Background Document: RoC: Styrene; 2010 4.3MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf

... Human Exposure The primary use of styrene is in the manufacture of polystyrene, which is ... The possibility of polystyrene dimer and trimer extracts from food containers mimicking ...

CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB

https://ntp.niehs.nih.gov/ntp/ohat/styrene/styrene_monograph.pdf

... and is used in the produc- tion of polystyrene resins and as a co-polymer with ... of residual styrene monomer allowed in polystyrene intended for use in contact with food. ...

Abstract for TR-76 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr076

In addition to its use by the textile industry, TBP is also a fire retardant additive for polystyrene and polyurethane foams, polyvinyl chloride and phenolic resins, intumescent ...

Abstract for TR-170 - Solution of beta-Nitrostyrene and Styrene... 62KB

https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr170

as a chain stopper in styrene type polymerization reactions for the production of polystyrene plastics, synthetic rubber, and resins. b-Nitrostyrene also possesses antibacterial, ...

MonoMac6 In Vitro Pyrogen Test Method: ICCVAM Recommended Protocol 711KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-mm6il6.pdf

... Water bath 3.2.1.2 Consumables . Centrifuge tubes; polystyrene (15 and 50 mL) . Combitips; ... Pipettes; sterile . Plates; microtiter, 96-well, polystyrene, tissue culture . ...

RoC Profile: Hexamethylphosphoramide; 15th RoC 2021 127KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hexamethylphosphoramide.pdf

It is also used as a polymerization catalyst, a stabilizer against thermal degradation in polystyrene, an additive to polyvinyl and polyolefin resins to protect against degradation ...

Whole Blood IL-1 In Vitro Pyrogen Test Method: ICCVAM Recommended... 638KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-wbil1b.pdf

... polystyrene (15 and 50 mL) . Combitips; repeating pipetter (1.0 and 2.5 mL) . Needle set; multifly, pyrogen-free, 19 mm, 21 gauge . Plates; microtiter, 96-well, polystyrene, ...

Cryo Whole Blood IL-1 In Vitro Pyrogen Test Method: ICCVAM Recommended... 577KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-wbil1bcryo.pdf

... polystyrene (15 and 50 mL) . Combitips; repeating pipetter (1.0 and 2.5 mL) . Needle set; multifly, pyrogen-free, 19 mm, 21 gauge . Plates; microtiter, 96-well, polystyrene, ...

Whole Blood IL-6 In Vitro Pyrogen Test Method: ICCVAM Recommended... 712KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-wbil6.pdf

... polystyrene (15 and 50 mL) . Combitips; repeating pipetter (1.0 and 2.5 mL) . Needle set; multifly, pyrogen-free, 19 mm, 21 gauge . Plates; microtiter, 96-well, polystyrene, ...

PBMC In Vitro Pyrogen Test Method: ICCVAM Recommended Protocol 666KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-pbmcil6.pdf

... Vortex mixer 3.2.1.2 Consumables . Centrifuge tubes; polystyrene (15 and 50 mL) . ... Plates; microtiter, 96-well, polystyrene, tissue culture . Pyrogen-free saline (PFS) . ...

RoC Profile: 4-Dimethylaminoazobenzene; 15th RoC 2021 183KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylaminoazobenzene.pdf

... Use 4-Dimethylaminoazobenzene is an industrial chemical that has been used to color polishes and other wax products, polystyrene, gasoline, and soap. It has been used as a pH ...

RoC Profile: Tris(2,3-dibromopropyl) Phosphate; 15th RoC 2021 132KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tris_dibromopropyl_phosphate.pdf

... insulation, furniture, and automobile and aircraft interior parts, as well as in polystyrene foam, acrylic carpets and sheets, water flotation devices, polyvinyl and phenolic ...

RoC Profile: Styrene-7,8-oxide; 15th RoC 2021 144KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styreneoxide.pdf

... base resins and 16 samples of polystyrene articles. Con- centrations of styrene oxide in typical polystyrene materials were low, ranging from undetectable (< 0.5 mg/kg) to 3 mg/kg. ...

RoC Profile: Styrene; 15th RoC 2021 252KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styrene.pdf

... in the synthesis and manufacture of polystyrene and hundreds of different copoly- mers, ... be grouped into six major categories: polystyrene (50%), styrene-butadiene rub- ber ...

RoC Profile: Thioacetamide; 15th RoC 2021 124KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/thioacetamide.pdf

... Research on Cancer. pp. 77-83. Jin Y, Zhu YH, Yang XL, Jiang HB, Li CZ. 2006. In situ synthesis of sulfide-coated polystyrene composites for the fabrication of photonic crystals. ...

Nomination Background: Decabromodiphenyl ether (CASRN: 1163-19... 246KB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/cpscfrsnomination_supp_062_508.pdf

... in FR-treated high-impact polystyrene sleepwear, and home furnishings (Birnbaum & Staskal 2004; (HIPS), electronic equipment, automobile interiors, infant FRCA 1998; WHO 1997). ...

TR-185: Styrene (CASRN100-42-5) 3.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr185.pdf

... Styrene is used in the manufacture of high impact or rubber- modified polystyrene (32.9 percent of total U.S. styrene use), polystyrene (25.9 percent), styrene-butadiene rubber ...

Styrene Expert Panel Report Part A; RoC; July 21-22, 2008 756KB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/styrene_panelreportparta_508.pdf

... scientific literature assessing the estrogenicity of polystyrene and related compounds. ... It has been hypothesized that polystyrene or styrene metabolites can mimic a physiological ...

Evaluating the technical quality of a triculture gut model to... 3.7MB

https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wk02_Petersen_GutModels2023_508.pdf

... We tested fluorescence and non-fluorescence polystyrene particles (NF PS and F PS) as well as different concentrations of CdSO 4 (values are µM) using TEER and the MTS assay ...

TR-202: a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and... 4.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr202.pdf

... in clear 19" x 10-1/2" x 8" polystyrene cages (Maryland Plastics, Federalsburg, Maryland). Each cage was fitted with a special tight-fitting polystyrene lid adapted to hold two ...

RoC Background Document: Ethyl Acrylate; Dec. 2-3, 1998 834KB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/ethylacryl_noapps_508.pdf

... 1986). 2.4 Occupational exposure In a polystyrene production plant, airborne EA ... of workers exposure to low levels of airborne monomers in a polystyrene production plant. ...

NeuwirthComment 128KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2015/june/presentations/neuwirth20151112_508.pdf

... IM, Bouwmeester H. Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats. Journal of Nanoparticle Research 2015; ...

TR-076: Tris (2,3-Dibromopropyl) Phosphate (CASRN 126-72-7) 4.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr076.pdf

... In addition to its use by the textile industry, TBP is also a fire retardant additive for polystyrene and polyurethane foams, "* The CAS registry number is 126-72-7. 1 polyvinyl ...

TR-170: a Solution of -Nitrostyrene and Styrene (CASRN 102-96... 4.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr170.pdf

... as a chain stopper in styrene type poly- merization reactions for the production of polystyrene plastics, synthetic rubber, and resins (Hawley, 1971). p-Nitrostyrene also possesses ...

ICCVAM Test Method Evaluation Report: Five In Vitro Pyrogenicity... 7.4MB

https://ntp.niehs.nih.gov/iccvam/docs/pyrogen/tmer/pyrotmer2008.pdf

... polystyrene (15 and 50 mL) . Combitips; repeating pipetter (1.0 and 2.5 mL) . Needle set; multifly, pyrogen-free, 19 mm, 21 gauge . Plates; microtiter, 96-well, polystyrene, ...

Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf

... SO was found in 9 base resins and 16 samples of polystyrene articles that come into contact with food. Concentrations of SO in typical polystyrene materials were low, ranging from ...

TR-198: a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and... 7.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr198.pdf

... Rats were housed 3 per cage and mice 10 per cage in polystyrene cages (Maryland Plastics, Federalsburg, Md.) covered with a special tight-fitting polystyrene lid adapted to hold two ...

ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

... Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs; or Corning/... Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs or Corning/...

RR-12: Synthetic Turf/Recycled Tire Crumb Rubber: Characterization... 761KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr12_508.pdf

... Crumb rubber pellets (100 mg/mL) were incubated in cell type-specific culture medium (10 mL) in 15-mL polystyrene conical tubes for 3 hours or 1, 4, or 7 days at ambient, 37°C, or ...

TOX-85: Toxicity Study of Tetrabromobisphenol A-bis(2,3-dibromopropyl... 2.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox085_508.pdf

... It was considered by the EPA for an alternative to the flame retardant hexabromocyclododecane (CASRNs 25637-99-4 and 3194-55-6) in expanded and extruded polystyrene foam insulation ...

TR-222: Disperse Yellow 3 (CASRN 2832-40-8) in F344 Rats and... 6.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr222.pdf

... is a monoazo dye, of low aqueous solubility, used to color nylon, polyvinyl chloride and acrylic fibers, wools and furs, cellulose acetate, polystyrene, and other thermoplastics. ...

TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB

https://ntp.niehs.nih.gov/go/tr209

... Rats were housed 3 per cage and mice 10 per cage in polystyrene cages (Table 1) covered with a special tight-fitting polystyrene lid adapted to hold two metal filter housings and a ...

TOX-14: p-Chloro-a,a,a-Trifluorotoluene (CASRN 98-56-6) 2.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox014.pdf

... Rats were housed 3 per cage, and mice 5 per cage, on hardwood chip bedding in polystyrene ... The animals were housed in polystyrene cages in a room maintained at 22 ± 2 ° C and 50 ...

TR-314: Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and... 11.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr314.pdf

... Residual methyl methacrylate has been detected in commercial polystyrene plastics at a ... of the re- sidual monomer content in some polystyrene plastics by gas chromatography. ...

RoC References: Antimony and Other Antimony Compounds; Aug. 17... 830KB

https://ntp.niehs.nih.gov/ntp/roc/references/antimonyreferences_508.pdf

... high impact polystyrene (HIPS-Br) for bromine and bromine-free plastic recovery. ... studies of the decomposition of flame retardant containing high-impact polystyrene. ...

TR-573: Styrene-acrylonitrile trimer in F344/N Rats (Perinatal... 5.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr573_508.pdf

... polymers, i.e., polystyrene fragments contain styrene units as dimers, trimers, etc. ... Nucleic Acids Res. 35, 7485-7496. Huff, J.E. (1984). Styrene, styrene oxide, polystyrene, ...

TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr201.pdf

... Fluorescent lighting was provided 12 hours each day. Mice were housed 10 per cage in clear polystyrene cages (Table 1) covered with a special tight-fitting polystyrene lid adapted ...

Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

... that disposable 55-mm polystyrene Petri dishes should be used if a substantial amount of the test substance binds to glass, but not to polystyrene, or when metabolic ...

ICCVAM Recommended Protocol: BALB/c 3T3 Neutral Red Uptake Assay 424KB

https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invidocs/phiiiprot/3t3phiii.pdf

... solutions into labeled, sterile reservoirs (e.g., Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs; or Corning/Transtar model 4878 disposable reservoir ...

ICCVAM Recommended Protocol: NHK Neutral Red Uptake Assay 413KB

https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invidocs/phiiiprot/nhkphiii.pdf

... solutions into labeled, sterile reservoirs (e.g., Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs or Corning/Transtar model 4878 disposable reservoir liners, ...

Minutes: BSC; Feb. 24, 2009 209KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/february/minutes022409.pdf

... Styrene is used worldwide in the production of polymers for rubber reinforced plastics and polystyrene food containers. The 2006 U.S. production was 11.4 billion pounds. ...

TR-309: Decabromodiphenyl Oxide (CASRN 1163-19-5) In F344/N Rats... 17.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr309.pdf

... Decabromodiphenyl oxide is used as a flame re- tardant primarily in high-impact polystyrene but is also used in adhesives, epoxy resins, syn- thetic fibers, and plastics such ...

TR-534: Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and... 10.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr534.pdf

... PRODUCTION, USE, AND HUMAN EXPOSURE Divinylbenzene is a specialty monomer used primarily to make cross-linked polystyrene resins (Kirk-Othmer, 1983). Divinylbenzene monomer is ...

TR-543: alpha-Methylstyrene (CASRN 98-83-9) in F344/N Rats and... 8.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr543.pdf

... There is no specific information available on consumer exposure. However, "-methylstyrene is reportedly an outgassing product of polystyrene insulation materials (Halacy, 1983). ...

BALB/c 3T3 NRU Cytotoxicity Test Method: ICCVAM Recommended Protocol 345KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/ivcyto-balbc.pdf

... solutions into labeled, sterile reservoirs (e.g., Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs; or Corning/Transtar model 4878 disposable reservoir ...

NHK 3T3 NRU Cytotoxicity Test Method: ICCVAM Recommended Protocol 378KB

https://ntp.niehs.nih.gov/iccvam/docs/protocols/ivcyto-nhk.pdf

... solutions into labeled, sterile reservoirs (e.g., Corning/Costar model 4870 sterile polystyrene 50 mL reagent reservoirs; or Corning/Transtar model 4878 disposable reservoir ...

Minutes: BSC; April 17, 1996 335KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/april/19960417_bsc_508.pdf

.../paint mist dust, phenol-formaldehyde resin dust, polyester-polystyrene dust, synthetic polymer process emissions, thermoplastic pyrolysis products, welding fumes, and wood dust. ...

Public Comment: Ethylbenzene; Jack Snyder; RoC; Jan. 19, 2012 288KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/snyder20120228.pdf

... Toxicol. 33:591--- 653. Nicholson, W.J., Selikoff, I.J., and Seidman, H. (1978). Mortality experience of sytrene--- polystyrene polymerization workers. Scand. J. Work Environ. ...

RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf

... Methyl methacrylate and polymethyl methacrylate ...... 187 Propylene and polypropylene ...... 213 Styrene, polystyrene and ...

OECD Guidance Document 129: Using Cytotoxicity Tests to Estimate... 1.4MB

https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd129.pdf

... as follows: a) Weigh the test substance into a glass tube (glass is preferred but polystyrene may be acceptable) and add routine culture medium to obtain a concentration of 200 ...