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RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
... formula, mol wt CASRN Synonyms Uses Structure Tetraethyl lead Pb(C 2 H 5 ) 4 323.446 78-00-2 motor fuel anti-knock compound, lead tetraethyl, tetraethylplumbane, TEL, and ...
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RoC Profile: Lead and Lead Compounds; 15th RoC 2021 190KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lead.pdf
Lead and Lead Compounds CAS No. 7439-92-1 (Lead) No separate CAS No. assigned for lead compounds as a class Reasonably anticipated to be human carcinogens First listed in the ...
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NTP Monograph on Health Effects of Low-Level Lead 12.9MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
Toxicology Program NTP NTP Monograph Health Effects of Low-Level Lead June 2012 THIS PAGE LEFT INTENTIONALLY BLANK NTP MONOGRAPH ON HEALTH EFFECTS OF LOW-LEVEL LEAD June 13, 2012 ...
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NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/appendicesathrue_final_508.pdf
APPENDICES A - E: HUMAN STUDIES CONSIDERED IN DEVELOPING CONCLUSIONS U.S. Department of Health and Human Services Office of Health Assessment and Translation Division of the ...
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TR-151: Lead Dimethyldithiocarbamate (CASRN 19010-66-3) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr151.pdf
1979 National Cancer Institute CARCINOGENESIS Technical Report Series NO. 151 BIOASSAY OF LEAD DIMETHYLDITHIOCARBAMATE FOR POSSIBLE CARCINOGENICITY CAS No. 19010-66-3 NCI-CG-TR-151 ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix A... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixa_final_508.pdf
APPENDIX A: HUMAN STUDIES OF NEUROLOGICAL EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS U.S. Department of Health and Human Services Office of Health Assessment and ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix E... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixe_final_508.pdf
E: HUMAN STUDIES OF REPRODUCTIVE AND DEVELOPMENTAL EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix E: Human Studies of Reproductive and Developmental Effects of Pb ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix C... 1.2MB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixc_final_508.pdf
C: HUMAN STUDIES OF CARDIOVASCULAR EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix C: Human Studies of Cardiovascular Effects of Pb Considered in Developing ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix B... 873KB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixb_final_508.pdf
B: HUMAN STUDIES OF IMMUNE EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix B: Human Studies of Immune Effects of Pb Considered in Developing Conclusions NTP Monograph ...
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NTP Monograph on Health Effects of Low-Level Lead Appendix D... 543KB
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixd_final_508.pdf
D: HUMAN STUDIES OF RENAL EFFECTS OF LEAD CONSIDERED IN DEVELOPING CONCLUSIONS Appendix D: Human Studies of Renal Effects of Pb Considered in Developing Conclusions NTP Monograph ...
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Lead dimethyldithiocarbamate: Target Organs and Levels of Evidence... 56KB
https://ntp.niehs.nih.gov/data/tr/100s/tr151levels
5 Lead dimethyldithiocarbamate: Target Organs and Levels of Evidence for TR-151 Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CASRN 19010-66-3) Chemical ...
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Minutes: MPRP; Nov. 17-18, 2011 236KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2011/november/minutes20111118.pdf
Table of Contents I. Attendees ...... 2 II. Introductions and ...
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Health Effects of Low-level Lead 67KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/lead
36443 Health Effects of Low-level Lead Lead in water and image of child Topic Overview CASRN: 7439-92-1 Status: Evaluation completed Background Information Although reductions in ...
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Abstract for RACB94009 65KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb94009
9abs Abstract for RACB94009 Reproductive Toxicity of in Lead Acetate Trihydrate in Sprague-Dawley Rats CASRN: 6080-56-4 Chemical Formula: C4H6O4Pb3H2O Molecular Weight: 379.33 ...
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Abstract for RACB84059 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb84059
9abs Abstract for RACB84059 Lead Acetate Trihydrate: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water CASRN: 301-04-2 Chemical Formula: ...
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Abstract for RACB82102 61KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb82102
2abs Abstract for RACB82102 Lead Acetate Trihydrate: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water CASRN: 301-04-2 Chemical Formula: ...
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Actions on Lead Monograph: MPRP; Nov. 17-18, 2011 103KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2011/november/actionsleadmonograph_508.pdf
Actions on Draft NTP Monograph on Health Effects of Low-Level Lead Peer Review Panel Meeting on November 17-18, 2011 The NTP Monograph Peer-Review Panel ("the Panel") was convened ...
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Abstract for TR-151 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr151
1abs Abstract for TR-151 Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity CASRN: 19010-66-3 Chemical Formula: C6H12N2S4Pb Molecular Weight: 451.6704 Synonyms/...
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Minutes: BSC RoC; Oct. 14, 2003 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2003/rocmin101403.pdf
National Toxicology Program Board of Scientific Directors Report on Carcinogens Subcommittee Meeting October 14, 2003 Marriott at Metro Center Bethesda, Maryland Summary Minutes ...
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Comment: Antimony Trioxide (Attachment); Caroline Braibant, Geert... 9.7MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/braibant_attach2.pdf
CHEMICAL SAFETY REPORT Substance Name: diantimony trioxide EC Number: 215-175-0 CAS Number: 1309-64-4 Registrant's Identity: Campine NV Lead Registrant of Diantimony trioxide- JS ...
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Minutes: BSC; May 10, 2010 200KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/may/minutes20100510.pdf
National Toxicology Program Board of Scientific Counselors May 10, 2010 National Institute of Environmental Health Sciences Research Triangle Park, NC Table of Contents I. ...
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Minutes: BSC; June 21-22, 2012 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/june/bscminutes20120622_508.pdf
National Toxicology Program Board of Scientific Counselors Summary Minutes June 21-22, 2012 National Institute of Environmental Health Sciences Research Triangle Park, NC Contents ...
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Abstract for TR-86 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr086
86abs Abstract for TR-86 Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity CASRN: 106-93-4 Chemical Formula: C2H4Br2 Molecular Weight: 187.862 Synonyms/Common Names: DBE; ...
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Documents Provided to the NTP Board of Scientific Counselors... 55.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf
DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review NTP Monograph 08 September ...
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Minutes: BSC; Dec. 6, 2007 262KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2007/december/bsc_mins2007dec06_508.pdf
National Toxicology Program Board of Scientific Counselors December 6, 2007 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes I. ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
impact Public Health Impact The public impact of NTP's work can be measured through its use by other agencies, often to support the establishment of regulations or guidelines to ...
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Abstract for TR-389 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr389
9abs Abstract for TR-389 Toxicology and Carcinogeneis Studies of Sodium Azide in F344 Rats (Gavage Studies) CASRN: 26628-22-8 Chemical Formula: Na N3 Molecular Weight: 65.02 ...
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Esophagus - Ulcer - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/esophagus/Ulcer
Esophageal erosions, ulcers, and necrosis are frequently the result of gavage accidents. Such trauma can lead to perforation, periesophageal abscesses, and fibrosis. An erosion is ...
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Carpels Antimony Trioxide public comment 545KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/publiccomm/carpels20180110_508.pdf
Comments On Monograph ATO V20180107 Campine - Environment department Page 1 of 11 Comments on the draft Report on Carcinogens Monograph on antimony trioxide (ATO) (R. Cortvrindt, ...
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RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB
https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf
ORoC Bibliography for Antimony and Other Antimony Compounds (as of 8/17/2017) 1. Abbaspour A, Najafi M. 2003. Simultaneous determination of Sb(III) and Sb(V) by partial least ...
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NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf
NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night April 2021 Night Shift Work and Light at Night and Cancer i National Toxicology Program Cancer Hazard ...
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Salivary Gland, Duct - Concretion - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Duct-Concretion
Concretions (mineralization of material in the ductular lumen) occur infrequently but are most commonly seen in older animals as a background lesion. They may be seen with atrophy. ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
CADMIUM FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by Integrated ...
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Monograph: Summary of NTP Cancer Hazard Conclusions: Exposure... 870KB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal_summary20210400_508.pdf
Summary of NTP Cancer Hazard Conclusions Exposure Circumstances That Cause Circadian Disruption: Persistent Night Shift Work Certain Lighting Conditions April 2021 Summary of NTP ...
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Comment: National Toxicological Program (NTP) Board of Scientific... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/presentations/05_kennedy_bsc_508.pdf
National Toxicological Program (NTP) Board of Scientific Counselors (BSC) David Kennedy DDS For The Preventative Dental Health Association (NTP) Board of Scientific Counselors ...
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Abstract for TR-55 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr055
55abs Abstract for TR-55 Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity CASRN: 107-06-2 Chemical Formula: C2H4Cl2 Molecular Weight: 98.9596 Synonyms/Common Names: ...
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Protocol to Evaluate the State of the Science for Transgenerational... 855KB
https://ntp.niehs.nih.gov/ntp/ohat/transgenerational/protocol201506_508.pdf
Transgenerational Inheritance of Health Effects Page 1 of 48 PROTOCOL TO EVALUATE THE STATE OF THE SCIENCE FOR TRANSGENERATIONAL INHERITANCE OF HEALTH EFFECTS Project Leader: ...
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Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf
Revised Draft: Report on Carcinogens Monograph on Antimony Trioxide August 15, 2018 Office of the Report on Carcinogens Division of the National Toxicology Program National ...
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Highlights From 2020 OECD WNT Meeting (ICCVAM Public Forum 2020... 284KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2020/ppt/15-oecd-hall-508.pdf
OECD TEST GUIDELINES PROGRAMME UPDATE ICCVAM Public Forum Webcast Thursday, 21 May 2020 Wanda Hall USG National Coordinator for the OECD TG Programme (hall.wanda@epa.gov) 2 No. ...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
EVIDENCE MAP OF INFLAMMATION-BASED ATHEROSCLEROSIS ASSOCIATED WITH ENVIRONMENTAL EXPOSURES July 2023 Integrative Health Assessments Branch Division Translational Toxicology ...
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FDA Update: ICCVAM Public Forum 2015 301KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/fda-iccvampubforum-2015-508.pdf
FDA-ICCVAM 3Rs A. Jacobs May 27, 2015 Tox21 activities in the past year . CDER was the lead center until 2014 . CFSAN and the FDA Foods program took over as the lead in 2014 . ...
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Human Cancer Studies; Suril Mehta; RoC; Jan. 24, 2018 644KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/presentations/humancancerstudies_508.pdf
Human Cancer Studies Suril Mehta, MPH Office of the Report on Carcinogens National Institute of Environmental Health Sciences January 24, 2018 Draft RoC Monograph on Antimony ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... By-products (Selected) 77-09-8 see Phenolphthalein 77-78-1 see Dimethyl Sulfate 78-00-2 (tetraethyl lead) see Lead and Lead Compounds 78-79-5 see Isoprene 79-01-6 see ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
Chromium Hexavalent Compounds CAS No. 18540-29-9 Known to be human carcinogens First listed in the First Annual Report on Carcinogens (1980) Carcinogenicity Chromium hexavalent ...
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TR-581: Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr581_508.pdf
The Toxicology STudieS of cobalT MeTal (caSRN 7440-48-4) iN f344/N RaTS aNd b6c3f1/N Mice aNd Toxicology aNd caRciNogeNeSiS STudieS of cobalT MeTal iN f344/NTac RaTS aNd b6c3f1/N ...
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Tooth, Ameloblast - Atrophy - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/tooth/Ameloblast-Atrophy
Ameloblasts (Figure 1 image opens in a pop-up window and Figure 3 image opens in a pop-up window , arrows) are the cells responsible for enamel production. Focal atrophy of ...
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Skeletal Muscle- Nonneoplastic Lesion Atlas 277KB
https://ntp.niehs.nih.gov/atlas/nnl/musculoskeletal-system/skeletal-muscle
Musculoskeletal System Skeletal Muscle Narrative Image of normal in the skeletal muscle from a male B6C3F1/N mouse in a subchronic study Figure 1. Normal skeletal muscle in a male ...
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Lung - Vacuolization, Cytoplasmic - Nonneoplastic Lesion Atlas 294KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/lung/VacuolizationCytoplasmic
Cytoplasmic vacuolization in the lungs is most commonly seen in the airway epithelium of mice (Figure 1 image opens in a pop-up window , Figure 2 image opens in a pop-up window , ...
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NTP Review of Shift Work at Night, Light at Night, and Circadian... 111KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/shiftwork
NSW_LAN NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption Black and white drawing of person at laptop working late into the night Topic Overview Status: ...
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Breakout Group A Summary: Workshop on Predictive Models for Acute... 82KB
https://ntp.niehs.nih.gov/iccvam/meetings/at-models-2018/ppt/24-bgasummary.pdf
Interagency Coordinating Committee on the Validation of Alternative Methods Breakout Group A: Practical Applications . What are the challenges that need to be addressed to ...
