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Search suggestions for "81-07-2".

  1. CEBS Data Related to Saccharin (81-07-2) https://cebs.niehs.nih.gov/cebs/test_article/81-07-2


43 results found for "81-07-2".

  1. RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf

    BACKGROUND DOCUMENT for SACCHARIN FINAL MARCH 1999 Prepared for the October 30-31, 1997, ... N01-ES-25346 NTP Report on Carcinogens 1997 Background Document for Saccharin TABLE OF ...

  2. Abstract for RACB83072 61KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb83072

    2abs Abstract for RACB83072 Sodium Saccharin: Reproduction and Fertility Assessment in ... Sodium saccharin (NaSac), used as an artificial sweetener since the late 1800's, was ...

  3. 15th RoC: Appendix B 103KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_b.pdf

    Ethyl acrylate 140-88-5 reasonably anticipated Eighth RoC (1998) See following profile Saccharin 81-07-2 reasonably anticipated Eighth RoC (1998) See following profile Appendix B: ...

  4. Appendices A-G; 15th RoC 2021 448KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

    ... Ethyl acrylate 140-88-5 reasonably anticipated Eighth RoC (1998) See following profile Saccharin 81-07-2 reasonably anticipated Eighth RoC (1998) See following profile Appendix B: ...

  5. Minutes: BSC; March 27, 1984 3.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1984/march/bsc_minutes19840327_508.pdf

    6 DNA Adducts, and Mutagenicity (3) Saccharin 6 Contents (Cont'd) Page Numbers VIII . ... and colon carcinogenesis ; and (10) saccharin as a tumor promoter . 5 0 0 (1) ...

  6. Response to 81 FR 42718: Miguel Sogorb 100KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/sogorb-81fr42718.pdf

    or mild maternal toxicity) and penicillin G and saccharin as non-embryotoxicants (those that only induce embryotoxicity concurrently with severe maternal toxicity or lethality). ...

  7. TOX-88: Toxicity Studies of p-Toluenesulfonamide (CASRN 70-55... 3.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox88_508.pdf

    ... chloramine-T 3-5 . p-Toluenesulfonamide may be present as a contaminant in saccharin 6 . ... L, Williams R, Renwick A. The fate of saccharin impurities: The excretion and metabolism ...

  8. A BIOMARKER BASED DEVELOPMENTAL ... 919KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-sot.pdf

    ... NON NON NON Levothyroxine NON NON NON Penicillin G NON NON NON Retinol NON NON NON Saccharin NON NON NON Thiamine NON NON NON 13-cis Retinoic Acid TER TER TER 5-Fluorouracil TER ...

  9. TOWARD VALIDATION OF A HUMAN IN... 1.1MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf

    ... Pharmaceutical TER 12 Retinol Pharmaceutical TER 3 Warfarin Pharmaceutical NON 300 Saccharin Pharmaceutical NON 300 Thiamine Pharmaceutical NON 300 Excellent Performance Across ...

  10. DEVELOPMENT OF A TARGETED BIOMARKER... 3.4MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/palmerposter.pdf

    ... NON 43 NON 10 NON Penicillin G NON >300 NON >300 NON Retinol NON 22 NON 0.5 TER Saccharin NON >300 NON >300 NON Thiamine NON >300 NON >300 NON B1: Acetaminophen NON 278 NON ...

  11. Reproductive Abstracts 202KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... in CD-1 Mice When Administered in Feed 1984 Reproductive RACB83072 Sodium Saccharin Sodium Saccharin (CASRN: 128-44-9): Reproduction and Fertility Assessment in CD-1 Mice When ...

  12. Study Abstracts 375KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... in CD-1 Mice When Administered in Feed 1984 Reproductive RACB83072 Sodium Saccharin Sodium Saccharin (CASRN: 128-44-9): Reproduction and Fertility Assessment in CD-1 Mice When ...

  13. Completed RoC Evaluations 119KB

    https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc

    ... Riddelliine Reasonably anticipated to be a human carcinogen Background Document Request Archived Materials Saccharin Delisted Background Document Appendix A Appendix B Appendix C ...

  14. IVIVE to Facilitate Animal-free Risk Assessment of Potential... 3.5MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Chang-poster.pdf

    ... for IVIVE included: o Single value o Median value of replicates o Maximum tested concentration (for negative results) trans-Retinoic acid Arotinoid acid Gentian violet Saccharin

  15. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... PHMSA amends the Hazardous Materials Regulations by removing saccharin and its salts from ... EPA recently removed saccharin and its salts from their list of hazardous substances ...

  16. Comparison of devTOX quickPredict Assay With Other Methods 1.0MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf

    ... Retinol 2.4 N/A N/A C NON NON (1) DT (3) DT (3) DT (2,6,14) NON (4) DT (7) NON NON Rotenone N/A N/A N/A n.d. DT n.d. DT (6) n.d. DT (5,12,14) n.d. n.d. DT DT Saccharin 1.4 24 N/A A ...

  17. RoC Background Document: Alcoholic Beverage Consumption; Dec... 5.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/05alcoholicbevcon_508.pdf

    ... consumption. (Labels on saccharin-containing wines, distilled spirits, and malt beverages, however, must warn of a cancer risk from saccharin consumption [27 CFR 4.32, 5.32, ...

  18. Public Comment: Pulegone Christie Harman; RoC; Sept. 20, 2013 126KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/harman20131018_508.pdf

    ... Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography. Scanning Microsc. ...

  19. Comparison of the Stemina devTOX quickPredict system with other... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf

    ... Rotenone DT n.d. n.d. DT (6) n.d. DT (5,12,14) n.d. n.d. 0.84 DT DT N/A N/A N/A Threshold Rodent Saccharin NON A NON (1) NON (3,4) NON (3,4) NON (2,3,8) NON (1,2,5,9) DT (4) NON ...

  20. Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

    ... In Phase II (Bantle et al., 1994b), caffeine, 5-fluorouracil, saccharin, and sodium ... activation based on their negative (saccharin, sodium cyclamate) and positive ...

  21. TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB

    https://ntp.niehs.nih.gov/go/tr371

    ... Toluene is blended with gasoline and is used as a n intermediate in the synthesis of benzoic acid, benzyl and benzoyl derivatives, saccharin, medi- cines, dyes, perfumes, toluene ...

  22. Minutes: BSC; May 24, 2000 495KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2000/may/2000052400bscsummmins_508.pdf

    ... Saccharin and ethyl acrylate are delisted from the Report. Several additional nominations ... delisted from the Report received 5-6,000 "hits"; saccharin is included in that table. Dr. ...

  23. GMM-01: Genetically Modified Model Report on Aspartame (Feed... 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm01_508.pdf

    ... sweeteners; a diet low in sucrose and contain- ing 38 mg aspartame/kg body weight; or a diet low in sucrose and containing 12 mg saccharin/kg body weight (Wolraich et al., 1994). ...

  24. TR-403: Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1Mice... 15.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr403.pdf

    ... No hyperplastic or papillomatous lesions were found in the bladders of animals that received resorcinol, though saccharin, the positive control, produced significant increases in ...

  25. Minutes: BSC; Feb. 5, 1998 713KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1998/february/19980205bscmins_508.pdf

    ... Saccharin had been petitioned for delisting from the Report which was supported by RG1 and RG2, while the Board Subcommittee recommended that saccharin remain listed in the Report ...

  26. TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf

    ... M . , J. St.J. Wakefield, and J. Chowaniec. "Evaluation of a New Model to Detect Bladder Carcinogens: Results Obtained with Saccharin, Cyclamate and Cyclophosphamide." Chem. Biol. ...

  27. TR-548: Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats... 6.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr548.pdf

    ... for levels of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. ...

  28. TR-547: Ethinyl Estradiol (multigenerational) (CASRN 57-63-6... 8.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr547.pdf

    ... Male and female offspring were assessed for lev- els of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and ...

  29. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... nicotinate 437-74-1 6865.26 15.8 14121.6 32.5 17336.9 39.9 434.51 32.5 314 Saccharin 81-07-2 3004.32 16.4 NA NA 17000.0 92.8 183.19 92.8 315 Isobenzoic furano dione 2518.04 17 ...

  30. ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf

    ... 14897-39-3 697.77 5.04 Solid Heterocyclic Compounds, Polycyclic Compounds NTP Saccharin - 81-07-2 183.18 0.64 Solid Sulfur Compounds; Heterocyclic Compounds Gerberick Salicylic ...

  31. TR-245: Melamine (CASRN 108-78-1) in F344/N Rats and B6C3F1Mice... 8.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr245.pdf

    ... tumors was found in male rats fed diets containing saccharin (Arnold et al., 1980). ... toxicity of ortho-toluenesulfona- mide and sodium saccharin in the rat. Toxicol. Appl. ...

  32. TOX-79: Genistein (CASRN 446-72-0) 2.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox079.pdf

    ... wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. ... Running wheel activity and saccharin-flavored solution consumption showed significant sex ...

  33. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... nicotinate 15.8 32.5 14121.6 314 Saccharin 16.4 92.8 17000.0 315 Isobenzoic furano ... 1,2,6-Hexanetriol 123 119 15969.8 314 Saccharin 16.4 92.8 17000.0 129 Dimethyl sulfoxide ...

  34. TR-336: Penicillin VK (CASRN 132-98-9) in F344/N Rats and B6C3F1Mice... 9.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr336.pdf

    ... Chemother. 14:261-265. 5. Ashby, J . ; Ishidate, M., J r . (1986) Clasto- genicity in vitro of the Na, K, Ca and Mg salts of saccharin; and of magnesium chloride; consid- eration ...

  35. TR-377: CS2 (94 o-Chlorobenzalmalononitrile, CASRN 2698-41-1... 12.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr377.pdf

    ... Toxicol. 54:139- 144. 56. Riggin, R.M.; Margard, W.L.; Kinzer, G.W. (1983) Characterization of impurities in com- mercial lots of sodium saccharin produced by the Sherwin-Williams ...

  36. TR-416: o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1... 24.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr416.pdf

    ... Comparative bladder tumor promoting activity o f sodium saccharin, sodium ... Lack o f bladder tumor promoting activity in rats fed sodium saccharin in AIN-7GA diet. ...

  37. Handbook for Preparing the RoC Monograph 2.0MB

    https://ntp.niehs.nih.gov/ntp/roc/handbook/roc_handbook_508.pdf

    ... Compelling mechanistic data that the mechanisms of urinary-bladder tumor formation in rats were not relevant to humans led to the removal of saccharin from the RoC (NTP 2014c). ...

  38. TR-557: beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1... 16.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr557.pdf

    ... Turner, S.D., Tinwell, H., Piegorsch, W., Schmezer, P., and Ashby, J. (2001). The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats. ...

  39. TR-383: 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr383.pdf

    ... Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats. Cancer Res. 51, 1766- 1777. Cox, D.R. (1972). ...

  40. TR-393: Sodium Fluoride (CASRN 7681-49-4)in F344/N Rats and B6C3F1Mice... 21.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr393.pdf

    ... Ashby, J., and Ishidate, M., Jr. (1986). Clastogenicity in vitro o f the Na, K, Ca and Mg salts o f saccharin; and of chloride; magnesium consideration o f significance. Mutat. ...

  41. CERHR Monograph: Amphetamines 4.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf

    ... Preference.for.saccharin-containing.solution. over.tap.water.was.lost.at.an.earlier.age.wh... There.is.inadequate.de- tail.in.this.report..The. saccharin. preference. ...

  42. Final RoC Background Document for Formaldehyde 5.8MB

    https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf

    ... and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation. ...

  43. CERHR Monograph: Soy Infant Formula 122.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf

    ... and the other containing either 0.03% saccharin (PND 69 - 71) or 3% saline (PND 73 - 75). ... There was no detected treatment-related taste preference for saccharin-treated water, but ...

 
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