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RoC Profile: Heterocyclic Amines (Selected); 15th RoC 2021 184KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/heterocyclicamines.pdf
. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) was first listed in the Eleventh ... (2004). . 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) was first listed in the Tenth ...
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Minutes: BSC RoC; Nov. 11, 2008 624KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/roc_minutes20021120.pdf
2-Amino-3,4-dimethylamidazo{4,5-f}quinoline (MeIQ); 2-Amino-3,8-dimethylimidazo{4,5-... Selected Heterocyclic Amines (HCAs): 2-Amino-3,4-dimethylamidazo{4,5-f}quinoline (MeIQ) ; ...
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Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf
... 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8- ... Another HCA, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was reviewed by the National ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
2-amino-3,4-dimethylimidazo[4,5-f]quinoline see Heterocyclic Amines (Selected) ... 2-amino-3-methyl-3H-imidazo(4,5-f)quinoline see Heterocyclic Amines (Selected), ...
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TR-456: 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7... 17.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr456.pdf
... It was selected for evaluation because it is a derivative of quinoline, a known rodent ...,4-trimethylquinoline for 13 weeks. . . quinoline by dermal application in acetone for 2 ...
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TOX-8: D&C Yellow No. 11 (CASRN 8003-22-3) 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox008.pdf
... SL; Oil Yellow SIS; Petrol Yellow C; Quinolin Yellow A Spirit Soluble; Quinoline Yellow Base; Quinoline Yellow Spirit Soluble; Quinoline Yellow SS; Solvent Yellow 33; Waxoline ...
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Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf
... to form 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino- 3-methylimidazo[4,5-f]... imidazo[4,5-f]quinoline and 2-nitrosoamino-3,8-dimethylimidazo- [4,5-f]quinoxaline. ...
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Agenda: BSC RoC; Nov. 19-20, 2002 50KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2002/nov2002rocagenda.pdf
Listing in the 11th Report (three nominations)\ 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) (77094-11-2) 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) ...
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TR-463: D&C Yellow No. 11 (CASRN 8003-22-3) in F344 Rats (Feed... 12.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr463.pdf
... Yellow 33, Nitro Fast Yellow SL, Oil Yellow SIS, Petrol Yellow C, Quinoline Yellow A Spirit Soluble, Quinoline Yellow Base, Quinoline Yellow Spirit Soluble, Quinoline Yellow SS, ...
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Abstract for TR-456 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr456
It was selected for evaluation because it is a derivative of quinoline, a known rodent carcinogen, and was regarded as having potential carcinogenic activity. Because of the ...
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Completed RoC Evaluations 119KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc
Request Archived Materials 2-Amino-3,4-dimethylimidazo[4-5-f]quinoline (MeIQ) Reasonably ... Background Document Request Archived Materials 2-Amino-3-methylimidazo[4,5-f]quinoline ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... 2-Amino-3,4-dimethylimidazo[4,5-f] quinoline (see Heterocyclic Amines [Selected]) ... 2-Amino-3-methylimidazo[4,5-f]quinoline (see Heterocyclic Amines [Selected]) ...
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TR-276: 8-Hydroxyquinoline (CASRN 148-24-3) in F344/N Rats and... 8.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr276.pdf
... unknown) fed 100-250mg/kg 8-hydroxy- quinoline for 30-40days (Galea and Popa, 1972). ... Neurotoxic effects of halogenated 8-hydroxy- quinoline (5-chloro-7-iodo-8-hydroxyquinoline...
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RoC Profile: Nitrobenzene; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrobenzene.pdf
... Most nitrobenzene (97%) is used in the manufacture of aniline (IARC 1996, HSDB 2009). Miscellaneous uses include the manufacture of benzidine, quinoline, azobenzene, pyroxylin ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... 2-amino-3,4-dimethylimidazo[4,5-f]quinoline see Heterocyclic Amines (Selected) ... 2-amino-3-methyl-3H-imidazo(4,5-f)quinoline see Heterocyclic Amines (Selected), ...
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Comment: Meat-related exposures; Claire Kruger, Spherix Consulting... 87KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/kruger20161010.pdf
... ML, Chang WC, Zenser TV. Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3- methylimidazo[4,5-f]quinoline. ...
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RoC Background Document for Nitrobenzene; Sept. 19, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nbpub_no_appendices_508.pdf
... of compounds including benzidine and quinoline, in the production of isocyanates, ... Nitrobenzene also is used in the manufacture of benzidine, quinoline, azobenzene, and ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... (2-amino-3-methylimidazo-[4,5-f]quinoline [IQ]) see Heterocyclic Amines (Selected) 77094-11-2 (2-amino-3,4-dimethylimidazo[4,5-f]quinoline [MeIQ]) see Heterocyclic Amines ...
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... Aromatic Compounds Benzene Fluoranthene Benzo[a]pyrene o-Toluidine 2-Napthylamine Quinoline 400-500 µg 1.3 µg 0.2 µg 3.0 µg 0.06 µg 18 µg 50 µg 0.27 µg 0.04 µg 0.16 µg ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... 1 Terpene 1 Pyrimidine 3 Triazine 1 Quinoline 1 Triazole 1 Resorcylic acid lactone 1 ... Apomorphine 58-00-4 Heterocycle; Quinoline Pharmaceutical Atrazine 1912-24-9 ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... Three heterocyclic amines 2-Amino--methyl-6-phenylimidazo[4,5-b] pyridine (PhIP), 2- Amino-3,4-dimethylimidazo[4,5-f] quinoline (MeIQ), and 2-Amino-3,8- dimethylimidazo[4,5-f] ...
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National Toxicology Program, Board of Scientific Counselors 106KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2001/may/2001052501bscsummmins_508.pdf
... The initial list of nominations for the 11 th Edition of the RoC includes the following: 1-Amino- 2,4-dibromoanthraquinone, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), ...
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TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf
... benzo[a] pyrene, 2-amino-3-methylimidazo[4,5-f]quinoline, and tobacco smoke 66-71 . ... of 2- amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: ...
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TR-565: Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats... 7.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr565.pdf
... induced in human sperm exposed in vitro to the known food mutagens 3-amino-1-methyl-5H-pyrido [4,3-b] indole and 2-amino-3-methylimidazo [4,5-f] quinoline (Anderson et al., 1997). ...
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TR-143: 1,5-Naphthalenediamine (CASRN 2243-62-1) 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr143.pdf
... International Statistical Institute Review 39:148-169, 1971. Hall, C.M., "Pharmaceutical Compositions Containing 1,4,7,10-Tetra- hydro-1,7-dioxoquino-8,7-h quinoline-3,9-dicarboxyl...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... nitro-5-[3-(trifluoromethyl)- phenoxy]quinoline - 189746-15-4 408.34 6.09 Solid ... trifluoromethylphenoxy) quinoline - 106635-87-4 593.61 8.70 Solid ...
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TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf
... Cryobiology 11:160- 169. 10. Ashwood-Smith, M.J.; Towers, G.H.N.; Abramowski, Z.; Poulton, G.A.; Liu, M. (1982) PhotDbiological studies with dictamnine, a furo- quinoline alkaloid. ...
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TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf
... Here I described the outline of our experimental procedures and results of the chemical transformation. CHEMICALS 4-nitorquinoline-1-oxide (UNQO) and 4-amino-quinoline- 1-oxide ...
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RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/naphthalenepub_508.pdf
... LaVoie, E.J., S. Dolan, P. Little, C.X. Wang, S. Sugie, and A. Rivenson. 1988. Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats. ...
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Background Document: RoC: Captafol; 2010 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf
... Yamamoto A, Cui L, Ogiso T, Ito N, Shirai T. 1996. Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline- induction of hepatic hemangioendothelial sarcomas. ...
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TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats... 16.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr470.pdf
... Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. JNCI 76, 283-289. McFee, A.F. (1989). Genotoxic potency of three quinoline compounds evaluated ...
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TR-553: Photococarcinogenesis Study of Aloe Vera[CASRN 481-72... 6.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr553.pdf
... T. (1990). Formation of a nitro derivative of 2-amino-3,4- dimethylimidazo[4,5-f]quinoline by photo-irradiation. Carcinogenesis 11, 869-871. Hunter, D., and Frumkin, A. (1991). ...
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TR-601: Di(2-ethylhexyl) Phthalate Administered in Feed to Sprague... 4.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr601_508.pdf
... analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2- ethylhexyl)phthalate. ...
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Draft TR-601: Di(2-ethylhexyl) Phthalate (CASRN 117-81-7) Administered... 3.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr601_508.pdf
... of liver DNA in gpt delta transgenic rats treated with the 36 hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2- 37 ethylhexyl)phthalate. ...
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ICCVAM Test Method Evaluation Report on the Applicability Domain... 16.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ad/tmer-revmay2012.pdf
... fluorophenoxy)quinoline 124495-18-7 308.14 5.69 Liquid Heterocyclic Compounds Quinoxyfen / 5,7-dichloro-4-(4- fluorophenoxy)quinoline/ 124495-18-7 308.14 5.69 ...
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DART-08: Modified One-Generation Study of Bisphenol AF (CASRN... 5.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/dart/dart08_508.pdf
... (dimethyl sulfoxide). b The positive controls in the absence of metabolic activation were 2-nitrofluorene (TA98), sodium azide (TA100), and 4-nitro- quinoline-N-oxide (E. coli). ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... Intermediate in chemical synthesis Quinoxyfen SC 5,7-dichloro-4-(4- fluorophenoxy) quinoline 124495-18-7 308.10 5.69 Liquid NA Formulations; Heterocyclic compounds Herbicide ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
... ammonium salt of fluorinated alkylaryl amide. 721.9080 Nitro methyl quinoline. 721.9100 Substituted quinoline. 721.9220 Reaction products of secondary alkyl amines with a ...