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TR-524: Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and... 2.8MB
https://ntp.niehs.nih.gov/go/tr524
NTP TECHNICAL REPORT ON THE PHOTOCARCINOGENESIS STUDY OF GLYCOLIC ACID AND SALICYLIC ACID (CAS NOS. 79-14-1 AND 69-72-7) IN SKH-1 MICE (SIMULATED SOLAR LIGHT AND TOPICAL ...
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Target Organs and Levels of Evidence for TR-524 56KB
https://ntp.niehs.nih.gov/data/tr/500s/tr524levels
Target Organs and Levels of Evidence for TR-524 Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and ...
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Abstract for TR-524 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr524
Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid in SKH-1 Mice (Simulated Solar Light and Topical Application Study) Substances: Glycolic acid (CASRN 79-14-1) ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf
... Rather, de- velopmental toxicity appears to result from the accumulation of glycolic acid, ... the enzymes that metabolize glycolic acid, there should be no developmental toxicity. ...
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Agenda: BSC TRRS; Sept. 27-28, 2005 83KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2005/sept/trrs27sept2005agenda_508.pdf
in topically applied cream with light from a 6.5kW solar light simulator/ 79-14-1 and 69-72-7, respectively TR 524 In many cosmetic formulations for the treatment of ...
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Minutes: BSC TRRS; Sept. 27, 2005 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2005/sept/trrs27sept2005mins_508.pdf
... the effects of an alpha hydroxy acid (glycolic acid) and a beta hydroxy acid (salicylic ... formulation containing 4% or 10% glycolic acid (pH 3.5) or 2% or 4% salicylic acid ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... in Species/Sex NE No Evidence NE No Evidence TR-524 09/27/05 Glycolic Acid (Photocarcinogenesis Study) 79-14-1 NT Chemical Not Tested in Species/Sex NT Chemical Not Tested in ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
... DT (14) DT (Strong, 11) DT (17) DT DT Glycerol N/A N/A N/A n.d. NON n.d. NON (6) NON (6) DT (14) n.d. NON NON NON Glycolic Acid N/A 275 5,000 n.d. DT n.d. DT (6) n.d. n.d. n.d. DT ...
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Study Reports 1.0MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-524 PDF (17.15 MB) Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf
... 10.5 1.73 Severe SCNM SCNM SCNM Hagino et al. (1999)/Submitted Y. Ohno Data Glycolic acid 79-14-1 1 10% Solution 1.76 19.5 1.00 Severe 5.00 100.00 Severe 2B III NI Hagino et al. ...
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Comparison of the Stemina devTOX quickPredict system with other... 2.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf
... Positive Exposure (μM) [Daston et al., 2014] Prediction Model Species Used for "Truth Classification" Glycolic Acid NON │ DT n.d. n.d. DT (6) n.d. n.d. n.d. DT (15) 0.54 n.d. ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/go/tr413
... Male, but not female, rats fed 1.0% to 2.0%glycolic
acid in the diet for up to 35 ... The effect o f partial hepatectomy on the toxicity o f ethylene glycol, glycolic
acid, ...
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Technical Reports 862KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-524 PDF (17.15 MB) Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical ...
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TR-536: Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy... 5.4MB
https://ntp.niehs.nih.gov/go/tr536
... Dermal application of glycolic acid did not alter the photocarcinogenesis of simulated ... (2007). Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CAS Nos. 79-14-1 ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-524 PDF (17.15 MB) Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical ...
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TR-396: Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats... 14.5MB
https://ntp.niehs.nih.gov/go/tr396
... acid (thiodiglycolic acid) (33%-42%), glycolic acid (3%-5%), and oxalic acid (0.1%-0.2%). ... assay (TA100) with glycolic
acid, a minor metabolite (Yamaguchi and Nakagawa, 1983). ...
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TR-406: g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1Mice... 11.0MB
https://ntp.niehs.nih.gov/go/tr406
... In other experiments, increased urinary excretion o f S-3,4-dihydroxybutyric acid, glycolic acid, and the hydroxyepoxide tautomer of 4-hydroxy- 3-oxobutyric acid was observed in ...
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TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 3.0MB
https://ntp.niehs.nih.gov/go/tr511
... 30% was excreted as HEAA. Ethylene glycol and the ethylene glycol metab- olites, glycolic acid and oxalic acid, were not detected, indicating that diethylene glycol is not ...
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Minutes: BSC; June 15, 2006 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2006/june/bsc_mins_20060613_508.pdf
... A photoprotective affect of salicylic acid was observed, but glycolic acid did not alter the latency of SSL to 16 ___...
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TR-273: Trichloroethylene (CASRN 79-01-6) in Four Strains of... 16.9MB
https://ntp.niehs.nih.gov/go/tr273
... under pressure a t 150"C to produce glycolic acid and with sulfuric acid to give mono- chloroacetic acid Conoersionfactor: 1 ppm in air is equivalent to 5.37mg/m3 (USITC, 1982). ...
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TR-553: Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice... 2.9MB
https://ntp.niehs.nih.gov/go/tr553
... A previous photococar- cinogenesis study of glycolic acid and salicyclic acid that was ... The previous photococarcinogenesis study with glycolic acid and salicyclic acid showed ...
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Draft ROC Monograph: Haloacetic Acids; June 6, 2017 3.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph.pdf
... acid, glyoxylic acid, glycolic acid, oxalic acid, and some unidentified ... metabolites glycine, oxalic acid, and glycolic acid, or decarboxylated to form CO 2. A ...
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Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf
... acid, glyoxylic acid, glycolic acid, oxalic acid, and some unidentified ... Ultimate metabolites glyoxylic acid, glycolic acid, oxalic acids, glycine, unknown ...
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... Smoke Compound Sample Concentration range type Low High Units Glycolic acid MS 37.00 126.00 µg/cig Glycolic acid SS 35.00 77.00 µg/cig Guaiacol, 4-vinyl- SS 24.00 32.00 µg/cig ...
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Public Health Impact 1.4MB
https://ntp.niehs.nih.gov/media/impact
... National Toxicology Program (NTP). 2007. NTP technical report on the photocarcinogenesis study of glycolic acid and salicylic acid (CASRN 79-14-1 and 69-72-7) in SKH-1 mice ...
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TOX-26: Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol... 8.2MB
https://ntp.niehs.nih.gov/go/tox026
... Based on chromatographic analyses, the unknown metabolite was not glycolic acid, glyoxylic acid, or oxalic acid, all of which are possible metabolites of ethylene glycol. Other ...
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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 11.9MB
https://ntp.niehs.nih.gov/go/tr568
... of dermocosmetic skin formulations containing vitamin A and/or glycolic acid. J. Cosmet. ... (2007). Photocarcinogenesis Study of Glycolic Acid and Salicyclic Acid (CAS Nos. 79-14-1 ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... Arch Dermatol 91:171-177. Cosmetic Ingredient Review Expert Panel. 1998. Final report on the safety assessment of glycolic
acid, ammonium, calcium, potassium, and sodium ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
... Contact Dermatitis 55:140-147. Cosmetic Ingredient Review Expert Panel. 1998. Final report on the safety assessment of glycolic
acid, ammonium, calcium, potassium, and sodium ...
