben reported on initial studies with chloral hydrate, a hypnotic used extensively in pediatric medicine and C dentistry . He noted that the TSSRC for chloral hydrate included ...

  21. Minutes: BSC; Oct. 18, 1994 174KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/october/19941018_bsc_508.pdf

    ... those on allyl acetate and metabolites, chloral hydrate, methylene blue trihydrate, ... Allaben reported that with the first chemical, chloral hydrate, metabolism/pharmacokinetic ...

  22. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... P Clear Evidence TR-503 05/18/00 Chloral Hydrate (Ad Libitum and Dietary ... Tested in Species/Sex TR-502 05/18/00 Chloral Hydrate 302-17-0 NT Chemical Not Tested ...

  23. Short-Term Toxicity Reports 224KB

    https://ntp.niehs.nih.gov/publications/reports/tox

    ... N/A Short-Term Toxicity TOX-59 PDF (10.23 MB) Toxicity and Metabolism Studies of Chloral Hydrate (CASRN 302-17-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1999 ...

  24. Minutes: BSC; May 24, 2000 495KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2000/may/2000052400bscsummmins_508.pdf

    ... study through this IAG: studies for chloral hydrate and fumonisin B1 are complete and ... Chloral Hydrate (TR 502 and TR 503 feed restriction study) - sedative used in children - ...

  25. Technical Reports 903KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary ... Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice ...

  26. Protocol: Methods for preparing the RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/tce_final20140625_508.pdf

    ... acid, dichloroacetic acid, chloral hydrate, S- (1,2-dichlorovinyl)glutathion... acid, dichloroacetic acid, chloral hydrate, S- (1,2-dichlorovinyl)glutathion...

  27. Protocol: Methods for preparing the draft RoC Monograph: TCE 1.2MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/tce_protocol12-31-13_508.pdf

    ... acid, dichloroacetic acid, chloral hydrate, S- (1,2-dichlorovinyl)glutathion... acid, dichloroacetic acid, chloral hydrate, S- (1,2-dichlorovinyl)glutathion...

  28. RoC Profile: Trichloroethylene; 15th RoC 2021 237KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichloroethylene.pdf

    ... carcinogenicity, because trichlo- roethylene and its oxidative metabolites trichloroacetic acid, dichloro- acetic acid, and chloral hydrate have similar toxic effects on the liver. ...

  29. Minutes: BSC TRRS; May 21, 1999 160KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1999/may/trrs21may1999mins_508.pdf

    ... FDA. Other agents being studied under the Agreement include chloral hydrate, malachite green, urethane and ethanol combinations, and most recently, endocrine disrupting compounds. ...

  30. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

    ... Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary ... Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice ...

  31. Study Reports 1.1MB

    https://ntp.niehs.nih.gov/publications/reports

    ... Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary ... Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice ...

  32. Minutes: BSC; Dec. 13, 1996 288KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/december/19961213_bsc_508.pdf

    ... Schwetz gave brief descriptions of the rationale for study of chloral hydrate, fumonisin B1, malachite green and urethane/ethanol under the agreement. NIOSH: Dr. Albert Munson, ...

  33. TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf

    ... Sites) in Control Male B6C3F 1 /Nctr BR Mice a Study Incidence in Controls Chloral hydrate 2/48 Chloral hydrate 1/48 Doxylamine 0/48 Fumonisin B 1 0/48 Pyrilamine 0/47 ...

  34. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... Sigma-Aldrich NA 169-7000 7.7 11.8-7000 Chloral hydrate 302-17-0 100.1 Sigma 8.4 4.7-1000 ... Free radicals inducing lipid peroxidation? Chloral hydrate 302-17-0 479 165.40 Organic ...

  35. ICCVAM Background Review Document (Vol 1): In Vitro Cytotoxicity... 16.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol1_nov2006.pdf

    ... Alcohol; Amine; Polycyclic compound Chloral hydrate 479 MEIC, RC, TESS, NTP ... Chloral hydrate, mercury II chloride, and potassium cyanide were noted by HSDB to be ...

  36. TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf

    ... Diet 2/47 (4.3%) Fumonisin B 1 (March 1999) Diet 1/46 (2.2%) Chloral Hydrate (July 2001) Gavage 4/48 (8.3%) Chloral Hydrate (October 2002) Gavage 5/47 (10.6%) Urethane and Ethanol ...

  37. TOX-4: 1,2-Dichloroethane (Ethylene Dichloride) (CASRN 107-06... 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox004.pdf

    ... abnormal), pituitary gland, preputial or chloral glands (rats), prostate, salivary glands, ... abnormal), pituitary gland, preputial or chloral glands (rats), prostate, salivary glands, ...

  38. RoC Profile: Haloacetic Acids; 15th RoC 2021 382KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/haloacetic_acids.pdf

    ... Environ Mol Mutagen 54(8): 629-637. Daniel FB, DeAngelo AB, Stober JA, Olson GR, Page NP. 1992. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic ...

  39. TR-342: Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1... 29.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr342.pdf

    ... Production Volume, Uses, and Environmental Effects Dichlorvos has been commercially manufac- tured since 1961 by reacting chloral with tri- methyl phosphite. The product is 93% ...

  40. TOX-6: Pentachlorobenzene (CASRN 608-93-5) 3.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox006.pdf

    ... conducted on females for 7 d before necropsy glands, pituitary gland, preputial or chloral gland (rats), rec- For animals not examined histologically , organ weights ob- tum, ...

  41. Minutes: BSC; April 17, 1996 335KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/april/19960417_bsc_508.pdf

    ... on four chemicals currently being studied under the IAG. The first to be studied is chloral hydrate, a hypnotic in long-time use and the agent of choice in pediatric medicine, ...

  42. TOX-3: Acetone (CASRN 67-64-1) 2.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox003.pdf

    ... cavity and turbmates, pancreas, para- thyroid glands, pituitary gland, preputial or chloral gland, rectum, salivary glands, skin, spinal cord and sciatic nerve < if neurologic ...

  43. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... Another example: the CNS effects of chloral hydrate result from the metabolite ... 192.3 0.99 619.6 3.19 194.22 0.99 264 Chloral hydrate 302-17-0 438.31 2.65 479.7 2.9 ...

  44. Draft ROC Monograph: Haloacetic Acids; June 6, 2017 3.1MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph.pdf

    ... trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, ... Page NP. 1992. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and ...

  45. Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf

    ... trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, ... Page NP. 1992. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and ...

  46. TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB

    https://ntp.niehs.nih.gov/go/tr575

    ... Adenoma Adenocarcinoma Adenoma or Adenocarcinoma Chloral Hydrate (July 2001) Gavage 4/48 (8.3%) 0/48 (0.0%) 4/48 (8.3%) Chloral Hydrate (October 2002) Gavage 5/47 (10.6%) 0/47 ...

  47. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... 112 48 Caffeine 2.64 0.99 192.3 264 Chloral hydrate 2.65 2.9 479.7 113 1 ... chloride 0.021 1.31 474.4 264 Chloral hydrate 2.65 2.9 479.7 265 Streptomycin ...

  48. Minutes: BSC; July 7, 2009 399KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/july/minutes20090724.pdf

    ... Technical reports on chloral hydrate with and without dietary restriction were published. ... With dietary restriction, chloral hydrate caused liver carcinogenesis through peroxisome ...

  49. TR-372: 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325... 12.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr372.pdf

    ... UEntKAL BODY SYSTEM None UBNiTAL SYSTEM Chloral gland Adenoma Carcinoma Bilateral, adenoma ... adenoma Carcinoma, metastatic, chloral gland Carcinoma, metastatic, multiple, ...

  50. TR-549: Bromochloroacetic Acid (CAS 5589-96-8) in F344/N Rats... 20.0MB

    https://ntp.niehs.nih.gov/go/tr549

    ... Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in ... Mutagenicity of three disinfection by-products: Di- and trichloroacetic acid and chloral ...

 
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