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39 results found for "77-92-9".

  1. Japanese Minimum Requirements for Biological Products 2.0MB

    https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf

    .........280 Test for Citric Acid Content ......Tri-sodium citrate 22.0 g 26.30 g Citric acid 8.0 g 3.27 g Glucose 22.0 g 23.20 g ...

  2. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    165.40 SIGMA C8383 100.1 Chloramphenicol 56-75-7 323.14 FLUKA 23275 > 99 Citric Acid 77-92-9 192.10 SIGMA C0759 98 Colchicine 64-86-8 399.45 FLUKA 27650 > 98 Cupric Sulfate ...

  3. RoC Profile: Reserpine; 15th RoC 2021 131KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/reserpine.pdf

    ... chloride, and glacial acetic acid; soluble in benzene and ethyl acetate; and slightly soluble in methanol, eth- anol, acetone, ether, and weak solutions of acetic and citric acids. ...

  4. RoC Background Document: Vinyl Fluoride; Jan. 20-21, 2000 468KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/vf_no_appendices_508.pdf

    ... It also is likely that incorporation of fluoroacetate into the citric acid cycle disrupts ... Incorporation of fluoroacetate into the citric acid cycle disrupts energy metabolism and ...

  5. ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf

    ... as a positive control, and 10% citric acid or 6% propionic acid as a negative control. ... 1-3-70841, #2 16 HCl + Sulfuric acid + Citric acid Acid Mixture 5,5,5 9.09 1 II II p72 p92 ...

  6. Nomination Background: d-Pseudoephedrine (CASRN: 90-82-4) 388KB

    https://ntp.niehs.nih.gov/sites/default/files/2024-10/ephedrinealkaloids_508.pdf

    ... sarsaparilla root, goldenseal, nettle leaf, gotu kola, spirulina, Royal jelly, citric acid, glycine, caffeine, croscarmellose sodium, protein hydrolysate, silica, modified ...

  7. Protocol: Use of Corrositex for Dermal Corrosivity Testing (2003... 205KB

    https://ntp.niehs.nih.gov/iccvam/methods/dermal/corrositex/corrdocs/sampprot.pdf

    ... solid or other Packing Group II corrosive)(6)(8) and negative control (e.g., citric acid at 10 wt. %; propionic acid at 6 wt. %) is evaluated in the appropriately labeled vial(s). ...

  8. TOX-76: Toxicity Studies of 2,4-Decadienal (CASRN 25152-84-5... 2.5MB

    https://ntp.niehs.nih.gov/go/tox076

    ... both with and without the addition of butylated hydroxytoluene/butylated hydroxyanisole/citric acid antioxidants at the maximum allowable concentration of 200 ppm (Canadian limit). ...

  9. ICCVAM Background Review Document (Vol 1): In Vitro Cytotoxicity... 16.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol1_nov2006.pdf

    ... Citric Acid 3000 * EPA, NTP, HPV Food additive 192.10 -1.72 Organic compound; Carboxylic ... In the 2000< LD 50 ≤5000 mg/kg category, citric acid, trichloroacetic acid and ...

  10. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... 7.6 4.7-1000 Chloramphenicol 56-75-7 > 99 Fluka 8.3 4.7-2500 7.8 9.15-2500 Citric acid 77-92-9 98 Sigma 2.9 23.5-10000 4.0 23.5-10000 F-5 In Vitro Cytotoxicity Test Methods BRD ...

  11. Predicting human developmental toxicity of pharmaceuticals using... 510KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf

    ... Succinic acid, isoleucine, and malate are part of the citric acid cycle, which produces ... Interruption of citric acid cycle reactions compromises cellular energy metabolism with ...

  12. TR-314: Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and... 11.4MB

    https://ntp.niehs.nih.gov/go/tr314

    ... Methyl methacrylate is metabolized via the citric acid cycle, which may involve the mito- chondria (Bratt and Hathway, 1977). Incubated with rat liver slices in vitro, methyl ...

  13. TR-345: Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1... 25.2MB

    https://ntp.niehs.nih.gov/go/tr345

    ... was deter- mined by high-performance liquid chromatog- raphy with a Waters pBondapak Cts column and a mobile phase of aqueous citric acid/phosphate buffer, pH 2.2:methanol (90:10). ...

  14. TR-524: Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and... 2.8MB

    https://ntp.niehs.nih.gov/go/tr524

    ... Ditre et al. (1996) investigated the effects of 25% solu- tions of glycolic acid, lactic acid, or citric acid on pho- toaged human skin. The forearms of patients were treated for 6 ...

  15. ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB

    https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf

    ... MEA-sulfosuccinate DMDM hydantoin Citric acid Triclosan Tetrasodium EDTA FD&C Yellow ... Cetrimonium chloride PEG-3 cocamide Citric acid Sodium chloride Ditallowdimonium ...

  16. RoC Monograph: Antimony Trioxide; October 2018 2.6MB

    https://ntp.niehs.nih.gov/ntp/roc/monographs/antimony_final20181019_508.pdf

    ... related to the presence of organic matter, particularly organic acids that also occur in plasma, such as citric acid, pyruvic acid, and fumaric acid (Filella et al. 2002a; 2002b). ...

  17. TR-020: Dapsone (CASRN 80-08-0) 3.0MB

    https://ntp.niehs.nih.gov/go/tr020

    ... Dapsone inhibits the oxidation of pyruvate in the citric acid cycle in rats and mice, and this is believed to be related to the toxicity of the chemical (Wu and Dubois, 1970). It ...

  18. Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf

    ... be related to the presence of organic matter, particularly organic acids that also occur in plasma, such as citric acid, pyruvic acid, and fumaric acid (Filella et al. 2002b, a). ...

  19. Antimony Draft Monograph; Nov. 29, 2017 3.5MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph.pdf

    ... to be related to the presence of organic matter, particularly organic acids that also occur in plasma, such as citric acid, pyruvic acid, and fumaric acid (Filella et al. 2002a,b). ...

  20. CERHR Monograph: Hydroxyurea 3.6MB

    https://ntp.niehs.nih.gov/go/hu_monograph

    ... The tablet is available in a 1000 mg strength. Inactive ingredients that may be present in capsules include citric acid, D&C Yellow #10, FD&C Blue #1, FD&C Red 40, D&C Red 28, D&C ...

  21. Peer Review Report: RoC Peer Review; Mar. 21-22, 2013 352KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/march/peerreviewrpt20130322_508.pdf

    ... With respect to the Jones and Walsh (1979) studies, he noted that Udenfriend's reagent (a mixture of iron, citric acid, EDTA, and oxygen) was used to oxidize 1-BP, which he ...

  22. Performance Standards for In Vitro Test Methods for Skin Corrosion 6.3MB

    https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/ps/ps044510.pdf

    ... Examples of noncorrosive substances used as negative controls in the validated reference test method include 10% citric acid or 6% propionic acid. Benchmark Controls: Benchmark ...

  23. RoC Monograph: 1-Bromopropane; September 2013 1.9MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

    ... Jones and Walsh confirmed formation of these molecules using Udenfriend's reagent (a mixture of iron, citric acid, EDTA, and oxygen) to oxidize 1- bromopropane in vitro; these ...

  24. TR-396: Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats... 14.5MB

    https://ntp.niehs.nih.gov/go/tr396

    ... monofluoro- acetate, which produces its toxic effects by inhibiting the citric acid cycle. ... and 0.5 pmol Icysteine, pH 7.4, and various citric acid (the substrate) concentrations. ...

  25. NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/leadappendixe_final_508.pdf

    ... Acid phosphatase = -0.202; p≤0.01 Citric acid =-0.217; p≤0.01 Blood Pb was not ... sperm, acid phosphatase, and citric acid (p<0.05), but not sperm count Seminal ...

  26. TR-289: Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1Mice... 16.4MB

    https://ntp.niehs.nih.gov/go/tr289

    ... Carlson and Brewer (1953) offered diets containing 0%-0.5%or 0%-1.0% (four concentra- tions) with 0.1%citric acid to groups of 10-23 male and female rats for 103 weeks. No adverse ...

  27. OECD Guidance Document 129: Using Cytotoxicity Tests to Estimate... 1.4MB

    https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd129.pdf

    ... 128 348 3491 Organic compound; Alcohol; Cyclic hydrocarbon; Nitro compound Citric acid 77-92-9 796 400 5929 Organic compound; Carboxylic acid Colchicine 64-86-8 0.034 0.007 15 ...

  28. Nomination Background: p-Synephrine (CASRN: 94-07-5) 1.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/bitterorange_508.pdf

    ... Fruit BERGAPTEN Fruit CITRANTIN* Fruit CITRIC-ACID Fruit COUMARIN Fruit DELTA-LIMONENE* ... Plant CINNAMIC-ACID Plant CITRAL Plant CITRIC-ACID Plant 54 CITRONELLAL Plant CITRONELLOL ...

  29. RoC References: Antimony and Other Antimony Compounds; Aug. 17... 599KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/references/antimonyreferences_508.pdf

    ... LL, Ke YQ, Guo QH, Hu SH. 2016. Using citric acid stabilizing reagent to improve ... effect of antimony compounds with citric acid and its application to the speciation ...

  30. CERHR Monograph: Potential Human Reproductive and Developmental... 1.4MB

    https://ntp.niehs.nih.gov/go/pg_monograph

    ... It is primarily metabolized to lactic acid and pyruvic acid, both of which are normal constituents of the citric acid cycle. CNS, hematologic, hyperosmotic, and cardiovascular ...

  31. TR-349: Two Pentachlorophenol Technical-Grade Mixtures (CASRN... 30.4MB

    https://ntp.niehs.nih.gov/go/tr349

    ... The effect was markedly greater when pyruvate was used as a substrate, indicating that the inductive effect apparently takes place primarily outside the citric acid cycle. The ...

  32. TR-245: Melamine (CASRN 108-78-1) in F344/N Rats and B6C3F1Mice... 8.1MB

    https://ntp.niehs.nih.gov/go/tr245

    ... - GPC 301 Solvent: pH 3 citric acid/phosphate buffer diluted 1 to 5 with H20, isocratic System 2 - Instrument: Waters ALC 202 Solvent: pH 5 citric acid/phosphate buffer diluted I ...

  33. Comment: Antimony Trioxide (Attachment); Caroline Braibant, Geert... 9.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/nominations/2016/publiccomm/braibant_attach2.pdf

    ... complexes of antimony with tartaric or citric acid are known to be stable and highly ... 1 g (nominal in water) 20 cc (in 4 % citric acid) Exposure: 21 daily treatments with ...

  34. Workshop Report: Alternative Methods to Replace Animal Use for... 10.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/biologics-docs/bontwkshprept.pdf

    ... 20x PBS solution 250ml Tween 20 2.5ml Distilled Water Made up to 5 Litres C. 0.05M Citric Acid, pH 4.0 (ABTS Substrate buffer) CHEMICALS AMOUNT AMOUNT (2.5L) Citrate monohydrate ...

  35. Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/hcaspub_508.pdf

    ... The test animals were given MeIQ (10 mg/kg per day) by gavage for 14 consecutive days. Animals in the control group received water acidified with citric acid to a pH of 3.5. One ...

  36. TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal... 1.3MB

    https://ntp.niehs.nih.gov/go/tr518

    ... Partisil 10 SCX analytical column with a mobile phase of 0.1 M citric acid/5% sodium dihydrogen citrate buffer that contained 0.1 M sodium chloride and a flow rate of 1 mL/minute. ...

  37. NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/appendicesathrue_final_508.pdf

    ... Acid phosphatase = -0.202; p≤0.01 Citric acid =-0.217; p≤0.01 Blood Pb was not ... sperm, acid phosphatase, and citric acid (p<0.05), but not sperm count Seminal ...

  38. TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

    https://ntp.niehs.nih.gov/go/tr044

    ... After developing, the cells were stained for 5 min with 0.1$ crystal violet in 0.1M citric acid. The number of grains per nucleus was counted on 100 cells per slide for each of the ...

  39. Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf

    ... Castor oil (U.S.P. or equivalent) Cedar oil Cinnamon and cinnamon oil Citric acid Citronella and citronella oil Cloves and clove oil Corn gluten meal Corn oil Cottonseed oil Dried ...

 
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