TR-392: Chlorinated Water (CASRNs. 7782-50-5 and 7681-52-9) and... 75.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr392.pdf

STUDIES OF CHLORINATED WATER (CAS NOS. 7782-50-5 and 7681-52-9) AND CHLORAMINATED WATER ... STUDIES OF CHLORINATED WATER (CAS NOS. 7782-50-5 and 7681-52-9) AND CHLORAMINATED WATER ...

Abstract for TR-392 67KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr392

Chlorinated water (CASRN 7782-50-5) Chlorinated water (CASRN 7681-52-9) Chloraminated water (CASRN 10599-90-3) Report Date: March 1992 Full Report PDF Abstract Chlorine and ...

Abstract for TR-544 74KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr544

Abstract Dibromoacetonitrile is formed as a result of the reaction of chlorine oxidizing compounds (e.g., chlorine gas, hypochlorous acid, and hypochlorite) with natural organic ...

Abstract for TR-517 70KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr517

Sodium chlorate is used as an oxidizing agent and bleach for paper pulp; to make chlorine ... as a stable by-product in drinking water that has been disinfected with chlorine dioxide. ...

RoC Profile: Polychlorinated Biphenyls; 15th RoC 2021 176KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polychlorinatedbiphenyls.pdf

y Polychlorinated biphenyls (number of chlorine atoms [x + y] = 1-10) Carcinogenicity ... In male mice, dietary administration of mixtures of PCBs with similar aver- age chlorine ...

Draft ROC Monograph: Haloacetic Acids; June 6, 2017 3.1MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph.pdf

... acids evaluated consist of nine chlorine and bromine-containing mono-, di- or ... or type of halogen substitution (e.g., chlorine, bromine, and iodine), to determine if ...

Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf

... acids evaluated consist of nine chlorine and bromine-containing mono-, di- or ... or type of halogen substitution (e.g., chlorine, bromine, and iodine), to determine if ...

RoC Profile: Haloacetic Acids; 15th RoC 2021 382KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/haloacetic_acids.pdf

Haloacetic acids are formed as by-products during the disinfection of water, as the result of re- actions between chlorine-based disinfection agents (chlorine, chlor- amine, and ...

Abstract for TER97005 62KB

https://ntp.niehs.nih.gov/publications/abstracts/dev/ter97005

Sodium chlorate is used as an oxidizing agent and bleach for paper pulp, to make chlorine dioxide used in water disinfection, in various manufacturing processes, and as a ...

Target Organs and Levels of Evidence for TR-392 58KB

https://ntp.niehs.nih.gov/data/tr/300s/tr392levels

Target Organs and Levels of Evidence for TR-392 Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN ...

Abstract for TR-583 81KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr583

Bromodichloroacetic acid is a haloacetic acid that forms when drinking water supplies containing natural organic matter are disinfected with chlorine-containing oxidizing compounds ...

Abstract for TOX-45 62KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox045

The National Cancer Institute and National Toxicology Program have performed 2-year toxicology and carcinogenesis studies with a number of ethanes substituted with chlorine or ...

Abstract for TR-532 68KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr532

Bromodichloromethane is a by-product of the chlorination of drinking water. It is formed by the halogen substitution and oxidation reactions of chlorine with naturally occurring ...

Abstract for GMM-5 86KB

https://ntp.niehs.nih.gov/publications/reports/gmm/gmm05

Bromodichloromethane is a by-product of the chlorination of drinking water. It is formed by the halogen substitution and oxidation reactions of chlorine and naturally occurring ...

RoC Review of Haloacetic Acids Found as Water Disinfection By... 88KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/haa

one or more halogen atoms such as chlorine, bromine, and iodine. HAAs are formed during the disinfection of water from a reaction between chlorine-based disinfection agents and ...

BSC Meeting: Draft RoC Concept: Di- and Tri- Haloacetic Acids... 240KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/april/haa_508.pdf

These consist of seven chlorine and bromine containing di- or tri-acetic acids either ... Drinking Water* Halogen Di-HAA Tri-HAA Chlorine Dichloroacetic acid (DCA) ...

Abstract for TR-38 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr038

PCBs were developed in 1929 primarily for use as heat transfer fluids and dielectrics (insulators). Aroclor® 1254, a biphenyl containing approximately 54% chlorine, is a ...

Public comment on Haloacetic Acids; Tasha Stoiber, EWG; July... 1.6MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/publiccomm/stoiber20170711_508.pdf

when disinfectants such as chlorine interact with plant and animal waste in source water. ... Dichloroacetic acid, containing two chlorine atoms; Dibromoacetic acid, containing ...

TR-517: Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and... 10.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr517.pdf

... Background Sodium chlorate occurs when drinking water is disinfected by chlorine dioxide. ... agent and bleach for paper pulp; to make chlorine dioxide used in water disinfection; in ...

NTP Review of Halogenated Flame Retardants 60KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/ongoing/hfr

Substance Overview Halogenated flame retardants encompass a large group of bromine or chlorine-containing chemicals that all share a similar function (i.e., fire retardation). ...

Public comment on Haloacetic Acids; Mark Gibson, ACC; July 2017 618KB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/publiccomm/nordgren20170714_508.pdf

... since the inception of continuous chlorine use in conjunction with filtration in ... 8 Most of these systems rely on chlorine or a chlorine-based disinfection process ...

Target Organs and Levels of Evidence for TR-305 58KB

https://ntp.niehs.nih.gov/data/tr/300s/tr305levels

Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN ... Chlorinated paraffins: C23, 43% chlorine 108171-27-3 08/14/1985 Gavage FR: ...

DOT Update: ICCVAM Public Forum 2015 265KB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/dot-iccvampubforum-2015-508.pdf

√ Solids √ √ CLASSIFICATION Gas Division 2.3 Hazard Zone A Arsine Hazard Zone B Chlorine Hazard Zone C Sulfur Dioxide Dust & Mists Division 6.1 Packing Group I PG II PG III ...

Target Organs and Levels of Evidence for TR-308 59KB

https://ntp.niehs.nih.gov/data/tr/300s/tr308levels

Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C12, 60% Chlorine) (CASRN ... Chlorinated paraffins: C12, 60% chlorine 108171-26-2 08/14/1985 Gavage R: ...

DOT PHMSA Update: ICCVAM Public Forum 2017 243KB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2017/03p-hwang-dot-508.pdf

Inhalation Gas Division 2.3 Hazard Zone A Hazard Zone B Hazard Zone C Hazard Zone D Arsine Chlorine Sulfur Dioxide Ammonia LC50≤200ppm 200ppm<LC50≤1000ppm 1000 ...

TR-308: Chlorinated Paraffins (C12, 60Chlorine) (CASRN 108171... 12.0MB

https://ntp.niehs.nih.gov/go/tr308

STUDIES OF CHLORINATED PARAFFINS (Ci2, 60% CHLORINE) (CAS NO. 63449-39-8) IN F344/N RATS ... TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORINATED PARAFFINS (C12,60% CHLORINE) (CAS NO. ...

TR-305: Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171... 13.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr305.pdf

STUDIES OF CHLORINATED PARAFFINS (C2a, 43% CHLORINE) (CAS NO. 63449-39-8) IN F344/N RATS ... STUDIES OF CHLORINATED PARAFFINS (C23, 43% CHLORINE) (CAS NO. 63449-39-8) IN F344/N RATS ...

Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf

... by treating allyl chloride with chlorine and water (which forms hypochlorous acid). ... of glycerol (1,2,3-trihydroxypropane) have been replaced by one or two chlorine atoms. ...

RoC Profile: 3,3'-Dimethylbenzidine and Dyes Metabolized to 3... 158KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylbenzidineanddyes.pdf

... for the detection of blood, gold, and chlorine and as a curing agent for urethane ... terms, see the Glossary. for determining chlorine in water using 3,3'-dimethylbenzidine be ...

Biocides & Potential Respiratory Health Outcomes 60KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/ongoing/biocides

7681-52-9 Chlorinated Isocyanurate Trichloro-s-triazinetrione 87-90-1 Chlorine Dioxide (in solution) Chlorine dioxide 10049-04-4 DDAC QUAT 1-Decanaminium, N-decyl-N, N-dimethyl ...

TR-532: Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats... 7.2MB

https://ntp.niehs.nih.gov/go/tr532

... It is formed by the halogen sub- stitution and oxidation reactions of chlorine with ... and oxidation reac- tions of chlorine with naturally occurring organic matter ...

TR-294: Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in... 6.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr294.pdf

... Sodium hypochlorite (0.05 ml, 10%effective chlorine ad- ministered 45 times over 245 days) ... Chloroform and other halogenated organic com- pounds are reaction products of chlorine in ...

TR-544: Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats... 7.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr544.pdf

... Synonym: 2,2-dibromoacetonitrile Dibromoacetonitrile is formed as a result of the reaction of chlorine oxidizing compounds (e.g., chlorine gas, hypochlorous acid, and hypochlorite) ...

RoC Profile: Chlorendic Acid; 15th RoC 2021 124KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorendicacid.pdf

It is slightly soluble in water and in nonpolar organic solvents, but it is readily soluble in methanol, ethanol, and acetone. It emits chlorine when heated to decomposition (IARC ...

TOX-45: Renal Selected Halogenated Ethanes 1.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox045.pdf

... and carcinogenesis studies with a number of ethanes substituted with chlorine or bromine. ... of halogens (chlorine, bromine, and fluorine) ; iodinated compounds were not studied. ...

Predictive Toxicology at U.S. Army CCDC CBC (ICCVAM Public Forum... 1.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2019/11-glover-army_ccdc_cbc_508.pdf

Korean War Vietnam War War in Iraq War in Afghanistan 1915 First large-scale wartime use of chlorine gas occurs in Belgium 1899 Hague convention bans the use of "asphyxiating or ...

RoC Profile: Bromodichloromethane; 15th RoC 2021 133KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromodichloromethane.pdf

... main route of human exposure is through exposure to chlorine- treated water (IARC 1991). ... is likely to continue as long as chlorine and organic trihalomethane precursors ...

Agency Reponse to ICCVAM Recommendations on In Vitro Pyrogen... 125KB

https://ntp.niehs.nih.gov/iccvam/methods/pyrogen/transmitnov08/epa-response.pdf

Internet Address (URL) . http://www.epa.gov Recycled/Recyclable. Printed with Vegetable Oil Based Inks on 100% Postconsumer. Process Chlorine Free Recycled Paper /s/ EPA is pleased ...

RoC Profile: Chlorinated Paraffins (C12, 60% Chlorine); 15th... 135KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorinatedparaffins.pdf

Chlorinated Paraffins (C 12 , 60% Chlorine) CAS No. 108171-26-2 Reasonably anticipated to ... Carcinogenicity Chlorinated paraffins (C 12 , 60% chlorine) are reasonably anticipated to ...

Agency Response to ICCVAM Recommendations on In Vitro Cytotoxicity... 496KB

https://ntp.niehs.nih.gov/iccvam/methods/acutetox/transmitfeb08/epa-response.pdf

Recycled/Recyclable . Printed with Vegetable Oil Based Inks on 100% Postconsumer, Process Chlorine Free Recycled Paper EPA also agrees with ICCV AM's conclusion that these in vitro ...

Agency Response to ICCVAM Recommendations on LUMI-CELL Test Method 1.5MB

https://ntp.niehs.nih.gov/iccvam/methods/endocrine/transmitfeb12/epa-response-508.pdf

and Policy Internet Address (URL ) . http//wwwepa.gov Recycled/Recyc lable . Printed with Vegetable Oil Based Inks on 100% Postconsumer, Process Chlorine Free Recycled Paper /s/

RoC Profile: Propylene Oxide; 15th RoC 2021 196KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/propyleneoxide.pdf

... Propylene oxide is very flammable, but it is stable under normal storage con- ditions (Akron 2009). It is very reactive, particularly with chlorine, ammonia, strong oxidants, and ...

RoC Profile: Toxaphene; 15th RoC 2021 149KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/toxaphene.pdf

... by reacting chlorine gas with techni- cal camphene in the presence of ultraviolet radiation and catalysts, yielding chlorinated camphene containing 67% to 69% chlorine by weight. ...

Federal Agency Response to ICCVAM Recommendations on the LLNA 1.9MB

https://ntp.niehs.nih.gov/iccvam/methods/immunotox/transmitjuly11/epa-response.pdf

... Recycled/Recyclable' Printed with Vegetable Oil Based Inks on 100% Postconsumer. Process Chlorine Free Recycled Paper 2) Alternatives: A summary of EPA's commitment to promoting ...

Agency Response to ICCVAM Recommendations on In Vitro Ocular... 143KB

https://ntp.niehs.nih.gov/iccvam/methods/ocutox/ivocutox/transmit/eparesponse.pdf

... Internet Address (URL) . http://www.epa.gov Recycled/Recyclable . Printed with Vegetable Oil Based Inks on 100% Postconsumer, Process Chlorine Free Recycled Paper The toxics ...

TOX-6: Pentachlorobenzene (CASRN 608-93-5) 3.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox006.pdf

... to its higher degree of chlorine substitution (Oliver and Niimi, 1983; Matthews, 1986). ... probably because its high degree of chlorine substitution inhibits formation of the ...

Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

... of glacial acetic acid by the action of chlorine in the presence of sunlight, ultraviolet ... These by-products can arise in the environment from a reaction between chlorine and hurnic ...

RoC Profile: Melphalan; 15th RoC 2021 124KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/melphalan.pdf

... One study reported that expo- sure of hospital personnel to melphalan could be reduced by treating excess solutions, spills, and urinals with chlorine bleach (Hansel et al. 1997). ...

TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf

... of hydrocarbons containing chlorine (PCBs) that are similar in structure to dioxins. ... Increasing the chlorine content results in the mixture taking on the consistency of a ...

TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf

... of hydrocarbons containing chlorine (PCBs) that are similar in structure to dioxins. ... Increasing the chlorine content results in the mixture taking on the consistency of a ...