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TOX-18: Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) 4.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox018.pdf
National Toxicology Program Toxicity Report Series Number 18 NTP Technical Report on Toxicity Studies of JM:ethyl Ethyl Ketone Peroxide (CAS No. 1338-23-4) in Dim.ethyl Phthalate ...
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Abstract for TER88046 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter88046
Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone in Mice CASRN: 78-93-3 Chemical Formula: C4H8O Molecular Weight: 72.1062 Report Date: February ...
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Abstract for TOX-18 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox018
8abs Abstract for TOX-18 Toxicity Studies of Methyl Ethyl Ketone Peroxide in Dimethyl Phthalate (45:55) Administered Topically to F344/N Rats and B6C3F1 Mice Substances: Methyl ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds The Results of an Independent Peer Review Evaluation ...
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Recommended Performance Standards for the LLNA 2.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf
Recommended Performance Standards: Murine Local Lymph Node Assay Interagency Coordinating Committee on the Validation of Alternative Methods National Toxicology Program ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
... 64-19-7 176 x Major Major Major Major Minor Major 2-Butanone; Methyl ethyl ketone 78-93-3 6569 x Major Major Major Major Major Major Ethanol 64-17-5 702 x Major Major Major ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential ...
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Minutes: BSC TRRS; June 23, 1992 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1992/june/trrs23june1992mins_508.pdf
from Peer Review of Draft Technical Reports of Long-Term Toxicology and Carcinogenesis Studies and Short-Tern Toxicity Studies by the Technical Reports Review Subcommittee June ...
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TOX-51: Methyl Ethyl Ketoxime 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox051.pdf
National Toxicology Program Toxicity Report Series Number 51 NTP Technical Report on the Toxicity Studies of Methyl Ethyl Ketoxime (CAS No. 96-29-7) Administered in Drinking Water ...
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Presentation: Conducting and Interpreting the Murine Local Lymph... 495KB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/4-woolhiser.pdf
Toxicology & Environmental Research and Consulting Conducting and Interpreting the Murine Local Lymph Node Assay (LLNA) Mike Woolhiser, Ph.D. Science & Technology Leader, TERC The ...
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RoC Profile: Mirex; 15th RoC 2021 138KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/mirex.pdf
Mirex CAS No. 2385-85-5 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as 1,1a,2,2,3,3a,4,5,5,5a,5b,6-dod...
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RoC Profile: 4,4'-Methylenebis(2-chloroaniline); 15th RoC 2021 143KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylenebis_chloroaniline.pdf
2-chloroaniline) CAS No. 101-14-4 Reasonably anticipated to be a human carcinogen First listed in the Third Annual Report on Carcinogens (1983) Also known as methylene-bis-ortho-ch...
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TOX-2: n-Hexane(CASRN 110-54-3) 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox002.pdf
NTP REPORT ON THE TOXICITY STUDIES OF n-HEXANE IN B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 January 1991 NTP ...
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Captafol/o-Nitrotoluene Expert Panel Report Part A; RoC expert... 162KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/captafol_report_parta_508.pdf
Part A - Peer Review of the Background Document on Captafol The Report on Carcinogens (RoC) expert panel for Captafol/ortho-Nitrotoluene met at the Sheraton Chapel Hill Hotel on ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf
Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity X. Chang 1 , E. Reinke 1 , A. Daniel 1 , D.G. Allen 1 , M. Mumtaz 2 , N. Kleinstreuer 3 1 Inotiv, RTP, NC; ...
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Public Comment: Methyl isobutyl ketone; Steven Risotto; RoC;... 379KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/risotto20131018_508.pdf
October 18, 2013 Dr. Ruth Lunn Director Office of the Report on Carcinogens National Toxicology Program National Institute for Environmental Health Sciences Research Triangle ...
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National Toxicology Program Toxicity Report Series 590KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox037.pdf
7 NTP Technical Report on Toxicity Studies of Sodium Cyanide (CAS No. 143-33-9) Administered in Drinking Water to F344/N Rats and B6C3F 1 Mice Charles D. Hébert, Ph.D., Study ...
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Peer Review Panel Report: Validation Status of the LLNA (2008... 6.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llnaprprept2008.pdf
NICEATM ICCVAM National Toxicology Program Interagency Coordinating Interagency Center for the Evaluation Committee on the Validation of Alternative Toxicological Methods of ...
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LLNA BrdU-ELISA Test Method: ICCVAM Recommended Protocol 272KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llna-brdu-elisa.pdf
2-Bromodeoxyuridine-ELISA Test Method (LLNA: BrdU-ELISA), a Nonradioactive Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and ...
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LLNA:DA Test Method: ICCVAM Recommended Protocol 279KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llna-da.pdf
DA A Nonradioactive Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products Originally published as Appendix B of "ICCVAM Test ...
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Update Protocol for the LLNA 656KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/llnaupdated.pdf
Updated Protocol for the Murine Local Lymph Node Assay Originally published as Appendix A of "Recommended Performance Standards: Murine Local Lymph Node Assay" NIH Publication No. ...
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TR-572: Methyl trans-styryl ketone (CASRN 1896-62-4) in F344... 8.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr572_508.pdf
METHYL trans-STYRYL KETONE (CAS NO. 1896-62-4) IN F344/N RATS AND B6C3F1 MICE (FEED AND DERMAL STUDIES) National Toxicology Program P.O. Box 12233 Research Triangle Park, NC 27709 ...
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OECD Test Guideline 429: Skin Sensitisation: Local Lymph Node... 291KB
https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-tg429-2010.pdf
OECD/OCDE 429 Adopted: 22 July 2010 © OECD, (2010) You are free to use this material for personal, non-commercial purposes without seeking prior consent from the OECD, provided ...
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TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox059.pdf
59 NTP Technical Report on the Toxicity and Metabolism Studies of Chloral Hydrate (CAS No. 302-17-0) Administered by Gavage to F344/N Rats and B6C3F Mice 1 Frederick A. Beland, ...
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Short-Term Toxicity Reports 224KB
https://ntp.niehs.nih.gov/publications/reports/tox
TOX-106 PDF (2.68 MB) Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
NIH Publication Number 11-7709 . . . . . . . . . . . . 1000000 . ...... _ . ...... . 100000 1 . : 1 ... . i... . >. 1000 . . . :.. ~ - . .. +----.- i. y A r : 10000 100 ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
... pharmaceuticals Methyl ethyl ketone 78-93-3 Ketone Solvent; Manufacture of lacquers, ... > 75 2 Reference Methyl ethyl ketone 78-93-3 liquid 100% 99 1 68 1.665 93 Very severe ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... P500207 (Sigma-Aldrich, Milwaukee, WI) 78-93-3 2/8/2016 3.6 mL 99.7 Clear Liquid Ambient ... 4-methoxy- 111-32-0 104.15 2-Butanone 78-93-3 72.11 2-Butene, (E)- 624-64-6 56.11 ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
ICCVAM Test Method Evaluation Report The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential ...
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Nomination Background: Isoamyl acetate (CASRN: 123-92-2) 205KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/isoamylacetate_508.pdf
SUMMARY OF DATA FOR CHEMICAL SELECTION Isoamyl Acetate CAS No. 123-92-2 Prepared for NTP by Technical Resources International, Inc Prepared on 11/94 Under NCI Contract No. ...
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TOX-30: Dibutyl Phthalate (CASRN 84-74-2) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox030.pdf
0 NTP Technical Report on Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F Mice 1 Daniel S. Marsman, D.V.M., Ph.D., Study ...
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Background Document: RoC: Captafol; 2010 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf
Captafol June 20, 2008 U.S. Department of Health and Human Services Public Health Service National Toxicology Program Research Triangle Park, NC 27709 This Page Intentionally Left ...
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TR-313: Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro... 13.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr313.pdf
3 ("1- <~ -.,~ J'~.l~Vdl0.~ TOXICOLOGY AND CARCINOGEl'fESIS STUDIES OF MIRE X (1, la,2,2,3,3a,4,5,5,5a,5 b,6- Dodecac hlorooctahydro-1 ,3,4- metheno-lH- cyclo buta[cd]pentalene) ...
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TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF CHLORAL HYDRATE (AD LIBITUM AND DIETARY CONTROLLED) (CAS NO. 302-17-0) IN MALE B6C3F 1 MICE (GAVAGE STUDY) ...
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GMM-04: Genetically Modified Model Report on Pentaerythritol... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm04_508.pdf
PeNTaeRyThRiTol TRiacRylaTe (TechNical GRade) (caSRN 3524-68-3) iN f344/N RaTS, B6c3f1 Mice, aNd GeNeTically Modified (fVB TG.ac heMizyGouS) Mice (deRMal STudieS) NTP GMM 04 ...
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TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORAL HYDRATE (CAS NO. 302-17-0) IN B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf
... al. (1995) Methyl ethyl ketone 78-93-3 liquid S undiluted 99% Fisher 1 2 2.2 23.1 2A 1 II I R36 R41 Balls et al. (1995) Methyl ethyl ketone 78-93-3 liquid S undiluted 99% Fisher 2 ...
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TR-291: Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1Mice... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr291.pdf
91 c TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOPHORONE (CAS NO. 78-59-1) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...
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RoC Profile: Formaldehyde; 15th RoC 2021 298KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf
Formaldehyde CAS No. 50-00-0 Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) H 2 C=O Carcinogenicity Formaldehyde is known to be a ...
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TOX-69: Butanal Oxime (CASRN 110-69-0) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox069.pdf
69 NTP Technical Report on the Toxicity Studies of Butanal Oxime (CAS No. 110-69-0) Administered in Drinking Water and by Gavage to F344/N Rats and B6C3F 1 Mice January 2004 U.S. ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... Air Act by removing the compound methyl ethyl ketone (MEK) (2-Butanone) (CAS No. 78-93-3). ... Toxicology Studies: Teratology Study of Methyl Ethyl Ketone (CASRN 78-93-3) in Mice. ...
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TR-538: Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr538.pdf
ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box ...
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TR-220: C.I. Acid Red 14 (CASRN 3567-69-9) in F344/N Rats and... 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr220.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 220 CARCINOGENESIS BIOASSAY OF C. I. ACID RED 14 (CAS NO. 3567-69-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDY) U.S. ...
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TOX-45: Renal Selected Halogenated Ethanes 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox045.pdf
5 NTP Technical Report on Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats John R. Bucher, Ph.D., Study Scientist National Toxicology ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
ba Toxicology/Carcinogenicity Female scientist looking through a microscope in a laboratory Study Overview Study: Short-term toxicity, long-term carcinogenicity Species: Rats, mice ...
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TR-002: Trichloroethylene (CASRN 79-01-6) 19.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr002.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 2 February 1 9 7 6 CARCINOGENESIS BIOASSAY OF TRICHLOROETHYLENE CAS No. 79-01-6 NCI-CG-TR-2 U.S. DEPARTMENT OF ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
750897 About Technical Reports Long-term NTP toxicology and carcinogenicity studies usually involve exposing laboratory animals (rats and mice) to a substance for a period of two ...
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TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox35.pdf
Serie s Number 3 5 NTP Technical Report on Toxicity Studies o f A Chemical Mixture o f 25 Groundwater Contaminant s Administered in Drinking Water to F344/N Rats and B6C3F1 Mice ...