-
RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf
DYES METABOLIZED TO BENZIDINE (BENZIDINE DYE CLASS) FINAL MARCH1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of ...
-
Data Resources 107KB
https://ntp.niehs.nih.gov/iccvamreport/2021/technology/data-resources
Data Resources As momentum grows toward adoption of alternatives to animal use for chemical safety testing, curated data are needed to support method validation and establish ...
-
Peer Review Report: Draft Report on Carcinogens Monograph on... 167KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2017/july/sepreport20170724_508.pdf
National Toxicology Program Peer Review of Draft Report on Carcinogens (RoC) Monograph on Haloacetic Acids Found as Water Disinfection By-products July 24, 2017 National Institute ...
-
TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB
https://ntp.niehs.nih.gov/go/tr426
2 Selected Oral Gavage Vehicles, NTP TR 426 *! i l CONTRIBUTORS National Toxicology Program Evaluated and interpreted results and reported findings C.J. Alden, Ph.D. G.A. Boorman, ...
-
Documents Provided to the NTP Board of Scientific Counselors... 55.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf
DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review NTP Monograph 08 September ...
-
TR-269: Telone (Technical-Grade 1,3-Dichloropropane [CASRN 542... 8.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr269.pdf
9 (~ t-"'- SERVICts ~+,~~\._ TOXICOLOGY AND CARCINOGENESIS STUDIES OF TELONEIIQD (Technical-Grade 1,3-Dichloropropene [CAS No. 542-75-6] Containing 1.0% Epichlorohydrin as a ...
-
ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (Volume 2) ...
-
Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf
National Toxicology Program's Report of the Organized by the National Institute of Environmental Health Sciences, NIH National Toxicology Program Sponsored by the U.S. ...
-
Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
Formaldehyde January 22, 2010 U.S. Department of Health and Human Services Public Health Service National Toxicology Program Research Triangle Park, NC 27709 This Page ...
-
ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products Interagency ...
-
CERHR Monograph: Soy Infant Formula 122.6MB
https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf
National Toxicology Program U.S. Department of Health and Human Services C E R H R N T P Center for the Evaluation of Risks to Human Reproduction NIH Publication No. 10-5995 ...
-
Draft ROC Monograph: Haloacetic Acids; June 6, 2017 3.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph.pdf
Draft Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products Peer-Review Draft June 6, 2017 Office of the Report on Carcinogens Division of ...
-
Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
FINAL Report on Carcinogens Background Document for Styrene September 29, 2008 U.S. Department of Health and Human Services Public Health Servces National Toxicology Program ...
-
RoC Review of Haloacetic Acids Found as Water Disinfection By... 88KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/haa
HAAs RoC Review of Haloacetic Acids Found as Water Disinfection By-products The recent Report on Carcinogens is now available. Glass of water with chemical formulas composited on ...
-
ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
ICCVAM Test Method Evaluation Report The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential ...
-
Leadership 64KB
https://ntp.niehs.nih.gov/iccvamreport/2021/leadership
Leadership As an interagency committee of the U.S. federal government, ICCVAM takes a leadership role in promoting the use of NAMs. ICCVAM agencies promote new testing approaches ...
-
Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
impact Public Health Impact The public impact of NTP's work can be measured through its use by other agencies, often to support the establishment of regulations or guidelines to ...
-
Background Document: RoC: Glass Wool Fibers; 2010 3.7MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf
Report on Carcinogens Background Document for Glass Wool Fibers September 2009 National Toxicology Program U.S. Department of Health and Human Services Public Health Service ...
-
ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
ICCVAM Test Method Evaluation Report The LUMI-CELL ® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of ...
-
BSC Meeting: Draft RoC Concept: Di- and Tri- Haloacetic Acids... 240KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/april/haa_508.pdf
1 Draft Report on Carcinogens Concept Di- and Tri- Haloacetic Acids Found as Water Disinfection By-Products March 2016 Gloria D. Jahnke, DVM, DABT Project Leader Office of the ...
-
Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf
This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally distributed by ...
-
Biological Relevance as a Better Benchmark (SACATM 2022 Meeting... 12.0MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2022/ppt/13_kleinstreuer_508.pdf
Biological Relevance as a Better Benchmark 2022 SACATM Meeting Nicole Kleinstreuer Acting NICEATM Director NIEHS/DTT/PTB Assessing Alternatives: A New Gold Standard Chemical ...
-
Background Document: RoC: Aristolochic Acids ; 2010 2.7MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/aristolochic_acids_final_508.pdf
Aristolochic Acids September 2, 2008 U.S. Department of Health and Human Services Public Health Services National Toxicology Program Research Triangle Park, NC 27709 This Page ...
-
Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
HTML NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review ...
-
ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products ...
-
ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of ...
-
ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential ...
-
Report of Ocular Peer Review Panel Meeting (2009) 947KB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/ocularprprept2009.pdf
Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches July 2009 Interagency Coordinating ...
-
RoC Background Document for X Radiation & Gamma Radiation and... 4.6MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/ir_rg2_public_508.pdf
FINAL Report on Carcinogens Background Document for X Radiation & Gamma Radiation and Neutrons June 18, 2003 Prepared for the: U.S. Department of Health and Human Services Public ...
-
RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
FINAL Report on Carcinogens Background Document for Lead and Lead Compounds May 8, 2003 Prepared for the: U.S. Department of Health and Human Services Public Health Service ...
-
ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
NIH Publication No: 03-4503 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and ...
-
ICCVAM Test Method Evaluation Report: Ocular Hazard Testing Strategy... 4.3MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/amcp/tmer-all.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and ...
-
The Revised Up-and-Down Procedure: A Test Method for Determining... 2.7MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_1.pdf
NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review Evaluation ...
-
Abstract for TR-561 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr561
1abs Abstract for TR-561 Toxicology and Carcinogenesis Studies of Tetralin in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Tetralin in Male NBR Rats (Inhalation studies) ...
-
NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf
NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night April 2021 Night Shift Work and Light at Night and Cancer i National Toxicology Program Cancer Hazard ...
-
Moving Beyond Animal Data as the Gold Standard; Nicole Kleinstreuer... 3.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2018/september/presentations/06kleinstreuer_508.pdf
Advancing Alternatives to Animal Testing lnteragency Coordinating Committee on the Validation of Alternative Methods Moving Beyond Animal Data as the Gold Standard Nicole ...
-
ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
NIH Publication No: 02-4502 ICCVAM Evaluation of EPISKIN(tm), EpiDerm(tm) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for ...
-
Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
NIH Publication Number 11-7709 . . . . . . . . . . . . 1000000 . ...... _ . ...... . 100000 1 . : 1 ... . i... . >. 1000 . . . :.. ~ - . .. +----.- i. y A r : 10000 100 ...
-
Draft monograph HAA appendices 3.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haa_appendices20171030.pdf
Revised Draft: Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products: Appendices October 30, 2017 Office of the Report on Carcinogens ...
-
NTP Working Group Report: Draft State of the Science Monograph... 20.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/wgrptbsc20230400.pdf
NTP Board of Scientific Counselors Working Group Report on the Draft State of the Science Monograph and the Draft Meta-Analysis Manuscript on Fluoride April 2023 NTP BSC Working ...
-
NTP Board of Scientific Counselors Working Group Report on the... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/bsc_wg_report_final_version_bsc_approved051623_508.pdf
NTP Board of Scientific Counselors Working Group Report on the Draft State of the Science Monograph and the Draft Meta-Analysis Manuscript on Fluoride Final Report: Approved by the ...
-
Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS National Institute of Infectious Diseases Japan, 2006 - 1 - MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS Notice: This English version ...
-
Abstract for TR-513 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr513
3abs Abstract for TR-513 Toxicology and Carcinogenesis Studies of Decalin in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies) ...
-
Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf
FINAL Report on Carcinogens Background Document for Selected Heterocyclic Amines: PhIP, MeIQ, and MeIQx September 19, 2002 Prepared for the: U.S. Department of Health and Human ...
-
RoC Background Document on Human Papillomaviruses: Genital-Mucosal... 2.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hpv_rg2_public_508.pdf
FINAL Report on Carcinogens Background Document for Human Papillomaviruses: Genital-Mucosal Types June 5, 2003 Prepared for the: U.S. Department of Health and Human Services ...
-
CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
-
RR-09: The CLARITY-BPA Core Study: A Perinatal and Chronic Extended... 5.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr09_508.pdf
The cLaRITY-BPa coRe sTudY: a PeRINaTaL aNd chRoNIc exTeNded-dose- RaNge sTudY of BIsPheNoL a IN RaTs NTP RR 9 SEPTEMBER 2018 NTP Research Report on the CLARITY-BPA Core Study: A ...
-
Abstract for TR-431 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr431
1abs Abstract for TR-431 Toxicology and Carcinogenesis Studies of Benzyl Acetate in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 140-11-4 Chemical Formula: C9H10O2 Molecular ...
-
The Gut as a Target Organ and Barrier: Challenges and Opportunities... 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/2023-10/Wb2_02_Kass_GutModels2023_508.pdf
THE GUT AS A TARGET ORGAN AND BARRIER: CHALLENGES AND OPPORTUNITIES FOR NAMs IN CHEMICAL RISK ASSESSMENT George Kass Lead Expert Disclaimer: The views, thoughts and opinions ...
-
Draft RoC Monograph Epstein-Barr virus (EBV): RoC Peer Review... 3.0MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph_appendices.pdf
Draft Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products: Appendices Peer-Review Draft June 6, 2017 Office of the Report on Carcinogens ...
