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TR-494: Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr494.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANTHRAQUINONE (CAS NO. 84-65-1) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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Abstract for TR-494 83KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494
Abstract for TR-494 Toxicology and Carcinogenesis Studies of Anthraquinone in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 84-65-1 Chemical Formula: C14H8O2 Molecular Weight: ...
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Minutes: BSC TRRS; Feb. 17, 2004 661KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf
......... 6 Anthraquinone ......The motion was approved with 11 yes votes and 1 no vote (Klaunig). Anthraquinone The draft ...
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Abstract for TR-383 76KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr383
Abstract 1-Amino-2,4-dibromoanthraquinone is an anthraquinone-derived vat dye, a member of a class of insoluble dyes that are impregnated into textile fibers. Five anthraquinone-de...
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Target Organs and Levels of Evidence for TR-494 61KB
https://ntp.niehs.nih.gov/data/tr/400s/tr494levels
Target Organs and Levels of Evidence for TR-494 Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) Chemical (Study ...
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Abstract for TR-493 79KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr493
Abstract Emodin is a naturally occurring anthraquinone present in the roots and bark of ... Anthraquinone glycosides are poorly absorbed from the gastrointestinal tract but are ...
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Abstract for TR-29 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr029
1-nitro-2-methyl-anthraquinone Report Date: 1978 Full Report PDF Abstract 2-Methyl-1-nitroanthraquinone, an intermediate in the synthesis of anthraquinone dyes, was selected ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
Meeting _____18 1. Public Comment on Anthraquinone ___...The report on the carcinogenicity of anthraquinone was re-evaluated in light of comments ...
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Abstract for TR-144 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr144
Full Report PDF Abstract 2-Aminoanthraquinone, an intermediate in the synthesis of anthraquinone dyes, was selected for bioassay by the National Cancer Institute in an attempt to ...
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Abstract for TR-111 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr111
Full Report PDF Abstract 1-Amino-2-methylanthraquinone,an intermediate in the synthesis of anthraquinone dyes and a dye itself, wasselected for bioassay by the National Cancer ...
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RoC Background Document for 1-Amino-2,4-dibromoanthraquinone... 941KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/adbaqpub_no_appendices_508.pdf
... (ADBAQ) is an anthraquinone vat dye that is used in the textile industry. ... is produced or is used as an intermediate for production of other anthraquinone dyes. ...
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Minutes: BSC TRRS; May 21, 1999 160KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1999/may/trrs21may1999mins_508.pdf
Mary S. Wolfe, Executive Secretary, at 919-541-3971. Technical Report CAS # Route Page # Gallium Arsenide 1303-00-0 Inhalation 3 Emodin 518-82-1 Feed 4 Anthraquinone 84-65-1 Feed 6 ...
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Abstract for TR-500 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr500
acid, synthetic resins, celluloid, and hydronaphthalenes; it is also used in the preparation of anthraquinone, indigo, salicylic acid, and 1-naphthyl-N-methylcarbamate insecticide. ...
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RoC Profile: 2-Aminoanthraquinone; 15th RoC 2021 110KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminoanthraquinone.pdf
Dietary administration of 2-amino anthraquinone caused liver cancer (hepatocellular carci- ... rela- tionship between human cancer and exposure specifically to 2-amino- anthraquinone. ...
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RoC Profile: 1-Amino-2,4-dibromoanthraquinone; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminodibromoanthraquinone.pdf
among workers in plants manufacturing anthraquinone dyes; how- ever, it is not known ... Some evidence suggests that anthraquinone-dye workers may have an increased risk of ...
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Abstract for TR-159 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr159
Phthalic anhydride itself is used as a monomer for synthetic resins such as glyptal, the alkyd resins, and the polyester resins. Phthalic anhydride is a precursor of anthraquinone, ...
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RoC Profile: 1-Amino-2-methylanthraquinone; 15th RoC 2021 107KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminomethylanthraquinone.pdf
Properties 1-Amino-2-methylanthraquinone is an anthraquinone dye and dye intermediate that ... U.S. imports of 1-amino-2-methyl- anthraquinone were last reported in 1972, when 120 kg ...
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TR-383: 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344... 11.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr383.pdf
... Five anthraquinone-derived dyes with representative and diverse structures, as well as the parent chemical, anthraquinone,wereselected for toxicology and carcino- genesis ...
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RoC Profile: Disperse Blue 1; 15th RoC 2021 128KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/disperseblue1.pdf
In genotoxocity studies of anthraquinone derivatives and related an- thracene derivatives, 35% of the compounds tested have shown some mutagenic activity. Of the anthraquinone ...
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Minutes: BSC RoC; Nov. 11, 2008 624KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/roc_minutes20021120.pdf
... Ruth Lunn, NIEHS, presented the nomination and said ADBAQ is an anthraquinone vat dye used ... ADBAQ, but there are some studies on anthraquinone dyes as a class in two populations of ...
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Prostate, Acinus - Cyst(s), Mucinous - Nonneoplastic Lesion Atlas 289KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/prostate/Acinus-Cyst(s)Mucinous
opens in a pop-up window and Figure 2 image opens in a pop-up window ) have been documented in a small number of treated F344 rats in emodin and anthraquinone chronic studies. ...
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Agenda: BSC TRRS; Feb. 17-18, 2004 82KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004agenda_508.pdf
female rats Malachite Green /569-64-2 and Leucomalachite Green /129-73-7 Anthraquinone /84-65-1 TR 527 TR 494 Dye; antifungal for fish Diet, Malachite Green - female rats and ...
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Prostate, Acinus - Cyst(s), Mucinous 698KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/male_reproductive/prostate/acincyst/prostate_acinus_cyst_mucinous_508_pdf.pdf
Mucinous cysts (Figure 1 and Figure 2) have been documented in a small number of treated F344 rats in emodin and anthraquinone chronic studies. Goblet cells are present in the ...
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TR-493: Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1Mice... 18.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr493.pdf
... Emodin is a naturally occurring anthraquinone present in the roots and bark of ... Anthraquinone glyco- sides are poorly absorbed from the gastrointestinal tract but are ...
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RoC Background Document: Danthron; Nov. 18-19, 1996 1.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/danthron1_508.pdf
... 1,8-dihydroxy- (9CI) Anthraquinone, 1,8-dihydroxy- (SCI) Altan Antrapurol ... 1 ,8-Dihydroxy -9,1 0-anthraquinone Dionone Dorbane Dorbanex Duo lax Istin ...
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National Toxicology Program, Board of Scientific Counselors 106KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2001/may/2001052501bscsummmins_508.pdf
... studies that were conducted for anthraquinone (a dosed feed study) and methyleugenol ... toxicokinetic data for anthraquinone showed a difference in response for rats versus mice. ...
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Minutes: BSC TRRS; June 21, 1994 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1994/june/trrs21june1994mins_508.pdf
... it being part of a class study of anthraquinone derivatives, describing the ... Huff reviewed the carcinogenic responses in anthraquinone derivatives that had been ...
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TR-029: 2-Methyl-1-Nitroanthraquinone (CASRN 129-15-7) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr029.pdf
... 1 GROWTH CURVES FOR 2-METHYL-l-NITRO- ANTHRAQUINONE CHRONIC STUDY RATS 16 2 SURVIVAL ... C01923), an intermediate in the synthesis of anthraquinone dyes, was selected for bioassay ...
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Polycyclic Aromatic Compounds 83KB
https://ntp.niehs.nih.gov/whatwestudy/topics/pacs
... NTP Technical Reports for PACs or Mixtures that Contain PACs by Report Number Report Description Anthraquinone (TR-494) In this study, anthraquinone (a substance used to make dyes ...
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RoC Profile: Danthron; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/danthron.pdf
Properties Danthron is an anthraquinone that exists at room temperature as a reddish or ... Patel PM, Selby PJ, Deacon J, Chilvers C, McElwain TJ. 1989. Anthraquinone laxatives and ...
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Studies on Historical Control Reports for NIH-07 Feed 312KB
https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf
Rats Fischer344 Oral Feed Anthraquinone Rats Fischer344 Oral Feed Manganese ... Mice B6C3F1 Oral Feed Anthraquinone Mice B6C3F1 Oral Feed Manganese ...
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TR-144: 2-Aminoanthraquinone (CASRN 117-79-3) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr144.pdf
... SUMMARY FOR B6C3F1 MICE-2-AMINO- ANTHRAQUINONE FEEDING EXPERIMENT 12 TIME-ADJUSTED ... IN MALE RATS TREATED WITH 2-AMINO- ANTHRAQUINONE C-3 C2 SUMMARY OF THE INCIDENCE OF ...
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TR-111: 1-Amino-2-methylanthraquinone (CASRN 82-28-0) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr111.pdf
... ANTHRAQUINONE CHRONIC STUDY RATS 23 GROWTH CURVES FOR l-AMINO-2-METHYLANTHRA- QUINONE CHRONIC STUDY MICE 39 SURVIVAL COMPARISONS OF 1-AMINO-2-METHYL- ANTHRAQUINONE CHRONIC ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf
539 Graves, Steven Purity Analyses for Toxicology Studies - A Case Study with Anthraquinone 391 Harvey, E. Influence of Diet on endpoints Typically Used in 13-Week Toxicity ...
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TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf
... The isolated compounds are largely phenolic in nature, and many are anthraquinone C-glycosides, anthrones, and free anthraquinones (Park et al., 1998). The levels of anthraquinone ...
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RoC Background Document: Disperse Blue I; Nov. 18-19, 1996 2.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/disperse_blue_508.pdf
... (9CI) Anthraquinone, I ,4,5,8-tetraamino- (SCI) Acetate Blue G Acetoquinone Blue L Acetoquinone Blue R Acetylon Fast Blue G Amacel Blue GG Amacel Pure Blue B Anthraquinone, I ...
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TR-553: Photococarcinogenesis Study of Aloe Vera[CASRN 481-72... 6.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr553.pdf
... The isolated compounds are largely phenolic in nature, and many are anthraquinone C-glycosides, anthrones, and free anthraquinones (Park et al., 1998). The levels of anthraquinone ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence NE No Evidence EE Equivocal Evidence TR-494 02/17/04 Anthraquinone 84-65-1 SE Some Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-493 05/21/...
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TR-500: Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation... 8.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr500.pdf
... it is also used in the preparation of anthraquinone, indigo, salicylic acid, and ... It is also used in the preparation of anthraquinone, indigo, salicylic acid, and ...
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Public Comment: Coconut diethanolamide; Linda Loretz; RoC; Sept... 2.3MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/loretz20131016_508.pdf
... if anthraquinone levels in the ingredient do not exceed SO ppm". The Panel "considered the available data on the several Aloe Barbadensis extracts and found that anthraquinone ...
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TR-299: C.I. Disperse Blue 1 (A commercial dye containing approximatel... 15.0MB
https://ntp.niehs.nih.gov/go/tr299
... approximately 50% 1,4,5,8-tetraamino- anthraquinone, 30%other compounds structurally ... various anthraquinone derivatives have been shown to induce lung and liver tumors. ...
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Minutes: BSC TRRS; March 29, 1985 795KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1985/mar/85mar29trrsmins_508.pdf
... Huff commented that the chemical is mutagenic, and in other long- term studies, various anthraquinone derivatives have been shown to induce lung 3 and liver tumors. Or. Hooper ...
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TR-159: Phthalic Anhydride (CASRN 85-44-9) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr159.pdf
... Phthalic anhydride is a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and xanthene dyes (Towle et al., 1968; Noller, 1966). Reaction of phthalic ...
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References Relevant to the 2007 LLNA Nomination to ICCVAM 70KB
https://ntp.niehs.nih.gov/iccvam/methods/immunotox/llnadocs/llna-2007-refs.pdf
... Food and Chemical Toxicology 40:1719-1725. D Sailstad, J Tepper, D Doerfler, M Qasim, M Selgrade. 1994. Evaluation of an azo and two anthraquinone dyes for allergic potential. ...
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Protocol: Systematic Review of Inflammation-based Atherosclerosis... 1001KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosisjuly2023_508.pdf
... 'Acenaphthenequinone':ti,ab OR 'Methylanthraquinone':ti,ab OR "1,4-Anthraquinone":ti,ab OR "9,10- Anthraquinone":ti,ab OR "1,4-Benzoquinone":ti,ab OR "9-Fluorenone":ti,ab OR ...
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TR-118: 5-Nitroacenaphthene (CASRN 602-87-9) 4.4MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr118.pdf
... Control rats were in a room with other rats receiving diets containing amitrole (61-82-5); 2-methyl-l-nitro- anthraquinone (129-15-7); and 3-nitro-p-acetophenetide (1777-84-0). ...
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TR-054: 2,4-Dinitrotoluene (CASRN 121-14-2) 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr054.pdf
... High dose control mice shared a room with other mice receiving diets treated with 2-methyl-l-nitro- anthraquinone (129-15-7); p-cresidine (120-71-8); fenaminosulf (140-56-7); ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-494 PDF (10.64 MB) Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2005 Technical Report TR-493 ...
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TR-126: 2,5-Toluenediamine Sulfate (CASRN 6369-59-1) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr126.pdf
... 2,4-dini- trotoluene (121-14-2); 4-nitroanthranilic acid (619-17-0); 2-amino- anthraquinone (117-79-3); 3-amino-4-ethoxyacetanilide (17026-81-2); 3-amino-9-ethylcarbazole ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... 50% 1,4,5,8-tetra amino anthraquinone, 30% other compounds structurally related to 1,4,5,8-tetra amino anthraquinone and 20% water in F344/N Rats and B6C3F1 Mice (Feed Studies). ...